Comedian Shane Mauss ( @shane_mauss ) returns to the show to talk about his upcoming comedy special TRIPS: The First Dose , how LSD affects blind people , misophonia's link to anxiety and depression , the goring of a matador's ass , plants 'hearing' rain coming and Shane's comedy/science podcast Here We Are ....
May 11, 2026•1 hr 12 min
Comedian Brandie Posey ( @brandazzle ) returns to the show to talk with Jesse, Andy and Matt about the geography of Jersey, Brandie's label Burn This Records and her new comedy special Milk Job , Andy's other ska band , why humans can't regenerate limbs , a huge volcano refilling with magma , the dude who got both his arms reattached in 1992 , whether Yellowstone is due for an eruption and Fruit Love Island ....
May 03, 2026•1 hr 17 min
Comedian/speechwriter Chandler Dean ( @chandlerjdean ) joins Jesse, Andy and Matt to talk about his show Abolish Everything! , Jesse's over-the-top stuffed animal purchase , poop speed as a health indicator , the Bristol Stool Chart , medical fake poo , Jesse's obsessions with fake foods , giant stuff and really tiny stuff , Artemis II's avatar crewmates , the magic of Tiny Empath Babies , videos of Tiny Empath Babies and more videos of Tiny Empath Babies ....
Apr 25, 2026•1 hr 17 min
Comedian Amber Preston ( @prestonparty ) returns to help Andy, Jesse and Matt celebrate the big six-oh-one and talk about Artemis II, frozen urine in space , a microbe that makes you stronger , Trump's insane handshakes , sharks testing positive for cocaine and sperm difficulties in zero-g ....
Apr 17, 2026•1 hr 16 min
Comedian Katie Novotny ( @katienovotnyyyyy ) joins Matt and Andy to discuss her special Son of Your Dreams , whale junk , headbutting whales , the 20-year cycle of fashion , an evolved arsenic tolerance , Thai children who can see underwater and a Warsaw Poland Bros. song Andy plays on ....
Apr 06, 2026•1 hr 9 min
Comedian Monica Nevi ( @monicanevi ) joins Andy, Jesse and Matt to talk about her special Big Stepdad Energy , what VO2 max means, esports scholarships, vasectomy rate spikes during March Madness , the effect of carbonated water on gamer performance , a bunch of human brain cells in a petri dish playing Doom , unlocking the antibacterial secrets of frogs and using frogs to keep milk from spoiling ....
Mar 29, 2026•1 hr 4 min
Comedian Matthew Coe ( @matthew_coe__ ) joins Jesse, Andy and Matt to talk about parents watching comedy, Matthew's show My Therapist Knows Your Name, Matthew's hypoplastic right heart syndrome, the closing of the foramen ovale , a Japanese study of falling cats , a robot handling potato chips , and an averted Moon asteroid close call ....
Mar 19, 2026•1 hr 13 min
Comedian Jackie Kashian ( @jackiekashian ) returns to the show to talk with Jesse and Matt about her new standup special Alter-Kashian , huge amounts of hydrogen inside the Earth's core , weird things yawning does in your brain and a possible universal vaccine . See Matt on tour in Seattle and Portland , and Andy on tour in Santa Barbara ....
Mar 05, 2026•1 hr 6 min
Comedian and former marine biologist Forrest Shaw ( @forrestshaw ) returns to the show to talk with Matt, Andy and Jesse about his new live show The Ocean Hates You , his addiction podcast I've Got A Problem , bonnethead sharks , the rise of online sports gambling , a Kalshi market about aliens , and the myth of alpha wolves ....
Feb 26, 2026•1 hr 17 min
Comedian Aisha Alfa ( @aishaalfa ) joins Jesse, Andy and Matt to talk about comedy in Winnipeg, Jesse's Megyn Kelly-loved Olympics tweet , the cult movie Phantom of the Paradise , Andy's family friend Olympic ice dancer , the German word for a living stork with an arrow in it , the penis injection Olympic ski jumping controversy , an amazing artificial lung feat , Jesse's artificial lung cat bed, Aisha's newsletter and Andy's upcoming ska shows ....
Feb 17, 2026•1 hr 5 min
Comedian David Huntsberger returns to the show to talk with Matt, Jesse and Andy about his podcast Intercepts , his new platform The Endless Abyss , the lost art of sketch comedy albums , the world's worst redaction , Redactle , how dogs build their vocabularies like toddlers , Stella the talking dog , dumb dogs , breed stereotypes , Bad Will Hunting , the worst logo and name in education , longevity in meat-eaters and the foresight of The Machine Stops ....
Feb 04, 2026•1 hr 8 min
Comedian/neuroscientist Diya Basrai ( @diyabasrai ) joins Jesse, Andy and Matt to talk about Moravec's Paradox , whether there's something meat-specific about intelligence, a less-pessimistic AI take , a tool-using cow , Diya's comedy special and his comedy/science live show Uncontrolled Variables ....
Jan 30, 2026•1 hr 10 min
Comedian Jon Stringer ( @jonjstringer ) joins Andy, Jesse and Matt to talk about living in a converted rural Kansas church, the intricacies of comedy competitions and cruise ship comedy, dry ice PVC soupcan launchers, the oldest known use of poison arrows , retail blowguns and their misuse , vibe-coding a band manager, why you should stop using hydrogen peroxide on cuts , sword canes and pendulous doorknockers ....
Jan 21, 2026•1 hr 10 min
Comedian Imaan Hadchiti ( @imaanfrankhadchiti ) joins Jesse, Andy and Matt to talk about Rima syndrome, the movie Tiptoes , the passing of an art legend , sniffing farts to prevent Alzheimer's , what actually causes ice to be slippery , when physical aging really kicks in and making paralyzed rats walk again in a really creepy way ....
Jan 13, 2026•1 hr 15 min
Comedian/actor/writer/composer Waen Shepherd ( @waenshep ) joins Andy, Jesse and Matt to talk about the new album from his alter ego Gary Le Strange , the biology of elves , the best chocolate chip cookie recipe , a runaway supermassive black hole , a lemon-shaped exoplanet and the music of Gary Wilson ....
Jan 04, 2026•1 hr 13 min
Comedian/host/author Chris Duffy ( @chrisiduffy ) returns to the show to talk with Jesse, Andy and Matt about his new book Humor Me: How Laughing More Can Make You Present, Creative, Connected, and Happy , his radio show/podcast You're The Expert , his TED podcast How To Be a Better Human , the unintentionally phallic Covid-era Terry Crews video Chris worked on with Matt and Andy , prescribing standup to improve mental health , training Swedish crows to pick up cigarette butts and a frozen worm ...
Dec 28, 2025•1 hr 10 min
Comedian Buddy Fitzpatrick ( @buddycomic ) joins Andy, Matt and Jesse to talk about Batman's effect on subway chivalry , the rooms of Madonna Inn , ladyfingers , manmade fire from 350,000 years earlier than previously thought , monogamy across the animal kingdom and an insane chain of rabies transmission via organ transplantation ....
Dec 16, 2025•1 hr 18 min
Comedian Adam Burke ( @atpburke ) joins Andy, Jesse and Matt to talk about Adam's new comedy special Unamerican , debunking the Stanford Prison Experiment , classic '80s Arnold movies, Matt and Jesse performing together in Nashville, the preacher who shot an escaped lab monkey , AIs that believe themselves to be more rational than humans , 3D printing with a mosquito proboscis , Andy's upcoming orchestra shows and Matt's upcoming San Deigo standup show ....
Dec 09, 2025•1 hr 24 min
Comedian/writer/ NPR host Ophira Eisenberg ( @ophirae ) joins Andy, Jesse and Matt to talk about her podcast Parenting Is a Joke , her upcoming special produced by Lewis Black, the effect of venting on anger , a rage room show Andy worked on , why you should leave uncontacted tribes alone , the wombat-thief influencer and why you should speak up to seagulls ....
Nov 28, 2025•1 hr 25 min
Comedian Jess Zenisek ( @jeffzenisek ) joins Andy, Jesse and Matt to talk about tennis, homophobic sports stereotypes, Jesse's new ski persona, Mr. Wizard , Jeff's hair care regimen, a tiny tyrannosaur , a better rock-paper-scissors strategy , gray hair's relationship to cancer , t he worst music to play during sex and the banger Parked By The Lake ....
Nov 14, 2025•1 hr 12 min
Comedian/playwright Drew Droege ( @drew_droege ) joins Matt, Jesse and Andy to talk about his new off-Broadway play Messy White Gays , X-ray NBA poker fraud and why birds sing after a solar eclipse .
Nov 10, 2025•52 min
Wonderful NY comic Mehran Khagani ( @themehran ) joins Jesse and Matt to talk about escaping from Iran, working at the Harvard School of Public Health, hyrax butt drag fossil marks, Canadian heart transplants and the most pristine star in the universe! In the patreon bonus we get into penguin micronaps. Click here to support Probably Science via Patreon...
Oct 29, 2025•54 min
Comedian/actor Jen Kober ( @jenkober ) joins Andy, Jesse and Matt to talk about comedy in Louisiana, Oktoberfest , buxom wenches, the connection between fish buttholes and fingers , a koala chlamydia vaccine , Jesse's newfound raccoon fame , light-powered gears that fit inside a strand of hair and Jen's membership in the Star Wars canon ....
Oct 20, 2025•1 hr 12 min
NASA astrophysicist and JPL Exoplanet Science Ambassador Anjali Tripathi joins Andy, Jesse and Matt to talk about exoplanets and the different ways of finding them including radial velocity, transits and gravitational microlensing , the challenges of studying planetary atmospheres, why telescopes are built in deserts or in space, Anjali's time at the White House Office of Science and Technology Policy, science communication projects like the Logic 44ever rap video , the upcoming Nancy Grace Roma...
Oct 05, 2025•1 hr 21 min
Comedian Michelle Murphy ( @meeshoffleash ) joins Andy, Matt and Jesse to talk about playing tennis for Grinnell, the Enhanced Games , celebrities trying their hands at winter sports , Jesse's accidental mermaid book purchase and the Dr. Seuss book he was aiming for , Burning Man missionaries, LSD to fight anxiety and surprisingly not too uncommon iridescent mammals ....
Sep 27, 2025•1 hr 21 min
Comedian Ken Reid ( @kennethwreid ) joins Jesse, Matt and Andy to talk about growing up a child of television, mud wrestling, Ken's podcast TV Guidance Counselor , an HIV prevention breakthrough , the insanity of Movie 43 , the human washing machine no one asked for , blasting plastic waste with a plasma torch , Doja Cat's nod to Max Headroom , Ladies and Gentlemen, The Fabulous Stains , the reason plastic recycling mostly ended , Andy's Oktoberfest shows in Lake Arrowhead and John Williams polk...
Sep 17, 2025•1 hr 16 min
Comedian Ryan O'Flanagan ( @ryanoflan ) joins Matt, Jesse and Andy to talk about Ryan and Andy's chance encounter in a bar in Leadville, Married With Children tattoos , neanderthals and homo sapiens interbreeding , a novel telescope shape to help search for exoplanets , an insane impression of a neanderthal voice and Ryan's podcast Laser Show ....
Sep 09, 2025•1 hr 12 min
Comedian Myq Kaplan ( @myqkaplan ) returns to the show to talk to Andy, Jesse and Matt about growing out his eyebrows during the pandemic, babies distinguishing Ps from Bs, linguistics, sign language variations, standups aping Shane Gillis, the Mr. Beast voice, birds' preference for crapping in the air , strong link versus weak link problems , Ryan North , whether you should pay for bad art, what sequels always get wrong and Myq's great Substack ....
Aug 29, 2025•1 hr 12 min
Comedian and host of the SSRI'M OK podcast Macey Isaacs joins the gang to talk about a meteorite that's older than our planet ! AI and attachment theory ! And some more AI nonsense before Andy's connection quit in a fury! In the Patreon bonus we find out why living near the ocean extends your life. Follow Macey on instagram and check out her podcast, and her Don't Tell special when it drops! Click here to support Probably Science via Patreon Click here to subscribe in Apple Podcasts Click here t...
Aug 20, 2025•1 hr 2 min
Comedian/mathematician/ YouTuber /author Matt Parker ( @standupmaths ) joins Jesse, Andy and Matt to talk about his new book Love Triangle: How Trigonometry Shapes the World , his podcast A Problem Squared , his Edinburgh Fringe show Getting Triggy With It , Mathstodon , a hawk that uses traffic patterns to target prey , desire paths , Earth's leaking core , the Gibeon meteor , Matt's comedy tour dates and Andy's Colorado music dates ....
Aug 11, 2025•1 hr 6 min