If we go back to my case, I've been taking it since I was 14. Why at 400 some guys feel completely fine and some guys can't get out of bed in the morning?
What's the point? A lovely head of hair, no sex drive, there's no point. What's the best type of exercise for proving testosterone levels? You need to take some talk early, but in trying for a baby you can absolutely smash in here,
feel really good. Testosterone is most often talked about in terms of sexual function. So women that... report loss of libido, loss of pleasure from sex, sometimes Testosterone is piggybacked on to HRT.
Welcome to episode 6 of the Best of Both Worlds podcast and part 2 in our series on Testosterone. This is the ultimate in healthcare conversations where we look to discuss,
consider and potentially find the humour in our quest as healthcare practitioners to optimize performance. That is all for today. sports performance, psychological performance, emotional performance and just performance in life in general.
We hope to learn with you, to share with you and create powerful high performance lives. I'm Matt Winter, Doctor of Physical Therapy with Training and Functional Medicine and I'm here with Paul Macaulay, Senior Podiatrist,
otherwise known on TikTok. As the legendary Paul the Podiatrist. Welcome back Dr Neil Forrest, let's begin our conversation . of part two on testosterone.
Let's talk about testosterone therapy, something I know a lot about as I've been taking it since I was 14 years old. So what are your opinions in general? Is it something that you support and what are your indications for it?
Okay, so the support part is easy. Of course I do, I mean you're sitting here right now talking about the fact that you're using it, you're getting better. from it and I prescribe it for patients and so yeah,
I think that's the easy part. How and when you use it is the big question. So there are some cases that are super clear cut,
right? So I don't know if you're going to talk more about your experience but someone that has an endocrine or a genetic. genetic condition that gives them a true testosterone deficiency.
It's kind of a no -brainer, right? You're not going to want to try and restore to physiological levels. I think when it becomes a more nuanced conversation is more in this spectrum of age -related decline in people who don't have a identifiable endocrine reason for it and so then it's a question.
question of who gets it, under what conditions and how. And so I think it has to be very, very individualized for a number of reasons,
partly because the absolute number doesn't always tell you the whole story, and partly because the causes of that person's low number are so multifactorial. So I think the nice way to think about that,
this is is if you think about the stages of testosterone production or triggering in the body. So you've got the hypothalamus in the brain, which secretes a hormone called GNRH,
gonadotropin releasing hormone. That tells the pituitary gland to release LH and FSH, leucinizing and follicle stimulating hormone, which are present in men and women. And then it's those hormones that then have a bearing on that.
cells in the testes in men to produce testosterone. So there's various stages of that that can be impaired and the whole thing's a negative feedback loop.
So testosterone levels are high, that's sensed and the hypothalamus and the pejoratory stop triggering the testes to produce testosterone. Does that make sense so far? So is the problem that your testes just aren't capable of producing as much testosterone as we need or want to have,
or is their production being switched off at higher levels by the pejorative gland? And so, I think the nice way to think about this is to sort of use patient examples or use human examples.
So, you see a guy that is obese, he smokes, drinks. every night, doesn't do any form of exercise, has a super stressful job, he sleeps terrible,
his diet's full of processed food, and you check his testosterone levels only. You might see a low -ish testosterone level and think, "Well, there's your problem. I'll give you some testosterone." But actually,
if you checked his FSH and LH levels, they should be high. You know, if his testosterone level is low, the pituitary... pituitary gland, the brain should be saying, "Where's the testosterone?
Come on, let's produce some more." And they're churning out FSH and LH to try and stimulate the testes. So if that hasn't happened, let's say we check his levels and what I'd expect to see in this guy is low LH and low FSH.
That's because his lifestyle is impairing those things. So he's metabolically unhealthy. His circadian rhythm's off because his sleep is out, his court is all sky -high and so he's not triggering production and he might see more benefit from adjusting his lifestyle and addressing those other issues and then we find his testes are naturally capable of producing all the the testosterone he needs.
So it's so good to outline the physiology of that. I think you know instinctively we might know know that this guy clearly needs to sort out His lifestyle factors.
He's overweight. He's not sleeping and we'll come back to I really want to ask you about Lifestyle or pillars of lifestyle medicine that we can use to increase testosterone naturally but I didn't realize particularly that it was to do with the health of the pituitary gland and Is that what you're suggesting there?
So these factors they directly affect the pituitary gland health and therefore the output Yeah who do they tell us to check testosterone levels in one of those is anyone with obesity or any man with obesity and one is anyone with diabetes so metabolic health is a huge part of this this process and again you know some of this is probably the body doing what it's supposed to do it's prioritizing certain things I've got
a lot of inflammation I've got a lot of stress I'm not saying sleeping. I don't need testosterone right now. So, you know, some of it has very sound physiological basis.
It's sort of adaptive rather than maladaptive, right? Yeah, exactly. The problem with stress is it's supposed to be finite. It's supposed to be short -lived in evolutionary terms.
I mean, so, you know, you're a gazelle grazing on the savannah, lion jumps out the bush. bushes, chases you around for 10 minutes. It either catches you and kills you or you escape and the stress has gone and you just go back to doing what you were doing and plodding along and that's fine.
That's a fight or flight response and the body is well -tuned into that and very optimized to handle that. That's why we have cortisol and adrenaline and the ability to run away from danger.
When... also whether and how to treat or not medically,
you know, that can be a deciding factor. - I guess there are other medical causes there, right, that can enter. - If we like circle back to, when I asked you about testosterone replacement therapy, and you said that you're in support of it,
and if we go back to like my case, I've been taking it since I was 14, I take it every 10 weeks. In the NHS, in the UK, they were like, "You're gonna stick it 10 weeks," and that's it, like no more.
- Yeah. - Probably because of budgets. But I came here to Singapore. the forms of testosterone,
the formulations that are available. So I think what you're talking about is NABEDO. NABEDO is the brand name of an injection of testosterone and decanoate. So it's a form of testosterone that we can give.
It's one of the two forms of testosterone treatment that's commonly available in Singapore, the other one being a gel. It seems, I mean I listened to a lot of podcasts around this topic based in the US,
doesn't seem to be a thing there at all. So in America... you have testosterone gels, but you also have bead implants. You have out and out testosterone injections,
so guys drawing up with a needle and syringe and injecting themselves every day, every other day, twice a week, pick your regimen. That's not so much of a thing here,
and I know it's not so much of a thing in the UK as well. And I'm talking in the medical context. here, not in the illegal sort of performance enhancing procurement, where I'm sure injections that you do yourself are available.
So NABEDO is an injection that would be administered normally by a medical professional, you wouldn't do it to yourself. Actually, the guidelines for NABEDO are 12 weeks. So the standard recommendation is that you have an injection every 12 weeks,
and that that maintains your testosterone level. But it is uneven. So as you mentioned, it can be higher at the beginning and then people feel it turning off. And responses vary. So I wouldn't necessarily stick to 12 weeks.
I would wanna know what your levels are doing and how you feel at those levels. Strictly speaking, there's no medical reason that you can't have it more frequently than that. And I do have guys who have it much less frequently than that.
I actually find that having an injection every six weeks months seems to be good enough for what they want. So that's in in in Singapore and I guess we you know we're here we should talk in a Singapore context.
We've got this NABEDO injection and we've got testosterone gel. The annoying thing about the gel is it comes in sachets so you can't even get the pump which and androgel pump is why you know very widely available in Europe.
I don't know why we can't get them here but right now we can't because it's just a more convenient way to dispense. When I start someone out, I tend to prefer to start them on topical testosterone,
because it's really easy to back out of if you don't like it. You know what I mean? You can start whenever you want. The problem with an injection that lasts 10 weeks or 12 weeks or whatever is once, I've done it to you.
- Yeah, it's there, it's in. - That's it, so if you decide after two weeks you hate it, you feel terrible. Which is unlikely, of course. I hope that I've. given you the injection for the right reasons, but if you do, we're stuck with that decision.
So what I would generally do is start someone off on topical, get them to a level they're happy with, and then if they wanted to continue and they wanted the convenience of an injection,
migrate them over to that over time. That's how I'd approach it. I think as we become more informed as a population group there seems to be a little bit more push for things like health screenings and of course I think that's a very much a double edged sword and we see that a lot here.
Is there a role for screening testosterone levels if so when would you think about starting that and then is there a level that we're looking at that's normal or that defines abnormal?
Okay. Okay. so I don't tend to randomly screen people. So I would test more based on reported symptoms than just wanting to know your level.
So there are some things where I want to know your level without you experiencing anything from it. So I might want to know your cholesterol level or your blood pressure level. And you can't tell me what that is in any way based on how you feel.
Just have to know the number. I don't think testosterone... is like that because you see people with very different levels feeling very different symptoms so actually knowing the number at random isn't that useful.
I'd never deny anyone who wanted to check it so if I'm seeing someone who's in for a screening anyway and we're checking their general blood work they want to do a testosterone level. No problem at all but I'm not gonna go out sort of saying.
randomly, get it checked for no reason. Clearly, for men, it tends to be with age where it starts to be more on their mind,
so it would be far more common for a guy in his 50s to ask me to check his testosterone than in the 20s. But in anyone who is experiencing symptoms at any age, it might be something to think about.
So then is the question. is standardized too so you need to do it in the morning so sometimes a guy will come to see me I won't know why he's coming in we'll have the conversation at four o 'clock in the afternoon and I'll say look sorry we can't do the blood test now you're gonna have to come back tomorrow or at the weekend and we'll do it in the morning so that's that's the the timing part of it it's just a
blood test so the test itself is pretty easy at Oslo we think pretty carefully about where we send our blood tests to big labs in Singapore that process most of the blood tests here for testosterone.
And I actually send mine to a different lab because just from experience of being here a while, for this particular test, that's the lab I've found consistent trustworthy results and reference ranges from.
And generally when we check it on the testosterone front, not talking about FSH and LH and all these other things that we might want to test, but purely from a test. perspective we test free and total testosterone levels.
I guess we should explain what those are. Yeah so free testosterone we've got floating around and then testosterone that's not free is attached to sex binding SHBG sex hormone binding globulin which is like shuttler right we send it around the body and albumin so most of of our testosterone,
most of us 90 something percent is bound to either albumin or SHBG. And it's only the free testosterone that exerts any of the effect of testosterone.
So you have this massive amount and most of it is inactive at any given time. Of course it can be unbound and can go on to exert its effect. Is there any supplement you can take to get less stuff to split off the binders?
Some of the supplements that are purported to increase testosterone levels, if you trust the data, have been shown to boost free testosterone preferentially.
Those other things that we mentioned, Albumin and SHBG, we can check those levels as well so we can see. I mean, that's how the lab are calculating in part of the of the free testosterone calculation.
The other the other thing that not in the lab that I use that but you see sometimes quoted if you might if you're reading around this topic you might see is the free androgen index which is another way of trying to express this idea of how much bioavailable testosterone you might have.
They're all slightly different ways of trying to say the same thing but it's the free testosterone we're most. interested in. So someone might have a very high,
healthy level of total testosterone, but if they're free testosterone on the floor, they could still be experiencing symptoms. From what I understand, the bound testosterone is still useful.
It's just making its way around the body being bound. It's being taken somewhere, potentially. Why would someone then have a very high bound testosterone, but it's not being able to become...
free testosterone? Is there an issue there in a pathway somewhere? So sometimes it can be related to their metabolic health. So again, when we come back to lifestyle on this, there may be some conditions,
particularly things that affect the liver that might affect your albumin levels. So we do see people with alcohol issues have lower testosterone levels, people with fatty liver, but that's,
again, that's bound into metabolism. and pre -diabetes and that sort of thing. So that's elevated albumin. Is that right? Yes, yes, correct. So then causing that testosterone to bind and not be available.
Got it. Yeah, that's the theory. But again, I mean, I think the other thing that we definitely see in day -to -day clinical practice is we know what the numbers are and we've got a sort of reference range,
but that the quoted lab reference range, I think, are as quotes. the lab quotan a very standard reference range but why is it that we see let's let's take within the reference range at a level of 400 so lower lower part of the range but not terrible why at 400 some guys feel completely fine no problem at all no reported symptoms and some guys can't get out of bed in the morning it's just nothing I don't know if
you can relate to this from yeah well if I if I don't don't if I don't have my injection like on time like I'm I'm got bad brain fog can't get my words out can't but do you know what your levels go to within that?
Yeah, yeah, cuz that that might be that might be very different to someone else You know it at the same levels. So what is it that? That we can't measure That that isn't giving us the whole story as you said that all of those symptoms can be multifactorial anyway.
They can. But I think even when we're just talking about testosterone, so one thing that we can't measure very easily is DHT. So one of the end products of testosterone that we haven't talked about,
as well as estrogen, is dihydrotestosterone DHT. Now that is about five times more potent in its stimulation of the androgen receptor than testosterone.
So it's like like testosterone plus plus, much harder to measure outside of a research lab context. It's hard for me to just get DHT levels.
So it may be, your response might differ because you don't convert enough. Yeah. So there's a hormone called, is it 5 -alpha reductase? That's the inhibitors for hellos.
Exactly. Yeah. Exactly. And so their testosterone levels by not that an impressive amount on a blood test.
Some take very high doses and don't notice any impact. So I'm just going to try and summarize this for people listening. So we've got testosterone and then we have the free test,
we can separate that into free testosterone and bound testosterone. Generally what's active is our free testosterone. It can be overly bound potentially because of levels of albumin in the blood which then kind of renders that.
and a lovely head of hair, no sex drive. There's no point, is there? - Well, that's the view that I would take. You have to accept the fact, you know, I pick up a lot of guys when they've already been taking Propecia for a long time and they say they feel fine.
So it's then very hard to argue with, right? They don't have any of the symptoms. But I think, I mean, one of the great challenges with Propecia is never being able to prove the counterfactual.
Yeah, how much hair would you have? And they'll say,
"Oh, well, my dad weren't bald." Or, I don't know. It's hard to know what it would have been like if you hadn't been taking this stuff for five years. - No, I'm not, don't worry, I'm no way doing that.
Absolutely, I'd rather needle my head myself. - Well, you know, it has to be individualized, right? You know, what's important to you, you know, the balance of risk and reward and all the rest of it.
- Looks, yeah, looks. - I don't know where I've got this rep from. - Hey, well, your mom told me it's from your dad. - That's exactly where I got it from. Right, okay. - Okay, so, we're all... I think the big threat,
so your listeners already know what the six lifestyle medicine pillars are. Good. We hope so if they've watched you there. If not, can we block them from listening? So they all have a role to play.
They're all really important. But probably the big three, I would say, from a testosterone perspective would be sleep, sleep, managing stress.
stress, and exercise. So it's not that diet doesn't have a role. I've already mentioned that people with very high alcohol intakes have impaired testosterone. It's not that that's not important,
but these are, you know, when we're talking about testosterone specifically, it's so important. Sleep, because we've already mentioned that this circadian variation in the way it's secreted,
just means that if you stop someone from sleeping, you yna ymgweithio gwybod am y teisio ar y rhywbeth.
Ac rydyn ni 'n amser. Rhyw bai. Mae 'r cyntaf yn gallu cyffredinol, a 'r gynhyrch yn gallu 'r gynhyrch? Rydyn ni 'n byw 'r cyffredinol i 'r cyffredinol… …eg ar y cyffredinol i eich cyffredinol.
Rydyn ni 'n meddwl i 'r cyffredinol i 'r cyffredinol. Rydyn ni 'n meddwl i 'r cyffredinol i 'r cyffredinol, yn ychwanegai 'r cyffredinol,
ond ydych chi 'n gweithio 'n gweithio 'n gweithio 'n gweithio 'n gweithio 'n gweithio. Yeah, absolutely. I know typically what I've advised is strength training and I think there's certainly research showing high intensity training also gives you a huge boost in testosterone but high intensity training is not suitable for everyone and it's often high risk depending on the form of high intensity training you're doing.
So probably the best thing is to start something and do it safely and do it consistently and then I think I'd go with you in a mix of. of, you know, zone two plus strength training is really important.
I mean, this is what we're all aiming for, right? Isn't it? It's our foundation of zone two through the week, which I'm sure you've talked about on previous podcasts, with the shorter duration,
high intensity, and then the strength training on top of that. This is, you know, it's hard to argue that this is the option. a hormonal impact of that.
So they're doing the strength training. So they're doing the best form of training for the testosterone, but it's not working for them. So it's about, you know, adapting and, you know, sort of filling in the gaps.
And I think the best type of exercise for anyone, it's like the best diet for anyone, it's the one that you can stick to consistent, right? You know, you are always gonna say that. 'Cause it's like,
you know, you could go and sort of try and do your three rep max on a bench press. press later on this afternoon. But if you're not willing to do that week in, week out,
then who cares that you did it once and make any difference? - So generally getting in the gym, getting moving, doing exercise is great for us all round and potentially with testosterone as well. Is there's too much of a good thing at any point?
- Yes, absolutely. So I guess this would fall back into a stress category for real. in other sex hormone levels.
And so overtraining is essentially placing an inappropriate stress on the body. It's not giving the body a chance to recover and adapt. And you're gonna see down regulation of not just testosterone,
but various hormones in that setting. So recovery is key. - And that's why it's been redefined as reds rather than the female athlete triad. So it's not just about females.
This is one where we can steal back a bit. bit. Overtraining can affect men's hormones as well. I think we see it a little bit more in endurance training. I've certainly noticed it a little bit in that kind of middle -aged male group that tend to do a lot of endurance work.
There's a big group of cyclists there, you see them a lot, the middle -aged men and lycra crew, where they potentially just do endurance training. They do a lot of it at a fair fairly high intensity, and they struggle to lose weight,
actually. Sometimes you see they've got quite a lot of abdominal fat, and they might have issues that they disclose regarding drive, apathy, the mood things I talked about,
and sex drive as well. And I often have a conversation with them about, "Actually, is your exercise appropriate at this point? Is that appropriate?" move their energy right now then that's something that we need to try and adjust and help them adapt to.
I do think that there's also a problem you know we talked about the ideal sort of exercise regimen and too much of any one type of exercise is probably not helpful from a health perspective.
Now I recognize that people enjoy certain things. I play football a couple of times a week, spend an hour of my life getting kicked by other people, high chance that I'm gonna injure my knee.
or break my leg or whatever, and I accept that that's not from my sort of health span longevity perspective. I could get that cardio training in another way that was much safer from a long -term perspective,
but you've got to accept that some people do what they love doing, but if that's harming them, then I think it's on us to try and explain that to them and help them find alternatives. ways to manage that.
I think one of the reasons that performance enhancing illegal performance enhancing drug drug's work is their recovery agents, right? So your guys, your middle -aged men in Lycra that you see if you flip it to the sort of the professional cyclist abusing steroids or EPO or whatever it is,
it's allowing them to train to that level and even testosterone and testosterone and recover and go again. again and go again and go again. Now that's clearly it's not great for them in the long term but it's a it's a useful window into how these hormones contribute to recovery and performance.
Yeah even if it helps keep them motivated on the job right. Yeah. Back to your football you know you're talking about you getting kicked. You being the Liverpool puddling surely you're the one doing the kicking. Very good.
I'm not I'm not bigger strong enough to do that. unfortunately, but yeah. No, I mean, it is, you know, I think it comes back to that, you know, what's the best type of exercise, the one that someone's gonna stick to consistently.
So it can be hard to tell a guy who's passionate about cycling, who's clearly overdoing, or passionate about lifting weights. Have you thought about, you know, long -term health and maybe doing this or that,
but it's conversation. - And people are very, very attached. to these things, but also it's their social connection, which is another pillar of lifestyle medicine. So I guess we've got to be aware that when we make these suggestions.
- Yeah, stress management. - Stress management. - Sleep, yeah, all comes into all those things. I think, I mean, you mentioned that they're actually, you know, they can struggle to lose weight. They might have central fat deposition.
I mean, part of that is adaptation, right? The body, if you don't sort of constantly surprise it with it. new movements, new form of exercise, it is very easy to sort of get stuck in a rut by doing the same thing.
And also, as you said, it's a stressor, right? So you've got potentially a high cortisol from the training, which is going to increase adipose storage, fat storage, potentially around the abdomen. So yeah, they might be shooting themselves on the foot a little bit with it.
I mean, I think if we took someone who was training, doing intensive training, and measured a bunch of their parameters. their blood pressure, their cortisol levels, their ferritin levels, their CK,
a bunch of markers, and then you showed them to a doctor without explaining the context, they'd say, "Oh, this person's in trouble." The whole point of exercise is that it's a temporary stressor,
and then the body adapts to those things. But if you don't give it a chance to adapt after it's done them, then you don't get the benefit of the stressor. So it has to be a temporary stressor. thing Well, it's that I know,
you know, I always gnaws out on interleukins But I said IL -6 goes up in a previous podcast But actually IL -6 is pro -inflammatory, but then it eventually comes down because you get this spike and adaptation And then if you're always spiking IL -6,
you're constantly inflamed Okay, so that's the exercise. Yeah, so sleep you mentioned sleep What what's some advice that you give to your patients regarding? sleep? So a lot of what we talk about,
and this you could do a whole podcast on, of course, I mean, Matt Walker has a whole podcast series on sleep. Yeah, amazing. Another liver puddler, actually. Yeah, and he's liver puddin', he looks a little bit like me.
So if we combined us, we'd get Matt Walker. Brilliant. So again, if we focus on lifestyle, you know, it's around sleep, hygiene measures and routine.
So people tend to respond better if they go to bed and get up at similar times of day, even even at the weekend, which some people don't want to hear. This idea that you can repay a sleep debt at the weekend isn't maybe up to an hour or two,
but beyond that it's not gonna happen. So consistency is one thing, so getting the body into habit. You can do the hoobum and stuff, your morning sunlight, you're seeing the sunset, seeing the sun. seems to have an impact.
He talks about circadian dead zones in the middle of the day where getting sunlight isn't bad for you, but doesn't seem to benefit your sleep. So it seems to be morning and evening that make a difference. So you could combine that with your exercise.
Screens is what I'm always getting asked about. And I think it's two things with screens. One is the light, so shining blue light into your eyes just before you go to bed.
the ones I recommend the most would be a form of magnesium that is able to cross the blood -brain barrier or is readily absorbed at least like magnesium 3 and 8 is the one I use at bedtime or magnesium glycinate in the day.
L3 and 8, another commonly available sleep supplements. Not one if you get vivid dreams or you're a sleepwalker, but other than that can be worth a try. What else have we got?
Ashwagandha, lemon balm extract. Are there any others I recommend? recommend? - So people often talk about melatonin. From what I've heard in a low dose is pretty more effective and potentially it's great for jet lag and it sort of gets you to the start block of sleep but doesn't actually help with your sleep.
Is that something that you go along with? Do you ever prescribe it or suggest it? - So I mean, yeah, we do prescribe it but you don't need a prescription to get it in Singapore. So I think the way to think about melatonin melatonin is it doesn't,
it doesn't make you fall asleep in its natural form. When it's released, it prepares the body for sleep. So you don't take it just before you want to get to sleep, you need to take it a little while before.
My worry about melatonin is with sustained use. So are we down regulating natural melatonin production the same way that you give someone testosterone for long enough you might,
you know, nap over time. time down -regulate their natural production The same thing happens with melatonin. So I use it for things like jet lag I might use it to break a cycle of sleeplessness and it can be really helpful if people respond to it But it's not something that I would take Indefinitely like those other supplements I mentioned,
which if someone wants to take magnesium, they can take it forever Yeah, brilliant and a lot of people are deficient. I think yeah, and your body's very good at dealing with the excess apnea.
So I think, do you see that in patients with sleep apnea, they might suffer? Is there any correlation with testosterone issues? Yes. Yeah. Don't even need to elaborate too much on that one,
100%. I mean, it's tied into a lot of people with sleep apnea have poor metabolic health as well. Correct. Yeah. Not all of them. Yeah. But yeah, absolutely. And anything that you do that disrupts sleep,
whether it's from sleep apnea to going and kicking them out of bed or... setting an alarm or making them work, shift work, anything that disrupts sleep will have this negative impact on testosterone production.
And again, back to that cortisol effect, so if you can't breathe at night, that's a huge stress to the body. Dr, you mentioned blood pressure going up, you know, your whole stress hormone cascade. And then big,
big cardiovascular risk factor. So, so yeah, so it, you know, working out if someone has sleep apnea, you know, I guess that the sleep advice I was giving in terms of lifestyle and supplements is more generic when we're assuming there isn't a greater underlying problem.
For someone who has the symptoms of sleep apnea, which I'm not going to go over because I'm sure they were covered in your previous podcast, then that would need to be addressed. Interestingly, with the sort of the advent of the newer weight loss medications in the US,
A number of CPAP manufacturers are apparently struggling somewhat because people are losing so much weight that they don't need to use their CPAP machines anymore.
It's an interesting side effect of the weight loss medicine craze that's going on there. I don't want to say good, that's nasty, but no, good. Interesting. Interesting the way these things pan out.
I mean, I wish people could, you know, do that naturally and hopefully with the exercise advice and the stress management and some of the breathing retraining they can do naturally. So if I wanted to boost my testosterone sort of more naturally,
what supplements would you recommend? So "recommends" may be a strong word, but yeah, which ones would I not dissuade you from taking? There's loads out there. I think you've got to be careful about what's in them,
because a lot of them are mixed ingredients. They're often branded. branded in a similar way to you see pre -workout and you know that there'll be all there'll be caffeine there'll be all kinds in there so what are we actually interested in probably the two most common commonly seen in my practice would be Tonka Ali particularly in this part of the world because it's a Southeast Asian traditional treatment for libido and
fertility and erections and that kind of thing early seems to improve free and total testosterone levels may have some role in regulating stress hormone levels as well.
Haven't seen people running into big problems in terms of effects with it. The absolute numbers that you see in terms of increase in testosterone in studies aren't that impressive,
but as we've already alluded to, you see people responding in some cases quite well to fairly minimal. changes in their absolute numbers, so it might be worth a try.
I think you're unlikely to tip yourself into excess with the supplements. I did get asked recently by a guy who was already taking three testosterone boosting supplements whether he should add a fourth,
and didn't know what his testosterone level was, so maybe just know what your level is, and then you could make that decision. I'm not... sure that stacking them on top of each other is really gonna have a huge impact one of my one of the blokes play golf with hey I didn't I'd never heard a tonka alley but we were just like discussing health and I was like telling about that my lower testosterone he's like me you
need to take some tonka early being trying for a baby being absolutely smashing it feel really good yeah so and did you take him up on his advice I did I did take him up on it I did take some I don't take it out regularly,
but sometimes I do and I do feel a bit of a you know Bit of a boost. Yeah, yeah, but that's because it comes with horny goat weed Well, I don't know if mine does does it is it the one which I sent do I send you the link? Yeah? Yeah,
it does I left I left out on the side. I'm sure the sure the helper found that amusing. I Yeah, I enjoyed it Good and did you try it?
Yeah, I did I did I took it for a few weeks they have any effect on you Oh or boy? - Really hard to say, to be honest. I actually stopped it because I didn't feel like a huge effect on it,
but... And I was wondering, can it affect, can taking these supplements, can it affect things like skin health, for example? So if your testosterone is going up,
can that affect your skin health? - Yeah, so testosterone has an impact on your skin. And whether the... supplements could push your testosterone to a level where they did. I mean, you would have to see the individual response,
but one of the symptoms of excess androgen is acne. - So that's what I thought. So I took it and got so much testosterone. - Well, it must be, well, that's it.
I don't want to go on about it, but yeah, that's why I thought there might be some. - Now it may be transient, you know, you may have said, well, if you just kept going with you, the acne would settle down. It's just an adaptation.
But absolutely, that could have been a genuine side effect. And actually, while we're on that, in terms of side effects of supplementation, what are the big risks in terms of supplementing testosterone?
So, yeah, the symptoms of testosterone excess, we've already mentioned acne. There are other concerns. So we know that testosterone causes hair growth on the bits of the body we don't.
particularly want to grow more hair and hair loss on the scalp. So if that's an important thing to you, you have to recognize that male pattern baldness happens because of testosterone in the scalp and so that's a potential side effect.
It can affect sperm count and so this is a really important conversation to have with anyone who still has plans to start or continue a family.
So the prostate, there's long been a debate, does testosterone therapy cause prostate cancer? It appears the answer is no, but you definitely don't want to be giving it to a guy who has prostate cancer and doesn't know about it.
So prostate screening, if age appropriate, might be something that's worthwhile before doing this. Fairly easy to do. For a guy who's got a very enlarged prostate that's giving him symptoms.
its beneficial effects on metabolism. I think for most guys, it's going to benefit them in that regard in the long term rather than have a negative impact.
As it supports growth in general, does it, aside from prostate cancer, are there any risks for overall cancer risk? Or if you already have cancer,
can it worsen things? Not that I'm aware of. Do you mean that it would it would it would it increase children? proliferation and that kind of not that I'm aware of you know,
so the issue with Certain prostate cancers and and on the estrogen side breast cancer in women is that those tumor cells have Hormone receptors that are then stimulated by the hormone.
Yeah, I Can't give you a plausible explanation for why someone with pancreatic cancer would have that stimulated by taking testosterone. So it has to be a testosterone sensitivity.
Yeah, yeah, so in men we're really looking at prostate being the worry in women ovarian and breast cancers I guess would be a concern.
I mean listen if someone is has one of these cancers that's the conversation I'm having with them we might leave their hormone levels for another time. You've got to sort it out.
sort out the primary issue and then worry about what you're going to do next So I guess on that note we spoke last time when we spoke about each room we spoke about men So to be fair we should talk about women when we're talking about testosterone is Testosterone something women need to be considering Yes,
it is clearly they they have far level lower levels than The men but it doesn't mean that it's not And those women can become very symptomatic from the low testosterone.
Testosterone also dips after the menopause quite considerably. So in that context, in the menopause HRT context, testosterone is most often talked about in terms of sexual function.
So women that report loss of libido, loss of pleasure from sex, pain, discomfort, that kind of thing. Sometimes testosterone is piggybacked onto HRT to benefit.
of women were sort of cheating in male preparation and trying to work out a way of giving it very infrequently or at a low dose, which is annoying, but that's where we're at at the moment.
- That's very informative. Thank you. It's been a very informative podcast. Thank you very much. - It's been a pleasure. - Let's see if we can summarize things a little bit for people listening.
And if you could leave our listeners with three key take -home messages. messages, what would they be? This is one that you gave me in advance, so I'm cheating a bit here.
I had a chance to think about it. I would say the first thing is you've got to know whether there's a problem. So knowing the symptoms, hopefully we've played a small role in helping people with that.
If you don't know what the symptoms are, how are you ever going to know that it's an issue? So awareness is one thing. My number two would be remembering. and better metabolic cardiovascular health and all the rest of it.
So I think that's really important. And the final thing is, I would say, and you might say, well, you would say this, wouldn't it? But I would say, get good advice, if you're gonna, particularly if you're gonna go down the treatment route.
Don't do things without knowing what your levels are. It's super easy to get your levels checked. So don't do it by yourself. I don't think this is as much of an issue in Singapore because it's harder to come by.
In the U .S. there's a testosterone clinic on every high street corner and they're just giving the stuff out. So I don't think that's as much of an issue here, but you know,
if you're thinking about it, bounce your ideas off someone. I hope the impression you've got from me in this podcast is there's no hard of fast rules. It's not you can't have testosterone, you can.
It's very individualized, but it's good to have a conversation with someone who's... who's experienced in using it before just jumping in at the deep end. And also getting a baseline and then being able to retest and seeing does that correlate with how I'm feeling as well.
Brilliant. Fantastic. All right so now we're out through the bulk of today and we're going to go through to our two favourite segments. We'll start with our pet peeves and that's where we discuss our pet peeve of our profession.
So if you wanna give us your pet peeve of your profession. - Ah, so I thought of one that was about, you know, it was almost in defense of my profession,
my pet peeve rather than about something that doctors do. So am I allowed two pet peeves? - Yeah, how two pet peeves? 'Cause then we can not explain. - Can we discuss that?
Is he allowed two pet peeves? (laughing) Is he? he deserve it? We'll let him have two and then if one's rubbish we can cut one out. So one's in defence of doctors and one's in criticism of doctors.
We're here to talk about testosterone so I think the thing that maybe the medical profession doesn't do well is it's too rigid in its approach to how this is managed.
So people have the levels checked. at is understanding the individualization,
personalization of managing testosterone. But I think on the flip side of that, what I increasingly see on social media is this oversimplification of the process.
Do this one thing and it'll fix everything. And this idea that doctors don't know or don't care about the underlying causes.
your doctor doesn't understand or here's the thing that your doctor won't tell you and I think we're all as guilty of that as anyone else at times but I think there's this great trend for for doctor bashing on social media sometimes to sensationalize.
We're not all terrible people. I mean I think it's come from an awful system rather than awful doctors so I think if ever it has come from from anything,
it's come from, you've worked in the NHS, you know, you get three and a half minutes for the patient, you have to do what you have to do. And then perhaps in some other places in the world, it's similar. So I always think if there is ever a thought,
it's with the systems that people have to work in. - Yeah, and it fits with a sort of a conspiracy view of the world that, you know, the medical profession is in league with big pharma to stop you from-- - Getting better.
- From getting better, yeah. - Yeah. you know there are some terrible aspects to Big Pharma of course but you know if I think that someone needs testosterone treatment there's nothing to do with the pharmacist.
I don't even know who makes Nabeeda you know so it's not a scam it's not it's not that I'm you know ignoring the lifestyle factors or anything like that it's trying to find the best solution for the individual.
I think it's been very clear that that's exactly your approach to medicine today. That's good. Thanks for sharing that. That's good. And our final segment is our Magic One segment.
Not like that. And this is where we... That's a terrible answer. But we're never gonna stop it. It's gonna be in a few years,
300 episodes old. Okay so and this is where we decipher like our... one wish for our patient group. Okay, so. So yeah,
I had a good think about this one. And this isn't true for all, you know, some of my patients do manage to do this. So I guess I don't need the magic one for everyone. But we talked so much about lifestyle in terms of sleep and exercise and all that good stuff.
And what I do. really like people to see is the value of the process as well as the end result because some of this management of hormones is quite long -winded it's not like you know you come to see me with an ear infection and I give you some medicine and it gets better and the whole the whole episode is over in five days there's a lot of trial and error here and part of the joy is in the process of making
tiny little incremental gains. And I think some of the people I see are so worried about the end result that they miss all the great stuff that they're able to do in the getting there.
It's just not binary. So I don't know if that's a slightly weird one, but if I could make people see the value of the process as well as the result, then I think people would be,
would be. with their management. It's not a weird at all is it? And the same like James Clear said, everyone's got a goal but it's the processes you put in place that are the most important thing.
Yeah and I think that the people who do often do well are the ones that can take pleasure and motivation from the process and be slightly less,
you know, results driven it's it's all over then that would be my uh that would be my wish love that love it very good thank you so much for listening and joining us in our collaborative journey to health and performance please do smash the like button send your comments if you have anything you specifically want to see from us or any guests that you want us to have on and in the next episode we'll be talking about
the role of muscle in sexual health we're looking forward to that one and it definitely links into what we've been discussing today thanks again to Dr Neil Forrest and for all of you listening, value the process and take good care of yourselves.
Thank you.
Maximizing Testosterone Levels: Dr Neil Forrest Tips on optimizing Testosterone on The BOBW Podcast
Episode description
This Best of Both Worlds Podcast episode, hosted by Matt Winter and Paul Macaulay, delves into the complex world of optimizing testosterone, featuring Dr. Neil Forrest as a guest. Paul shares his personal experiences with testosterone therapy since age 14. The conversation navigates through the variability of individual responses to low testosterone levels and the multifactorial causes of low testosterone.
They discuss the physiological mechanisms of testosterone production, involving stages from the hypothalamus to hormone regulation. Lifestyle factors such as obesity, stress, and poor sleep are highlighted as influencers on testosterone levels. The discussion extends to the impact of testosterone on various aspects of life beyond se**** function, emphasizing its role in metabolic and cardiovascular health.
Different forms of testosterone replacement therapy, including NEBIDO injections and testosterone gel, are explored, with attention to frequency and individualized approaches. The importance of screening testosterone levels based on reported symptoms and lifestyle factors is emphasized, alongside the need for professional guidance in treatment decisions.
Moreover, the episode, hosted by Matt and Paul, tackles broader topics in healthcare, weaving humor and discussion to engage viewers. Themes of lifestyle medicine, stress management, and the balance between enjoyment and health risks are touched upon. The overarching message emphasizes awareness of symptoms, prioritization of health, and seeking informed advice when considering testosterone optimization.