Welcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: Reagan-Udall Foundation at FDA Gerotherapeutics in Aging Event Recording available: Affecting the Aging Trajectory: Regulatory Constructs for Gerotherapeutic Drug, Biologic and Device Development https://reaganudall.org/news-and-events/events/affecting-aging-trajectory-regulatory-constructs-gerotherapeutic-drug UK Biobank Pharma Proteomics Project (UKB-PPP) , one of the world’s large...
Jun 16, 2026•40 min•Ep. 27
Welcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date. https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies Research articles and news UK Biobank Pharma Proteomics Project Full Cohort Study: Thermo Fisher Scientific’s Olink Platform S...
Jun 09, 2026•53 min•Ep. 26
Welcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: Olink tools and software · Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/ UK Biobank Pharma Proteomics Project (UKB-PPP) , one of the world’s largest scientific studies of blood protein biomark...
Sep 09, 2025•45 min•Ep. 25
Welcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: Olink® Reveal, accessible NGS-based proteomics for every lab: https://olink.com/products/olink-reveal Olink tools and software · Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/ · Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ prote...
Jan 28, 2025•33 min•Ep. 24
Welcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: Olink tools and software · Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/ · Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/pro...
Jan 17, 2025•49 min•Ep. 23
Welcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: Olink tools and software Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/ Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/product...
Nov 12, 2024•57 min•Ep. 22
Welcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: UK Biobank Pharma Proteomics Project (UKB-PPP) , one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies UKB-PPP online resources developed by Nick Lehner and Maria Wörheide https://metabolomips.org/ukbbpgwas/ Metabolomics and Pro...
Mar 05, 2024•48 min•Ep. 21
Welcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: Olink tools and software • Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/ • Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/pro...
Nov 16, 2023•44 min•Ep. 20
Welcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources from this episode: Published study of primary focus Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C. Proteogenomic links to human metabolic diseases. Nat Metab. 2023 Mar;5(3):516-528. doi: 10.1038/s42255-023-00753-7. Epub 2023 Feb 23. Erratum in: Nat Metab. 2023 Mar 19;: PMID: 36823471; PMCID: PMC7614946. https://pubmed.ncbi.nlm.nih.gov/36823471/ Laborator...
Oct 26, 2023•45 min•Ep. 19
Welcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources from this episode: Published study of primary focus Álvez MB, Edfors F, von Feilitzen K, Zwahlen M, Mardinoglu A, Edqvist PH, Sjöblom T, Lundin E, Rameika N, Enblad G, Lindman H, Höglund M, Hesselager G, Stålberg K, Enblad M, Simonson OE, Häggman M, Axelsson T, Åberg M, Nordlund J, Zhong W, Karlsson M, Gyllensten U, Ponten F, Fagerberg L, Uhlén M. Next generation pan-cancer blood proteome profiling using proxi...
Oct 03, 2023•43 min•Ep. 18
Welcome to Olink Proteomics in Proximity Podcast! Below are some useful resources from this episode: Highlighted publication: Girerd N, et al. Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study. Circ Heart Fail. 2023 May;16(5):e009694. doi: 10.1161/CIRCHEARTFAILURE.122.009694 https://pubmed.ncbi.nlm.nih.gov/37192292/ Large-scale cardiovascular studies: · Heart “OMics” in AGE...
Aug 16, 2023•31 min•Ep. 17
Welcome to Olink Proteomics in Proximity Podcast! Below are some useful resources from this episode: Highlighted article from the UK Biobank Pharma Proteomics Project (UKB-PPP): Styrkarsdottir U, Lund SH, Thorleifsson G, Saevarsdottir S, Gudbjartsson DF, Thorsteinsdottir U, Stefansson K. Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource. Arthritis Rheumatol. 202...
Jul 27, 2023•37 min•Ep. 16
Welcome to Olink Proteomics in Proximity Podcast! Below are some useful resources from this episode: Highlighted pre-print article: Malarstig A, Grassman F, Dahl L, et al. Evaluation of Circulating Plasma Proteins in Breast Cancer: A Mendelian Randomization Analysis. ResearchSquare 2023.04.04. DOI: https://doi.org/10.21203/rs.3.rs-2749047/v1 Highlighted platform that was used to measure proteins in this study with a next-generation sequencing (NGS) readout (Olink® Explore 3072): https://olink.co...
May 31, 2023•45 min•Ep. 15
Welcome to Olink Proteomics in Proximity Podcast! Below are some useful resources from this episode: Highlighted publication: Grasberger H, Magis AT, Sheng E, Conomos MP, Zhang M, Garzotto LS, Hou G, Bishu S, Nagao-Kitamoto H, El-Zaatari M, Kitamoto S, Kamada N, Stidham RW, Akiba Y, Kaunitz J, Haberman Y, Kugathasan S, Denson LA, Omenn GS, Kao JY. DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk. J Clin Invest. ...
May 12, 2023•30 min•Ep. 14
Welcome to Olink Proteomics in Proximity Podcast! Below are some useful resources from this episode: Highlighted publication: Diaz-Canestro C, Chen J, Liu Y, Han H, Wang Y, Honoré E, Lee CH, Lam KSL, Tse MA, Xu A. A machine-learning algorithm integrating baseline serum proteomic signatures predicts exercise responsiveness in overweight males with prediabetes. Cell Rep Med. 2023 Feb 21;4(2):100944. doi: 10.1016/j.xcrm.2023.100944. Epub 2023 Feb 13: https://www.cell.com/cell-reports-medicine/pdf/S...
Apr 19, 2023•28 min•Ep. 13
Highlighted publication: Zannad F, Ferreira JP, Butler J, Filippatos G, Januzzi JL, Sumin M, Zwick M, Saadati M, Pocock SJ, Sattar N, Anker SD, Packer M. Effect of empagliflozin on circulating proteomics in heart failure: mechanistic insights into the EMPEROR programme. Eur Heart J. (2022) 43(48):4991-5002. doi: 10.1093/eurheartj/ehac495 . PMID: 36017745; PMCID: PMC9769969 . Review paper of research by Voltar Longo and David Sinclair on longevity and aging, mentioning sirtuins and mTOR. Longo VD...
Mar 15, 2023•27 min•Ep. 12
All about Olink Flex: https://olink.com/flex Olink Insight (where you can build a 21-plex Olink Flex panel from 200 proteins): https://insight.olink.com Sweden’s Science for Life laboratory website: https://www.scilifelab.se/about-us/ In case you were wondering, Proteomics in Proximity refers to the principle underlying Olink Proteomics assay technology called the Proximity Extension Assay (PEA), and more information about the assay and how it works can be found here. Would you like to subscribe...
Feb 16, 2023•32 min•Ep. 11
Primary reference: Loriot Y and Italiano A et al. Plasma proteomics identifies leukemia inhibitory factor (LIF) as a novel predictive biomarker of immune-checkpoint blockade resistance. Ann Oncol. (2021) 32(11):1381-1390. doi:10.1016/j.annonc.2021.08.1748 Olink Insight Knowledge Platform with Hilda Andersson, Episode 6, Proteomics in Proximity . Description of the MATCH-R clinical trial, “A Prospective Trial to Study the Evolution of Clonal Architecture of Tumors From Patients Treated With Molec...
Feb 03, 2023•27 min•Ep. 10
Primary reference: Ticau S and Nioi P et al. (2021) Neurofilament Light Chain as a Biomarker of Hereditary Transthyretin-Mediated Amyloidosis. Neurology. 96(3):e412-e422. doi:10.1212/WNL.0000000000011090 Information about the APOLLO clinical trial: “APOLLO: The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis” Link to NCT01960348 at the US National Library of Medicine’s Clinical Trials database https://clinicaltrials.gov/ct2/s...
Jan 20, 2023•26 min•Ep. 9
The 2019 Cell Reports paper, “Chromatin Remodeling in Response to BRCA2-Crisis” by J Gruber and M Snyder et al. is available online here . Dr. Michael Snyder’s Stanford laboratory home page is here . A 1998 Oncogene paper, “The BRCA2 is a histone acetyltransferase” by S Habibur and E S P Reddy et al. is located online here . A 2014 Cancer Discovery paper, “R-loop Processing by BRCA2 is Required for Genomic Stability” is located here . And more about TIP60 can be found in this recent 2022 Oncogen...
Dec 21, 2022•19 min•Ep. 8
Primary reference: Suhre K, Sarwath H, Engelke R, Sohail MU, Cho SJ, Whalen W, Alvarez-Mulett S, Krumsiek J, Choi AMK, Schmidt F. Identification of Robust Protein Associations With COVID-19 Disease Based on Five Clinical Studies. Front Immunol. 2022 12:781100. doi:10.3389/fimmu.2021.781100 Dr. Karsten Suhre’s Weill Cornell Medicine laboratory page: https://vivo.weill.cornell.edu/display/cwid-kas2049 Leukemia Inhibitory Factor reference: Loriot Y, Marabelle A, Guégan JP, et al. Plasma proteomics ...
Dec 07, 2022•47 min•Ep. 7
To access Olink Insight free of charge, visit https://insight.olink.com The first two data stories, with Normal Range data and COVID-19 data, has been recently updated with the first Disease Atlas, with data characterizing 15 cancer types. This is available on Olink Insight here: https://insight.olink.com/data-stories/disease-atlas-cancer To access the COVID-19 Data Story dataset itself, information about the study and how to access the data is available on our website here: https://olink.com/ap...
Nov 23, 2022•39 min•Ep. 6
List of names and affiliations mentioned in the UK Biobank context: Mark McCarthy (Genentech), Slavé Petrovski (AstraZeneca), Chris Whelan (Johnson and Johnson), Erin Smith (Takeda Pharmaceuticals), Melissa Miller (Pfizer), Ben Sun (Biogen). The ASHG announcement , honoring Sir Peter Donnelly, CEO of Genomics plc and Emeritus Professor of Statistical Science at the University of Oxford with the William Allan Award. A list of the many abstracts and plenary presentations at ASHG 2022 that mention ...
Nov 09, 2022•24 min•Ep. 5
One of the first publications using Olink technology came out by Enroth S and Gyllensten U et al. Nature Communications 2014 “Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs”. Link to the paper is here: DOI:10.1038/ncomms5684 To access the Olink Insight platform for protein biomarker data discovery free-of-charge with an email address, click here: https://insight.olink.com And be sure to check out the Publication Explorer! A recent publicati...
Nov 03, 2022•39 min•Ep. 4
The 2022 Science Advances paper, “Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods” by Daniel H Katz and Rob Gerszten et al. is available online here . A highly informative Twitter thread by the first author Dr. Daniel Katz reviewing the figures of the paper is available here . If you are interested in learning more about the use of proteomics in multiomic strategies, here’s link to the Olink website where examples...
Oct 25, 2022•32 min•Ep. 3
Show Notes for PiP Ep 02 “Empower Genomics with Proteomics” For more information about the UK Biobank, an Olink to Science blog post called “Genetic Regulation of the Human Plasma Proteome in the UK Biobank” is available here . The preprint publication itself is available here on bioRxiv . If you’d like to see a great 15 minute presentation on what the goals are for the UK Biobank Pharma Proteomics Project, Dr. Chris Whelan (Biogen) presented this YouTube video at one of the UK Biobank’s scienti...
Oct 12, 2022•40 min•Ep. 2
In case you would like to learn more about our backgrounds, Cindy’s LinkedIn is here , Sarantis’ is here , and Dale’s is here . For more information about the UK Biobank, an Olink to Science blog post called “Genetic Regulation of the Human Plasma Proteome in the UK Biobank” is available here . The preprint publication itself is available here on bioRxiv . If you’d like to see a great 15 minute presentation on what the goals are for the UK Biobank Pharma Proteomics Project, Dr. Chris Whelan (Bio...
Sep 27, 2022•37 min•Ep. 1
Co-hosts Dale Yuzuki, Cindy Lawley and Sarantis Chlamydas from Olink Proteomics talk about the intersection of proteomics with genomics for drug target discovery, the application of proteomics to reveal disease biomarkers, and current trends in using proteomics to unlock biological mechanisms. In case you were wondering, "in Proximity" refers to Olink's underpinning technology called the Proximity Extension Assay, to allow highly multiplexed protein analysis from small sample volumes for pharmac...
Sep 19, 2022•2 min
