Ep. 109: “Phagocyte Cell Biology” Featuring Dr. Johnathan Canton

Guest:

Dr. Johnathan Canton is an Assistant Professor at the University of Calgary, where his lab uses advanced microscopy techniques to study dendritic cells, macrophages, and innate immunity. He talks about his career journey from studying tropical parasites to investigating phagocytes. He also discusses using advanced microscopy techniques, studying the mechanisms of dendritic cell cross-presentation, and running a farm in Belize. (35:55)

Featured Products and Resources:

• Check out the program for IUIS 2025!
• The STEMdiff Monocyte Kit generates millions of monocytes that are ready for downstream assays, or further development into macrophages or dendritic cells.

The Immunology Round Up

Armored CAR T Cells – A CRISPR knock-in strategy can engineer CAR T cells that secrete proinflammatory cytokines directly within a tumor without causing toxicity. (2:15)

Immune Invasion in Lung Cancer – Organoid immune co-cultures enable identifying immune evasion at subclonal resolution. (7:55)

Chromatin Remodeling in Chronic Inflammation – Researchers identified a mechanism that separates the chronic and acute inflammation responses. (19:00)

Reversing CD8⁺ T Cell Dysfunction – Scientists identified IL-27 as a tractable immunotherapeutic target in chronic hepatitis B virus infection. (25:40)

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