Mind & Matter - podcast cover

Mind & Matter

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.


Not medical advice.

At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.


As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.


I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.


My beliefs:


Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

  • “Γνῶθι σεαυτόν” (Know thyself)
  • “Μηδὲν ἄγαν” (Nothing in excess)
  • “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)

Episodes

The Age of Scientific Wellness: Why the Future of Medicine Is Personalized, Predictive, Data-Rich, and in Your Hands | Nathan Price | 112

Send us a text Nick talks to Dr. Nathan Price, who is a professor at the Institute of Systems Biology and Chief Science Officer of Thorne HealthTech. They discuss topics related to his new book, "The Age of Scientific Wellness: Why the Future of Medicine is Personalized, Data-Rich, and in Your Hands." Listen to Nick's previous discussion with Dr. Nathan Price. *Not medical advice. Support the show All episodes, show notes, transcripts, and more at the M&M Substack Affiliates: ...

Apr 13, 20231 hr 26 minSeason 3Ep. 112

Critical Periods, Neuroplasticity, Language, Synesthesia, Childhood Development, AI, DTC Marketing, Customer Segmentation, Orita.ai | Dan Brady | 111

Send us a text Nick talks to Daniel Brady, PhD a neuroscientist who studied sensory systems in the developing brain. Dr. Brady is also the co-founder and CEO of Orita.ai, a startup using machine learning & AI to solve data problems for direct-to-consumer brands. They discuss: critical periods of learning, childhood brain development, neuroplasticity, synesthesia, language acquisition, Orita.ai, machine learning & AI, customer segmentation, data science, and more. *Not medical advice. Sup...

Apr 05, 202345 minSeason 3Ep. 111

Neurogenesis, Stem Cells, Neuroplasticity, Aging, Exercise, Fasting & PTSD | Rusty Gage | 110

Send us a text Nick talks to Dr. Rusty Gage, a neurobiologist at the Salk Institute whose lab studies how genes & environment interact to influence brain development, including the process of adult neurogenesis. They discuss: what neurogenesis is and how it works; lifestyle factors that influence neurogenesis, such as exercise, intermittent fasting, etc.; molecular pathways involved in neurogenesis; depression & PTSD; memory formation and the function of newly born adult neurons; and mor...

Mar 20, 20231 hr 21 minSeason 3Ep. 110

Cannabis Lab Testing, THC, CBD, Cannabinoids, Terpenes, Pesticides, Heavy Metals, Consumer Safety, Marijuana Industry | Nick Mosley | 109

Send us a text Nick talks with Nick Mosley, who is CEO of a cannabis testing lab called Confidence Analytics, which conducts analytical testing for legal cannabis products in Washington & California. They discuss: how analytical testing for cannabis products works; THC, CBD, and cannabinoid content; terpenes; pesticides, heavy metals, and microbial contaminants; the phenomenon of THC inflation & lab shopping in the legal marijuana industry; how consumers can discern whether cannabis prod...

Mar 17, 202349 minSeason 3Ep. 109

Mind & Matter Podcast | Nick Jikomes, PhD | Neuroscience, Psychedelics, Psychology, Psychology, Molecular Biology, Genetics, Evolution, Metabolism, Nutrition, Biotech

Send us a text What is Mind & Matter? Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers about alive today about how your body & mind react to what they’re fed. The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today. Learning philosophy At M&M, we are interested in trying to figure out how things work, not affirming our exis...

Mar 14, 20232 min0

Biology of Monogamy, Sexual & Parental Behavior, Social Attachment, Oxytocin, Sex Hormones, Childhood Psychosis, Menopause & Brain Development | Devanand Manoli | 108

Send us a text Nick talks to psychiatrist & neuroscientist Devanand Manoli, MD, PhD, whose lab at UCSF studies the neural basis of social behavior & attachment in prairie voles. As a psychiatrist, he also treats patients with childhood psychosis. They discuss: the neural basis of pair bonding, monogamy, and parental & sexual behavior; oxytocin, vasopressin, testosterone & estrogen; evolution of behavior; menopause & multigenerational parental care; childhood psychosis; and mo...

Mar 08, 20231 hr 52 minSeason 3Ep. 108

Evolution of Complex Behavior, Perception, Cognition, Consciousness & the Brain | Paul Cisek | 107

Send us a text Nick talks to Dr. Paul Cisek, a neuroscientist at the University of Montreal who studies sensorimotor control & decision making in primates. They discuss: the evolution of the brain from the earliest nervous systems to humans; metabolism & state control; the evolution of behavior; sensation, perception, cognition, decision making & consciousness; language & representation; why neuroscience needs evolutionary thinking; and more. *Not medical advice. Support the show...

Feb 27, 20232 hr 4 minSeason 3Ep. 107

Dietary Nutrients, Taste, Whole vs. Processed Food, Obesity, Biology of Feeding Behavior | Stephen Simpson & David Raubenheimer | 106

Send us a text Nick talks to Dr. Stephen Simpson & Dr. David Raubenheimer, both professors at the University of Sydney who have been research collaborators for many years. Their research focuses on understanding animal feeding behavior, especially how & why different animals use their sensory systems in order to consume foods so that their diets contain the right balance of nutrients. Understanding animals in the evolutionary & ecological contexts they evolved to survive in enables u...

Feb 20, 20231 hr 50 minSeason 3Ep. 106

Metabolism, Obesity & Psychedelics for Metabolic Disease | Christoffer Clemmensen | 105

Send us a text Nick talks to Dr. Christoffer Clemmensen, who runs the Metabolism & Molecular Pharmacology group at the University of Copenhagen in Denmark. His lab studies the biological basis of obesity & other metabolic disorders. They discuss: the causes of obesity; environmental and biological factors influencing predisposition to obesity; novel anti-obesity drugs; gut hormones & peptides regulating food intake; whether psychedelics like psilocybin may be useful for treating obes...

Feb 07, 20231 hr 22 minSeason 3Ep. 105

Benefits & Risks of UV Radiation & Sunlight, Skin Health, Vitamin D, Nitric Oxide, Evolution of Skin Color | Richard Weller | 104

Send us a text Nick talks to academic dermatologist Dr. Richard Weller about: skin health; benefits & risks of sunlight & UV radiation exposure; nitric oxide, blood pressure & cardiovascular health; vitamin D; sunscreen & tanning; the evolution of skin color & skin physiology; and more. *Not medical advice. Support the show All episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra —Ketone body BHB + potassium, calcium & magnesium, formu...

Jan 23, 20231 hr 41 minSeason 3Ep. 104

Microbiome, Exercise, Diet, Metabolism, Circadian Rhythms, Endocannabinoids & Health | Christoph Thaiss | 103

Send us a text Nick talks to biologist Dr. Christoph Thaiss, a professor at the University of Pennsylvania. His lab studies how the body detects & responds to environmental stimuli, with a focus on interactions between the gut microbiome, immune & nervous systems. They discuss: sensory systems of the body & basic principles of how they work; gut microbiome & the consequences of depleting it with antibiotics; endocannabinoids & exercise; how microbiome composition influences t...

Jan 17, 20231 hr 42 minSeason 3Ep. 103

Biochemistry & Molecular Biology of Serotonin Receptors, Tryptamines & Psychedelics | Ryan Gumpper | 102

Send us a text Nick talks to biochemist & biophysicist Dr Ryan Gumpper, a postdoc in Dr. Bryan Roth's lab at the University of North Carolina. They discuss the biochemistry, molecular biology & biophysics of serotonin receptors, including the molecular details for what happens when serotonin and tryptamines psychedelics (e.g. LSD) bind to 5HT2A receptors in the brain. They also discuss how understand these details relates to the quest to discover novel psychedelic-derived compounds ...

Jan 12, 20231 hr 15 minSeason 3Ep. 102

Consciousness, Anesthesia, Coma, Vegetative States, Sleep Pills (Ambien), Ketamine, AI & ChatGPT | Alex Proekt | 101

Send us a text Nick talks to anesthesiologist & neuroscientist Dr. Alex Proekt, who runs a lab at the University of Pennsylvania, about altered states of consciousness. They discuss: NREM & REM sleep, anesthesia & anesthetic drugs like propofol; coma & vegetative states; sleeping pills like Ambien; the relationship between consciousness & the underlying brain dynamics; how ketamine differs from other anesthetics & what it does to brain activity; AI & ChatGPT. *Not med...

Dec 26, 20221 hr 37 minSeason 2Ep. 101

Infectious Disease, Epidemiology, Pandemics, Health Policy, Big Science, Politicization of Science | Jay Bhattacharya | 100

Send us a text Nick talks to Jay Bhattacharya, MD, PhD, who is a professor of medicine & economics at Stanford University. They discuss various aspects of the COVID pandemic, such as: how infectious, transmissible, and deadly SARS-CoV-2 is; mRNA vaccines, how well they stop transmission vs. severe COVID, and whether they can induce negative side effects such as myocarditis; how well masks really work; Jay's inclusion in the "TwitterFiles" and the suppression of speech on socia...

Dec 19, 20222 hr 1 minSeason 2Ep. 100

Developmental Neurobiology, Brain Organoids, Human-Animal Transplantation, Reverse Engineering the Human Brain | Sergiu Pasca | 99

Send us a text Nick talks to Dr. Sergiu Pasca, a developmental neuroscientist and professor at Stanford University. They discuss topics related to human brain development, the origins of neuropsychiatric disease like autism & schizophrenia, new technologies for studying brain development, stem cells, and recent experiments from Dr. Pasca'a lab utilizing brain "organoids," "assembloids," and human-animal transplantations. *Not medical advice. Support the show All epis...

Dec 15, 20221 hr 12 minSeason 2Ep. 99

Neural Computation, Artificial Intelligence, Neuromodulators, Serotonin, Psychedelics, Subjective Experience | Zach Mainen | 98

Send us a text Nick talks to computational neuroscientist Dr. Zach Mainen, a neuroscientist and director of the Champalimaud Neuroscience Programme at the Centre of the Unknown in Lisbon, Portugal. His lab studies the neuroscience of decision making, neuromodulation & behavior using both experimental and computational approaches. They discuss: what kinds of things animal brains are actually computing, and to what extent we can think about brains like computers; the difference between neurotr...

Nov 28, 20222 hr 24 minSeason 2Ep. 98

How Did the SARS-CoV-2 Virus Originate? | Alex Washburne | 97

Send us a text Nick talks to mathematical biologist Dr. Alex Washburne about the origins of the SARS-CoV-2 virus. *Not medical advice. Support the show All episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra —Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND fo...

Nov 21, 20221 hr 45 minSeason 2Ep. 97

MDMA, Microdosing LSD, THC & Memory, Human Psychopharmacology | Harriet de Wit | 96

Send us a text Nick talks to experimental psychologist Dr. Harriet de Wit, a professor at the University of Chicago whose lab studies the behavioral effects of psychoactive drugs on humans. They discuss: the effects of MDMA on emotional perception and touch sensation; the effects of microdosing LSD; THC's impact on memory. *Not medical advice. Support the show All episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra —Ketone body BHB + potassium, calcium ...

Nov 15, 202257 minSeason 2Ep. 96

Purpose, Value, Evolution, Consciousness, Sentience, Life & Emergence of Mind From Matter | Terrence Deacon | M&M 95

Send us a text Nick talks to biological anthropologist & neuroscientist Dr. Terrence Deacon, who is a professor of biological anthropologist at UC-Berkeley and a leading thinker on the evolution of language, consciousness and human cognition. They discuss: how end-directed systems, such as life, can emerge from non-life; how complexity evolves once life originates; the origins of sentience and a sense of self; the evolution of the nervous system and consciousness; information, value, and &qu...

Nov 07, 20222 hr 30 minSeason 2Ep. 95

Neuroscience of Pleasure, Reward, Liking vs. Wanting, Motivation, Food vs. Drug Addiction & Emotion | Kent Berridge | 94

Send us a text Nick talks to neuroscientist Dr. Kent Berridge, a professor of psychology & neuroscience at the University of Michigan. They discuss: the neurobiology of the brain processes rewards and generates pleasure & motivation; the difference between "liking" and "wanting"; hunger and whether food addiction is similar to drug addiction; emotion and consciousness; and more. *This content is never meant to serve as medical advice. Support the show All episodes, sh...

Oct 31, 20221 hr 33 minSeason 2Ep. 94

Marijuana, Cognition, Psychosis, Addiction, Cannabinoids, THC, CBD, THCV | Amir Englund | 93

Send us a text Nick talks to Dr. Amir Englund, a psychopharmacologist at the Institute of Psychiatry, Psychology & Neuroscience at King's College, London. Dr. Englund's research focuses on the effects of cannabis, medical marijuana and specific cannabinoids (e.g. THC, CBD, THCV) on human cognitive function. They discuss topics including: what is the addiction liability of marijuana? What are the acute & chronic cognitive effects of THC, including how it impacts memory & exe...

Oct 24, 20221 hr 31 minSeason 2Ep. 93

Diet, Protein, Amino Acids, Fasting, Metabolic Health & Aging | Dudley Lamming | 92

Send us a text Nick talks to molecular physiologist Dr. Dudley Lamming, a professor of medicine at the University of Wisconsin-Madison whose lab studies how the body responds to the nutrient and calorie content of food. We discuss: how the protein and amino acid composition of food impacts metabolic health & aging; branched chain amino acids & disease; sex differences between males & females in how diet affects health; fasting, calorie restriction & fasting; and more. *Not medica...

Oct 18, 20221 hr 7 minSeason 2Ep. 92

Population Genetics, Personal Genomics, History & Human Evolution | Razib Khan | 91

Send us a text Nick talks to genetics researcher & writer Razib Khan. Razib did graduate work in genetics at the University of California-Davis and recently founded a genomics data startup. He also runs a Substack, "Unsupervised Learning," where he writes a lot of fascinating articles on the subjects of human evolutionary & population genetics, personal genomics, and more. Nick and Razib discussed: how the story of human evolution has changed over the past two decades; genomics...

Oct 11, 20221 hr 45 minSeason 2Ep. 91

How Does Ketamine Work & Is It Addictive? | Christian Lüscher | 90

Send us a text Nick talks to Christian Lüscher, MD, PhD, a neuroscientist at the University of Geneva whose lab studies the cellular mechanisms that underlie drug reinforcement, dependence and addiction. Dr. Lüscher talks about the nature of addictive drugs in the brain, how ketamine works, and the latest research from his lab look at how ketamine's unique effects within the brain's reward circuitry enable it to be psychoactive & reinforcing, but have a very low addiction liability...

Oct 04, 202246 minSeason 2Ep. 90

Neuroscience of Aggression, Sex, Behavior, Hormones, Emotion & Consciousness | David Anderson | 89

Send us a text Nick talks to neuroscientist Dr. David Anderson, a professor at Caltech whose lab studies the neurobiological basis of animal behavior and emotion. They discuss: technologies for understanding cause-and-effect in the brain; neurobiological basis of animal behavior, including aggression/fighting, mating, feeding, and social behavior; how hormones such as estrogen regulate behavior; emotions, feelings, and consciousness; and David's new book, "The Nature of the Beast.&quot...

Sep 28, 20221 hr 53 minSeason 2Ep. 89

Depression, Serotonin, SSRIs, Psychiatry, Mental Health & Social Media | Joanna Moncrieff | M&M 88

Send us a text Nick talks to psychiatrist Dr. Joanna Moncrieff about depression. What causes it? How do SSRIs work? How well do antidepressants work? What are the risks & benefits of long-term antidepressant use? What is the evidence that depression is caused by a chemical imbalance (too little serotonin) in the brain? How is social media & technology influencing mental health? Learn more about topics in psychiatry . *This content is never meant to serve as medical advice. Support the sh...

Sep 21, 20221 hr 26 minSeason 2Ep. 88

Sociology, Social Psychology, Homelessness, Drug Addiction, Cultural Capital, Elite Overproduction & Decline of Civilization | Leighton Woodhouse | 87

Send us a text Nick talks to journalist & documentary filmmaker Leighton Woodhouse. They discuss: homelessness & drug addiction; religion & ideology; sociology & social psychology; the social function of laws and norms; economic vs. cultural capital & the "overproduction of elites"; institutional science; civilizational decline & the future of American society. *Not medical advice. Support the show All episodes, show notes, transcripts, and more at the M&M S...

Sep 15, 20221 hr 52 minSeason 2Ep. 87

Shamanism, Psychedelics, Social Behavior, Religion & Evolution of Human Culture | Michael Winkelman | 86

Send us a text Nick talks to anthropologist Dr. Michael Winkelman, who was a professor at Arizona State University for many years, where he studied topics related to shamanism as practiced by early hunter gatherer societies, and other topics related to human cultural evolution. He is now retired and conducts independent research from Brazil, where he now lives. They discuss: what shamanism is & the core features of shamanic ritual practices across historical hunter gatherer cultures; how the...

Aug 31, 20221 hr 34 minSeason 2Ep. 86

Biochemistry of Psilocybin Production, Psychedelic Tryptamines & Magic Mushrooms | Dirk Hoffmeister | 85

Send us a text Nick talks to pharmaceutical microbiologist Dr. Dirk Hoffmeister, who is professor at the Hans Knöll Institute in Germany. Professor Hoffmeister has a background in botany and mycology, the study of fungi. His lab studies various aspects of fungal biochemistry & molecular biology, including the biochemistry and molecular genetics of psilocybin production in magic mushrooms. We spoke about various topics in mycology, mostly related to Psilocybe mushrooms. This included: how psi...

Aug 25, 20221 hr 33 minSeason 2Ep. 85

Climatology, Climate Change, Computer Modeling, Green Energy, Politicization of Science | Judith Curry | 84

Send us a text Nick talks to climatologist Dr. Judith Curry, the former chair of the School of Earth and Atmospheric Sciences at the Georgia Institute of Technology. Her research interests have included hurricanes, atmospheric modeling, air-sea interactions, and a variety of other areas in climate science. She runs Climate, Etc., an online blog focused on climate science. She is also writing a new book called, “Climate Uncertainty & Risk,” which she described towards the end of the podcast. ...

Aug 18, 20221 hr 48 minSeason 2Ep. 84
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