BRCA Reversion Mutations
Apr 24, 2025•13 min
Listen to this episode in Metacast mobile app
Don't just listen to podcasts. Learn from them with transcripts, summaries, and chapters for every episode. Skim, search, and bookmark insights. Learn more
Episode description
BRCA revision mutations may explain some of the limited benefit seen in long-term follow-up studies with PARP inhibitors.
Bibliography:
1: BRCA reversion mutations predict resistance. https://doi.org/10.1158/2159-8290.CD-18-0715
2: SOLO3 Final OS Data. https://doi.org/10.1200/JCO.24.00933
3: Elucidating acquired PARP inhibitor resistance in advanced prostate cancer. https://doi.org/10.1016/j.ccell.2024.10.015
For the best experience, listen in Metacast app for iOS or Android