Episode description

Professor Stephen Quake's research has helped countless patients avoid the pain and suffering that can come with invasive diagnostic testing. Russ and Stephen discuss his work to develop a number of noninvasive blood tests to help detect preterm births, genetic disorders like Down Syndrome, cancer, and organ transplant rejection. It’s an episode that reminds us of the power of good science. We hope you’ll take another listen and enjoy.

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Chapters:

(00:00:00) Introduction

Host Russ Altman introduces the episode featuring Dr. Stephen Quake, highlighting his contributions to non-invasive blood tests. 

(00:00:46) Understanding DNA in Diagnostics

Introduction to the revelation of detecting DNA in the bloodstream, shedding light on various bodily processes.

(00:02:24) The Beginning of Dr. Quake’s work with Cell Free DNA

Dr. Quake tells the story of his journey into research with cell free DNA beginning with searching for a less risky alternative to an amniocentesis

(00:05:11) Impact on Prenatal Testing

The transformation in prenatal diagnostics, replacing invasive tests  & understanding the detection capabilities for prenatal genetic disorders like using cell-free DNA.

(00:06:39) Transplant Rejection Monitoring

The discovery of cell free DNA & it’s use in heart & lung transplant patients detecting early rejection & the real-life implications of this technology.

(00:10:35) Unveiling Infectious Agents

The detection of infectious agents in blood & the real life applications of this discovery

(00:14:52) Advances in Cancer Detection

Discussion shifts to cancer detection using cell-free DNA, emphasizing the important application of monitoring cancer progression and treatment efficacy. 

(00:17:18) Predicting Preterm Birth

Dr. Quake delves into the groundbreaking research predicting preterm births using cell-free RNA and DNA, sharing insights into discoveries indicating preterm birth risks and gestational age predictions and the significance of this.

(00:21:42) The Chan Zuckerberg Biohub's Mission

The origins and bold mission of Steve Quake’s current work at the Chan Zuckerberg Biohub, to cure, treat, or prevent all human diseases by the end of the century and the feasibility of such an ambitious goal. 

(00:24:03) Biohub's Research Strategy

Biohub's strategy focusing on cell biology and infectious diseases internally, while funding nearly a hundred faculty across diverse areas in Bay Area Universities.

(00:26:26) Conclusion 

Connect With Us:

Episode Transcripts >>> The Future of Everything Website

Connect with Russ >>> Threads / Bluesky / Mastodon

Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook