Send us a text Podcast episodes are fully available to paid subscribers on the M&M Substack and on YouTube . Partial versions are available elsewhere. About the Guest: Alex Wiltschko holds a PhD in neuroscience from Harvard, focusing on olfaction. He transitioned from academic research to AI at Google before founding Osmo, where he applies his expertise in digitizing scents. He aims to innovate in areas like fragrance design and health applications. Episode Summary: Dr. Wiltschko explores th...
Dec 22, 2024•50 min•Season 4Ep. 201
Send us a text The complex science of dietary lipids (fats) and inflammation, with actionable advice for managing health through dietary choices. Note: Full episodes are available to paid subscribers on the M&M Substack and are free on YouTube . Partial versions are available elsewhere. About the guest: Tim Yeatman, MD is a surgical oncologist and professor of surgery at the University of South Florida, also serving as an Associate Center Director for Translational Research and Clinical Inno...
Dec 17, 2024•54 min•Season 4Ep. 200
Send us a text Podcast episodes are fully available to paid subscribers on the M&M Substack and freely on YouTube . Partial versions are available elsewhere. About the guest: Ben Potter, PhD is an archaeologist & Professor of Anthropology at the University of Alaska-Fairbanks. James Chatters, PhD is a retired archaeologist and paleontologist. They recently published a paper on the diet of the Clovis people of North America at the end of the last Ice Age. Episode summary: Nick talks to Dr...
Dec 12, 2024•1 hr 53 min•Season 4Ep. 199
Send us a text Podcast episodes are fully available to paid subscribers on the M&M Substack and full video versions are free on YouTube . This episode will not be posted on YouTube due to the controversial nature of the content. About the guest: Jessica Rose, PhD is a computational biologist who has been studying and analyzing data from the Vaccine Adverse Event Responding System (VAERS) related to COVID. Episode summary: Nick and Dr. Rose discuss: Vaccine Adverse Event Responding System (VA...
Dec 07, 2024•45 min•Season 4Ep. 198
Send us a text Full episodes are available to paid subscribers on the M&M Substack and free on YouTube . This is a free, partial version. About the guest: Andrew Cutler, PhD is a machine learning engineer who has studied natural language processing, psychometrics & personality using quantitative methods. He writes about the origins of consciousness on his Substack, "Vectors of Mind" Episode summary: Nick and Dr. Cutler discuss: language & recursion; human evolution & th...
Dec 04, 2024•57 min•Season 4Ep. 197
Send us a text Full episodes are available to paid subscribers on the M&M Substack and free on YouTube . This is a free, partial version. About the guest: Rosemary Bagot, PhD is an Associate Professor in the Department of Psychology at McGill University and the Canada Research Chair in Behavioural Neurogenomics. Her lab studies the neurobiology of stress at the molecular, circuit, and behavioral levels. Episode summary: Nick and Dr. Bagot discuss the hypothalamic-pituitary-adrenal (HPA) Axis...
Nov 30, 2024•40 min•Season 4Ep. 191
Send us a text About the guest: Jibran Khokhar, PhD is Associate Professor of Anatomy & Cell Biology at Western University in Ontario. His lab studies the neurobiology of the co-occurrence of psychiatric illnesses like schizophrenia with substance use disorders. Episode summary: Nick and Kevin discuss high comorbidity among mental illness, the dopamine reward system, antipsychotics & other psychiatric drugs; the relationship between THC (marijuana) and psychosis; sex differences in the b...
Nov 26, 2024•1 hr 40 min•Season 4Ep. 190
Send us a text Full episodes are available to paid subscribers on the M&M Substack and free on YouTube . This is a free, partial version. About the guest: Kevin McKernan is the founder and Chief Science Officer of Medicinal Genomics. He has worked in biotechnology since the early 1990s, when he was involved in the Human Genome Project. Episode summary: Nick and Kevin discuss: components of the COVID vaccines, including modified mRNA & lipid nanoparticles; DNA contamination in COVID vacci...
Nov 21, 2024•33 min•Season 4Ep. 196
Send us a text About the guest: Andrzej Slominski, MD, PhD is a dermapathologist and skin biologist who has spent decades studying skin biology, especially regarding endocrinology (hormones), stress response, photobiology, and more. Episode summary: Nick and Dr. Slominski discuss: hormone production in the skin; vitamin D photobiology; risks and benefits of UVB light; skin cancer & sunscreen; protective effects of melatonin production in the skin; and more. Related episodes: M&M #104 : B...
Nov 18, 2024•1 hr 3 min•Season 4Ep. 189
Send us a text About the guest: Joshua Siegel, MD, PhD is a psychiatrist & systems neuroscience at New York University. He uses functional imaging to study the effects of psychedelics and other drugs on the human brain. Episode summary: Nick and Dr. Siegel discuss: fMRI and how it works; relationship between neural activity and blood flow; functional connectivity & the default mode network of the human brain; the functional effects of psilocybin on the brain; the role that subjective &am...
Nov 13, 2024•1 hr 12 min•Season 4Ep. 188
Send us a text About the guest: Richard Cytowic is a neurologist, poplar science writer and professor at the George Washington University. Episode summary: Nick and Dr. Cytowic discuss: the effects of smart phones and social media on the developing and adult brain; artificial blue light vs. broad spectrum natural light; attention & addiction to technology; sensory overstimulation & “virtual autism”; synesthesia and multimodal sensory perception; and more. Related episodes: M&M 78 : N...
Nov 10, 2024•1 hr 9 min•Season 4Ep. 187
Send us a text About the guest: Thomas Weimbs, PhD is a biologist at UC-Santa Barbara whose lab studies kidney function in health and disease. Episode summary: Nick and Dr. Weimbs discuss: basic kidney biology; kidney stones and their causes, including dietary oxalates and fructose; the kidney damaging effects of common pharmaceuticals like Ibuprofen; the beneficial effects of BHB and ketosis for kidney health; the myth that high protein intake is bad for the kidney; kidney diseases and their ca...
Nov 06, 2024•1 hr 9 min•Season 4Ep. 186
Send us a text Full version available on Substack and YouTube . About the guest: Nick Norwitz, PhD received his PhD in Physiology at Oxford University and is finishing his MD degree at Harvard Medical School. He is also an independent content creator focused on making metabolic health mainstream. Episode summary: Nick and Dr. Norwitz discuss: blood lipids & cholesterol; high cholesterol levels and what they can mean for different people; the “lean mass hyper-responder” phenotype to carb rest...
Oct 31, 2024•43 min•Season 4Ep. 195
Send us a text Full version available on Substack and YouTube . About the guest: Nicole Avena, PhD is a neuroscientist at Mount Sinai. She studies the effects of sugar and diet on animal behavior and the brain. She is also the author of, “Sugarless.” Episode summary: Nick and Dr. Avena discuss: drug addiction vs. food addiction; glucose, fructose & artificial sweeteners; the extent to which sugar consumption can drive dependency & withdrawal; fructose metabolism & live health; sweetn...
Oct 30, 2024•1 hr 4 min•Season 4Ep. 185
Send us a text About the guest: Angel Nadal, PhD is a biologist in Spain whose lab studies endocrine disruptors (e.g. microplastics), hormones (estrogen, insulin), and the endocrine functions of the pancreas in health & disease. Episode summary: Nick and Dr. Nadal discuss: endocrine biology of the pancreas; insulin and estrogen signaling in the pancreas; BPA, microplastics, and other xenoestrogens; pregnancy & fetal development; effects of hormone disruptors in males vs. females; and mor...
Oct 27, 2024•1 hr 7 min•Season 4Ep. 184
Send us a text About the guest: Gary Churchill, PhD is a statistician & geneticist at the Jackson Research laboratory in Maine. His lab uses a systems approach to investigate the genetics of complex biological traits in health & disease. Episode summary: Nick and Dr. Churchill discuss: his recent papers looking at the effects of caloric restriction & intermittent fasting on nearly 1,000 genetically diverse mice; how dietary restrictions affect longevity, metabolic health, immunity, a...
Oct 23, 2024•59 min•Season 4Ep. 183
Send us a text About the guest: Ev Fedorenko is a neuroscientist at MIT. Her lab studies the neural basis of language, speech, and thought in the human brain. *Full episode available free on Substack & YouTube . Episode summary: Nick and Dr. Fedorenko discuss: the relationship between language and thought; the extent to which language is for thinking vs. communication; Noam Chomsky’s Universal Grammar theory; Sapir-Whorf hypothesis; language acquisition & language learning; language netw...
Oct 19, 2024•1 hr 12 min•Season 4Ep. 182
Send us a text About the guest: Nir Lipsman, MD, PhD is a neurosurgeon and neuroscientist at the University of Toronto. Episode summary: Nick and Dr. Lipsman discuss: neurosurgery; the blood-brain barrier and how it works; using focused ultrasound technology to non-invasively treat patients; regulatory impediments to clinical research; costs, constraints, and future applications of ultrasound tech for treating psychiatric conditions; and more. Related episodes: M&M #168 : Sleep: Neural Circu...
Oct 15, 2024•1 hr 4 min•Season 4Ep. 181
Send us a text About the guest: Marcelo Dietrich, MD, PhD is an associate professor in Comparative Medicine & Neuroscience at Yale University, where his lab studies the neural basis of behavior in mammals. Episode summary: Nick and Dr. Dietrich discuss: maternal care behavior, mother-infant bonding, and feeding in infant mammals; neural circuits regulating hunger & satiety; brain development & early social learning; behavioral variability among individuals; and more. Related episode:...
Oct 11, 2024•1 hr 20 min•Season 4Ep. 180
Send us a text About the guest: Maxime Aubert, PhD is a geochemist & archeologist at Griffiths University in Australia. He specializes in the application of advanced analytical techniques to date the age of ancient rock art and hominin fossils. Episode summary: Nick and Dr. Aubert discuss: the oldest known cave art and what it depicts; human evolution & interbreeding with different human sub-species; the origins of anatomically modern humans & advanced cognition; and more. Related ep...
Oct 08, 2024•1 hr 19 min•Season 4Ep. 179
Send us a text About the guest: Nick Jikomes, PhD is the creator and host of the podcast. You can read more about him here . Episode summary: Nick answers questions from listeners on topics such as: his scientific background & interests; staying up-to-date on research & selecting guests; thoughts on psychedelic science & drug use; questions related to diet, metabolic health & fat loss; controversial ideas worth considering; and more. *This content is never meant to serve as medic...
Sep 27, 2024•33 min
Send us a text About the guest: June Round, PhD is a microbiologist whose lab at the University of Utah studies microbiome-host interactions, gut microbiota, immunity, metabolism, obesity, and other disorders. Episode summary: Nick and Dr. Round discuss: how the immune system and gut microbiome interact; dietary fiber & short-chain fatty acid production by gut microbes; nutrient absorption; obesity & metabolic syndrome; type I diabetes; cleanliness, development & the “hygiene hypothe...
Sep 20, 2024•1 hr 22 min•Season 4Ep. 178
Send us a text About the guest: Gregory Scherrer, PharmD, PhD is a neuroscientist whose lab at the University of North Carolina studies the neural basis of pain, including its sensory, emotional, and cognitive components. Episode summary: Nick and Dr. Scherrer discuss: the neural basis of pain sensation & pain perception; opioids & the opioid system; cognitive modulation of painful experiences; neural basis of placebo effects; endogenous opioid system; and more. Related episodes: M&M...
Sep 15, 2024•1 hr 18 min•Season 4Ep. 177
Send us a text Special episode: Episodes in the Independent Scholars (IS) series are available in full to paid subscribers on the M&M Substack . This is a free, partial version. About the guest: Steven Rofrano became interested in human health & food, including ancestral vs. modern diets, from personal experiences in diet & allergies during college. He is co-founder and CEO at Ancient Crunch, Inc., which provides alternatives to widely consumed ultra-processed snack foods. Before bec...
Sep 11, 2024•36 min•Season 4Ep. 194
Send us a text About the guest: Gary Taubes is a researcher, science historian, and science journalist. He has written several books, including “Rethinking Diabetes.” Episode summary: Nick and Gary Taubes discuss: the field of nutrition epidemiology and why it’s filled with so much junk science; social factors influencing scientific research; the history of obesity & diabetes research; the energy balance vs. carbohydrate-insulin models of obesity; fats, carbs & insulin resistance; and mo...
Sep 06, 2024•1 hr 42 min•Season 4Ep. 176
Send us a text About the guest: Austin Argentieri, PhD is a researcher in the Analytic & Translational Genetics Unit at the Massachusetts General Hospital with academic appointments at Harvard & the Broad Institute. His research focuses on large-scale analyses to to understand human aging. Episode summary: Nick and Dr. Argentieri discuss: chronological vs. biological age; DNA methylation and aging clocks; proteomics and protein measurements in aging research; health, longevity, and human...
Sep 03, 2024•1 hr 33 min•Season 4Ep. 175
Send us a text About the guest: Sean Hartig, PhD is an associate professor at the Baylor College of Medicine, where is lab studies adipose (fat) tissue, metabolic regulation, and obesity & energy balance disorders. Episode summary: Nick and Dr. Hartig discuss: visceral vs. subcutaneous fat; white, brown, and beige adipose tissue; physiology of fat cells; obesity, insulin resistance, and leptin resistance; hormones & fertility; GLP-1 drugs for weight loss; and more. Related episodes: Obes...
Aug 29, 2024•1 hr 44 min•Season 4Ep. 174
Send us a text About the guest: Robin Carhart-Harris, PhD is a neuroscientist & psychopharmacologist. His lab at the University of California-San Francisco studies the effects of psychedelics and other drugs on the human brain, using neuroimaging and other approaches. Episode summary: Nick and Dr. Carhart-Harris discuss: psychedelics & the human brain; functional connectivity & entropy in brain patterns; the “entropic brain” hypothesis of psychedelic drug action; psychiatry & dep...
Aug 24, 2024•1 hr 58 min•Season 4Ep. 173
Send us a text About the guest: Caetano Reis e Sousa, DPhil is an immunologist and Principal Group Leader at the Francis Crick Institute in London. His lab studies immune system function, including its ability to fight infection and cancer. Episode summary: Nick and Dr. Reis e Sousa discuss: dendritic cells & innate immunity; how the immune system recognizes pathogens, damaged cells, and cancer cells; gut microbiome & non-pathogenic bacteria; inflammation; vitamin D & gut-immune inte...
Aug 21, 2024•1 hr 12 min•Season 4Ep. 172
Send us a text About the guest: Robert Barton, PhD is an evolutionary anthropologist and Professor at Durham University. He studies the evolution of the brain and behavior across species, including humans. Episode summary: Nick and Dr. Barton discuss: mammalian brain evolution; how brain and body size scale across mammals; how metabolism relates to brain size and function; the evolution of the neocortex & cerebellum in primates & humans; the concept of “intelligence” and whether it relat...
Aug 18, 2024•1 hr 39 min•Season 4Ep. 171