Listen to a blog summary of a recent research paper published in Volume 13, entitled, "A novel group of genes that cause endocrine resistance in breast cancer identified by dynamic gene expression analysis." _________________________________ Hormones can cause tumor growth in some subtypes of breast cancer. Endocrine therapy, also known as hormone therapy, is a type of cancer treatment that removes or blocks the hormones which fuel breast cancer growth. This treatment is often given as adjuvant ...
Apr 15, 2022•8 min
Jonathan Kelber and Francesca Sanchez from the Department of Biology, California State University Northridge, Northridge CA, discuss a research paper they co-authored for Oncotarget in 2019, entitled, "Secretomes from metastatic breast cancer cells, enriched for a prognostically unfavorable LCN2 axis, induce anti-inflammatory MSC actions and a tumor-supportive premetastatic lung." DOI - https://doi.org/10.18632/oncotarget.26903 Correspondence to - jonathan.kelber@csun.edu Abstract Cancer metasta...
Apr 14, 2022•9 min
Listen to a blog summary of a trending research paper published by Oncotarget in Volume 13, entitled, "Role of the prorenin receptor in endometrial cancer cell growth." _________________________________ In the United States and worldwide, the incidence and mortality rates of endometrial cancer among women have been increasing in recent years. While endometrial cancer is highly treatable, the primary treatment is a surgical hysterectomy. Hysterectomies can have serious side effects and painful pe...
Apr 07, 2022•7 min
Mariana Perepitchka, Yekaterina Galat, and Dr. Vasiliy Galat discuss their 2020 research paper published by Oncotarget, entitled, "Down syndrome iPSC model: endothelial perspective on tumor development." DOI - https://doi.org/10.18632/oncotarget.27712 Correspondence to - Mariana Perepitchka - mperepitchka@u.northwestern.edu, Yekaterina Galat - ygalat@luriechildrens.org, and Vasiliy Galat - v-galat@northwestern.edu Abstract Trisomy 21 (T21), known as Down syndrome (DS), is a widely studied chromo...
Mar 31, 2022•6 min
BUFFALO, NY-March 22, 2022 – Impact Journals publishes scholarly journals in biomedical sciences with a focus on all areas of cancer and aging research. Impact Journals will be participating as an exhibitor at the American Association for Cancer Research (AACR) 2022 annual meeting from April 8-13, 2022, in New Orleans, Louisiana. This year, the AACR conference is entitled, “Decoding Cancer Complexity | Integrating Science | Transforming Patient Outcomes.” Oncotarget and Aging (Aging-US) are Impa...
Mar 28, 2022•2 min
Listen to a blog summary of a trending research paper published in Volume 13, entitled, “Correlation of nuclear pIGF-1R/IGF-1R and YAP/TAZ in a tissue microarray with outcomes in osteosarcoma patients.” __________________________ Osteosarcoma (OS) is a fairly uncommon type of bone cancer that primarily develops in the long bones found in the arms and legs. While most osteosarcomas occur in patients between the ages of 10 and 30 years old, half of all osteosarcomas develop in children. Osteosarco...
Mar 25, 2022•6 min
Listen to a blog summary of a trending research paper published by Oncotarget in Volume 13, entitled, "Transplantation of autologous bone marrow pre-loaded ex vivo with oncolytic myxoma virus is efficacious against drug-resistant Vk*MYC mouse myeloma.“ ______________________ Multiple myeloma (MM) is a currently incurable cancer of blood plasma cells. Autologous stem cell transplantation (ASCT) has had efficacious results among eligible patients. However, even after ASCT, a significant number of ...
Mar 18, 2022•8 min
Listen to a blog summary of a trending editorial co-authored by researchers Jennifer Y. Sheng and Vered Stearns from Johns Hopkins School of Medicine and the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, entitled, "Innovating and expanding weight loss strategies for breast cancer survivors.” ___ After being diagnosed with breast cancer, up to 96% of women have reported gaining weight. Medications, inactivity, food choice, and food quantity can all lead to weight gain. Studies have sho...
Mar 10, 2022•7 min
The genetic changes that occur within the protein-coding gene NOTCH1 have not yet been fully studied or classified. Despite a lack in research, previous studies have suggested that NOTCH1 may be a potential target for novel cancer therapies, particularly against triple-negative breast cancer (TNBC). NOTCH1 variants in TNBC tend to cluster in the PEST region and have previously been linked to gamma secretase inhibitor (GSI) sensitivity and chemotherapy resistance. “Furthermore, TNBC patients with...
Feb 24, 2022•7 min
Franco Cortese from the Biogerontology Research Foundation, London, UK, details a review he co-authored that was published by Oncotarget in Volume 9, Issue 18, entitled, “Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization.” DOI - https://doi.org/10.18632/oncotarget.24461 Correspondence to - Ivan V. Ozerov - ivan@insilicomedicine.com, Morten Scheibye-Knudsen - mscheibye@sund.ku.dk, and Alex ...
Feb 23, 2022•11 min
Dr. Dae Joon Kim and Liza Morales from the Department of Biomedical Sciences, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX, detail a priority research paper they co-authored that was published by Oncotarget in Volume 8, Issue 53, entitled, “UVB-induced nuclear translocation of TC-PTP by AKT/14-3-3σ axis inhibits keratinocyte survival and proliferation.” DOI - https://doi.org/10.18632/oncotarget.21794 Correspondence to - Dae Joon Kim - dae.kim@utrgv.edu Abstract Underst...
Feb 21, 2022•9 min
Acute myeloid leukemia (AML) is a cancer of the blood that begins in the bone marrow and progresses quickly if left untreated. AML can occur both in adults and children and is often treated with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Allo-HSCT is a procedure that replaces stem cells that were damaged or destroyed after radiation and/or chemotherapy treatment with stem cells from healthy donors. While allo-HSCT provides a high rate of curability in AML patients, the succe...
Feb 18, 2022•7 min
Dr. Bishal Gyawali from the Institute of Cancer Policy, London and Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, discusses an editorial he authored that was published by Oncotarget in Volume 8, Issue 52, entitled, “Cancer drugs in LMICs: cheap but unaffordable.” DOI - https://doi.org/10.18632/oncotarget.21976 (PDF download) Full text - https://www.oncotarget.com/article/21976/ Correspondence to - Bishal Gyawali - bg.bishalgyawali@gmail.com; https://twitter.com/onc...
Feb 15, 2022•8 min
Iron is essential for human life, however, this element can also become toxic in high doses. Contrary to iron anemia, iron overload occurs when the body accumulates more iron than it can use, and this excess iron is damaging to cells and tissues. Famous for their atypical growth patterns, cancer cells accumulate a surplus of iron to support their irregular growth and metabolism. Thus, the metabolism of cancer cells may be exploited by targeting their proclivity to require and retain iron. “Iron ...
Feb 10, 2022•7 min
Dr. Derrick Haslem and Dr. Lincoln Nadauld from the Precision Genomics Program, Intermountain Healthcare, Saint George, UT, discuss a research paper they co-authored that was published by Oncotarget as the cover for Volume 9, Issue 15, entitled, “Precision oncology in advanced cancer patients improves overall survival with lower weekly healthcare costs.” DOI - https://doi.org/10.18632/oncotarget.24384 Correspondence to - Lincoln D. Nadauld - lincoln.nadauld@imail.org Abstract The impact of preci...
Feb 08, 2022•14 min
Adrenocortical carcinoma (ACC) is a rare and aggressive cancer that forms in the outer layer of the adrenal gland tissue above the kidneys. According to the National Institutes of Health, the occurrence of ACC in the United States is believed to only affect one to two people per million, per year. This highly-rare disease also challenges patients and researchers due to its post-diagnosis five-year survival rate of a mere 51%. At this time, there are no known external factors that cause this dise...
Feb 02, 2022•7 min
A type of mental fog—known as “chemo brain”—is widely experienced by patients who have undergone cancer treatment. Cancer research institutions define chemo brain as impaired cognition, including cloudiness, memory loss and/or lack of concentration, that occurs before, during and/or after cancer treatment. This condition can negatively impact quality of life in a significant way. Chemo brain not only affects recovering individuals but also their loved ones, who often must take on additional care...
Feb 02, 2022•8 min
Dr. Nerymar Ortiz-Otero from the Meinig School of Biomedical Engineering, Cornell University, discusses a research paper she co-authored that was published by Oncotarget in Volume 11, Issue 12, entitled, “Cancer associated fibroblasts confer shear resistance to circulating tumor cells during prostate cancer metastatic progression.” DOI - https://doi.org/10.18632/oncotarget.27510 Correspondence to - Michael R. King - mike.king@vanderbilt.edu Abstract Previous studies have demonstrated that CTCs d...
Jan 27, 2022•7 min
Listen to a list of the 10 most-viewed oncology-focussed papers on Oncotarget.com in 2021. 10 - “Metformin and berberine, two versatile drugs in treatment of common metabolic diseases” DOI - https://doi.org/10.18632/oncotarget.20807 9 - “Cell fusion as a link between the SARS-CoV-2 spike protein, COVID-19 complications, and vaccine side effects” https://doi.org/10.18632/oncotarget.28088 8 - “Physical activity and telomere length: Impact of aging and potential mechanisms of action” https://doi.or...
Jan 21, 2022•7 min
Dr. Sandip Pravin Patel, Dr. Karen Yun and Dr. Karen Mccowen from the University of California San Diego, discuss a research paper they co-authored that was published by Oncotarget in Volume 11, Issue 28, entitled, “Rapid onset type 1 diabetes with anti-PD-1 directed therapy.” DOI - https://doi.org/10.18632/oncotarget.27665 Correspondence to - Sandip Pravin Patel - patel@ucsd.edu Abstract Type 1 diabetes is a rare immune-related adverse event (irAE) caused by checkpoint inhibitors with serious r...
Jan 18, 2022•13 min
Dr. Sridhar Mani from Medicine and Genetics of The Albert Einstein College of Medicine, Bronx, NY, details his editorial published by Oncotarget in Volume 11, Issue 19, entitled, “Microbial metabolite mimicry: one step closer to drug discovery.” DOI - https://doi.org/10.18632/oncotarget.27591 Correspondence to - Sridhar Mani - sridhar.mani@einsteinmed.org Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.27591 K...
Jan 17, 2022•17 min
Head and neck cancer is a group of various tumors located in the oral cavity, oropharynx, larynx, and hypopharynx. Head and neck cell squamous-cell carcinomas (HNSCC) often result from tobacco use or human papillomavirus (HPV+) infection. In locally advanced HNSCC, the current therapies used are combined surgery, radiotherapy and chemotherapy. Despite the use of traditional treatments, up to 50% of patients relapse due to the increase in mutational burden as HNSCC advances. Few studies have inve...
Jan 14, 2022•8 min
BUFFALO, NY, January 6, 2022 – Since its inception in 2010, Oncotarget has operated as a traditional-style journal that publishes online page numbered issues of peer-reviewed papers. Final paginated issues were then released in their permanent form to Pubmed. As of 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form. This means that qualified, rigorously peer-reviewed articles will be publ...
Jan 06, 2022•3 min
Statistics from the American Cancer Society indicate that endometrial cancer (EC) is on the rise among women in the United States. While it more commonly affects older women, researchers are finding that EC is the only gynecological cancer today increasing in incidence and mortality among younger women. Not to be confused with the benign condition of endometriosis, EC tumors are highly heterogeneous and are a challenge to diagnose and treat. Since these heterogeneous tumors also develop in diffe...
Dec 24, 2021•6 min
Oncotarget published "Host targeted antiviral (HTA): functional inhibitor compounds of scaffold protein RACK1 inhibit herpes simplex virus proliferation" which reported that due to the small number of molecular targets in viruses and the rapid evolution of viral genes, it is very challenging to develop specific antiviral drugs. In addition, HIV-1 and Herpes Simplex virus are known to use IRES as well. By utilizing the crystal structure of the RACK1A protein from the model plant Arabidopsis and u...
Dec 23, 2021•11 min
The cover for issue 29 of Oncotarget features Figure 2, "Categorisation of samples analysed," from Laes, et al. - OncoDNA treatment recommendation followed in 60% of cases - 93% of treatment decisions were made based on a holistic approach combining next generation sequencing (NGS) and multiple biomarker analysis provided by OncoDNA - 27% of late-stage patients treated with OncoDNA-recommended therapies had overall survival less than 12 months, compared to a typical average of no more than six m...
Dec 22, 2021•7 min
Oncotarget published "Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma" which reported that prior work has characterized changes in the mutation burden between primary and recurrent tumors; however, little work has characterized the changes in neoantigen evolution. These authors characterized genomic and neoantigen changes between 23 paired primary and recurrent head and neck squamous cell carcinoma (HNSCC) tumors. Within these tumo...
Dec 21, 2021•9 min
Lung cancer continues to be the leading cause of cancer deaths world-wide. Variations in the stage of diagnosis, subtypes and types of mutated genes provide a challenge for researchers who are developing targeted treatments to help rid patients of lung cancer. To this end, many researchers are interested in employing cancer-testis antigens (CTAs), which are minimally expressed in normal tissues, but strongly expressed in solid tumors. Therefore, CTAs are appealing therapeutic targets. The Kita-K...
Dec 09, 2021•8 min
View the latest oncology-focused research published in this week’s issue of Oncotarget, Volume 12, Issue 25. https://www.oncotarget.com/archive/v12/i25/ Research Paper (Cover) - “Molecular characterization of Kita-Kyushu lung cancer antigen (KK-LC-1) expressing carcinomas” https://doi.org/10.18632/oncotarget.28132 Research Paper - “Radiomics in predicting recurrence for patients with locally advanced breast cancer using quantitative ultrasound” https://doi.org/10.18632/oncotarget.28139 Research ...
Dec 07, 2021•5 min
Oncotarget Volume 11 Issue 15 reported that several zebrafish T-ALL models have been reported, but until recently, robust D. rerio B-ALL models were not described. Here, the Research Team has shown new B-ALL findings in one of these models, fish expressing transgenic human MYC. They describe B-ALL incidence in a large cohort of hMYC fish, and show B-ALL in two new lines where T-ALL does not interfere with B-ALL detection. Dr. J. Kimble Frazer from the Department of Cell Biology and the Departmen...
Dec 02, 2021•26 min
