>> Hunter Hoover: If I'm sumaggluting myself on the daily, but I'm still eating like two to seven pieces of pizza for lunch and I'm just goblin down sugar drinks and I refuse to exercise in any way, I have a feeling it's not going to have the accomplished effect. Welcome back to Privy. Privy is a podcast about bathrooms recorded from my home bathroom. I'm your host, Hunter Hoover, and I love bathrooms. Welcome back everyone. Thank you so much for being here.
Um, thank you for joining us as we're closing out February. February is a short month and it's a challenging month. There's a lot of frustration. There's a lot of, I think unexpected surprises in February. You know, I think there's a lot of folks that, that come towards the end of the year, they'renn have, they're gonna have a lot of, a lot of extra stuff going on. And in February is one of those months where sometimes that type stuff happens.
Uh, I want to note here at the top of the show, I have a co worker, uh, at the high school I work at who has told me, he's told me on a number of occasions, he's like, hey, I got some pretty sweet bathroom store. Like I used to work as this. You worker, like worked with kids. I've got some stories to tell. The incredible bummer is he is unwilling to come
on the show. I've been working on it. There's actually a handful of people that I know who are like, yeah, I've got some sweet stories, but they're unwilling to come on the show. It's a real bummer. It's real unfortunate because the world needs their bathroom wisdom, but they are unwilling to share it. It's an ongoing problem. It's an apprehension that I find that a lot of people have when they
begin interfacing with this show. You know, maybe they're met with some embarrassment, like, oh, I'm listening to this guy talk about bathrooms. He says he likes bathrooms. I sure like bathrooms. I would much rather do this than diaper dumpy myself. But, um, these bathroom stories, they need shared. So I'm going to put a little call out here at the top of the show. If you have what you believe is a bathroom story that you'd love to share, hit me
up. Those who've heard, ah, an episode where I've had someone on before know that you do not have to carry the bulk of the episode. You do not have to carry the episode with your story. Now, your story will probably be the highlight of the show. It usually is. But I always have some things that I need to be asking people about bathrooms. So if you're interested, hit me up privycastmail.com. it's
February. The other thing that happens in February, besides leading to post your regret, uh, is a lot of people have abandoned a lot of those, uh, diets and things that they, you know, they started out the beginning of the year and maybe January is a little bumpy. In February is the month we're going to lock it down. But by the time Valentine's Day rolls around and everybody's gobbled up their, their dang, you know, they've gotten there, Valentine's candy, they've blown the New Year's
resolution. It's done, it's failed. And so while these New Year's resolutions and health fads are all but totally cast by the wayside by this point in the year, there's another fad that seems to be a little more prominent than I think it needs to be. And before we jump into this fad and specifically how this fad affects our bathrooming, we need to do a little history lesson in privy, cast style. In 1902, British physiologist William Bayless and Ernest Starling. Those are some very British
names, by the way, I might add. They discovered a chemical, uh, a compound in our bodies called secretin. It's the first hormone which they discovered helps regulate pancreatic secretions. This discovery marked the beginning of research into gastrointestinal hormones and their role in the metabolic process. In other words, they started to learn about how the very yummy drippy juices that our internal organs produce help break down the food and metabolize
the food that we eat. Just an FYI, in today's episode, we're going to say the word secretion a lot. So if the word secretion is a word that bothers you, um, I'm sorry, but we're going to say secretion a lot this episode. It's an unfortunate byproduct of us talking about these things, but what's a guy to do? Secretion. The idea of incretins were more of a concept. The term in cretin or in incretin was introduced to describe gut derived factors that enhance insulin secretion in response to oral
glucose. So you eat the yummy sugar glucose, yum, yum, yum, yum, yum, yum, yum, yum, yum, yum, yum, and then your gut it. This in incretin is this thing that helps enhance insulin secretion in order to respond to that intake glucose. Like, you eat a big fat brownie, big sloppy, wet brownie, a big old sloppy guy, and they're like, he's gonna have more in incretins due to the brownie. However, the specific hormones responsible weren't, uh,
immediately identified. It wasn't like, hey, this is the one to one of what's going on here. It seems incretin, or incretin is tied specifically to the glucose you eat and as a result is related to the digestive systems in our bodies. Here on Privy, we're a big fan of digestion. I had a big old fancy meatball sub with fancy ham on it this afternoon, this evening, so very delicious. And I'm going to learn a little bit about digestion here in the coming hours, I'll tell you what.
But the incretin phenomenon was used to describe this observation. Researchers labeled this in the 1960s and 70s, and they came to believe that oral glucose intake stimulates a stronger insulin response compared to intravenous glucose. So, um, in other words, like, if you eat something that is high in sugar, it causes a greater response than if you just straight up inject the sugar straight into the good old SS bloodstream right there and get it right on
in. This M phenomenon that when you eat it, it produces a greater insulin response became known as the Crein effect. But the hormones responsible for this phenomenon were not really perceived or that well known or could not be identified. It took them a bit, but by 1971, they pinned down what was causing this thing. An incretin hormone was discovered, known as GIP, I.e. gastric inhibitory polypeptide. This gastric inhibitory polypeptide was identified as an incretin hormone.
However, GIP's effectiveness was limited to individual type, limited in individuals with type 2 diabetes. So people with type 2 diabetes, that GIP, they had the GIP, you know what I'm saying? The GIP was really gipping on. And so that caused these scientists to wonder, why do people with this specific type of diabetes, type 2 diabetes, have this gastric inhibitory polypeptide? And. Or, uh, rather, why are they so
limited in it? Like, why does their body not seem to produce or not seem to have the same reaction in the face of glucose as others? In the 1980s, advances in molecular biology revealed that there was actually a gene that had some things to do with these matters. The proglucagon gene in the pancreas produces multiple peptides, including glucagon. Researchers found that in the intestines the same gene produces different peptides, GLP1 and GLP2. Now I will notice this is different
than GIP. We've been talking about GIP. This is GLP. And these two, GLP1 and GLP 2 are responsible for helping break down sugars in the body. In 1985 they isolated GLP2 when a team, uh, uh, led by Dr. Joel Haernner. Haernner, Haernner and other colleagues from Harvard Medical School identified GLP1 as one of the products of proglucagone. They determined that it exists in these two active forms, both of which are port to insulantropic agents. I think that's agents that respond
to or need to respond to insulin. But like that's a lot of science mumbo jumbo, right? And I acknowledge I just went on a science mumbo jumbo jumbo. Mumbo jumbo. But so what, what does this bad boy do exactly? Like what is this thing? I mean we got like medical history lesson and a chemistry lesson all wrapped up in the first 10 minutes of this episode and you've barely even talked about the bathroom. Weren't trying to be doctors here.
What's this even, what's this got to do with anything? So the scientists found that GLP1 could stimulate glucose dependent insulin release from pancreatic beta cells, a key function in maintaining blood glucose levels. GLP1 delays gastric empty, which usually results in you taking a poo and acts on the brain to promote satiaiety and reduce appetite. So this peptide, GLP1 is found to be able to reduce your appetite and slow the rate by which you have to drop. A Chaz Royale could be helpful.
Seems unhelpful to me. If I don't drop, if I'm ir, regul it. Like I'm pretty regular guy, I stay pretty regular. I'm not going to lie about it. If I get off on my shazz schedule, I know it like I know it. And so it's important to me to make sure that my shazz schedule stays pretty regular. But GLP1 delays gastric empty, empty. And somehow they've also found that this peptide, this hormone peptide, I don't even know, I'm not a scientist. I don't understand what freaking
peptide is. Like I have a game or there is a game, I don't know if I have it. I have to go check my very good board game wall. But there's a game called Peptide. I assume it has something to do with that. But somehow they found that this thing can also be good for your heart. It improves cardiovascular function and may
have other protective effects. Problem is this peptide, GLP1, it's like a two minute half life, meaning if you are to introduce it to the system, if you do it orally, like if you snack it down, if you GLP1 straight down the topside mouth hole in two minutes it's going to be rendered completely ineffective. You can't do it orally. And so they went looking for something a little more stable. Just like them teenagers that are dating, you know what I'm saying? They're looking
for something a little more stable. Early studies using synthetic GLP1 showed promising results however in improving blood glucose control in individuals with type 2 diabetes. So they needed this thing to resist degrading that happens within the body. So if you put this peptide in, it is going to naturally degrade and it
degrades quick like two minutes. And so they're trying to figure out a way and they began to work on synthetic versions of GLP1 that would have a greater half life and maybe be able to be introduced in different ways. The GLP1 receptor agonists, I don't know what that means, um, such as xenotide, are introduced in the 2000s. Novo Nordisk, a Danish pharmaceutical company, began to work on semagglutide in the
2000s. If you're looking for a good name for your baby, if you find yourself suddenly or otherwise in the market for a good name for your baby or maybe your enemy, look no farther than sumaagglutide. Sumagglutide was designed as a modified GLP1 analog with an extended half life, meaning it lasts longer once it's introduced to this system of about one week. This was achieved by substituting specific. It's all chemistry, you chemistry, wemistry,
just friggin Bill Nye the science guy thing. Out of this medication they added a fatty acid side chain to enhance binding. I don't even know, it's a bunch of pharmaceutical mumbo jumbo. But Novo Nordisck conducted extensive preclinical studies followed by clinical trials to establish semaglutides safety and uh, efficacy. In 2017 this drugmaglutide gained approval by the FDA to treat type 2 diabetes.
It was introduced as a once weekly injectable treatment, a uh, convenient option compared to the daily injections. Nowadays similar drugs are not only used to treat type 2 diabetes. Somaglutide and other similar drugs began to be explored for their benefits in treating obesity. Observations from diabetes Trials showed that semaglutide also led to significant weight loss. Novo Nordisk initiated trials to study higher doses of somaglutrid in treating
obesity. So you know, you just give them the shot, make them skinnier. Clinical trials for obesity began in 2021 where they showed they can lower body weight when paired with lifestyle changes. That uh, lifestyle changes seems to be pretty important. Like if I'm sumaggluting myself on the daily but I'm still eating like two to seven pieces of pizza for lunch and I'm just goblin down sugar drinks and I refuse to exercise in any way, I have a feeling it's not going to have
the accomplished effect. I think that lifestyle change is pretty important to this situation. Those lifestyle changes like they're important. That's what I'm saying. But the drug gained approval, Semaglutide and others, uh, it gained approval for weight loss in 2021 under the brand name Wegoi for chronic weight management in adults with obesity or overweight and at least one weight related condition such as hypertension or uh, dyslipidemia. I don't know.
In other words if they deemed that a person is big enough to where they're going to have health complications either now or down the line they would, we would prescribe them Wagoi. It is a fat loss drug. A weight loss drug. Sorry I can't weight loss. But another similar drug, Ozempic took on the role of the diabetes management while Wagoi was more the weight loss
drug. These are still injections and researchers are exploring oral formulations already approved as Ribosis and investigating Semaglutide for other potential indications such as non alcoholics. They can't say that word, don't know it. But Ozempicmalutide gained a significant popularity in the last few years as a weight loss drug due to its remarkable effectiveness, its mechanism of action and the growing demand for safe and effective treatments for obesity.
Apparently exercise, dieting and self control just won't cut it. Here uh, are the primary reasons for Ozempics popularity. First of all Ozempic had exceptional weight loss results and it could also treat diabetes which is this type 2 diabetes is often a condition that they see that runs like side by side with obesity. This was also related to a new view of obesity as being a quote medical condition. Now I'm going to say something. I'm not a skinny person, I'm full bodied as the kids say. I'm a
size 2x. I understand the level of fat kid. I have achieved. But here's the deal. I am not fat because I have a medical problem called obesity. I'm fat because I ate, again, a very sloppy meatball sub sandwich, and within the hour purchased a large shamrock shake, which I shared with my family. But I did do it. Do you know what I'm saying? Like, I'm not blaming a medical condition for the fact that I like Oreos. I'm not blaming a medical condition for the fact that video games are more fun
than exercising. It's just true. And so it has nothing to do with me thoroughly enjoying pizza and ice cream. It's a medical problem. That's pretty much what these people are trying to say. But Ozempic also got a lot of press. Even though there were alternatives out there, social media and other celebrity endorsements really drove Ozempic'popularity way, way up. Another reason that people point to Ozempic'popularity was the global pandemic.
This thing called the novel coronavirus, uh, uh, echo chamber, in which men and women, but like, kind of like man, decided to really hunker down and start podcasts. You know, it's just weird. It's a weird phenomenon. It's weird. I've seen a lot of people wearing masks again recently. And I'm not here to make a comment about the masks, but it is kind of traumatizing when I see that. And people are going to hear that and like, shut up. Yes, as you should. But my thing is like, the whole mask
thing was kind of hellish to me. It was very awful. I. The minute that, oh, I remember the day that they lifted the MAS mandate, and I was like, you'll never be able to put it back on. You got me. Fool me once, shame on. Shame on me or fame on you or whatever. And you're not gonna fool me twice on this. Like, uh, it's just an unbearably awful experience. But here we are. We must soldier forth. But the global pandemic, the novel coronavirus, caused a huge spike in profit from the pharmaceutical
company. It's weird how that worked. It's weird how as we directly, you know, were pushing this idea of a need for a vaccine, we were also making wooy bucks off of that vaccine. It's fascinating to me, you know, I don't know if there could possibly any collusion or like, anybody that was like, pushing an agenda in order to make a trainload of money. Fat shot. Uh, also it's considered like.
So in this, they, they began to, as, as the coronavirus pandemic ended they needed, they had these new profit margins that were kind of unheard of. Like, how do we meet these profit mar. Like how do we, how do we meet these, these profit expectations again? And so they began to push Ozempic as a fat loss, weight loss drug, uh, in order to drive up some sales, uh, some profit margins on, on these companies, pharmaceutical
companies. Also, because the procedure and the use of this medication can be considered medical, a lot of it is covered by insurance. As we discussed, Ozempic and other similar drugs take a significant role in your bathroom. They come up a lot there. They're going to affect you when you get in the zone. It should be noted if you're looking to Ozempic for weight loss or blood sugar regulation and you're concerned about the bathroom, should be aware of a number of things.
Before I continue, another thing you should be aware of is that I'm not a doctor. I've never been to medical school. I don't even, like, I barely go to the doctor to be checked up. And so don't take anything that I tell you for medical advice. This is explicitly not medical advice and nothing in this episode has been. But you should be aware if you're looking toward Ozempic or other similar drugs for weight loss control, about a number of ways that it is reported to affect you
in the bathroom. Now, depending on where you look, there are reports that say Ozempic can cause both diarrhea and somehow constipation. And, uh, it's a baffling phenomenon. Truly, these drugs that have both diarrhea and constipation as a side effect always throw me for a loop because like in my brain diarrhea and constipation are like the opposites. And in my brain it's difficult to have the opposites at the same time. Like you're either plugged up or it's rocketing through
you. I'IT'S usually rocketing through me. You know what I'm saying? It's flying right through me. It is noted that you can also experience nausea and vomiting from Ozempic. Those two are a no fly for me. If a medication is non necessary, like if it is to treat something that I don't need to be treated and it causes nausea and vomiting. I don't know about that. Like I might be a hard skip on it. That's just me. So about 8% it says of people who have taken Ozempic experience
diarrhea. And there's a number of sources that say that if you avoid fat Rich foods and sugary drinks, it can help keep the diarrhea down. And that's because it's just passing that stuff through. It's not trying to break it down. It's just moving along the way. In some cases, it can be severe enough diarrhea that you elect to stop taking the medication that is reported to be a thing to happen. Some people, the squirts get so bad that they're like, I'm done. I'm done ozempicking
myself. But in most cases, the runs would go away on their own. In fact, if 8% of people who use Ozempic experience d, which is not nothing. I mean, imagine if you went to McDonald's and they gave you a bag of food and they said, hi, 8% of our food is going to give you flaming, raging diarrhea, Would you do it? Would you still eat it? I know I would. I would eat it and then I would get the pupils who have decided they're not going to eat it, and I would eat
theirs. But if 8% of this population experience diarrhea, GoodRx reports that 4% of those quit taking the medication due to rigorous diarrhea. And I want to know, like, that's actually a lot. Like 4% of people are like, the diarrhea has overcome me so much. The wild spray is more than I can handle. Usually the diarrhea will last for three days to a week. As your body adjusts, you'll likely be experiencing diarrhea.
Ozempic does this because it changes the way your body absorbs nutrients and impacts how quickly things move down the digestive tract. What's even more wild is on Ozempic, many people experience again both diarrhea and constipation at the same time. When this happens, it can result in something fun. A phrase which is haunting to me. And we all hoped to never have to face a phrase called overflow diarrhea. Help us, Father, for we have strayed far from you. Overflow
diarrhea. Dear Lord, just, just help us. And if the idea of overflow diarrhea isn't scary enough, in these cases, the overflow diarrhea is happening in what could possibly be the worst place for overflow diarrhea to happen Inside of your body, in your colon and digestive tract. What happens is you get constipated and the poo sets up and it's like it just hardens right there inside you just smashed, just doink, just really clogged up the pen
down in there. Then as the Ozempic makes the diarrhea run wild. It runs into the poop plug mid tr mid system and it begins, because it cannot pass through, it begins to eek out the edges of the turd log that is still in the system. It's so fun. Just a seepy turd log. Other reports state that it affects urination, but the correlation is not as strong to speak to whether this is directly related to the use of Ozempic or not.
And all of these things beg the question, the rapid fat loss, the way it affects your bathroomoming, the trouble with constipation and diarrhea, uh, all these things asked is is it safe? And the answer is sort of. Ozempic and other similar drugs are FDA approved for type 2 diabetes. So as of the point of this record, it's not technically approved as a weight loss drug. Now often it will still be used as a weight loss drug and they'll say well you know, we're treating pre type 2 diabetes by doing
this. Weight loss is a side effect of Ozempic and cocaine, so there's that. It's not recommended for weight loss. But I'm not a doctor and this isn't medical advice so talk to your doctor if you want to shed some pounds quick. I guess you could stab yourself in the tummy with thosezempic. I mean it seems like it would work. It's worked for lots of people. Talk to your doctor in treating type 2 diabetes which can develop into life altering or
problematic changes. It has side effects which include the possibilities of developing thyroid tumors and causing pancreatitis. My mom had pancreatitis when I was in school and I remember that experience being pretty awful for her. Like pretty awful. It's not a miracle shot that's going to make you skinny, but it will, except for it comes with some side effects. Impossible ongoing problems for the person who uses it. I'm fat. Hello, it's me. The diary of a chunky kid.
And as a bigger guy I'm convinced that the path forward is found not in Ozempic and taking these tummy injections and trying to lose weight via a uh, medication, but that the path forward comes through, for lack of a better way of saying it, trying to eat better, eat smarter and working harder. It's the best path forward for
losing weight. But if you want to tummy jab yourself with some Ozempic and get strange leaky gut, constipation, diarrhea, you just go right ahead and tell me your experience. Privycastmail, dot com. This will bring us to the end of another episode of Privy. Thank you so much for being here. Thank you for joining us. Uh, thank you for listening. I know I say this Share the show on social media. Take you don't have to be this episode. Go find maybe the most interesting looking
episode. Uh, maybe your favorite episode. I know I have some of my favorites. But go find one that you think and share it out to your social media. Share with a friend, tag the show, do what you need to do. Get the word out there about this thing. Do you know what I'm saying? Um, you can follow the show at Privycast, you can follow me and I'm @allet7. Leave the show a
rating, a review and encourage others to do show. For every rating or review you leave, we donate a dollar to the Wounded warriors program reminding you to keep pooping in the free world. That free world was not always free. And some money to Living Water International as a reminder that we need to pursue cleaner water for all. Not everyone has it and everyone should have it. Uh, as always, send us an email privycastmail.com. uh, thanks to Kevin and Poddtington for the use of your music
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Um, if you're thinking about joining doing a podcast, use the link down below. It just helps them know that we're doing this and that we like Podbean. Uh, it's a good program, so check that out. Thanks for being here on another episode of Privy. Keep hoping in the free world, own your stank. And now, as always, don't forget to flush.