Lipopolysaccharide Causes Acquired CFTR Dysfunction in Murine Nasal Airways

Editor-in-Chief Cecelia E. Schmalbach, MD, MSc, is joined by senior author Bradford A. Woodworth, MD, and Associate Editor Dana L. Crosby, MD, MPH, to discuss how lipopolysaccharide can be used to generate a model of acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction in murine nasal airways as outlined in the paper “Lipopolysaccharide Causes Acquired CFTR Dysfunction in Murine Nasal Airways,” which published in the May 2025 issue of Otolaryngology–Head and Neck Surgery. They talk about CFTR as a potential driving process in recalcitrant chronic rhinosinusitis.

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