If you're looking to leverage the insane power of modern GPUs for data science and ML, you might think you'll need to use some low-level programming language such as C++. But the folks over at NVIDIA have been hard at work building Python SDKs which provide nearly native level of performance when doing Pythonic GPU programming. Bryce Adelstein Lelbach is here to tell us about programming your GPU in pure Python. Episode sponsors Posit Agntcy Talk Python Courses Links from the show Bryce Adelstei...
Jun 11, 2025•57 min•Ep. 509
If you've heard the phrase "Automate the boring things" for Python, this episode starts with that idea and takes it to another level. We have Glyph back on the podcast to talk about "Programming YOUR computer with Python." We dive into a bunch of tools and frameworks and especially spend some time on integrating with existing platform APIs (e.g. macOS's BrowserKit and Window's COM APIs) to build desktop apps in Python that make you happier and more productive. Let's dive in! Episode sponsors Pos...
Jun 06, 2025•1 hr 12 min•Ep. 508
If you want to leverage the power of LLMs in your Python apps, you would be wise to consider an agentic framework. Agentic empowers the LLMs to use tools and take further action based on what it has learned at that point. And frameworks provide all the necessary building blocks to weave these into your apps with features like long-term memory and durable resumability. I'm excited to have Sydney Runkle back on the podcast to dive into building Python apps with LangChain and LangGraph. Episode spo...
Jun 02, 2025•1 hr 4 min•Ep. 507
The folks over at Astral have made some big-time impacts in the Python space with uv and ruff. They are back with another amazing project named ty. You may have known it as Red-Knot. But it's coming up on release time for the first version and with the release it comes with a new official name: ty. We have Charlie Marsh and Carl Meyer on the show to tell us all about this new project. Episode sponsors Posit Auth0 Talk Python Courses Links from the show Talk Python's Rock Solid Python: Type Hints...
May 19, 2025•1 hr 4 min•Ep. 506
Python has many string formatting styles which have been added to the language over the years. Early Python used the % operator to injected formatted values into strings. And we have string.format() which offers several powerful styles. Both were verbose and indirect, so f-strings were added in Python 3.6. But these f-strings lacked security features (think little bobby tables) and they manifested as fully-formed strings to runtime code. Today we talk about the next evolution of Python string fo...
May 13, 2025•1 hr 12 min•Ep. 505
What trends and technologies should you be paying attention to today? Are there hot new database servers you should check out? Or will that just be a flash in the pan? I love these forward looking episodes and this one is super fun. I've put together an amazing panel: Gina Häußge, Ines Montani, Richard Campbell, and Calvin Hendryx-Parker. We dive into the recent Stack Overflow Developer survey results as a sounding board for our thoughts on rising and falling trends in the Python and broader dev...
May 05, 2025•1 hr 10 min•Ep. 504
Pandas is at a the core of virtually all data science done in Python, that is virtually all data science. Since it's beginning, Pandas has been based upon numpy. But changes are afoot to update those internals and you can now optionally use PyArrow. PyArrow comes with a ton of benefits including it's columnar format which makes answering analytical questions faster, support for a range of high performance file formats, inter-machine data streaming, faster file IO and more. Reuven Lerner is here ...
Apr 28, 2025•1 hr 9 min•Ep. 503
Do you or your company need accounting software? Well, there are plenty of SaaS products out there that you can give your data to. but maybe you also really like Django and would rather have a foundation to build your own accounting system exactly as you need for your company or your product. On this episode, we're diving into Django Ledger, created by Miguel Sanda, which can do just that. Episode sponsors Auth0 Talk Python Courses Links from the show Miguel Sanda on Twitter : @elarroba Miguel o...
Apr 21, 2025•1 hr 4 min•Ep. 502
Have you ever spent an afternoon wrestling with a Jupyter notebook, hoping that you ran the cells in just the right order, only to realize your outputs were completely out of sync? Today's guest has a fresh take on solving that exact problem. Akshay Agrawal is here to introduce Marimo, a reactive Python notebook that ensures your code and outputs always stay in lockstep. And that's just the start! We'll also dig into Akshay's background at Google Brain and Stanford, what it's like to work on the...
Apr 14, 2025•1 hr 1 min•Ep. 501
We're sitting down with Eric Matthes, the educator, author, and developer behind Django Simple Deploy. If you've ever struggled with taking that final step of getting your Django app onto a live server (without spending days wrestling with DevOps complexities), then give Django Simple Deploy a look. Eric shares how Django Simple Deploy automates away the boilerplate parts of deployment, so you can focus on building features instead of deciphering endless configs. We'll talk about this new projec...
Apr 10, 2025•58 min•Ep. 500
This episode is all about Beeware, the project that working towards true native apps built on Python, especially for iOS and Android. Russell's been at this for more than a decade, and the progress is now hitting critical mass. We'll talk about the Toga GUI toolkit, building and shipping your apps with Briefcase, the newly official support for iOS and Android in CPython, and so much more. I can't wait to explore how BeeWare opens up the entire mobile ecosystem for Python developers, let's jump r...
Mar 31, 2025•1 hr 8 min•Ep. 499
In this episode, we welcome back Will McGugan, the creator of the wildly popular Rich library and founder of Textualize. We'll dive into Will's latest article on "Algorithms for High Performance Terminal Apps" and explore how he's quietly revolutionizing what's possible in the terminal, from smooth animations and dynamic widgets to full-on TUI (or should we say GUI?) frameworks. Whether you're looking to supercharge your command-line tools or just curious how Python can push the limits of text-b...
Mar 24, 2025•1 hr 8 min•Ep. 498
Have you ever wondered why certain data points stand out so dramatically? They might hold the key to everything from fraud detection to groundbreaking discoveries. This week on Talk Python to Me, we dive into the world of outlier detection with Python with Brett Kennedy. You'll learn how outliers can signal errors, highlight novel insights, or even reveal hidden patterns lurking in the data you thought you understood. We'll explore fresh research developments, practical use cases, and how outlie...
Mar 21, 2025•55 min•Ep. 497
Today we explore the wild world of Python deployment with my friend, Calvin Hendryx-Parker from Six Feet Up. We’ll tackle some of the biggest challenges in taking a Python app from “it works on my machine” to production, covering inconsistent environments, conflicting dependencies, and sneaky security pitfalls. Along the way, Calvin shares how containerization with Docker and Kubernetes can both simplify and complicate deployments, especially for smaller teams. Finally, we’ll introduce Scaf, a p...
Mar 14, 2025•1 hr 20 min•Ep. 496
On this episode, I'm joined by Dr. Geoff Boeing, an assistant professor at the University of Southern California whose research spans urban planning, spatial analysis, and data science. We explore why OpenStreetMap is such a powerful source of global map data—and how Geoff's Python library, OSMnx, makes that data easier to download, model, and visualize. Along the way, we talk about what shapes city streets around the world, how urban design influences everything from daily commutes to disaster ...
Feb 24, 2025•1 hr 2 min•Ep. 495
As Python developers, we're incredibly lucky to have over half a million packages that we can use to build our applications with over at PyPI. However, when it comes to choosing a UI framework, the options get narrowed down very quickly. Intersect those choices with the ones that work on mobile, and you have a very short list. Flutter is a UI framework for building desktop and mobile applications, and is in fact the one that we used to build the Talk Python courses app, you'd find at talkpython....
Feb 21, 2025•1 hr•Ep. 494
In this episode, I'm joined by JJ Allaire, founder and executive chairman at Posit, and Carlos Scheidegger, a software engineer at Posit, to explore Quarto, an open-source tool revolutionizing technical publishing. We discuss how Quarto empowers users to seamlessly transform Jupyter notebooks into polished reports, dashboards, e-books, websites, and more. JJ shares his journey from creating RStudio to developing Quarto as a versatile, multi-language tool, while Carlos delves into its roots in re...
Feb 09, 2025•1 hr 5 min•Ep. 493
Join me as I chat with Rich Iannone and Michael Chow from Posit where we explore the transformative power of data tables with the Great Tables library. We'll cover practical applications of Great Tables, showcasing how thoughtful design and advanced formatting can elevate your data presentations. And you'll learn about innovative features like nano plots and interactive elements and the importance of structure, format, and style in crafting tables that both inform and inspire. Whether you're a s...
Jan 30, 2025•1 hr 4 min•Ep. 492
Join me for an insightful conversation with Alex Monahan, who works on documentation, tutorials, and training at DuckDB Labs. We explore why DuckDB is gaining momentum among Python and data enthusiasts, from its in-process database design to its blazingly fast, columnar architecture. We also dive into indexing strategies, concurrency considerations, and the fascinating way MotherDuck (the cloud companion to DuckDB) handles large-scale data seamlessly. Don’t miss this chance to learn how a single...
Dec 27, 2024•1 hr 2 min•Ep. 491
If you're a Django developer, I'm sure you've heard so many people raving about FastAPI and Pydantic. But you really love Django and don't want to switch. Then you might want to give Django Ninja a serious look. Django Ninja is highly inspired by FastAPI, but is also deeply integrated into Django itself. We have Vitaliy Kucheryaviy the creator of Django Ninja on this show to tell us all about it. Episode sponsors Sentry Error Monitoring, Code TALKPYTHON Bluehost Talk Python Courses Links from th...
Dec 24, 2024•1 hr 5 min•Ep. 490
Peter Wang has been pushing Python forward since the early days of its data science roots. We're lucky to have him back on the show. We're going to talk about the Anaconda Toolbox for Excel as well as many other trends and topics that are hot in the Python space right now. I'm sure you'll enjoy listening to the two of us exchanging our takes on the topics and trends. Episode sponsors Sentry Error Monitoring, Code TALKPYTHON Bluehost Talk Python Courses Links from the show Peter on BSky : @wang.s...
Dec 20, 2024•1 hr 9 min•Ep. 489
LanceDB is a developer-friendly, open source database for AI. It's used by well-known companies such as Midjourney and Character.ai. We have Chang She, the CEO and cofounder of LanceDB on to give us a look at the concept of multi-modal data and how you can use LanceDB in your own Python apps. Episode sponsors Sentry Error Monitoring, Code TALKPYTHON Bluehost Talk Python Courses Links from the show Chang She : @changhiskhan Chang on Github : github.com LanceDB : lancedb.com LanceDB Source : githu...
Dec 12, 2024•58 min•Ep. 488
There has been a lot of changes in the low-level Python space these days. The biggest has to be how many projects have rewritten core performance-intensive sections in Rust. Or even the wholesale adoption of Rust for newer projects such as uv and ruff. On this episode, we dive into the tools and workflow needed to build these portions of Python apps in Rust with David Seddon and Samuel Colvin. Episode sponsors Posit Data Citizens Podcast Talk Python Courses Links from the show Samuel Colvin : gi...
Dec 01, 2024•1 hr 2 min•Ep. 487
If you are a .NET developer or work in a place that has some of those folks, wouldn't it be great to fully leverage the entirety of PyPI with it's almost 600,000 packages inside your .NET code? But how would you do this? Previous efforts have let you write Python syntax but using the full libraries (especially the C-based ones) has been out of reach, until CSnakes. This project by Anthony Shaw and Aaron Powell unlocks some pretty serious integration between the two languages. We have them both h...
Nov 22, 2024•1 hr 3 min•Ep. 486
What do developers need to know about AppSec and building secure software? We have Tanya Janca (AKA SheHacksPurple) on the show to tell us all about it. We talk about what developers should expect from threat modeling events as well as concrete tips for security your apps and services. Episode sponsors Posit Bluehost Talk Python Courses Links from the show Tanya on X : @shehackspurple She Hacks Purple website : shehackspurple.ca White House recommends memory safe languages : whitehouse.gov Pytho...
Nov 15, 2024•1 hr 9 min•Ep. 485
See the full show notes for this episode on the website at talkpython.fm/484
Nov 05, 2024•58 min•Ep. 484
See the full show notes for this episode on the website at talkpython.fm/483
Oct 29, 2024•1 hr 3 min•Ep. 483
See the full show notes for this episode on the website at talkpython.fm/482
Oct 24, 2024•1 hr 10 min•Ep. 482
See the full show notes for this episode on the website at talkpython.fm/481
Oct 17, 2024•1 hr 3 min•Ep. 481
See the full show notes for this episode on the website at talkpython.fm/480
Oct 09, 2024•59 min•Ep. 480
