Mind & Matter - podcast cover

Mind & Matter

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.


Not medical advice.

At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.


As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.


I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.


My beliefs:


Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

  • “Γνῶθι σεαυτόν” (Know thyself)
  • “Μηδὲν ἄγαν” (Nothing in excess)
  • “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)

Episodes

Aroma, Olfaction & Using AI to Digitize Smell | Alex Wiltschko | 201

Send us a text Podcast episodes are fully available to paid subscribers on the M&M Substack and on YouTube . Partial versions are available elsewhere. About the Guest: Alex Wiltschko holds a PhD in neuroscience from Harvard, focusing on olfaction. He transitioned from academic research to AI at Google before founding Osmo, where he applies his expertise in digitizing scents. He aims to innovate in areas like fragrance design and health applications. Episode Summary: Dr. Wiltschko explores th...

Dec 22, 202450 minSeason 4Ep. 201

Dietary Fats & Seed Oils in Inflammation, Colon Cancer & Chronic Disease | Tim Yeatman & Ganesh Halade | 200

Send us a text The complex science of dietary lipids (fats) and inflammation, with actionable advice for managing health through dietary choices. Note: Full episodes are available to paid subscribers on the M&M Substack and are free on YouTube . Partial versions are available elsewhere. About the guest: Tim Yeatman, MD is a surgical oncologist and professor of surgery at the University of South Florida, also serving as an Associate Center Director for Translational Research and Clinical Inno...

Dec 17, 202454 minSeason 4Ep. 200

Ancient Diets, Human Carnivory, Mammoth Hunting, Clovis Culture & Origin of Native Americans | Ben Potter & Jim Chatters | 199

Send us a text Podcast episodes are fully available to paid subscribers on the M&M Substack and freely on YouTube . Partial versions are available elsewhere. About the guest: Ben Potter, PhD is an archaeologist & Professor of Anthropology at the University of Alaska-Fairbanks. James Chatters, PhD is a retired archaeologist and paleontologist. They recently published a paper on the diet of the Clovis people of North America at the end of the last Ice Age. Episode summary: Nick talks to Dr...

Dec 12, 20241 hr 53 minSeason 4Ep. 199

Vaccine Adverse Events & mRNA Biotechnology | Jessica Rose | 198

Send us a text Podcast episodes are fully available to paid subscribers on the M&M Substack and full video versions are free on YouTube . This episode will not be posted on YouTube due to the controversial nature of the content. About the guest: Jessica Rose, PhD is a computational biologist who has been studying and analyzing data from the Vaccine Adverse Event Responding System (VAERS) related to COVID. Episode summary: Nick and Dr. Rose discuss: Vaccine Adverse Event Responding System (VA...

Dec 07, 202445 minSeason 4Ep. 198

Creation Myths, Stoned Apes & the Eve Theory of Consciousness | Andrew Cutler

Send us a text Full episodes are available to paid subscribers on the M&M Substack and free on YouTube . This is a free, partial version. About the guest: Andrew Cutler, PhD is a machine learning engineer who has studied natural language processing, psychometrics & personality using quantitative methods. He writes about the origins of consciousness on his Substack, "Vectors of Mind" Episode summary: Nick and Dr. Cutler discuss: language & recursion; human evolution & th...

Dec 04, 202457 minSeason 4Ep. 197

Neurobiology of Stress: Resilience, HPA Axis, Stress Hormones, Sex Differences, Early Life | Rosemary Bagot | 191

Send us a text Full episodes are available to paid subscribers on the M&M Substack and free on YouTube . This is a free, partial version. About the guest: Rosemary Bagot, PhD is an Associate Professor in the Department of Psychology at McGill University and the Canada Research Chair in Behavioural Neurogenomics. Her lab studies the neurobiology of stress at the molecular, circuit, and behavioral levels. Episode summary: Nick and Dr. Bagot discuss the hypothalamic-pituitary-adrenal (HPA) Axis...

Nov 30, 202440 minSeason 4Ep. 191

Mental Illness & Substance Abuse: Genetics, Psychosis, THC, Dopamine & the Brain | Jibran Khokhar | 190

Send us a text About the guest: Jibran Khokhar, PhD is Associate Professor of Anatomy & Cell Biology at Western University in Ontario. His lab studies the neurobiology of the co-occurrence of psychiatric illnesses like schizophrenia with substance use disorders. Episode summary: Nick and Kevin discuss high comorbidity among mental illness, the dopamine reward system, antipsychotics & other psychiatric drugs; the relationship between THC (marijuana) and psychosis; sex differences in the b...

Nov 26, 20241 hr 40 minSeason 4Ep. 190

Vaccine Contamination & Fiat Science | Kevin McKernan | 196

Send us a text Full episodes are available to paid subscribers on the M&M Substack and free on YouTube . This is a free, partial version. About the guest: Kevin McKernan is the founder and Chief Science Officer of Medicinal Genomics. He has worked in biotechnology since the early 1990s, when he was involved in the Human Genome Project. Episode summary: Nick and Kevin discuss: components of the COVID vaccines, including modified mRNA & lipid nanoparticles; DNA contamination in COVID vacci...

Nov 21, 202433 minSeason 4Ep. 196

Skin Biology: Hormones, Light, Vitamin D, Melatonin & Stress | Andrzej Slominski | 189

Send us a text About the guest: Andrzej Slominski, MD, PhD is a dermapathologist and skin biologist who has spent decades studying skin biology, especially regarding endocrinology (hormones), stress response, photobiology, and more. Episode summary: Nick and Dr. Slominski discuss: hormone production in the skin; vitamin D photobiology; risks and benefits of UVB light; skin cancer & sunscreen; protective effects of melatonin production in the skin; and more. Related episodes: M&M #104 : B...

Nov 18, 20241 hr 3 minSeason 4Ep. 189

Psychedelics, Functional Neuroimaging & the Human Brain | Joshua Siegel | 188

Send us a text About the guest: Joshua Siegel, MD, PhD is a psychiatrist & systems neuroscience at New York University. He uses functional imaging to study the effects of psychedelics and other drugs on the human brain. Episode summary: Nick and Dr. Siegel discuss: fMRI and how it works; relationship between neural activity and blood flow; functional connectivity & the default mode network of the human brain; the functional effects of psilocybin on the brain; the role that subjective &am...

Nov 13, 20241 hr 12 minSeason 4Ep. 188

Synesthesia & Effects of Digital Technology on Brain & Mental Health | Richard Cytowic | 187

Send us a text About the guest: Richard Cytowic is a neurologist, poplar science writer and professor at the George Washington University. Episode summary: Nick and Dr. Cytowic discuss: the effects of smart phones and social media on the developing and adult brain; artificial blue light vs. broad spectrum natural light; attention & addiction to technology; sensory overstimulation & “virtual autism”; synesthesia and multimodal sensory perception; and more. Related episodes: M&M 78 : N...

Nov 10, 20241 hr 9 minSeason 4Ep. 187

Kidney Biology: Simple Diet & Lifestyle Practices for Kidney Health | Thomas Weimbs | 186

Send us a text About the guest: Thomas Weimbs, PhD is a biologist at UC-Santa Barbara whose lab studies kidney function in health and disease. Episode summary: Nick and Dr. Weimbs discuss: basic kidney biology; kidney stones and their causes, including dietary oxalates and fructose; the kidney damaging effects of common pharmaceuticals like Ibuprofen; the beneficial effects of BHB and ketosis for kidney health; the myth that high protein intake is bad for the kidney; kidney diseases and their ca...

Nov 06, 20241 hr 9 minSeason 4Ep. 186

Self-Experimentation (n=1) in Metabolic Health, Lipid-Energy, Trust in Medical Institutions | Nick Norwitz | 195

Send us a text Full version available on Substack and YouTube . About the guest: Nick Norwitz, PhD received his PhD in Physiology at Oxford University and is finishing his MD degree at Harvard Medical School. He is also an independent content creator focused on making metabolic health mainstream. Episode summary: Nick and Dr. Norwitz discuss: blood lipids & cholesterol; high cholesterol levels and what they can mean for different people; the “lean mass hyper-responder” phenotype to carb rest...

Oct 31, 202443 minSeason 4Ep. 195

Sugar & Sweeteners: Are They Really Addictive or Unhealthy? | Nicole Avena | 185

Send us a text Full version available on Substack and YouTube . About the guest: Nicole Avena, PhD is a neuroscientist at Mount Sinai. She studies the effects of sugar and diet on animal behavior and the brain. She is also the author of, “Sugarless.” Episode summary: Nick and Dr. Avena discuss: drug addiction vs. food addiction; glucose, fructose & artificial sweeteners; the extent to which sugar consumption can drive dependency & withdrawal; fructose metabolism & live health; sweetn...

Oct 30, 20241 hr 4 minSeason 4Ep. 185

Endocrine Disruptors & Metabolism: Microplastics, BPA, Estrogen, Insulin, Pancreas & Metabolic Dysfunction | Angel Nadal | 184

Send us a text About the guest: Angel Nadal, PhD is a biologist in Spain whose lab studies endocrine disruptors (e.g. microplastics), hormones (estrogen, insulin), and the endocrine functions of the pancreas in health & disease. Episode summary: Nick and Dr. Nadal discuss: endocrine biology of the pancreas; insulin and estrogen signaling in the pancreas; BPA, microplastics, and other xenoestrogens; pregnancy & fetal development; effects of hormone disruptors in males vs. females; and mor...

Oct 27, 20241 hr 7 minSeason 4Ep. 184

Calorie Restriction & Fasting: Aging, Immunity, Health Biomarkers, Stress, Genetics | Gary Churchill | 183

Send us a text About the guest: Gary Churchill, PhD is a statistician & geneticist at the Jackson Research laboratory in Maine. His lab uses a systems approach to investigate the genetics of complex biological traits in health & disease. Episode summary: Nick and Dr. Churchill discuss: his recent papers looking at the effects of caloric restriction & intermittent fasting on nearly 1,000 genetically diverse mice; how dietary restrictions affect longevity, metabolic health, immunity, a...

Oct 23, 202459 minSeason 4Ep. 183

Neural Basis of Language in the Human Brain | Ev Fedorenko | 182

Send us a text About the guest: Ev Fedorenko is a neuroscientist at MIT. Her lab studies the neural basis of language, speech, and thought in the human brain. *Full episode available free on Substack & YouTube . Episode summary: Nick and Dr. Fedorenko discuss: the relationship between language and thought; the extent to which language is for thinking vs. communication; Noam Chomsky’s Universal Grammar theory; Sapir-Whorf hypothesis; language acquisition & language learning; language netw...

Oct 19, 20241 hr 12 minSeason 4Ep. 182

Neurosurgery, Blood-Brain Barrier, Ultrasound Technology for Brain Diseases & Disorders | Nir Lipsman | 181

Send us a text About the guest: Nir Lipsman, MD, PhD is a neurosurgeon and neuroscientist at the University of Toronto. Episode summary: Nick and Dr. Lipsman discuss: neurosurgery; the blood-brain barrier and how it works; using focused ultrasound technology to non-invasively treat patients; regulatory impediments to clinical research; costs, constraints, and future applications of ultrasound tech for treating psychiatric conditions; and more. Related episodes: M&M #168 : Sleep: Neural Circu...

Oct 15, 20241 hr 4 minSeason 4Ep. 181

Mother-Infant Bonding, Maternal Care & Breastfeeding, Neural Basis of Hunger & Social Behavior | Marcelo Dietrich | 180

Send us a text About the guest: Marcelo Dietrich, MD, PhD is an associate professor in Comparative Medicine & Neuroscience at Yale University, where his lab studies the neural basis of behavior in mammals. Episode summary: Nick and Dr. Dietrich discuss: maternal care behavior, mother-infant bonding, and feeding in infant mammals; neural circuits regulating hunger & satiety; brain development & early social learning; behavioral variability among individuals; and more. Related episode:...

Oct 11, 20241 hr 20 minSeason 4Ep. 180

Cave Art, Archaeology & the Emergence of Modern Humans | Maxime Aubert | 179

Send us a text About the guest: Maxime Aubert, PhD is a geochemist & archeologist at Griffiths University in Australia. He specializes in the application of advanced analytical techniques to date the age of ancient rock art and hominin fossils. Episode summary: Nick and Dr. Aubert discuss: the oldest known cave art and what it depicts; human evolution & interbreeding with different human sub-species; the origins of anatomically modern humans & advanced cognition; and more. Related ep...

Oct 08, 20241 hr 19 minSeason 4Ep. 179

Ask Me Anything 1 | Nick Jikomes

Send us a text About the guest: Nick Jikomes, PhD is the creator and host of the podcast. You can read more about him here . Episode summary: Nick answers questions from listeners on topics such as: his scientific background & interests; staying up-to-date on research & selecting guests; thoughts on psychedelic science & drug use; questions related to diet, metabolic health & fat loss; controversial ideas worth considering; and more. *This content is never meant to serve as medic...

Sep 27, 202433 min

Microbiome & Gut-Immune Interactions in Obesity & Metabolic Health | June Round | 178

Send us a text About the guest: June Round, PhD is a microbiologist whose lab at the University of Utah studies microbiome-host interactions, gut microbiota, immunity, metabolism, obesity, and other disorders. Episode summary: Nick and Dr. Round discuss: how the immune system and gut microbiome interact; dietary fiber & short-chain fatty acid production by gut microbes; nutrient absorption; obesity & metabolic syndrome; type I diabetes; cleanliness, development & the “hygiene hypothe...

Sep 20, 20241 hr 22 minSeason 4Ep. 178

Neural Basis of Pain, Placebo Effects, Opioid Pain Relief & Addiction | Gregory Scherrer | 177

Send us a text About the guest: Gregory Scherrer, PharmD, PhD is a neuroscientist whose lab at the University of North Carolina studies the neural basis of pain, including its sensory, emotional, and cognitive components. Episode summary: Nick and Dr. Scherrer discuss: the neural basis of pain sensation & pain perception; opioids & the opioid system; cognitive modulation of painful experiences; neural basis of placebo effects; endogenous opioid system; and more. Related episodes: M&M...

Sep 15, 20241 hr 18 minSeason 4Ep. 177

Ancestral vs. Modern Human Diets, Seed Oils, Inflammation, Fat Oxidation, Influence of Industry on Food Science | Steven Rofrano | 194

Send us a text Special episode: Episodes in the Independent Scholars (IS) series are available in full to paid subscribers on the M&M Substack . This is a free, partial version. About the guest: Steven Rofrano became interested in human health & food, including ancestral vs. modern diets, from personal experiences in diet & allergies during college. He is co-founder and CEO at Ancient Crunch, Inc., which provides alternatives to widely consumed ultra-processed snack foods. Before bec...

Sep 11, 202436 minSeason 4Ep. 194

Bad Science, Nutrition Epidemiology, History of Obesity Research, Diet & Metabolic Health | Gary Taubes | M&M 176

Send us a text About the guest: Gary Taubes is a researcher, science historian, and science journalist. He has written several books, including “Rethinking Diabetes.” Episode summary: Nick and Gary Taubes discuss: the field of nutrition epidemiology and why it’s filled with so much junk science; social factors influencing scientific research; the history of obesity & diabetes research; the energy balance vs. carbohydrate-insulin models of obesity; fats, carbs & insulin resistance; and mo...

Sep 06, 20241 hr 42 minSeason 4Ep. 176

Aging, Biological Clocks, Proteomics, Longevity & Healthspan | Austin Argentieri | 175

Send us a text About the guest: Austin Argentieri, PhD is a researcher in the Analytic & Translational Genetics Unit at the Massachusetts General Hospital with academic appointments at Harvard & the Broad Institute. His research focuses on large-scale analyses to to understand human aging. Episode summary: Nick and Dr. Argentieri discuss: chronological vs. biological age; DNA methylation and aging clocks; proteomics and protein measurements in aging research; health, longevity, and human...

Sep 03, 20241 hr 33 minSeason 4Ep. 175

Adipose Tissue & Body Fat: Obesity, Insulin, Leptin, Fertility, Weight Loss & GLP-1 Drugs | Sean Hartig | 174

Send us a text About the guest: Sean Hartig, PhD is an associate professor at the Baylor College of Medicine, where is lab studies adipose (fat) tissue, metabolic regulation, and obesity & energy balance disorders. Episode summary: Nick and Dr. Hartig discuss: visceral vs. subcutaneous fat; white, brown, and beige adipose tissue; physiology of fat cells; obesity, insulin resistance, and leptin resistance; hormones & fertility; GLP-1 drugs for weight loss; and more. Related episodes: Obes...

Aug 29, 20241 hr 44 minSeason 4Ep. 174

Psychedelics, Consciousness, Mental Health & the Entropic Brain | Robin Carhart-Harris | 173

Send us a text About the guest: Robin Carhart-Harris, PhD is a neuroscientist & psychopharmacologist. His lab at the University of California-San Francisco studies the effects of psychedelics and other drugs on the human brain, using neuroimaging and other approaches. Episode summary: Nick and Dr. Carhart-Harris discuss: psychedelics & the human brain; functional connectivity & entropy in brain patterns; the “entropic brain” hypothesis of psychedelic drug action; psychiatry & dep...

Aug 24, 20241 hr 58 minSeason 4Ep. 173

Immune System, Gut Microbiome, Vitamin D, Cancer, Innate Immunity, Inflammation & Gut-Immune Interactions | Caetano Reis e Sousa | 172

Send us a text About the guest: Caetano Reis e Sousa, DPhil is an immunologist and Principal Group Leader at the Francis Crick Institute in London. His lab studies immune system function, including its ability to fight infection and cancer. Episode summary: Nick and Dr. Reis e Sousa discuss: dendritic cells & innate immunity; how the immune system recognizes pathogens, damaged cells, and cancer cells; gut microbiome & non-pathogenic bacteria; inflammation; vitamin D & gut-immune inte...

Aug 21, 20241 hr 12 minSeason 4Ep. 172

Comparative Brain Evolution: Mammals, Primates & Humans | Robert Barton | 171

Send us a text About the guest: Robert Barton, PhD is an evolutionary anthropologist and Professor at Durham University. He studies the evolution of the brain and behavior across species, including humans. Episode summary: Nick and Dr. Barton discuss: mammalian brain evolution; how brain and body size scale across mammals; how metabolism relates to brain size and function; the evolution of the neocortex & cerebellum in primates & humans; the concept of “intelligence” and whether it relat...

Aug 18, 20241 hr 39 minSeason 4Ep. 171
For the best experience, listen in Metacast app for iOS or Android
Open in Metacast