Before he sold his company to Veradigm, Will Manidis’s Science.io developed an AI model that allowed doctors to translate mountains of medical documents into usable data to improve patient outcomes. Today Will is the SVP of AI at Veradigm, and he sits down with Nick and Beezer to discuss how AI is impacting healthcare, how we can develop health systems with better outcomes, and what the future of venture might look like when compared to traditional merchant banking. Learn more about Sapphire Par...
Jul 08, 2025•44 min•Season 1Ep. 101
Origins hosts Nick Chirls, GP at Asylum Ventures and Beezer Clarkson, LP at Sapphire Partners and co-founder of OpenLP, unpack their conversation with Zach Weinberg, Co-Founder and CEO of Curie.Bio. They discuss the “innovation energy” that drives new breakthroughs and take a closer look at Sapphire’s approach to biotech investing. Learn more about Sapphire Partners: sapphireventures.com/sapphire-partners Learn more about OpenLP: openlp.vc Learn more about Asylum Ventures: asylum.vc Learn more a...
Jun 17, 2025•11 min
Zach Weinberg, co-founder and CEO of Curie.Bio, is redefining early-stage biotech investing with an operator’s mindset and a founder-first philosophy. His approach combines funding with operational support and direct access to world-class drug hunters to dramatically increase odds of success. Today, Zach sits down with Nick Chirls, GP at Asylum Ventures and Beezer Clarkson, LP at Sapphire Partners to discuss the massive risk associated with traditional therapeutics startups, how pairing a drug d...
Jun 03, 2025•58 min•Season 1Ep. 100
Origins hosts Nick Chirls, GP at Asylum Ventures and Beezer Clarkson, LP at Sapphire Partners and co-founder of OpenLP, unpack their conversation with Theory Ventures’ Tomasz Tunguz, discussing how strategies that once set firms apart – like pre-seed or founder-centric investing – become industry standards over time. They dive deep on counter-positioning, adaptability, and the power of differentiation in today’s venture world. CHAPTERS : (0:00) Welcome to Origins (1:14) Is Tomasz an n=1? (5:51) ...
May 20, 2025•14 min
Tomasz Tunguz, Founder of Theory Ventures, is widely recognized for his analytical approach to venture investing. Now, he’s building Theory with a philosophy rooted in research and data-driven decision-making. Tomasz sits down with Nick Chirls, General Partner at Asylum Ventures and Beezer Clarkson, LP at Sapphire Partners and co-founder of OpenLP, to discuss spinouts and succession in established firms and the value of running high-risk, high-reward experiments at specialist firms like Theory. ...
May 06, 2025•40 min•Season 1Ep. 99
Origins host Beezer Clarkson sits down with her colleague Nate Leung, fellow LP and Partner at Sapphire Partners, to riff on her recent conversation with Nina Achadjian, Partner at Index Ventures. Together, Beezer and Nate walk through the steps Index took to become a franchise - the decisions they made and the mistakes they avoided, plus the firm’s ability to pick excellent companies early. They discuss the edge GPs gain by investing with a broader purpose, as well as the LP POV on the need for...
Apr 22, 2025•11 min
Nina Achadjian is a Partner at Index Ventures, where she invests across seed, venture, and growth stages in AI, enterprise software, and vertical SaaS. She sits down with Beezer Clarkson, LP at Sapphire Partners, and the two discuss Nina’s predictions for M&A in 2025, the importance of product market fit and what Nina looks for in a new hire. Plus, the two dig into Index’s recent IPO with ServiceTitan, and how they managed a high-profile exit in the difficult IPO market of 2024. Learn more a...
Apr 08, 2025•43 min•Season 1Ep. 98
Origins host Beezer Clarkson sits down with her colleague Laura Thompson, fellow LP and Partner at Sapphire Partners, to riff on her recent conversation with Thomas Kristensen, Partner at LGT Capital Partners. Together they discuss 2025’s sluggish exit market, and whether or not that’s a sign that venture is broken. They also discuss the importance of reinventing yourself to stay current with the market - even though LPs don’t love big changes - and if emerging managers can use founder product c...
Mar 25, 2025•12 min
Thomas Kristensen, Partner at LGT Capital Partners, has decades of experience backing the top players in venture, but as an LP, doesn’t love the term "franchise fund.” He sits down with Bezer Clarkson, Partner at Sapphire Partners, to discuss why GPs can’t rest on their laurels, that being a franchise shouldn’t be every VC’s ultimate goal, and how LPs can dig deep to find firms with a great founder product– and avoid ones that may look like franchises but could have already peaked. The two also ...
Mar 11, 2025•43 min
Beezer Clarkson, LP at Sapphire Partners, revisits her conversation from 2023 with David Clark, Investment Director at VenCap International plc. In this episode, she and co-host Nick Chirls, Partner at Asylum Ventures, dive into David’s nearly four decades of experience in investing in some of the most established VC funds across the US, Europe, China and India. David shares historical figures on where to find performance in venture and his findings from a recently uncovered 30 year trove of dat...
Feb 20, 2025•56 min
Origins host Beezer Clarkson sits down with her colleague Laura Thompson, fellow LP and Partner at Sapphire Partners, to unpack her recent conversation with Jessica Archibald, a GP at Top Tier Capital. They discuss Jessica’s engineering-based analytical approach to answering the question “what makes a franchise?” and discuss some surprising things they learned - Jessica’s view that there’s only one real way to do succession, the importance of breaking good and bad news in a way that creates a pe...
Jan 22, 2025•23 min
Jessica Archibald is a GP and member of the Investment Committee at Top Tier Capital Partners, where she is co lead of the funds team and participates extensively in the capital formation efforts of the firm. She and Beezer Clarkson, LP at Sapphire Partners, sit down for the next episode in this miniseries on franchise funds - what it takes to build one, and how some firms lose their franchise status. Jessica digs into Top Tier’s numbers to discuss the importance of getting reliable DPI in a set...
Jan 08, 2025•54 min•Season 1Ep. 96
Origins host Beezer Clarkson sits down with her colleague Laura Thompson, fellow LP and Partner at Sapphire Partners, to discuss her recent conversation with Stephen Bluestein, Partner of Primary Investments at Adams Street and formerly Packard Foundation, about what it takes to make (and potentially later break) a franchise fund in venture. Together, Beezer and Laura debrief their top takeaways, including: do the hallmarks of a franchise differ between GPs and LPs (or even amongst different LPs...
Dec 17, 2024•17 min
Stephen Bluestein has had an impressive career in Venture, beginning at Bessemer Venture Partners before moving to TCV, Light Street Capital, and the David and Lucille Packard Foundation, before landing in his current role as a partner in the primary investment team at Adams Street Partners. He sits down with Beezer Clarkson, LP at Sapphire Partners, to discuss what makes a fund a franchise. They discuss the importance of building and maintaining a brand that stands for something in the market, ...
Dec 10, 2024•51 min•Season 1Ep. 95
Nick Chirls, GP at Asylum Ventures, and Beezer Clarkson, LP at Sapphire Partners go deep into their recent conversation with Wesley Chan, the Co-Founder and Managing Partner of FPV Ventures. They unpack Wesley’s direct learnings from Sergey Brin coming up at Google, how it is the job of the investor to spot greatness, his views on company pivots (and how they oppose another recent guest, Mike Maples’ views on pivots), the difficulties of thinking independently in Silicon Valley, and the serendip...
Nov 26, 2024•16 min
Wesley Chan is a true legend in Silicon Valley. He spent time at Microsoft and HP, and in 2002 he jumped to Google. There, he worked as Sergey Brin’s Chief of Staff and founded Google Analytics and Google Voice - all before then founding and leading the seed investing program at Google Ventures as GP. Under his tenure, GV was the first institutional check into companies like Plaid, Gusto, Lucid, and Robinhood. Wesley sits down with Nick Chirls, GP at Asylum Ventures, and Beezer Clarkson, LP at S...
Nov 13, 2024•42 min•Season 1Ep. 94
Nick Chirls, GP at Asylum Ventures, and Beezer Clarkson, LP at Sapphire Partners, unpack their recent conversation with Jai Das, President + Partner at Sapphire Ventures and Mike Maples, Co-Founder + Partner at Floodgate, to answer their burning question: What changes in the way seed and growth investors think, and what stays the same? They discuss the crushing importance of team no matter the stage; the parallels in LP land (at the end of the day, you’re just backing people); the difference bet...
Oct 15, 2024•19 min
With a few dozen software exits under his belt (including Box, Square, Mulesoft & JFrog), nobody knows enterprise investing like Sapphire Ventures’ President + PartnerJai Das. Likewise, Floodgate co-founder + Partner Mike Maples Jr. is often credited with pioneering seed investing as we know it, with names like Twitter, Twitch and Lyft in his portfolio. Together, they join Nick Chirls, GP at Asylum Ventures, and Beezer Clarkson, LP at Sapphire Partners, to share how they pick winners at thei...
Oct 01, 2024•49 min•Ep. 93
A look at what’s to come on a brand new season of Origins , where we’ll dive into the VC ecosystem with the people who know it best, to learn how the people behind the capital really make decisions. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners/ Learn more about Asylum Ventures: asylum.vc
Sep 24, 2024•2 min
Nick Chirls, GP at Asylum Ventures, and Beezer Clarkson, LP at Sapphire Partners, go inside their recent conversation with Alt Capital’s Jack Altman to answer their burning question: What does the journey look like from VC-backed founder to angel investor to institutional VC? How does one successfully jump from investing their own capital to taking on LP dollars? Where is Jack comfortable taking bigger bets? Plus, the two of them go in-depth for the very first time on Nick’s new firm, Asylum Ven...
Sep 17, 2024•26 min
Jack Altman of Alt Capital has led quite a life in Silicon Valley. He’s gone from angel investing to founding a venture-backed company (HR platform Lattice), back to angel investing today, taking on outside capital as an institutional investor at Alt Capital. Jack sits down with Nick Chirls, GP at Asylum Ventures & Beezer Clarkson, LP at Sapphire Partners, to discuss learnings from his impressive career arc, including how to build a reputation by avoiding zero sum games, making decisions qui...
Sep 10, 2024•47 min•Ep. 92
Nick & Beezer go inside their recent conversation with Jason Shuman and Will Quist to discuss the right way to be a contrarian investor, how to do no harm as a VC, and dive into the answer to their burning question: do VCs actually add value? Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners/ Learn more about Notation Capital: https://notation.vc/ Learn more about Primary: https://www.primary.vc/ Learn more about Slow Ventures: https://slow.co/...
Aug 20, 2024•8 min
What do Primary GP Jason Shuman and Slow Ventures Partner Will Quist have in common? At first glance, not much, given how differently their firms approach firm building and VC "platforms." At Primary, their Impact team outnumbers investors 2:1, while Slow consists of 3 GPs, and 3 GPs only. But in a surprising twist, they agree on more than one would expect. They both see non-consensus investing as carrying big risk but also big opportunity. They are both seed investors and their respective firms...
Aug 06, 2024•40 min•Ep. 91
Joanna Rupp, Managing Director of Private Equity at the University of Chicago, sits down with Nick & Beezer to shine a light on the often opaque world of endowments, including what separates an endowment from a foundation, how they consider small funds v. big funds and the fallout from an avalanche of capital being thrown at VCs. Then (announcement!) Joanna and Beezer evaluate Nick’s new venture fund - the key pieces of diligence, what he needs to prove in the next few years for another inve...
Jun 27, 2024•38 min•Ep. 90
Nick and Beezer sit down with Frank Rotman, a founding partner and CIO at QED Investors to talk about his early days as the chief credit officer of Capital One, the fundamental flaw in the way founders and investors have been funding startups, the purpose associates serve and how those associates can better their skills, and how VCs can avoid being left in the exhaust of larger firms. Learn more about Sapphire Partners: https://sapphireventures.com/sapphire-partners/ Learn more about Notation Ca...
May 30, 2024•44 min•Ep. 89
In the first Origins episode of the year, Nick Chirls (Notation Capital) and Beezer Clarkson (Sapphire Partners) host Scott Kupor , a Managing Partner at Andreessen Horowitz. In his role as managing partner, Scott invests in growth-stage companies building in the bio and healthcare industries, manages the firm’s investor relations team, and is responsible for the firm’s growth initiatives. Scott was the first employee at Andreessen Horowitz and managed the firm’s growth from $300 million in ...
Mar 19, 2024•53 min
In the last Origins episode of the year, Nick Chirls (Notation Capital) and Beezer Clarkson (Sapphire Partners) host David Clark , Investment Director at VenCap International plc. With nearly four decades of experience in investing, David has backed some of the most established VC funds across the US, Europe, China and India and shares historical figures on where to find performance in venture. David recently uncovered 30 years of data from 400+ funds with 15,000+ underlying portfolio companies ...
Dec 13, 2023•56 min
In this episode of Origins, Nicholas Chirls (Notation) and Beezer Clarkson (Sapphire Partners) host Ed Sim, founder of Boldstart and Seyonne Kang, Partner at StepStone. Ed is the founder of boldstart ventures, a day-one partner and true believer for developer first, enterprise infra, & SaaS founders. He is currently a board member/observer of Snyk, Blockdaemon, Kustomer (sold to Meta), BigID, Protect AI, Env0, among many others. Seyonne is a member of the private equity team, focusing on ven...
Oct 03, 2023•1 hr 4 min
Beezer Clarkson of Sapphire Partners and Nick Chirls of Notation host Adam Valkin, Managing Director of General Catalyst at their NYC office. Adam Valkin is a Managing Director at General Catalyst. Adam leads the firm's global early-stage practice and co-led its international expansion. He has been at GC for over ten years after joining the firm from Accel London. He has a uniquely global perspective on venture and entrepreneurship and has experience as both an operator and investor. In this epi...
Aug 23, 2023•45 min
Melissa Lucas currently serves as the CIO for the investment vehicles of two extended families. She has decades of experience handling the unique investment needs of extended families, and investing across asset classes from venture capital to credit to equities. Prior to her work for families, she spent nearly a decade working at several subsidiaries of The Capital Group – first, as an investment analyst of, and later, as an investor in, the healthcare and chemical industries. In this episode w...
Jul 19, 2023•1 hr 3 min
