In this three-part series dedicated to the physician's perspective on living with a rare disease, Conference Forum reporter Danny McCarthy sits down with Tracy Frech, MD, to discuss Systemic Sclerosis. Tracy Frech, MD, is a rheumatologist at the University of Utah. At the university, she is the Director of the Systemic Sclerosis (SSc, scleroderma) Clinic at the University of Utah Hospital and the Director of Clinical Trials for the Division of Rheumatology. In her work, Dr Frech treats patients ...
Mar 19, 2020•24 min•Season 1Ep. 1
In this podcast moderated by Dr Michael Kalos, Janssen Oncology, you will hear a panel discussion from the 2019 IO Combinations 360° conference. Topic points include: What are the new opportunities in cell therapy for combinations?What the challenges are going to be with the microenvironment?What is being done to engineer cell therapy?How do you develop CARs and TCRs that deliver payloads?How do you manufacture all of this beyond mouse models to figure out how to effectively do this in patients?...
Mar 10, 2020•45 min
Anti-PD-1 therapy has transformed cancer care but most patients do not respond. It is increasingly clear that there will be no single biomarker of response to a PD-1, and that a multi-omic approach will be required. In this podcast, first recorded at the 4th annual IO Combinations 360° conference, Dr Danny Wells, Parker Institute for Cancer Immunotherapy will address: Orthogonality and correlation of response biomarkers across histologiesIntegration of multi-omic data sets for mechanistic insigh...
Mar 10, 2020•24 min
In this podcast, first recorded at the 4th annual IO Combinations 360° conference, Dr Darren Hodgson, AstraZeneca presented updates on PARP inhibition. Topics include: Strategies to target homologous recombination repair deficiencyMonotherapy indications and current development landscapeScientific hypotheses being explored in olaparib combinations To learn more about the upcoming IO Combinations 360° conference please visit, www.iocombinations360.com
Mar 09, 2020•25 min
First recorded at the 4th annual IO Combinations 360° conference, this talk provided by Dr Kenneth Hance, GSK addresses agonistic strategies, T and NK cell redirection and the use of genetic/phenotypic assocations to identify novel target space in IO. To learn more about the upcoming IO Combinations 360° conference please visit, www.iocombinations360.com
Mar 08, 2020•18 min
In this podcast, first recorded at the 4th annual IO Combinations 360° conference, Dr Laureen Ojalvo, EMD Serono provides an overview of the moleculte Bintrafusp alfa/M7824. This molecule is an innovative, first-in-class bifunctional fusion protein composed of an anti-PD-L1 mAb fused with 2 extracellular domains of TGF-βRII (a TGF-β “trap”). The mechanism of action, pre-clinical and phase 1 studies of this molecule is discussed as well as an overview of the next wave of clinical development. To ...
Mar 07, 2020•23 min
In this podcast, first recorded at the 4th annual IO Combinations 360° conference, Dr Willem Overwijk, Nektar Therapeutics discusses Bempegaldesleukin (NKTR-214): harnessing the IL-2 pathway in combination immunotherapies. Topics include: Bempegaldesleukin: Structure and function of an engineered IL-2 cytokine prodrug providing sustained IL-2Rβγ-biased signalingPreclinical PK, PD, MOA and combination with PD-1 checkpoint inhibitionClinical PK, PD, clinical response data and biomarkers in patient...
Mar 06, 2020•19 min
First recorded at the fourth annual IO Combinations 360° conference, this panel moderated by Dr Daniel Chen, IGM Biosciences discusses advancing bispecifics for combination immunotherapy. This discussion covers the following topics: What are the types of bispecifics and what are the limitations?What are the toxicity related side effects?What are teh next steps/levels for bispecifics?What does the future hold for bispecifics? Panelists include: Julie Bailis, PhD, AmgenRajkumar Ganesan, PhD, Janss...
Mar 02, 2020•43 min
In this podcast, you will hear a panel discussion from the 2019 IO Combinations 360° conference regarding how AI, machine learning and big data are used to inform combinations. Moderated by Matthew Albert, MD, PhD, Insitro Panelists: Edward Bowen, GSK Ryan Fukushima, Tempus Renée Deehan-Kenney, PhD, QuartzBio, part of Precision for Medicine To learn more about the 2020 IO Combinations 360° conference please visit www.iocombinations360.com
Mar 01, 2020•51 min
In this podcast, you will hear a panel discussion from the 2019 Clinical Research as a Care Option (CRAACO) conference with patients and advocates on weighing your care options and considering participation in a clinical trial. Some points include, Strategies and ideas to reduce the burden to patientsUnderstanding of clinical care with their physician?Communication, consent and data sharing Moderated by Cindy Geoghegan, Cancer Veteran, Patient Advocate Panelists: Allison Greiner Patient Advocate...
Feb 20, 2020•32 min
In this podcast, you will hear a panel discussion from the 2019 Clinical Research as a Care Option (CRAACO) conference on Understanding the Goals of Care Vs Research. The panelists explore points including, Goals for care vs goals for researchOversight and governanceIs there an ethical burden of breaking down the line between research and care?What is the hesitation behind embracing the blurring of this boundary?In areas like precision medicine, this is already blurring, how to manage?Hurdles st...
Feb 19, 2020•27 min
This 6 minute podcast summarizes what you can expect during the virtual Patients as Partners conference. Key topic areas include: BioPharma Strategies on Applying Patient Engagement Initiatives and Demonstrating ImpactDirect-to-Patient Clinical Trials Next Milestones and Actions to Get ThereMeasuring the Impact of Patient Engagement and Patient Centricity in Clinical Research and DevelopmentCurrent Efforts for Educating and Enrolling Diverse Populations in Clinical TrialsProgress on Patient Data...
Feb 18, 2020•6 min
In this podcast, you will hear a session from the 2019 Clinical Research as a Care Option (CRAACO) conference on How to Integrate Industry-Sponsored Clinical Trials Into Your Health System to Give Patients the Best Options. Points include, How to build your programsHow to become an integrated care & research organizationHow to integrate clinical research into your care systemRoswell Park and TrialScout’s strategic partnership Speakers: Irfan Khan, MD, CEO and Founder, Circuit Clinical Doug P...
Feb 18, 2020•22 min
In this podcast, you will hear a case study presentation from the 2019 Clinical Research as a Care Option (CRAACO) conference on how Sanford Health Systems has increased their clinical trial participation from 3% to 10% over the last 8 years by integrating clinical care and clinical research. Points include, Creating a system for all providers to work seamlesslyEducational programs and continual training across all areas of care and specialties for trial offeringsIdentifying gaps in trial availa...
Feb 17, 2020•28 min
In this podcast, you will hear a keynote presentation from the 2019 Clinical Research as a Care Option (CRAACO) conference. Dr Laura Esserman, the architect behind the I-SPY 2 TRIALTM has achieved remarkable progress with this clinical trial in improving the outcomes of early stage, breast cancer for patients who are at high risk for early recurrence. I-SPY 2 is also impacting far beyond breast cancer by increasing efficiencies that promise to accelerate the development and delivery of more effe...
Feb 14, 2020•39 min
In this podcast, you will hear a session from the 2019 Clinical Research as a Care Option (CRAACO) conference. Jeff James, CEO of Wilmington Health, presented a case study on how they are streamlining the processes behind integrating clinical care and clinical research, including: Going from a fragmented patient journey to a streamlined oneHow to take the patient experience to “just making it another visit type”How to take study protocols and make them more native to EMRGeneral best practices fo...
Feb 13, 2020•30 min
At the 2019 Clinical Research as a Care Option (CRAACO) conference, a panel discussed Barriers Health Systems Face in Integrating Clinical Care & Research, including: Financial barriers – Speaking to administration’s bottom lineHistorical barriers – Who are the key stakeholders that need to be converted into believers of the CRAACO movement?Logistical issues – How can we make study startup a more streamlined process?Culture change – Onboarding an outside group nested into an existing infrast...
Feb 12, 2020•25 min
In this podcast, you will hear a discussion from the 2019 Clinical Research as a Care Option (CRAACO) conference on Effectively Democratizing Access to Clinical Trials. This panel covers how making clinical research a care option is the ultimate opening of access to clinical trials. Including points on: Current state of affairs: Gross underrepresentation of minorities 5-6% are represented in trials, but it should be closer to 40%What are the barriers to opening access?How can we educate underser...
Feb 11, 2020•28 min
A new way of doing business was required to achieve the mission of serving patients suffering from rheumatoid arthritis. In this podcast, first recorded at the 2nd annual Drug Delivery West conference, William (Bill) Rich, Amgen and Daniele Fazio, Flex discuss how Amgen and Flex created an integrated, single team with co-executive sponsorship and overarching program management that enabled the successful development and launch of a novel combination product. To learn more about the 3rd annual Dr...
Feb 06, 2020•22 min
In this podcast, first recorded at the 2nd annual Drug Delivery West conference, Dr James Cunningham, Allergan leads a panel on exploring other routes of administration for ophthalmology. Discussion points include: Barries/challenges associated with drug delivery to the back of the eyeProlonging delivery & reducing frequency of administrationAlternative/less invasive routes of administration for delivery to the back of the eyeDelivery for emerging modalitiesImpact of delivery system design c...
Feb 06, 2020•43 min
First recorded at the 2nd annual Drug Delivery West conference, Dr Carlos Schuler, InCarda Therapeutics discusses transforming cardiovascular treatment with pulmonary delivery. This podcast discusses: Pioneering a novel approach for treating cardiovascular conditions by the oral inhalation routeWill be the ONLY non-invasive, self administered product for acute management of Paroxysmal Atrial Fibrilation, providing rapid cardioversionIn Phase 2: Dose dependent conversion observedWorking on enhanc...
Feb 05, 2020•16 min
In this podcast, first recorded at the 2nd annual Drug Delivery West conference, Dr Isabelle Aubert, University of Toronto, provides an introduction to MRI-guided focused ultrasound (MRIgFUS) and reviews applications in preclinical models of neurodegenerative disorders where therapeutic molecules, gene therapy vectors, and progenitor cells are injected intravenously and delivered from the blood to targeted areas of the brain with MRIgFUS. Dr Aubert will describe the seminal work of the Sunnybroo...
Feb 05, 2020•32 min
Bringing clinical research as a care option to patients is arguably the greatest change we can collaborate on to give patients the best choices of care and to help make clinical trial options easier for providers to access. This panel, moderated by Dr Irfan Khan, TrialScout and recorded at the 6th annual Patients as Partners US conference, will explore how to collaborate to create better strategies to inform patients on clinical research and trial participation. Key talking points include: Demys...
Jan 23, 2020•40 min
In this fireside chat, moderated by Ken Getz, Tufts CSDD/CISCRP and recorded at the 6th annual Patients as Partners US conference discusses the following: How do you create a culture that enables new strategic, operating and organizational models to flourish?How do you drive a patient-centric organization while continuing to execute on business imperatives? How do you balance that?How do you drive a patient-centric agenda through the value chain?How do you engage your employees and empower them ...
Jan 23, 2020•31 min
This case study presented by Thérèse Johnsen, Novartis and first recorded at the 6th annual Patients as Partners US conference, discusses how the patient perspective was included from the earliest planning of a clinical trial and how it impacted the design, trial sites and the patient experience throughout the study. To learn more about the 7th annual Patients as Partners US conference happening June 29-30, 2020 in Philadelphia, PA please visit www.patientsaspartners.org
Jan 22, 2020•24 min
This 5 minute podcast summary helps prepare listeners on what they can expect at the4th Annual Patients as Partners Europe event, taking place January 27th and 28th in London. The venue is the Millennium Gloucester Hotel. In a nutshell, Patient as Partners is the first conference in Europe dedicated to understanding how working with patients can drive greater clinical trial efficiencies throughout the entire medicines development process. It is ultimately about how to reduce risk in the developm...
Jan 06, 2020•7 min
Linda Kollmar, Executive Director, Scientific Medical Patient Perspective - Oncology, Merck, shares with the audience at the 6th annual Patients as Partners US conference, Merck's strategy for bringing on a patient, as an equal stakeholder of their clinical development team, to provide patient input in protocol development and trial design. Ms Kollmar walks the audience through how this was done, the role of the patient employee and the impact it has to date on the clinical development initiativ...
Dec 20, 2019•18 min
This podcast moderated by Mary Murray, BMS and recorded at the 6th annual Patients as Partners US conference discusses Improving Clinical Research and Trials Though Effective Pharma/Advocacy Partnerships. Topics include: What are the key elements that make for an effective partnership between Industry and Advocacy Groups?What is not getting done or being left on the table to increase partnership value?In relation to clinical trials what can we and what must we learn from existing experiences in ...
Dec 19, 2019•42 min
This podcast, first recorded at the 6th annual Patients as Partners US conference and moderated by Jan Nissen, Merck discusses the complexities of diversity and waht actions we can take to raise clinical trial awareness and enrollment that is reflective of the demographics of the populations. This panel discusses: What are some examples of how industry has approached diversity such as developing partnerships, education and awareness to identify and address the barriers of diversity?Is industry a...
Dec 19, 2019•40 min
If you truly want to bring patients in as stakeholders, we have to start at the beginning by understanding patients, their lifestyles and how the trial protocols are developed to reflect that. This session moderated by Dr Marilyn Metcalf, GSK and recorded at the 6th annual Patients as Partners US conference discusses understanding these dynamics and how they will help industry design appropriate initiatives that help meet its goals while aligning with patient's needs. This session addresses: Wha...
Dec 18, 2019•35 min
