In this week's episode, Reid and Aria unpack why trust is a practical skill, not just a feeling. Reid riffs on the importance of hands-on investor-founder relationships, boardroom decisions that can make or break a company, and investor behaviors that build durable trust. They also discuss what product teams and policymakers must do to earn user confidence in an age of AI. Along the way, Reid shares personal anecdotes regarding his work with OpenAI, crisis leadership, and bridging Silicon Valley...
Oct 15, 2025•37 min•Season 4Ep. 38
How can AI really help advance medicine? Should patients and care teams be seeking second opinions from LLMs? This week, Reid and Aria sit down with physician-scientist Dr. David Fajgenbaum, who repurposes existing drugs to save lives—including his own. David shares his journey from receiving last rites as a young medical student to co-founding Every Cure, a nonprofit using AI to come up with ways existing drugs can be repurposed to treat every disease and every patient possible. On this special...
Oct 08, 2025•1 hr 8 min•Season 4Ep. 39
This week, Reid and Aria dive into the debate over new $100,000 fees on H-1B visas, and discuss how immigration powers U.S. innovation and how to ensure startups aren’t shut out. They also cover developers’ mixed feelings about using AI in coding, the leap from 60% to 85% accuracy in medical AI predictions, and what it will take to bring regulators and clinicians on board. Plus, Reid shares why he’s skeptical of a three-day work week and reflects on the Trust in American Institutions Challenge, ...
Oct 01, 2025•35 min•Season 4Ep. 38
What’s the role of semiconductors—and the companies that make them—in powering human progress? What does it look like to innovate thoughtfully in a landscape where the demand for power may be higher than the supply? With AI evolving faster and faster, how can we keep up? Advanced Micro Devices (AMD) CEO Lisa Su joins the show to talk about hardware, global manufacturing, and risk-taking. She shares what she has learned leading AMD from near-bankruptcy a decade ago to its current standing as one ...
Sep 24, 2025•44 min•Season 4Ep. 37
This week, Reid and Aria discuss Apple’s new AirPods Pro 3 and live translation capabilities, AI-generated movies (specifically Critterz from OpenAI), and what really could be lost — or gained — as AI technology becomes more widespread. Plus, Reid reflects on his speech at the Bologna Business School two years ago, and how far AI has come since then in amplifying creativity and humanity. Select mentions: Superagency Bro-Botz ( https://www.youtube.com/@Bro-BotzDTI ) Reid’s Bologna Business School...
Sep 17, 2025•21 min•Season 4Ep. 36
What could we gain—and what might we lose—when technology begins to approximate the contours of human connection and presence? In this episode, Reid and Aria chat with comedian, actor, and political commentator Stephen Colbert. Best known for hosting The Colbert Report and The Late Show , Stephen combines a razor sharp satire with a sincere curiosity about the world. Together, Reid, Aria, and Stephen discuss the art of live performance, the many lessons one can learn from J.R.R. Tolkien, and the...
Sep 10, 2025•57 min•Season 4Ep. 35
This week, Reid and Aria discuss the challenges around integrating AI into organizations and workspaces, China’s recent pivot away from NVIDIA, and OpenAI’s new $50 million NGO-focused fund. Reid also offers his take on a recent Stanford study that looks at entry-level jobs at risk of AI replacement. For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/
Sep 03, 2025•23 min•Season 4Ep. 34
Gains in the quality of America’s K-12 education in the late 20th and early 21st century have largely plateaued—and , in several instances, reversed—in the last few decades. This week, Alpha School co-founder MacKenzie Price joins the show to discuss her fast-expanding network of AI-powered private schools, which she says represent the reform the system so badly needs. She explains why Alpha students learn core academics in two hours a day via a personalized learning platform—not human teachers—...
Aug 27, 2025•56 min•Season 4Ep. 33
This week, Reid and Aria discuss the much-anticipated launch of GPT-5, Figma's blockbuster IPO, Perplexity’s bid to acquire Google Chrome, and the end of AOL’s dial-up internet service. Plus, Reid offers his take on why some companies find explosive growth and others fade just as fast. For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/ Select mentions: For the Hamilton v.s. Satoshi Bitcoin Rap Battle: https://reid.medium.com/bitcoin-rap-battl...
Aug 20, 2025•18 min•Season 4Ep. 32
How can we take digitally-empowered democracy straight out of science fiction into reality? This week, Reid and Aria are joined by two digital democracy pioneers, Audrey Tang and Divya Siddarth. Audrey Tang is a cyber ambassador-at-large and former inaugural Minister of Digital Affairs for Taiwan. Their pioneering initiatives like the Sunflower Movement, g0v, and vTaiwan have fought misinformation and influenced policy decisions. Audrey is also a senior research fellow for the Collective Intelli...
Aug 13, 2025•52 min•Season 4Ep. 31
Could the very technology that requires massive amounts of energy to power it also be key to solving the climate crisis? This week, Reid and Aria discuss the global energy arms race and why the U.S. is lagging behind competitors like China. Reid weighs in on the environmental impact and human costs of AI infrastructure, along with mounting tensions between hyperscalers and the communities that host their data centers. For more info on the podcast and transcripts of all the episodes, visit https:...
Aug 06, 2025•17 min•Season 4Ep. 30
What can public libraries teach us about finding and sharing trustworthy information in the age of AI? How can—and should—AI build upon the technology that is books? This week, Reid and Aria head to the New York Public Library in Manhattan for a conversation with the storied institution’s president and CEO, Tony Marx. They explore the function of libraries in the age of AI, debate the future of work, and discuss what it looks like for civic institutions to embrace transformative technology witho...
Jul 30, 2025•52 min•Season 4Ep. 29
On Part II of last week’s Live Riff, co-hosted with Village Global, Reid fields audience member questions about scale product-market fit, license modeling, data sensitivities, and the future of customer service, along with positive use cases for deepfake technology and the making of Reid AI, his digital twin. He also tells a story from his PayPal days, when Peter Thiel gave him five days to come up with a solution to a problem that was putting money and user trust on the line. For more info on t...
Jul 23, 2025•24 min•Season 4Ep. 28
What’s the deal with hyperscalers’ recent string of acquisitions betting big on AI talent? When will business schools start requiring classes on managing agents? And how is—and isn’t—AI changing the path to scale and the future of work? Aria asks Reid about all of this and more in a special two-part Riff, recorded for a live audience of AI leaders and founders in New York City in partnership with Village Global in June. Special thanks to our friends at Village Global for co-hosting this Live Rei...
Jul 16, 2025•40 min
Crypto often feels like a microcosm of the broader government–tech relationship. On one extreme, you have true believers who see blockchain as the next frontier of economic empowerment and radical transparency. On the other, skeptics who point to ransomware attacks, illicit finance, and the flipside of anonymity—and call for an outright ban. This week on Possible, Reid and Aria talk crypto –– both the positives and negatives –– and how we can iterate toward better outcomes. Reid discusses pro-in...
Jul 09, 2025•28 min•Season 4Ep. 26
What if AI helped people develop and deepen their existing expertise, and better outfitted them for the jobs of the future? This week, Reid and Aria are joined by one of the world’s leading labor economists, David Autor, Ford Professor of Economics at MIT and co-director of its Work of the Future Task Force. He is also a Visiting Fellow in the Google Technology and Society Program. David’s landmark research on the China Shock has become foundational for policymakers grappling with globalization’...
Jul 02, 2025•1 hr 5 min•Season 4Ep. 25
Aria and Reid dive into the recent flurry of multibillion-dollar AI acquisitions—from OpenAI’s $3B Windsurf deal to Meta’s ~$15B stake in Scale AI—and what they reveal about how companies are racing to refactor for an AI-first future. Are acquihires overtaking acquisitions as the new strategic advantage? And how are companies balancing workforce shifts with long-term innovation? Plus, a look at the robotics boom, government investment in AI, and the underrated wisdom of Adam Smith. For more info...
Jun 25, 2025•26 min
What happens when we take numbers seriously—not just at face value, but in terms of their actual impact on our lives? This week, Reid and Aria are joined by UK-based mathematician and media personality Hannah Fry to explore this deceptively simple question. From cancer diagnoses to dating apps, Hannah makes the case that understanding the math behind our decisions—and the "game" we're really playing—is essential to building a better future. They discuss why regret minimization is often a better ...
Jun 18, 2025•52 min•Season 4Ep. 23
This episode has been re-uploaded to correct an error. If you are a subscriber and/or downloaded it on its release, consider deleting and redownloading it to hear the corrected audio. We apologize for the inconvenience. On this week's Riffs, Reid and Aria unpack last week’s conversation with Yuval Noah Harari, discussing AI's rapid advancements, its potential impacts on humanity, and the meaning of consciousness. Reid and Aria also discuss who will be responsible for making sure AI is aligned wi...
Jun 16, 2025•19 min•Season 4Ep. 22
What will it take to create AI that is as trustworthy, if not more trustworthy than humans? This week, Reid and Aria sit down with Yuval Noah Harari, historian, philosopher, and best-selling author of several books including Nexus, Sapiens and Homo Deus . When it comes to outlook on AI, Yuval, Reid, and Aria agree on the importance of building both human trust in AI and AI that is genuinely truth-seeking, but they differ on how possible it is to achieve. Together, they dig into their diverging o...
Jun 04, 2025•52 min•Season 4Ep. 21
On this week’s Riff, Reid reacts to Meta CEO Mark Zuckerberg’s suggestion that AIs can help address the loneliness epidemic and function as friends. He and Aria discuss why AIs can be great companions but not great friends, along with how to protect against agent misuse and deception. For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/
May 28, 2025•20 min•Season 4Ep. 20
How do we build products and platforms that support a healthy, prosperous future? What will it take to “make the internet fun again?” Should kids be using AI? This week, serial entrepreneur and investor Alexis Ohanian—who co-founded Reddit two decades ago and is currently working to reinvent the social news aggregator Digg—joins Reid and Aria to talk about (re)building online and offline communities in the age of AI. They hear from Alexis on his recent bid for U.S. TikTok, the startups and women...
May 21, 2025•54 min•Season 4Ep. 19
Reid breaks down OpenAI’s shift to a public benefit corporation—what it really means, why it matters, and why some critics are missing the point. Aria asks whether all frontier AI companies should follow suit. Reid and Aria discuss how educators can navigate the “messy middle” of AI in the classroom. They also dig into the future of assessment, what students (and job seekers) should be learning now to prepare for an AI future, and whether AI-intensive fields are worth the bet. For more info on t...
May 14, 2025•19 min•Season 4Ep. 18
What would it look like to keep all living creatures in the loop on the development of new technology? Reid sat down for a wide-ranging solo discussion with Jane Goodall on that very subject – and more. They talked about how to maintain hope and focus on local impact in today’s often chaotic world, how technology – and AI in particular – might be helpful for conservation, and Jane’s global youth program, Roots & Shoots. Plus, the Jane Goodall institute shared audio from a cutting edge acoust...
May 07, 2025•59 min•Season 4Ep. 17
Reid weighs in on the U.S. government’s latest antitrust action against Google and what it could mean for competition, innovation, and America’s tech edge. Aria also asks about the rise of Chinese electric vehicles and why BYD might be “the Tesla of tomorrow;” the geopolitical costs of tariffs; and whether saying “please” and “thank you” to ChatGPT is worth it. For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/...
Apr 30, 2025•22 min•Season 4Ep. 16
Why can the United States government help make a vaccine in a year but not build a high-speed train in a reasonable timeframe? What if our biggest problems—affordable housing shortages, energy limits, and scientific slowdowns—aren’t inevitable, but chosen? This week, Reid and Aria sit down with Derek Thompson—staff writer at The Atlantic and host of the podcast Plain English —to explore how a scarcity mindset is holding American society back. They cover how AI can revolutionize scientific discov...
Apr 23, 2025•54 min•Season 4Ep. 15
After Tobi Lütke, the CEO of Shopify, put out a memo stating all his employees should be expected to use AI every day, Reid offers his thoughts on AI in the workplace. He also talks about the interplay between AI, social media, mis/disinformation, and the importance of shaping technology instead of restricting technology. Plus, Reid speculates on how AI can be just as groundbreaking in the world of play as it can be in the world of work. For more info on the podcast and transcripts of all the ep...
Apr 16, 2025•15 min•Season 4Ep. 14
How can AI help us understand and master deeply complex systems—from the game Go, which has 10 to the power 170 possible positions a player could pursue, or proteins, which, on average, can fold in 10 to the power 300 possible ways? This week, Reid and Aria are joined by Demis Hassabis. Demis is a British artificial intelligence researcher, co-founder, and CEO of the AI company, DeepMind. Under his leadership, DeepMind developed Alpha Go, the first AI to defeat a human world champion in Go and l...
Apr 09, 2025•57 min•Season 4Ep. 13
In the wake of Atlantic editor-in-chief Jeffrey Goldberg’s accidental inclusion in senior government officials’ Signal group chat discussing war plans, Reid weighs in on how the U.S. government should—and shouldn’t—use encrypted messaging apps. He and Aria also discuss AI-powered breakthroughs in cancer detection and medical diagnostics, along with NVIDIA’s newly announced Superchip and OpenAI’s latest image generation capabilities. For more info on the podcast and transcripts of all the episode...
Apr 02, 2025•15 min•Season 4Ep. 12
The evolution of AI is changing the way we interact with the physical world, not just in how we use this technology, but also where and how we access it. In this episode, Reid and Aria sit down with Meta’s Chief Technology Officer, Andrew “Boz” Bosworth, who is pioneering wearables for the company. Boz’s journey in the tech sector has taken him from working on Microsoft Visio to founding Reality Labs, Meta’s AR and VR division. Now, he’s focused on the next frontier in mixed realities with his l...
Mar 26, 2025•49 min•Season 4Ep. 11
