More basics on randomized controlled trials - Part 2
I get into endpoints, surrogates, validation, blinding, crossover, and control arms.
Mar 02, 2023•43 min
Plenary Session
A podcast on medicine, oncology, & health policy.
Host: Vinay Prasad, MD MPH from University of California San Francisco.
Tweet your feedback to @Plenary_Session or e-mail [email protected]
Episodes
RCT 101 And Papa Heme
I talk RCTs 101; KM Plots; Blinding: 2:1 randomization: Concealment and more. Then Papa Heme Tells you How to Find your First Job
Feb 28, 2023•1 hr 10 min
Tom Newman And VP Discuss Public Health
Dr. Tom Newman UCSF Emeritus Professor & Superb teacher discusses VP's recent Public Health Videos. The two don't fully agree, but the discussion is worth your time.
Feb 22, 2023•57 min
5.41 - Michael Putman MCW debates me on recent policy Qs
Mike Putman, asst prof. EBM Rhematologist debates me on value of boosters, observational studies and more.
Feb 16, 2023•1 hr 7 min
Sensible Med Superbowl Plenary Session Crossover
A new podcast feed called Sensible Medicine is up; here is a sample of what we have to offer
Feb 13, 2023•54 min
5.39 - Sotorasib and Codebreak 200
I destroy the trial. Bad control arm. Informative Censoring. No OS gain. Authors DOWNPOWERED TRIAL. Fishy PFS. Fishy HRQoL. This trial should be in trash can.
Feb 10, 2023•45 min
Myeloma Twitter Just Makes Things Up - Lessons for All Oncologists & Expertise
I annotate an online case discussion; Every decision is not based in evidence. Madness
Jan 22, 2023•42 min
5.37 - Keynote Lecture on Physician Burnout
This lecture on Burnout will not be like any other you have heard
Jan 15, 2023•40 min
5.36 - ASH UPDATE #4 - GEM CESAR
I break down the GEM CESAR trial K, R, D, Pom, Dara, Dex, R, and Auto and all before you actually have cancer What a crazy trial!
Dec 30, 2022•22 min
5.35 - ASH Update #3 - the Ascent Trial
This uncontrolled trial of Dara-KRD claims to be looking for cure; Unfortunately, the PI has not thought through what that would look like, and accordingly all the claims are incorrect. Moreover the primary endpt is negative. Sad day for oncology
Dec 29, 2022•19 min
5.34 - ASH Update #2 - ALPINE - Zanibrutinib vs Ibrutinib - Deconstructed
Sample size games, primary endpoint, head to head trials in oncology Rate this podcast on itunes Coming next is Triangle trial
Dec 24, 2022•22 min
5.33 USC Grand Rounds Hematology
Grand rounds on heme and heme malignancies given 12/16 at University of Southern California (some parts removed) More ASH coming soon
Dec 23, 2022•48 min
5.32 - ASH Update #1 - Talquetamab NEJM
Is it acceptable to take someone with myeloma who has gotten just 2 regimens and put them on a phase 1? VP says hell no.
Dec 11, 2022•18 min
5.31 - MUST LISTEN Grand Rounds - COVID19 Updates
In this lecture given December 7, 2022, I cover 5 things: Vaccines Masking Long COVID Schools/Immunity Debt Paxlovid
Dec 08, 2022•55 min
5.30 Rajkumar vs Goodman; Long COVID vs Long URI
Should we treat smoldering MM, a debate Long COVID vs Long URI Review the show; Say Hi at ASH22
Dec 03, 2022•41 min
5.29 Smart Start is a useless Lymphoma study
Smart Start is a useless lymphoma study; We have to stop putting our careers ahead of patients. In the second part, I discuss the 'experts' featured on STAT. Wowzers. I will be at ask. Hit me up: [email protected]
Nov 27, 2022•50 min
5.28 - Pandemic Amnesty or Accountability with Paul Fenyves
I am joined by Cornell Professor Paul Fenyves; a practicing internist Dr. Fenyves walks us through COVID19 policy. We will be back soon with more cancer medicine. Including a devastating lymphoma one.
Nov 12, 2022•38 min
5.27 - Multiple Myeloma - Do Our Trials Help Patients?
I was invited to give this talk to a UK conference on Myeloma Please LEAVE A REVIEW of this podcast
Nov 08, 2022•28 min
5.26 - Hawaii Oncology Association Keynote Lecture
Lecture I gave this weekend in Hawaii to the Medical Oncology Association; One of the best audiences I've had
Nov 06, 2022•44 min
5.25 - Neurosurgery Grand Rounds by Vinay Prasad
I give Grand Rounds to UCSF Neurosurgery on how to read and interpret Neurosurgery Studies (Video and slides coming soon to YouTube) Also I discuss Bob Califf's Promotion of Paxlovid
Nov 03, 2022•1 hr 12 min
5.24 Vlad Kogan is back to discuss Kids Test Scores
Learning Loss is Devastating; Here are the data and what it means
Nov 01, 2022•1 hr 20 min
5.24 - Gerald Hsu MD PhD UCSF Heme Onc Program Director
Learn about UCSF Hematology Oncology Program with Dr. Gerald Hsu, MD PhD Malignant Heme and Program Director
Oct 28, 2022•1 hr 8 min
5.23 - Subclinical Myocarditis
A new study from Switzerland confirms the rate of subclinical myocarditis
Oct 19, 2022•13 min
5.23 - ID Ethicist joins me for a 6th discussion of COVID19 policy
LONG COVID, Vaccines, Paxlovid and More
Oct 18, 2022•1 hr 29 min
5.22 NordICC trial interview with PI Michael Bretthauer - Offer but don't Nudge
discuss NordICC with the trial PI Power calc specified 50% non-adherence ADR is on par with US studies from the time Colo quality good Perf rate lower than US! How does he counsel individuals & governments What he thinks of USPSTF
Oct 15, 2022•1 hr 9 min
5.21 Science Mag Editor Condemns Ladapo But Silent About Jha
A double standard to condemn data with limitations, based on political party, will destroy medicine. We will back to oncology soon, but this is important
Oct 14, 2022•35 min
5.20 The Great Colonoscopy Debate
Cifu, Mandrola and Prasad fight about colonoscopy
Oct 11, 2022•1 hr 1 min
5.19 - NEJM's first ever RCT of Colonoscopy-- Explained
I break down the history and data for the first ever randomized trial of colonoscopy, appearing in NEJM on Oct 9, 2022
Oct 09, 2022•31 min
5.18 Lecture to Heme Onc Fellows - POLO; Javelin 100 bladder
Polo Javelin 100 bladder Crossover Control arms How to read and keep up with the literature
Oct 08, 2022•47 min
5.17 - The State Of Precision Oncology
Invited Lecture to Cancer Center Directors
Oct 07, 2022•15 min
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