Shiri Gur-Cohen, Ph.D., UC San Diego, explains how her lab studies how epithelial stem cells communicate with their vascular microenvironment to advance regeneration and combat metastatic diseases. Series: "Stem Cell Channel" [Education] [Show ID: 38409]
How can we better understand the earliest stages of human development? Jianping Fu, Ph.D., University of Michigan, discusses his work using stem cell-derived embryoids. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38320]
Alysson Muotri discusses modeling Pitt-Hopkins syndrome (PTHS) using stem cells and brain organoids. He shares how rescuing TCF4 expression with CRISPR-mediated epigenetic induction of AAV vector delivery provides a gateway for targeted therapeutics for PTHS and related conditions. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38516]
Thomas C. Südhof, M.D., Stanford University, discusses facets of the fundamental cell biology of ApoE and APP analyzed in stem cell-derived human neurons. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38405]
The human placenta may hold important clues to the health of both mothers and babies. Mana Parast, M.D., Ph.D., discusses placental development, what we can learn from pathologic evaluation of the placenta after delivery, and modeling the placenta with stem cells. Karen Mestan, M.S., M.D., shares highlights in neonatal medicine, how to use the placenta as a diagnostic tool to improve the immediate and long term health of newborn patients, and what the role of the placenta could be in NICU manage...
Derrick J. Rossi, Ph.D., President and Chief Executive Officer of Convelo Therapeutics has a long history of pioneering methods to make stem cell–based treatments for disease a reality. He shares stories of science making its way from the lab and into biotech with the intention of improving the lives of patients. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38404]
Frank Furnari, Ph.D., of UC San Diego, shares his work using stem cells as a vehicle to generate models of brain cancer. Focusing on glioblastoma, he explains how tumor avatars could lead to new therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38514]
Jeffrey Magee, M.D., Ph.D., of Washington University in St. Louis, discusses how mechanisms that regulate hematopoietic stem cells change with age and how this shapes the biology of pediatric leukemia. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38398]
CIRM-funded Alpha Stem Cell Clinics are a network of California medical centers that specialize in delivering stem cell clinical trials to patients. Sandra Dillon shares how their work has impacted treatments for her rare cancer. Maria T. Millan, M.D., Mehrdad Abedi, M.D., Daniela A. Bota, M.D., Ph.D., Sheila Chari, Ph.D., Noah Federman, M.D., Catriona Jamieson, M.D., Ph.D., Sean Turbeville, Ph.D., and Leo D. Wang, M.D., Ph.D., discuss current clinical trials and the future of stem cell research...
How do epithelial stem cells enable renewal and regeneration of organs in adults? Ophir Klein, M.D., Ph.D., explains his research in stem cell-fueled tooth renewal and intestinal stem cells. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38318]
What if we could trick stem cells into thinking they were young again? What would the impact be on human health and aging? Shiri Gur-Cohen, Ph.D., shares her work. Series: "Women in Science" [Health and Medicine] [Show ID: 38216]
What challenges does aging pose to both individuals and society at large? What causes aging at the cellular and molecular level? Stem cell research is be key to finding solutions that increase our healthspan and change how we think about aging. Robert A.J. Signer, Ph.D., shares what is on the horizon. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38215]
Su-Chun Zhang, M.D., Ph.D., shares how neural transplantation cell therapies can be used to treat neurological conditions such as Parkinson's disease. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38203]
What challenges does aging pose to individuals and society at large? What causes aging at the cellular and molecular level? What if we could trick stem cells into thinking they were young again? If so, could we leverage stem cells to help live longer, healthier lives? These are just some of the fascinating questions researchers are exploring in today's closer look at the aging process. Robert A.J. Signer, Ph.D., and Shiri Gur-Cohen, Ph.D., examine aging at the molecular and cellular level to sho...
Thorold Theunissen, Ph.D., of the Washington University School of Medicine in St. Louis shares his work using naive stem cells to model trophoblast development. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37674]
Dilek Colak, PhD, shares the results of recent work identifying aberrant Ca2+ signaling in ASD astrocytes as a mechanism that contributes to specific behavioral and neuronal deficits. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37673]
Nicolas Rivron, PhD, shares his lab's work to better understand healthy embryo development. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37672]
Michele De Luca, MD, shares his research in gene therapy for epidermolysis bullosa and cell therapy for ocular burns. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37671]
A model of human cortical development could be used to instruct novel computational learning approaches. Alysson Muotri, Phd, Sujeeth Bharadwaj, PhD, Weiwei Yang, and Gabrial Silva, MSc, PhD, discuss the promise, the problems, and the potential when biology and artificial intelligence meet. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37556]
Don Cleveland, PhD, shares new research on the role of chromothripsis, targeting cancers driven by ecDNA and more. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37586]
Dan Kaufman, MD, PhD, David Traver, PhD, Gene Yeo, PhD, MBA, discuss the impact of genomics in relation to stell cell research including potential therapeutics for MDS and the role of the somite in hematopoietic stem cell fate. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37561]
There are at least 2,500 proteins that bind RNA. Gene Yeo, PhD, MBA, explains how his lab studies these RNA binding proteins and their impact on human health. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37589]
How can electronic medical records be used to improve patient care and outcomes? Epic Systems Judy Faulkner explains how data systems are being used to analyze trends in healthcare, COVID-19 protocols, cancer rates and more. Series: "Stem Cell Channel" [Science] [Show ID: 37563]
How are stem cells being used in regenerative medicine? Adam Engler, PhD, Sharon Gerecht, PhD, Laura Niklason, MD, PhD, and Jordan Miller, PhD, explain the promising research as well as the challenges. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37555]
Erik Viirre, MD, PhD, Christopher Mason, PhD, Jana Stoudemire, and Brinda Rana, MD, discuss how what we learn from space flight could impact terrestrial health as well as the health of future astronauts. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37559]
How can we improve the number of years we can live healthy lives? Jennifer Trowbridge, PhD, shares her recent work looking at hematopoietic stem cell aging. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37590]
How are hematopoietic stem cells born during the development of the vertebrate embryo? David Traver, PhD explains his work with zebrafish to understand these processes and the role of the somite in instruction of these cells. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37588]
If we can build living tissue whose form is patterned off natural organs, will it have the same function? Jordan Miller, PhD discusses the design space of engineered living tissues and the challenges presented. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37581]
Using a global collaboration established to find antibodies to fight Ebola, scientists have joined together to discover treatments for COVID-19. Erica Ollmann Saphire, Phd, of the La Jolla Institute for Immunology, shares how this collaboration, known as CoVIC, furthers science and public health while creating a template for rapid discovery. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37669]
Sharon Gerecht, PhD, explains how the microenvironment regulates vascular fate in assembly. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37579]
