The Generalist

Mario Gabriele•thegeneralist.substack.com

“The future is already here. It’s just not evenly distributed.” The Generalist Podcast brings you weekly conversations with the people who live in these pockets of the future – visionary founders, prescient investors, and original thinkers. Each episode is designed to introduce you to new ideas, technologies, and markets and help you prepare for the world of tomorrow.

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Episodes

The Substack Playbook: Inside The $650M Platform Rewriting Media, Trust, and Creator Economics | Chris Best & Hamish McKenzie (Co-Founders)

In a world where attention is fragmented and algorithms rule the content landscape, Chris Best and Hamish McKenzie are taking a radically different approach with Substack. Rather than chasing clicks, Substack focuses on a simple yet powerful idea: creators should own their work and make money directly from their audience through paid subscriptions. With over 5 million paid subscriptions and tens of millions of active readers, Substack has turned this model into a transformative force in media. I...

May 06, 2025•1 hr 26 min

Lessons from 20 Years of Venture Capital: Roelof Botha (Managing Partner and Steward at Sequoia Capital)

In this episode, Roelof Botha shares lessons from his 20 years in venture capital at Sequoia, discussing how to anticipate the future, assess opportunities, and avoid irrational exuberance. The conversation covers psychological biases, the importance of long-term thinking, Sequoia's culture, and the firm's approach to investing in companies from idea to IPO and beyond. Botha also touches on AI's impact, the US's position in the AI race, and the need for fiscal discipline.

Apr 29, 2025•1 hr 21 min

Shrinking the Gap Between Sci-Fi and Sci-Fact: Josh Wolfe (Co-Founder of Lux Capital)

Josh Wolfe is a co-founder of Lux Capital, where he funds the kinds of ventures that change everything: think gene-edited pig organs and technology that lets you “record” smells. His approach? Relentless curiosity. He reads dozens of newspapers daily to identify patterns, always staying a few steps ahead. In this episode of The Generalist, Josh shares how his firm backs companies that don’t just predict the future, but create it. In our conversation, we explore: • The revolutionary development o...

Apr 15, 2025•1 hr 27 min

How AI Will Enhance Human Potential, Not Replace It: Reid Hoffman

Science fiction has long warned of AI's dark side. Think: Robots turning against us, surveillance, and lost agency. But in this episode of The Generalist, Reid Hoffman, co-founder of LinkedIn and AI pioneer, shares a more hopeful future. His book Superagency argues for AI optimism, grounded in real-world experience. We talk about how AI can fuel creativity and how to ensure technology works for us, not the other way around. We explore: • Why Reid wrote Superagency —and his belief that AI lea...

Apr 08, 2025•1 hr 15 min

Introducing The Generalist Podcast

Welcome to The Generalist – a podcast about the future brought to you by Mario Gabriele. This isn’t your typical innovation podcast. Each week, we go beyond the headlines and into the minds of the founders, investors, and thinkers who are building tomorrow’s world. From AI to space exploration, nuclear fusion to new media, stablecoins to semiconductors, these are the people living in the future today. In just 60 minutes each episode, we’ll dive into the ideas, technologies, and strategies that a...

Mar 31, 2025•2 min

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