In this episode Dr Kaufmann talks about her system for rating molecules for their efficacy based on the scientific evidence available. She also discusses her new book which extends from her first book and adds more supplements to the list. Sandra Kaufmann, is a cell biologist who for the last seven years has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital. She is also the founder of the Kaufmann Antiaging Institute and the author of the book The Kaufmann Protocol: ...
Sep 13, 2022•7 min•Season 17Ep. 2
In this video Dr Kaufmann provides an introduction of what led her to start studying aging and the process that she used to develop her 7 tenets. She then goes through the tenets explaining what each one is. She uses the analogy of a factory to show how the pieces fit together. Sandra Kaufmann, is a cell biologist who for the last seven years has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital. She is also the founder of the Kaufmann Antiaging Institute and the aut...
Sep 11, 2022•15 min•Season 18Ep. 1
In this episode Dr Longo talks the diet and exercise for longevity and whether it is necessary to exercise when fasting. He also shares his own longevity protocol Valter Longo, PhD, is a professor of gerontology and biological sciences and the director of the Longevity Institute at the University of Southern California’s Leonard Davis School of Gerontology. Professor Longo has thirty years of experience in the field of longevity and healthy nutrition. His most recent studies focus on the use of ...
Sep 07, 2022•10 min•Season 17Ep. 6
In this episode Dr Longo talks about the best timing for intermittent fasting, which he says is 12/12 and why 16/8 is not optimal. We also talk about eating patterns during the feeding window. Valter Longo, PhD, is a professor of gerontology and biological sciences and the director of the Longevity Institute at the University of Southern California’s Leonard Davis School of Gerontology. Professor Longo has thirty years of experience in the field of longevity and healthy nutrition. His most recen...
Sep 04, 2022•9 min•Season 17Ep. 5
In this episode Dr Longo talks about how the fast mimicking diet can be used either in combination with other interventions or on its own to treat the major diseases of aging. He also covers progress towards getting the FMD approved as a drug by the FDA. Valter Longo, PhD, is a professor of gerontology and biological sciences and the director of the Longevity Institute at the University of Southern California’s Leonard Davis School of Gerontology. Professor Longo has thirty years of experience i...
Aug 31, 2022•13 min•Season 17Ep. 4
In this episode Dr. Longo talks about some of the practical aspects of the FMD, such as how often it should be followed and compares its benefits to those of exercise. Valter Longo, PhD, is a professor of gerontology and biological sciences and the director of the Longevity Institute at the University of Southern California’s Leonard Davis School of Gerontology. Professor Longo has thirty years of experience in the field of longevity and healthy nutrition. His most recent studies focus on the us...
Aug 28, 2022•10 min•Season 17Ep. 3
In this episode Dr. Longo talks about the benefits of the FMD and who it is most appropriate for. Valter Longo, PhD, is a professor of gerontology and biological sciences and the director of the Longevity Institute at the University of Southern California’s Leonard Davis School of Gerontology. Professor Longo has thirty years of experience in the field of longevity and healthy nutrition. His most recent studies focus on the use of Fast-Mimicking diet interventions to activate stem cell- based re...
Aug 25, 2022•8 min•Season 17Ep. 2
In this episode Dr. Longo talks about his views on fasting and provides an introduction of what the FMD is and why it was first created. Valter Longo, PhD, is a professor of gerontology and biological sciences and the director of the Longevity Institute at the University of Southern California’s Leonard Davis School of Gerontology. Professor Longo has thirty years of experience in the field of longevity and healthy nutrition. His most recent studies focus on the use of Fast-Mimicking diet interv...
Aug 20, 2022•11 min•Season 17Ep. 1
In this episode Dr Tanzi discusses whether Alzheimer's and other brain diseases are happening at a younger age and why that might be, along with his own protocol to maintaining a young and healthy mind! Dr. Rudolph Tanzi is the Director of the Genetics and Aging Research Unit, Co-Director of the McCance Center for Brain Health, Co-Director of the Mass General Institute for Neurodegenerative Disease, and Vice-Chair of Neurology (Research), at Massachusetts General Hospital, and the Joseph P. and ...
Aug 14, 2022•4 min•Season 16Ep. 5
In this episode Dr Tanzi talks about some of the future potential options are to treat Alzheimer's once it has started and neural inflammation has set in. Dr. Rudolph Tanzi is the Director of the Genetics and Aging Research Unit, Co-Director of the McCance Center for Brain Health, Co-Director of the Mass General Institute for Neurodegenerative Disease, and Vice-Chair of Neurology (Research), at Massachusetts General Hospital, and the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvar...
Aug 10, 2022•13 min•Season 16Ep. 4
In this episode Professor Tanzi talks about SHIELD, his acronym for the things that you can do to protect your brain. S - Sleep, H - Handle Stress, I - Interactions with friends, E - Exercise, L - Learn new things and D - Diet and we dive into detail on a few of them. Dr. Rudolph Tanzi is the Director of the Genetics and Aging Research Unit, Co-Director of the McCance Center for Brain Health, Co-Director of the Mass General Institute for Neurodegenerative Disease, and Vice-Chair of Neurology (Re...
Aug 07, 2022•17 min•Season 16Ep. 3
In this episode Professor Tanzi talks about the causes of Alzheimer's, from the plaques and tangles to neural inflammation, and what treatments exist for these symptoms. Dr. Rudolph Tanzi is the Director of the Genetics and Aging Research Unit, Co-Director of the McCance Center for Brain Health, Co-Director of the Mass General Institute for Neurodegenerative Disease, and Vice-Chair of Neurology (Research), at Massachusetts General Hospital, and the Joseph P. and Rose F. Kennedy Professor of Neur...
Aug 03, 2022•12 min•Season 16Ep. 2
Dr. Rudolph Tanzi is the Director of the Genetics and Aging Research Unit, Co-Director of the McCance Center for Brain Health, Co-Director of the Mass General Institute for Neurodegenerative Disease, and Vice-Chair of Neurology (Research), at Massachusetts General Hospital, and the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School. Dr. Tanzi co-discovered the first three Alzheimer’s disease genes, including APP and directs the Cure Alzheimer’s Fund Alzheimer’s Genome...
Jul 31, 2022•10 min•Season 17Ep. 1
In this episode Professor Harries discusses the attitude of governments to aging, the most promising aging technologies and her personal protocol for staying healthy. Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease. She is a Co-Founder & the Chief S...
Jul 27, 2022•8 min•Season 16Ep. 6
In this episode Professor Harries discusses her company Senisca, her theory of aging and getting funded for aging research Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease. She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.c...
Jul 25, 2022•9 min•Season 16Ep. 5
In this episode Professor Harries discusses how oligonucleotides can be used for as a very precise way to control gene expression. Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease. She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.s...
Jul 21, 2022•8 min•Season 16Ep. 4
In this episode Professor Harries discuss how she and her team used resveralogs initially and later HS2 donors to change the regulation of splicing factors and in doing so, reverse cellular senescence. We also touch on what a therapy based on this might look like in the clinic. Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing an...
Jul 17, 2022•7 min•Season 16Ep. 3
In this episode Professor Harries discuss whether RNA Splicing meets the criteria of a hallmark of aging. To qualify it should i) manifest during normal aging ii) its aggravation should accelerate aging and iii) it amelioration should slow or reverse aging. Prof Harries goes through each of these criteria with respect to RNA splicing. Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms gro...
Jul 13, 2022•10 min•Season 16Ep. 2
In this episode Professor Harries addresses some of the fundamental questions about RNA splicing and how it regulates gene expression Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease. She is a Co-Founder & the Chief Scientific Officer for SENISCA (ww...
Jul 10, 2022•13 min•Season 16Ep. 1
In this video Professor Robbins discusses reprogramming using the Yamanaka Factors as the most promising technology in aging and its relationship to DNA damage. He also talks about his personal protocol for longevity. Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota. He was part of a collaborative team that was the first to identify senotherapeutic comp...
Jul 06, 2022•11 min•Season 15Ep. 6
In this video Professor Robbins discusses the work his lab is doing with Exosomes or EV (Extra-Cellular Vesicles) and how these can impact senescent cells by suppressing SASP as senomorphics Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota. He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the s...
Jul 03, 2022•6 min•Season 15Ep. 5
In this video Professor Robbins discusses the work his lab is doing, investigate what makes centenarians different at the genetic level and then to develop drugs which can mimic these differences. One of these differences is in SIRT6 and he talks about what they are doing to better understand this in collaboration with Prof Vera Gorbunova and colleagues at the Albert Einstein College of Medicine. Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director ...
Jul 01, 2022•8 min•Season 15Ep. 4
In this video Professor Robbins discusses the process by which his and other labs look for possible senolytics. He also talks about fisetin and why he chooses to take it Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota. He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden ...
Jun 15, 2022•8 min•Season 15Ep. 3
In this video Professor Robbins discusses cellular senescence in general then dives into cellular senescence in the immune system. As immune cells are present through out the body, embedded in different tissues, their senescence has the ability to impact the system in ways that other senescent cells may not. Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnes...
Jun 12, 2022•10 min•Season 15Ep. 2
In this video Professor Robbins discusses his theory of aging, the Unitary Theory of Fundamental Aging and how that helped his choice to work on aging rather than specific diseases. Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota. He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent ...
Jun 04, 2022•9 min•Season 15Ep. 1
In this video Dr Gundry talks about his theory of aging (which involves the gut and mitochondria of course!) and also his longevity protocol. Dr Steven Gundry is a world-renowned heart surgeon, medical researcher, and author. During his 40-year career, Dr Gundry has performed 10,000 heart operations and developed patented, life-saving medical technology. He has published multiple bestselling books focused on nutrition and health including the New York Times best seller the Plant Paradox. In this...
May 29, 2022•7 min•Season 14Ep. 8
In this video Dr Gundry discusses other ways of encouraging mitochondrial uncoupling, particularly in brown fat. He also covers thermogenic compounds, like ginger and tumeric and why they make you feel hot. Dr Steven Gundry is a world-renowned heart surgeon, medical researcher, and author. During his 40-year career, Dr Gundry has performed 10,000 heart operations and developed patented, life-saving medical technology. He has published multiple bestselling books focused on nutrition and health in...
May 25, 2022•4 min•Season 14Ep. 7
In this video Dr Gundry discusses the top three supplements for healthy aging and also melatonin as a mitochondrial anti-oxidant Dr Steven Gundry is a world-renowned heart surgeon, medical researcher, and author. During his 40-year career, Dr Gundry has performed 10,000 heart operations and developed patented, life-saving medical technology. He has published multiple bestselling books focused on nutrition and health including the New York Times best seller the Plant Paradox. In this interview we...
May 22, 2022•9 min•Season 14Ep. 6
In this video Dr Gundry discusses essential fatty acids, including ALA or alpha linoleic acid and C15. We also discuss the long term impact of the keto diet. Dr Steven Gundry is a world-renowned heart surgeon, medical researcher, and author. During his 40-year career, Dr Gundry has performed 10,000 heart operations and developed patented, life-saving medical technology. He has published multiple bestselling books focused on nutrition and health including the New York Times best seller the Plant ...
May 18, 2022•12 min•Season 14Ep. 5
In this video Dr Gundry discusses eating windows, which are best and how long we need to be fasting for the generation of ketones to start. We also discuss leaky gut! Dr Steven Gundry is a world-renowned heart surgeon, medical researcher, and author. During his 40-year career, Dr Gundry has performed 10,000 heart operations and developed patented, life-saving medical technology. He has published multiple bestselling books focused on nutrition and health including the New York Times best seller t...
May 15, 2022•9 min•Season 13Ep. 4
