Welcome to the 28th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . This episode features a discussion with three authors of the Brain article entitled: The relationship between kidney health and neurodegenerative diseases Ms Melody Zuo , Dr Le Chang and Professor Sarah A Gagliano Taliun grace the Brain podcast with an insightful discussion into their recent review examining the connection between kidney disease and neurogeneration. They descr...
Jun 25, 2025•37 min
Welcome to the 27th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . This episode features a discussion with first author Dr Lucia M Li of the Brain article entitled: High-dimensional proteomic analysis for pathophysiological classification of traumatic brain injury Listen to the fascinating insights into classifying traumatic brain injury (TBI) using high dimensional proteomic analysis. TBI may start with a head injury but evidence suggests th...
May 14, 2025•25 min
Welcome to the 26th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . This episode features a discussion with first author Dr Marios Kritsilis and senior author Associate Professor Iben Lundgaard of the Brain article entitled: Loss of glymphatic homeostasis in heart failure This academic duo from Lund University discuss their fascinating findings exploring glymphatic homeostasis in a mouse model of heart failure. Counter-intuitively, there may b...
Apr 16, 2025•33 min
Welcome to the 25th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . This episode features a discussion with senior author Dr Tanya Stojkovic of the Brain article entitled: Congenital myasthenic syndromes in adults: clinical features, diagnosis and long-term prognosis Dr Stojkovic discusses findings from an impressive longitudinal adult cohort of congenital myasthenia syndrome and important issues around accurate diagnosis of congenital myasthe...
Feb 27, 2025•22 min
Welcome to the first episode of 2025 for The Brain Podcast - the official podcast of the journals Brain and Brain Communications . This episode features a discussion with senior author Dr Frank Porreca of the Brain article entitled: Nociceptors are functionally male or female: from mouse to monkey to man? Dr Porreca discusses important findings into the sexual dimorphic nature of nociception and how it could and indeed should affect clinical trial participant design, precision medicine and need ...
Jan 22, 2025•38 min
Welcome to the 23nd episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . In this episode, we bring on authors Dr Helen Devine and Professor Simon Mead to discuss their opinion article entitled: Academic neurology in the UK: a plea to turn away from the precipice. The discussions covers the growing concerns regarding the future of academic neurology in the UK and potential solutions. They discuss the parallels seen around the world as this is a grow...
Dec 11, 2024•29 min
Welcome to the 22nd episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . This episode features a discussion with senior author Dr Torsten Baldeweg of the Brain article entitled: Long-term neuropsychological trajectories in children with epilepsy: does surgery halt decline? Dr Baldeweg discusses fascinating insight into the long term cognitive outcomes from an impressively large cohort of 500 children who had undergone epilepsy surgery and neuropsyc...
Oct 16, 2024•28 min
Welcome to the 21th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . This episode features a discussion with the first author Dr Selina Yogeshwar of the Brain article entitled: HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease Dr Yogeshwar offers exciting insight into the genetic mechanisms of a relatively recently discovered disease anti-IgLON5. She also discusses foundational information into how neuroimmunology, ne...
Aug 14, 2024•34 min
Welcome to the 20th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . This episode features a discussion with the final author Dr Jun Li of the Brain article entitled: PAK2 is necessary for myelination in the peripheral nervous system How are peripheral nerve cells myelinated and what proteins are invoved? Is there a difference between PAK1 and PAK2? Listen for this and more in this exciting episode. Check out the full article on the Brain websi...
Jun 20, 2024•26 min
Welcome to the 18th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . This episode features a discussion with first author author Dr Stefanie Grabrucker of the Brain article entitled: Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis How does lifestyle and the environment affect cognition in Alzheimer's disease via the gut and what can we do about it? Listen for this and more in this exciting episode....
May 15, 2024•29 min
Welcome to the 17th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . This episode features a discussion with senior author Dr Bénédicte Ballanger of the Brain article entitled: Noradrenergic alterations in Parkinson’s disease: a combined 11C-yohimbine PET/neuromelanin MRI study Can this multi-modal study examining the role of Noradrenaline in Parkinson's disease offer insight into important neurotrasmitter pathophysiology and provide the basis ...
Apr 03, 2024•23 min
Welcome to the 16th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . We are very excited to feature a January issue Brain article, where we speak with senior author Dr Lasse M Giil entitled: Impaired glucose utilization in the brain of patients with delirium following hip fracture Delirium is a common condition with significant impact on patient outcome. This episode discussed potential intrinsic brain mechanisms that may underly delirium. The ...
Feb 14, 2024•16 min
Welcome to the 15th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . We are very excited to feature our first article from Brain Communications, where we speak with first author Dr Kiel Telesford of the article entitled: Neuron-binding antibody responses are associated with Black ethnicity in multiple sclerosis during natalizumab treatment This episode discussed racial differences in antibody response to natalizumab treatment for individuals of...
Nov 15, 2023•20 min
Welcome to the 14th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . In this episode we speak with Fu-Chin Liu, senior author of the article entitled: Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons. This article explores a potential genetic basis for disordered speech by a mutation in the transcription factor FOXP2. This was discovered in KE family members with speech disturbances was a landmark example of...
Oct 11, 2023•20 min
Welcome to the 13th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . In this episode we speak with Josef Parvizi, senior author of the article entitled: Multisite thalamic recordings to characterize seizure propagation in the human brain This article explores the role of the thalamus in seizure propagation and how multi-site intracranial electrode recordings identify new and unexpected findings regarding which thalamic nuclei may have the earli...
Sep 13, 2023•28 min
Welcome to the 12th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . In this episode we speak with Nico Melzer, senior author of the article entitled: A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies This article explores expanding entity of GAD-65 associated neurological syndromes, the exciting role of T-cells and potential therapeutic avenues that these findings may bring. Check out the full ...
Aug 14, 2023•16 min
Welcome to the 11th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . In this episode we speak with Ted Price, senior author of the article entitled: RNA profiling of human dorsal root ganglia (DRG) reveals sex differences in mechanisms promoting neuropathic pain This article explores exciting findings around differences in the DRG transcriptome which were only apparent when stratifying participants by sex and how these differences may inform me...
Jul 05, 2023•27 min
Welcome to the 11th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . In this episode we speak with Philip Insel, lead author of the article entitled: Tau positron emission tomography in preclinical Alzheimer’s disease The article explores the utility of tau PET imaging in three independent, large cohorts of cognitively normal individuals with high levels of amyloid (on PET imaging). We discuss specific areas of the brain with high tau concentra...
Mar 23, 2023•20 min•Ep. 11
Welcome to the 10th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . In this episode we speak with Hideaki Nishihara and Britta Engelhardt, lead authors of the article entitled: Intrinsic blood–brain barrier dysfunction contributes to multiple sclerosis pathogenesis This was a transcontinental recording with our guests dialing in from Japan and Europe. The article explores blood-brain barrier dysfunction as a pathogenic process of multiple scle...
Feb 23, 2023•29 min
Welcome to the 9th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . In this episode we chat with Professor Robyn S. Klein, senior author of the article entitled: COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis This article explores the ongoing challenge to better understand the mechanisms underlying the cognitive and neuropsychiatric sequlae of the Sars-CoV2 infection. We discuss the use of both animal model experi...
Feb 02, 2023•25 min
Welcome to another episode of The Brain Podcast (first for 2023!) - the official podcast for the journal Brain and sister journal Brain Communications . In this episode, three guests joined us to discuss the article entitled: Gene variant effects across sodium channelopathies predict function and guide precision therapy. Professor Andreas Brunklaus (first author) and Professor Stephanie Schorge (senior author) discuss their fascinating data-driven approach to better understand how mutations in s...
Jan 04, 2023•32 min
Welcome to the seventh episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications . In this episode we chat with Dr Nina M Rzechorzek , lead author of the article entitled: A daily temperature rhythm in the human brain predicts survival after brain injury We discuss how brain temperature was measured using invasive and non-invasive methods to identify a physiological daily rhythmicity. The loss of this brain rhythm was strongly predictive of survival in pa...
Dec 15, 2022•33 min
Welcome to The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications. In this episode we are joined by Professor Soon-Tae Lee to discuss his review article entitled Seronegative autoimmune encephalitis: clinical characteristics and factors associated with outcomes. Read the full article on the Brain website: https://doi.org/10.1093/brain/awac166 Maarten Titulaer and Robin van Steenhoven wrote an excellent commentary on the article https://doi.org/10.1...
Nov 24, 2022•25 min•Season 1Ep. 6
Welcome to The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications. In this episode we are joined by Associate Professor Pavan Bhargava to discuss his review article entitled The contribution of B cells to the cortical damage in multiple sclerosis. Read the full article on the Brain website: https://doi.org/10.1093/brain/awac233 This episode was hosted, edited and produced by Xin You Tai; co-hosted by Sarosh Irani; co-produced by Joanne Bell; origin...
Nov 21, 2022•22 min•Season 1Ep. 5
Welcome to The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications . In this episode we chat with Dr Georgia Melli, senior author of the article entitled: Tau protein quantification in skin biopsies differentiates tauopathies from alpha-synucleinopathies She discusses the use of skin biopsy to quantify pathological tau protein as an accessible and useful clinical tool in the diagnosis of neurodegenerative diseases. Check out the full article on the ...
Nov 15, 2022•18 min
Welcome to the third episode of The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications. In this episode we chat with Dr Kristiana Xhima and Professor Isabelle Aubert, lead and senior authors, respectively, of the article entitled: Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies. They discuss the exciting use of MRI-guided focussed ultrasound to improve blood-brain barrier penetration of a novel Alzh...
Oct 14, 2022•27 min
Welcome to another episode of The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications. We are joined by Professor Marsel Mesulam who will discuss his masterclass in clinico-pathological-neuroimaging analysis of primary progressive aphasias. Check out the full article on the Brain website: https://doi.org/10.1093/brain/awab410 This episode was hosted, edited and produced by Xin You Tai; co-hosted by Sarosh Irani; co-produced by Joanne Bell; original ...
Sep 08, 2022•22 min•Ep. 2
Welcome to the first episode of the Brain podcast- the official podcast for the journal Brain and sister journal Brain Communications. We are joined by Professor Roland Liblau who will tell us about his group's mouse model of narcolepsy in which autoimmune inflammation of orexinergic neurons is induced by influenza vaccination. Check out the full article on the Brain website: https://academic.oup.com/brain/article-abstract/145/6/2018/6581499 This episode was hosted, edited and produced by Xin Yo...
Aug 20, 2022•19 min•Season 1Ep. 1
