Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

Sean Carroll•www.preposterousuniverse.com

Ever wanted to know how music affects your brain, what quantum mechanics really is, or how black holes work? Do you wonder why you get emotional each time you see a certain movie, or how on earth video games are designed? Then you've come to the right place. Each week, Sean Carroll will host conversations with some of the most interesting thinkers in the world. From neuroscientists and engineers to authors and television producers, Sean and his guests talk about the biggest ideas in science, philosophy, culture and much more.

Last refreshed: June 29th, 2026 at 11:32 AM

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Episodes

359 | Solo: Theories of Dark Energy

The cosmological constant, as discussed last episode, provides a perfectly good (thus far) explanation for why we observe the universe to be accelerating. But it might not be the right explanation, and demonstrating that would be yet another foundational discovery. In this episode I discuss what is required to invent a plausible theory of dynamical dark energy , This includes considerations from particle physics, possible experimental tests, and the option that we should modify gravity rather th...

Jun 29, 2026•1 hr 56 min•Ep. 359

358 | Solo: Vacuum Energy and the Cosmological Constant

The most surprising discovery in fundamental physics during my career as a scientist was undoubtedly the acceleration of the universe , announced in 1998. The most straightforward explanation for these observations is a positive cosmological constant, or vacuum energy. I talk about the origin of the idea with Einstein, how quantum physicists started to think about it and understand the "cosmological constant problem," as well as how its discovery also raised the "coincidence problem." This is th...

Jun 22, 2026•2 hr•Ep. 358

357 | Jeff Coller on mRNA, Vaccines, and Bespoke Therapeutics

Messenger RNA (mRNA) plays a literally central role in the functioning of life as we know it, shuttling information back and forth between the DNA where it is stored to the ribosome where it is used to produce proteins. RNA may even have been the first molecule to kick-start the origin of life. Today, scientists are learning how to manipulate mRNA to cure and prevent diseases, whether through vaccination or literally editing one's DNA. Jeff Coller explains how it all works and how mRNA is revolu...

Jun 15, 2026•1 hr 20 min•Ep. 357

356 | Andrea Wulf on Enlightenment, Nature, Romanticism, and Modernity

All ideas have a history, no matter how inevitable and well-entrenched they may seem to us today. The later Enlightenment was a heady time when people were exploring new conceptions of nature, humanity, and the self. Andrea Wulf is a writer of narrative histories, examining the origins of ideas through the lives of the people who explored them. In this episode we discuss three of her books: The Invention of Nature , about Alexander von Humboldt and environmentalism; Magnificent Rebels , about th...

Jun 08, 2026•1 hr 17 min•Ep. 356

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