Send us Fan Mail Nick talks to Bryan Roth, MD, PhD, a Professor of Pharmacology at the University of North Carolina. Dr. Roth has been studying the molecular mechanisms of psychedelics since the 1980s. They discuss: serotonin 2A receptors in the mammalian brain; psychedelics & neuroplasticity; classic psychedelics (e.g. LSD, psilocybin, DMT) compared to drugs like ketamine & MDMA; TrkB receptors & BDNF; engineering novel drugs & psychiatric treatment methods; latest findings in p...
Jul 06, 2023•1 hr 17 min•Season 3Ep. 119
Send us Fan Mail Nick talks to ethnopharmacologist Dr. Dennis McKenna, who is the brother of psychonaut Terence McKenna and author of the book, "The Brotherhood of the Screaming Abyss." They discuss: the lives and psychedelic adventures of Dennis & Terence McKenna; experiences with psilocybin mushrooms & DMT; Carl Jung & psychology; the medical relevance of subjective psychedelic experiences; drugs, culture & society; and more. *Not medical advice Support the show Health Products...
Jun 28, 2023•1 hr 29 min•Season 3Ep. 118
Send us Fan Mail Nick talks to Daniel Karlin, MD, a board-certified physician in psychiatry, addiction medicine & clinical informatics who is the Chief Medical Officer at MindMed. They discuss: psychiatry; incentives in scientific & medical research; healthcare & mental health; psychedelics; LSD for anxiety; MDMA for autism; ibogaine derivatives for addiction; patient access & care; and more. *This content is never meant to serve as medical advice. Support the show Health Product...
Jun 09, 2023•1 hr 37 min•Season 3Ep. 117
Send us Fan Mail Nick talks to chemist & food scientist Dr. Selina Wang about: food quality & purity; cooking oils (avocado, olive, vegetable, etc.); fruits & vegetables; oxidation & purity of cooking oils; how to identify high quality, pure foods to purchase; and more. *Not medical advice. Support the show Health Products by M&M Partners: AquaTru : Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off ...
Jun 01, 2023•1 hr 24 min•Season 3Ep. 116
Send us Fan Mail Nick talks to Dr. Luc van Loon, Professor of Exercise Physiology & Nutrition at Maastricht University, about topics in exercise science, health & nutrition. They discuss: macronutrients & energy; protein quality & digestibility; endurance & resistance training; plant vs. animal protein; muscle conditioning & muscle fibers; sleep & aging; muscle physiology & metabolism; and more. To learn more about diet & metabolism, check out this content . *...
May 25, 2023•43 min•Season 3Ep. 115
Send us Fan Mail Nick talks to Dr. Iain Oswald, who has a PhD in chemistry from the University of Texas-Dallas and is principal scientist Abstrax Tech, a cannabis research and product development company. He is an expert in using cutting edge analytical chemistry techniques to study plant chemistry and has done a lot of work to decipher the chemistry of commercial cannabis, including lesser-known compounds found in the essential oils of marijuana plants and how these relate the sensory qualities...
May 08, 2023•54 min•Season 3Ep. 114
Send us Fan Mail Nick talks to board-certified toxicologist Dr. Echo Rufer. The conversation starts with a brief overview of what the science of toxicology is all about & a little bit about alcohol toxicity. They then discuss: differences between vaping and smoking; what toxins are produced through the combustion of plant material, especially tobacco & marijuana; cannabinoids like THC & CBD, as well as cannabis terpenes; relationship between dose, method of consumption & toxicity...
May 02, 2023•1 hr 14 min•Season 3Ep. 113
Send us Fan Mail Nick talks to Dr. Nathan Price, who is a professor at the Institute of Systems Biology and Chief Science Officer of Thorne HealthTech. They discuss topics related to his new book, "The Age of Scientific Wellness: Why the Future of Medicine is Personalized, Data-Rich, and in Your Hands." Listen to Nick's previous discussion with Dr. Nathan Price. *Not medical advice. Support the show Health Products by M&M Partners: AquaTru : Water filtration devices that remove microplastics...
Apr 13, 2023•1 hr 26 min•Season 3Ep. 112
Send us Fan Mail Nick talks to Daniel Brady, PhD a neuroscientist who studied sensory systems in the developing brain. Dr. Brady is also the co-founder and CEO of Orita.ai, a startup using machine learning & AI to solve data problems for direct-to-consumer brands. They discuss: critical periods of learning, childhood brain development, neuroplasticity, synesthesia, language acquisition, Orita.ai, machine learning & AI, customer segmentation, data science, and more. *Not medical advice. S...
Apr 05, 2023•45 min•Season 3Ep. 111
Send us Fan Mail Nick talks to Dr. Rusty Gage, a neurobiologist at the Salk Institute whose lab studies how genes & environment interact to influence brain development, including the process of adult neurogenesis. They discuss: what neurogenesis is and how it works; lifestyle factors that influence neurogenesis, such as exercise, intermittent fasting, etc.; molecular pathways involved in neurogenesis; depression & PTSD; memory formation and the function of newly born adult neurons; and m...
Mar 20, 2023•1 hr 21 min•Season 3Ep. 110
Send us Fan Mail Nick talks with Nick Mosley, who is CEO of a cannabis testing lab called Confidence Analytics, which conducts analytical testing for legal cannabis products in Washington & California. They discuss: how analytical testing for cannabis products works; THC, CBD, and cannabinoid content; terpenes; pesticides, heavy metals, and microbial contaminants; the phenomenon of THC inflation & lab shopping in the legal marijuana industry; how consumers can discern whether cannabis pr...
Mar 17, 2023•49 min•Season 3Ep. 109
Send us Fan Mail What is Mind & Matter? Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers about alive today about how your body & mind react to what they’re fed. The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today. Learning philosophy At M&M, we are interested in trying to figure out how things work, not affirming our ex...
Mar 14, 2023•2 min0
Send us Fan Mail Nick talks to psychiatrist & neuroscientist Devanand Manoli, MD, PhD, whose lab at UCSF studies the neural basis of social behavior & attachment in prairie voles. As a psychiatrist, he also treats patients with childhood psychosis. They discuss: the neural basis of pair bonding, monogamy, and parental & sexual behavior; oxytocin, vasopressin, testosterone & estrogen; evolution of behavior; menopause & multigenerational parental care; childhood psychosis; and ...
Mar 08, 2023•1 hr 52 min•Season 3Ep. 108
Send us Fan Mail Nick talks to Dr. Paul Cisek, a neuroscientist at the University of Montreal who studies sensorimotor control & decision making in primates. They discuss: the evolution of the brain from the earliest nervous systems to humans; metabolism & state control; the evolution of behavior; sensation, perception, cognition, decision making & consciousness; language & representation; why neuroscience needs evolutionary thinking; and more. *Not medical advice. Support the sh...
Feb 27, 2023•2 hr 4 min•Season 3Ep. 107
Send us Fan Mail Nick talks to Dr. Stephen Simpson & Dr. David Raubenheimer, both professors at the University of Sydney who have been research collaborators for many years. Their research focuses on understanding animal feeding behavior, especially how & why different animals use their sensory systems in order to consume foods so that their diets contain the right balance of nutrients. Understanding animals in the evolutionary & ecological contexts they evolved to survive in enables...
Feb 20, 2023•1 hr 50 min•Season 3Ep. 106
Send us Fan Mail Nick talks to Dr. Christoffer Clemmensen, who runs the Metabolism & Molecular Pharmacology group at the University of Copenhagen in Denmark. His lab studies the biological basis of obesity & other metabolic disorders. They discuss: the causes of obesity; environmental and biological factors influencing predisposition to obesity; novel anti-obesity drugs; gut hormones & peptides regulating food intake; whether psychedelics like psilocybin may be useful for treating ob...
Feb 07, 2023•1 hr 22 min•Season 3Ep. 105
Send us Fan Mail Nick talks to academic dermatologist Dr. Richard Weller about: skin health; benefits & risks of sunlight & UV radiation exposure; nitric oxide, blood pressure & cardiovascular health; vitamin D; sunscreen & tanning; the evolution of skin color & skin physiology; and more. *Not medical advice. Support the show Health Products by M&M Partners: AquaTru : Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. ...
Jan 23, 2023•1 hr 41 min•Season 3Ep. 104
Send us Fan Mail Nick talks to biologist Dr. Christoph Thaiss, a professor at the University of Pennsylvania. His lab studies how the body detects & responds to environmental stimuli, with a focus on interactions between the gut microbiome, immune & nervous systems. They discuss: sensory systems of the body & basic principles of how they work; gut microbiome & the consequences of depleting it with antibiotics; endocannabinoids & exercise; how microbiome composition influences...
Jan 17, 2023•1 hr 42 min•Season 3Ep. 103
Send us Fan Mail Nick talks to biochemist & biophysicist Dr Ryan Gumpper, a postdoc in Dr. Bryan Roth's lab at the University of North Carolina. They discuss the biochemistry, molecular biology & biophysics of serotonin receptors, including the molecular details for what happens when serotonin and tryptamines psychedelics (e.g. LSD) bind to 5HT2A receptors in the brain. They also discuss how understand these details relates to the quest to discover novel psychedelic-derived compounds wit...
Jan 12, 2023•1 hr 15 min•Season 3Ep. 102
Send us Fan Mail Nick talks to anesthesiologist & neuroscientist Dr. Alex Proekt, who runs a lab at the University of Pennsylvania, about altered states of consciousness. They discuss: NREM & REM sleep, anesthesia & anesthetic drugs like propofol; coma & vegetative states; sleeping pills like Ambien; the relationship between consciousness & the underlying brain dynamics; how ketamine differs from other anesthetics & what it does to brain activity; AI & ChatGPT. *Not m...
Dec 26, 2022•1 hr 37 min•Season 2Ep. 101
Send us Fan Mail Nick talks to Jay Bhattacharya, MD, PhD, who is a professor of medicine & economics at Stanford University. They discuss various aspects of the COVID pandemic, such as: how infectious, transmissible, and deadly SARS-CoV-2 is; mRNA vaccines, how well they stop transmission vs. severe COVID, and whether they can induce negative side effects such as myocarditis; how well masks really work; Jay's inclusion in the "TwitterFiles" and the suppression of speech on social media; what...
Dec 19, 2022•2 hr 1 min•Season 2Ep. 100
Send us Fan Mail Nick talks to Dr. Sergiu Pasca, a developmental neuroscientist and professor at Stanford University. They discuss topics related to human brain development, the origins of neuropsychiatric disease like autism & schizophrenia, new technologies for studying brain development, stem cells, and recent experiments from Dr. Pasca'a lab utilizing brain "organoids," "assembloids," and human-animal transplantations. *Not medical advice. Support the show Health Products by M&M Part...
Dec 15, 2022•1 hr 12 min•Season 2Ep. 99
Send us Fan Mail Nick talks to computational neuroscientist Dr. Zach Mainen, a neuroscientist and director of the Champalimaud Neuroscience Programme at the Centre of the Unknown in Lisbon, Portugal. His lab studies the neuroscience of decision making, neuromodulation & behavior using both experimental and computational approaches. They discuss: what kinds of things animal brains are actually computing, and to what extent we can think about brains like computers; the difference between neuro...
Nov 28, 2022•2 hr 24 min•Season 2Ep. 98
Send us Fan Mail Nick talks to mathematical biologist Dr. Alex Washburne about the origins of the SARS-CoV-2 virus. *Not medical advice. Support the show Health Products by M&M Partners: AquaTru : Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. OmegaQuant : At-home blood testing to see fatty acid profiles, including omega-3 fatty acids....
Nov 21, 2022•1 hr 45 min•Season 2Ep. 97
Send us Fan Mail Nick talks to experimental psychologist Dr. Harriet de Wit, a professor at the University of Chicago whose lab studies the behavioral effects of psychoactive drugs on humans. They discuss: the effects of MDMA on emotional perception and touch sensation; the effects of microdosing LSD; THC's impact on memory. *Not medical advice. Support the show Health Products by M&M Partners: AquaTru : Water filtration devices that remove microplastics, metals, bacteria, and more from your...
Nov 15, 2022•57 min•Season 2Ep. 96
Send us Fan Mail Nick talks to biological anthropologist & neuroscientist Dr. Terrence Deacon, who is a professor of biological anthropologist at UC-Berkeley and a leading thinker on the evolution of language, consciousness and human cognition. They discuss: how end-directed systems, such as life, can emerge from non-life; how complexity evolves once life originates; the origins of sentience and a sense of self; the evolution of the nervous system and consciousness; information, value, and "...
Nov 07, 2022•2 hr 30 min•Season 2Ep. 95
Send us Fan Mail Nick talks to neuroscientist Dr. Kent Berridge, a professor of psychology & neuroscience at the University of Michigan. They discuss: the neurobiology of the brain processes rewards and generates pleasure & motivation; the difference between "liking" and "wanting"; hunger and whether food addiction is similar to drug addiction; emotion and consciousness; and more. *This content is never meant to serve as medical advice. Support the show Health Products by M&M Partner...
Oct 31, 2022•1 hr 33 min•Season 2Ep. 94
Send us Fan Mail Nick talks to Dr. Amir Englund, a psychopharmacologist at the Institute of Psychiatry, Psychology & Neuroscience at King's College, London. Dr. Englund's research focuses on the effects of cannabis, medical marijuana and specific cannabinoids (e.g. THC, CBD, THCV) on human cognitive function. They discuss topics including: what is the addiction liability of marijuana? What are the acute & chronic cognitive effects of THC, including how it impacts memory & executive f...
Oct 24, 2022•1 hr 31 min•Season 2Ep. 93
Send us Fan Mail Nick talks to molecular physiologist Dr. Dudley Lamming, a professor of medicine at the University of Wisconsin-Madison whose lab studies how the body responds to the nutrient and calorie content of food. We discuss: how the protein and amino acid composition of food impacts metabolic health & aging; branched chain amino acids & disease; sex differences between males & females in how diet affects health; fasting, calorie restriction & fasting; and more. *Not medi...
Oct 18, 2022•1 hr 7 min•Season 2Ep. 92
Send us Fan Mail Nick talks to genetics researcher & writer Razib Khan. Razib did graduate work in genetics at the University of California-Davis and recently founded a genomics data startup. He also runs a Substack, "Unsupervised Learning," where he writes a lot of fascinating articles on the subjects of human evolutionary & population genetics, personal genomics, and more. Nick and Razib discussed: how the story of human evolution has changed over the past two decades; genomics technol...
Oct 11, 2022•1 hr 45 min•Season 2Ep. 91