The COVID19 vaccines were produced in record time, an amazing feat. However, additional challenges have been revealed in their distribution. Perhaps the most formidable barrier is the very last one– executing the vaccination. For years anti-vaccination groups have soiled the internet and public discourse with false or exaggerated claims of vaccine dangers. They have appealed to the emotional weak spots of concerned parents and the conspiratorial leanings of fringe science and politics to forward...
Mar 20, 2021•28 min•Ep. 284
This week’s podcast is a dissection of another popular podcast that features self-proclaimed experts in genetic engineering (familiarly GMO), and the falsehoods they propagate. Podcasts are great conduits to spread scientific information, but non-scientific views thrive also. It is amazing to listen to the bad information, and the participants’ willing acceptance and amplification that goes unchallenged. The episode is not mentioned by name, nor are the participants. This is not a personal criti...
Mar 13, 2021•1 hr 3 min•Ep. 283
At its core, gene editing works to break gene function by creating errors in a DNA sequence at a specific location. The process works by creating a precise cut that is repaired by the cell’s repair mechanisms, and those processes can be error prone. Those errors are the basis of the gene’s disruption. But in a population of cells, how do you account for and catalog all of the changes? Kevin Bloh is a research associate and a Ph.D. student with Christiana Care / University of Delaware. He describ...
Mar 06, 2021•27 min•Ep. 282
One of the major failures of addressing the COVID19 pandemic is the breakdown of testing. The NFL and White House were able to maintain business as usual because of daily, accurate testing. When the disease is detected, its spread can be controlled. Jo Bhakdi of Quantgene talks about testing and how his company has scaled up testing solutions to at least apply them commercially to businesses wishing to maintain operations and protect their employees. We talk about testing and how it may be scale...
Feb 27, 2021•1 hr•Ep. 281
Dr. Patrick Moore was a founding member of Greenpeace. In the years past its inception he worked tirelessly on ecological issues. Over time, he saw the group’s positions as less than scientific, leading to his defection. Soon after he became a leading advocate for the deployment of Golden Rice, the pro-Vitamin A rice that was invented to alleviate blindness and illness caused by a missing micronutrient in the Developing World. We discuss his roots, his efforts for Golden Rice, and conclude with ...
Feb 20, 2021•1 hr 29 min•Ep. 280
Bananas and other tropical crops have tremendous value, not just to farmers in the Developing World, but also as products that are enjoyed widely in highly industrialized nations. However, crops like bananas and coffee are threatened by pathogens that could severely curtail cultivation and availability. Tropic Biosciences is taking on these problems using a unique approach– using gene editing to adjust genetics in a way that attacks the pathogen without consequence in the original plant itself. ...
Feb 13, 2021•48 min•Ep. 279
Radiation is a natural energy that constantly bombards us. At the same time we have harnessed its power for medical imaging, therapeutics, energy and warfare. Collateral damage from radiation exposure, even in critical therapeutic contexts, can have profound effects on cellular health and ultimately survival. Dr. Fyodor Urnov of the University of Berkeley and the Innovative Genomics Institute is part of a team seeking to use gene editing as molecular medicine to speed recovery from radiation dam...
Feb 06, 2021•34 min•Ep. 278
The story of biotechnology’s response to the pandemic is an amazing one, and we continue coverage of these events as they arise. Today guest host Dr. Asha Brunings speaks with virus and immunology expert Dr. Brianne Baker. They discuss various topics of immunology with respect to the virus, discussing the new variants, the new vaccines, and a deep dive in to the mechanisms of immunity to the COVID19 symptom spectrum. Follow Dr. Barker ; @BioProfBarker Follow Dr. Brunings: @AshaBrunings And Dr. B...
Jan 30, 2021•41 min•Ep. 277
Algae efficiently convert carbon dioxide into oils, and they are now being bred to generate a suite of compounds that may be synthesized into fuel and polymers that are the basis of biodegradable plastics. Dr. Steve Mayfield is a Professor at the University of California San Diego, and the Director of the California Center for Algal Biotechnology. His work with algae shows how this rapidly growing photosynthetic organism can generate everything from fuels to plastics, from gasoline to surfboards...
Jan 23, 2021•50 min•Ep. 276
Certain aggressive cancers have profound effects on lifespan and quality of life. Patient prognosis can be grim, and therapies are harsh. Dr. Dan Peer of the University of Tel Aviv leads a group that has targeted gliomas and ovarian cancer with gene editing. Specifically, lipid nanoparticles are produced that target cancer cells, and introduce gene editing hardware that specifically inactivates genes required for cell division. The breakdown in proliferation impedes the cells’ growth. In animal ...
Jan 16, 2021•29 min•Ep. 275
Consumers have many opinions about food, and are continually bombarded by information from manufacturers to self-proclaimed experts. To gauge what they really think economists formulate approaches to learn what they are thinking and how they might behave in a purchasing scenario. Dr. Stuart Smyth has studied the interface between consumers and agricultural biotechnology. In this episode he presents the work from his group’s recent publication that discusses how consumers ultimately feel about pu...
Jan 09, 2021•36 min•Ep. 274
The COVID-19 pandemic overshadowed an incredible year of innovation in biotechnology. Today’s podcast is a simulcast between the Science Facts and Fallacies with Cameron English and Talking Biotech. We discuss six science stories that were true highlights of an incredible year in science, along with stories that help us understand the state of the science/society interface. # COLABRA Talking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research...
Jan 02, 2021•44 min•Ep. 273
The COVID19 vaccines have the potential to squelch a dangerous pandemic. However, the public has many questions about their safety and efficacy that could limit their broad administration. Some of the questions concern the immune system, how it is affected by the vaccine, why two doses are necessary, and if the response is durable. Today’s podcast interviews Dr. Asha Brunings about the immunology of the COVID vaccine and the disease itself. # COLABRA Talking Biotech is brought to you by Colabra ...
Dec 26, 2020•52 min•Ep. 272
Two mRNA vaccines have been approved to lead the fight against COVID19. Both have been rapidly approved with Emergency Use Authorization, which does not build public trust. Ultimately compelling the vaccine hesitant to receive the vaccination may be the most significant hurdle in the process. The science is complete, now the challenge is public acceptance. Today’s podcast is more detail on the vaccine, how it works, and the reasons for hesitancy. The New England Journal of Medicine published cli...
Dec 20, 2020•1 hr 15 min•Ep. 271
Apples seem rather ubiqutous, but what we see in the stores are just a sample of the genetic diversity that is out there. Today’s podcast discusses apple domestication and diversification with Dr. Norm Weeden. its early history and radiation are discussed. as well as an understanding of its genomics and genetics. # COLABRA Talking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colab...
Dec 12, 2020•48 min•Ep. 270
Despite its essential role in the economy and food security, agriculture has lagged behind with respect to adoption of new technology. This has happened for many reasons, partially from technology companies not realizing the opportunities in agriculture, and partially from high costs, and agriculture’s adherence to current practices. Dr. Adrian Percy has been a leader in agricultural reserach innovation and venture capital. We discuss the opportunities in agriculture and the limitations to succe...
Dec 05, 2020•36 min•Ep. 269
mRNA vaccines have recently been in the news as an exciting potential preventative of SARS-CoV2. The technology seems new, but has roots in the 1990’s and a long history of maturation, plagued by technical barriers and skepticism. However, the efficacy demonstrated in clinical trials is promising, and suggests that mRNA-based strategies may have a prominent role as vaccines and therapeutics against some of our most insidious diseases. Resources for this podcast: Hilleman 1994 – a conceptual revi...
Nov 28, 2020•40 min•Ep. 268
Technology is driving innovation on the farm, and there have been significant efforts in improving livestock. Whether it was to produce a novel therapeutic or to solve a critical disease in animals, genetic engineering techniques have been used to target significant animal and human problems. There are many more successful innovations than commercial successes, as the regulatory climate is highly unfavorable to animal recombinant DNA technology. Dr. Mark Westhusin from Texas A&M University h...
Nov 21, 2020•36 min•Ep. 267
Gene editing is a relatively new technology that has revolutionary applications in agriculture and medicine. The drawback to the technology is that it typically can only be used to disrupt a deleterious gene underlying a specific trait. Gene writing exploits a natural process in cells that allows researchers to install genes of interest, allowing replacement of damaged sequences that lead to negative health outcomes. Dr. Geoff von Maltzahn of Tessera describes what the new technology is and its ...
Nov 14, 2020•45 min•Ep. 266
The onion has tremendous value in culinary applications all over the world. Where did it come from? What are the major breeding efforts and the important traits. Today’s podcast discusses the onion’s origin and future directions with Dr. Michael Havey, USDA-ARS/University of Wisconsin onion breeder. He speaks of the onion’s interesting background, its surprising genome, and traits that will define the onion of the future. A very interesting discussion of an important world food crop. Havey Lab W...
Nov 07, 2020•40 min•Ep. 265
On Halloween it is hard to remember that the pumpkins used for decoration are actually an important food for indigenous people of the Americas. There are multiple species of pumpkins that originated in North and South America, and primarily used for food. Dr. Harry Paris is a retired Senior Researcher and fruit breeder from the Volcani Center in Israel. We discuss the origins of pumpkins, how they moved in the New World, as well as the diversity and uses for this important fruit. # COLABRA Talki...
Oct 31, 2020•43 min•Ep. 264
Gene editing moved quickly from the lab to application, so fast that the public is unsure how to think about it. We can cure disease, but are we playing with the natural order of things? These are questions that philosophers and ethicists wrestle with every day. in this week’s podcast we discuss the recent events in germline gene editing and how it is perceived by the public and by scientists. Follow Dr. Gyngell’s group: @Berg_MCRI # COLABRA Talking Biotech is brought to you by Colabra – an R&am...
Oct 24, 2020•38 min•Ep. 263
This week two scientists pioneering gene editing won the Nobel Prize for Chemistry. Days later, a group of perennial naysayers gathered to denounce the technology. Gene editing is a revolutionary technology that already has had amazing effects on medicine and some applications in agriculture. The potential is limitless. But this new technology can install precise changes in genes, emulating natural mutations. They also cannot be detected, at least discernably from naturally-occurring mutations. ...
Oct 17, 2020•1 hr 58 min•Ep. 262
Digestive cancers are among the most common and deadly cancers in the world, comprising metastases of the colon, esophagus, stomach and rectum. These all share some cellular commonalities, namely the presentation of a molecular signature that can now be a target for engineered therapies. Dr. Adam Snook has been studying the fingerprints of gastric cancers and developing gene therapy approaches that target cancer cells. He discusses the technology, and describes how it works, and how the technolo...
Oct 10, 2020•34 min•Ep. 261
Dr. Cami Ryan has examined the social factors that underlie decisions. Today these human tendencies are critical to understand, as everyone is bombarded by information through social media. How do issues like misinformation and disinformation erode the trust of scientific authorities? How do scientists and farmers, the experts, grab a piece of the pie in the new attention economy? Time is a commodity in short supply, and Dr. Ryan provides insight into how we can maximize our time in communicatin...
Oct 03, 2020•1 hr 1 min•Ep. 260
The human immunodeficiency virus remains prevalent in the population, yet it as silently moved out of the public’s consciousness, overshadowed by COVID19 and drug cocktails that can control its progression. Over the last three decades great progress has been made in understanding the virus and how it interacts with cells. This, plus the identification of genetic determinants of resistance to HIV have presented researchers with new drug targets. These may represent future therapies and perhaps cu...
Sep 26, 2020•39 min•Ep. 259
Sepsis is an infection of the blood. It can be critical and life threatening, and can complicate other co-morbidities. One of the main problems is that a number of bacterial and fungal pathogens can cause a septic state, so physicians are tasked with rapid identification of specific pathogens to render the most appropriate method of care. Unfortunately this usually involves broad treatments with multiple antibiotics and antifungals, as tests to identify discrete pathogens can take days. Dr. Alon...
Sep 19, 2020•33 min•Ep. 258
Indoor air contains a variety of harmful compounds. We invite many of these compounds into our homes in electronics, and others occur spontaneously from our water supply, and as homes become more energy efficient and dependent on air conditioning, these chemicals concentrate in our homes. Dr. Stuart Strand of the University of Washington explains what they are and their relative risk. He also describes a solution– plants genetically engineered to scrub these molecules from the indoor atmosphere....
Sep 12, 2020•49 min•Ep. 257
This week’s guest is the host! It was important to discuss communication tips during a pandemic, especially around popular myths and news stories involving COVID19. Kevin Folta provides counterarguments to today’s most prevalent claims around hydroxychloroquine, disease incidence, and the flu shot. It also marks five years since the New York Times story that portrayed Folta as a corporate patsy. While many aspects of his research and communications efforts thrive today, this deliberate act of ca...
Sep 06, 2020•53 min•Ep. 256
Florida is the canary in the coalmine for mosquito-transmitted disease in the USA. The Florida Keys are especially vulnerable. Traffic through this sensitive string of islands allows infected insects to be rapidly vectored to other areas of the keys, as well as to the mainland. Over the last decade there have been notable incidents of Zika, Chikunguna, Denge and other mosquito-borne diseases. Over the same time a self-limiting mosquito technology has been developed by Oxitec. The mosquitoes have...
Aug 29, 2020•28 min•Ep. 255
