Mind & Matter - podcast cover

Mind & Matter

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.


Not medical advice.

At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.


As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.


I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.


My beliefs:


Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

  • “Γνῶθι σεαυτόν” (Know thyself)
  • “Μηδὲν ἄγαν” (Nothing in excess)
  • “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)
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Episodes

Origins of Life, Alien Biochemistry, Extraterrestrial Biology, Assembly Theory & Consciousness | Lee Cronin | 28

Send us a text Nick talks to chemist Dr. Lee Cronin about life: how it originated on Earth, how we might detect signs of alien life in the universe, whether it can be created in the lab, and related topics. Lee talked about his work on "assembly theory," which provides a framework for thinking about these questions and providing an unbiased way to detect signatures of life in the universe. They also discussed how some of these ideas might relate to evolution, selection, consciousness, and time. ...

Jun 25, 20211 hr 43 minSeason 1Ep. 28

Genomics, CRISPR, Synthetic Biology, Biotechnology Startups, Dyslexia & Narcolepsy | George Church | 27

Send us a text Harvard-MIT geneticist George Church, PhD talks about advances in genome sequencing and editing technologies, interesting biotech startups using CRISPR genome editing to tackle human disease, and interesting areas in synthetic biology. Dr. Church also discussed how he has coped with both narcolepsy and dyslexia throughout his life, and became a successful scientist despite have these brain disorders. *This content is never meant to serve as medical advice. Support the show All epi...

Jun 18, 20211 hr 1 minSeason 1Ep. 27

MDMA (Ecstasy), Post-Traumatic Stress Disorder (PTSD), Psychotherapy & MAPS | Berra Yazar-Klosinski | 26

Send us a text Nick talks to Dr. Berra Yazar-Klosinski, the Chief Science Officer for the Multidisciplinary Association for Psychedelic Studies (MAPS). Berra talked about the results of MAPS' recent Phase III clinical trials for treating severe PTSD, how these studies are conducted, and what we know about the underlying biology of Post-Traumatic Stress Disorder (PTSD) and the drug MDMA. *Not medical advice. Support the show All episodes, show notes, transcripts, and more at the M&M Substack ...

Jun 11, 20211 hr 49 minSeason 1Ep. 26

Dimethyltryptamine (DMT), Brain Waves & the Psychedelic Experience | Chris Timmermann | 25

Send us a text Nick talks to neuroscientist & psychologist, Dr. Chris Timmermann, a scientist at the Centre for Psychedelic Research at Imperial College London. Chris led the first neuroimaging studies on the effects of the potent tryptamine psychedelic DMT on the brain. They discussed DMT and related psychedelics, including how DMT is normally consumed in both recreational and laboratory contexts, how people describe its effects, how it compares to psychedelics like psilocybin and LSD, and ...

Jun 04, 20211 hr 32 minSeason 1Ep. 25

Microbiome, Gut Health, Probiotics, Diet & Intermittent Fasting | Emeran Mayer | 24

Send us a text Nick talks to gastroenterologist and neuroscientist, Dr. Emeran Mayer. Emeran is a distinguished professor at UCLA and an expert in gut health and the microbiome. His last book was titled, “The Mind-Gut Connection: How the Hidden Conversation Within Our Bodies Impacts Our Mood, Our Choices, and Our Health.” His latest book builds on this, and is titled, “The Gut-Immune Connection.” Support the show All episodes, show notes, transcripts, and more at the M&M Substack Affiliates:...

May 28, 20211 hr 50 minSeason 1Ep. 24

Psilocybin Therapy, Alcohol Addiction & Being a Clinical Study Participant | Jon Kostakopoulos | 23

Send us a text Nick talks to Jon Kostakopoulos, an early participant in an NYU study looking at psilocybin for the treatment of alcoholism. Jon went through psilocybin-assisted psychotherapy over the course of many weeks for this study, which included three separate days of psilocybin administration. He talked about his battle with alcoholism leading up to the study, how he was recruited to the study, and what his psilocybin experiences were like. He also shared what he has been doing since his ...

May 21, 20211 hr 20 minSeason 1Ep. 23

Machine Learning, Animal Behavior, Artificial Intelligence & Giving Computers a Sense of Smell | Alex Wiltschko | 22

Send us a text Nick talks to neuroscientist and machine learning engineer, Alex Wiltschko, PhD. Alex is a senior scientist at Google Brain, where he leads the digital olfaction group, where are working to build machines with a sense of smell. Alex received a PhD in neurobiology from Harvard, where he developed sophisticated machine vision and machine learning techniques to study animal behavior. They discussed Alex's research, the neuroscience of olfactory perception and animal behavior, as well...

May 14, 20211 hr 41 minSeason 1Ep. 22

"Life's Edge," Extreme Lifeforms & the Origins of Life | Carl Zimmer | 21

Send us a text Nick talks to science writer and NYT columnist Carl Zimmer about his new book, "Life's Edge: The Search For What It Means To Be Alive." They discuss the scientific quest to understand life: what is it, how does it arise, and how might scientists identify it elsewhere in the universe? They also discuss Carl's approach to science writing, including where he draws inspiration and what his writing process looks like. *Not medical advice. Support the show All episodes, show notes, tran...

May 07, 20211 hr 27 minSeason 1Ep. 21

Language Evolution, Symbolic Cognition, Language Acquisition, Brain Development, Origin of the Human Mind | Terrence Deacon | 20

Send us a text Nick talks to biological anthropologist and cognitive scientist, Terrence Deacon. The conversation focuses on ideas from Terrence's book, "The Symbolic Species: The Co-Evolution of Language and the Brain." They spend nearly three hours talking about the origins of language. Topics include: what is language and how does it differ from animal communication? How do children acquire language so easily at a young age? What is symbolic cognition, how is it different from other forms of ...

Apr 29, 20212 hr 49 minSeason 1Ep. 20

CBD (Cannabidiol), Opioids & the Neurobiology of Addiction | Yasmin Hurd | 19

Send us a text Nick talks to Dr. Yasmin Hurd, a neuroscientist studying medical cannabis, CBD, and opioid addiction. Dr. Hurd is investigating the ability of CBD to help treat withdrawal symptoms and prevent relapse in opioid-addicted individuals. *Not medical advice. Support the show All episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra —Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% of...

Apr 23, 20211 hr 17 minSeason 1Ep. 19

Virus Biology, SARS-CoV-2, & Origins of COVID-19 | Alina Chan | 18

Send us a text Nick talks to genetic engineer Alina Chan, PhD. She is working on engineering new forms of gene therapy using viral vectors to target diverse patient populations. In addition to her core scientific focus, Alina has recently investigated genomic data related to SARS-CoV-2, the virus responsible for the COVID19 pandemic. They discuss the basics of virus biology, including what kind of virus SARS-CoV-2 is and how it infects human cells. They also talked about the published research o...

Apr 16, 20211 hr 29 minSeason 1Ep. 18

Scientific Publishing, Academic Peer Review & the Business of Science | Michael Eisen | 17

Send us a text Nick talks to Dr. Michael Eisen, a biologist at UC-Berkeley and editor-in-chief for eLife, a non-profit open access science journal. Throughout his career, Dr. Eisen has been an advocate of open science, the free release of the results of scientific research, and has been critical of traditional forms of scientific publishing, which often place scientific results behind a paywall. They discuss a variety of topics related to how academic science is conducted, including how it gets ...

Apr 09, 20211 hr 57 minSeason 1Ep. 17

Sleep, Dreaming, Memory & the Brain | Robert Stickgold | 16

Send us a text Nick talks to Dr. Bob Stickgold, a cognitive neuroscientist and sleep expert. Dr. Stickgold is a professor of psychiatry at Harvard Medical School and has been studying sleep, dreams, and memory for over 25 years. They discuss a variety of sleep topics, included sleep architecture and why there are different stages of sleep; the relationship between sleep stages and memory; how different drugs and disease states relate to sleep; how sleep differs as we develop and between species....

Apr 02, 20211 hr 44 minSeason 1Ep. 16

Chemical Analysis of Magic Mushrooms of the Pacific Northwest | Michael Beug | Bonus Episode

Send us a text This bonus episode is a lecture given by mushroom expert Dr. Michael Beug (probably from the 1980s). Professor Beug describes the results of his work analyzing the chemical contents of various psilocybin-containing ("magic") mushrooms native to the Pacific Northwest. You'll learn some interesting observations about different Psilocybe mushrooms, including how psilocybin content varies across species, and which species tend to be the most potent. Support the show All episodes, show...

Mar 31, 202128 min0

Medical Marijuana, Cannabis, Clinical Research & Cannabinoid Therapeutics | Ziva Cooper | 15

Send us a text Dr. Ziva Cooper, Director of the UCLA Cannabis Research Initiative, discusses the latest medical cannabis research. She goes into everything from the potential interactive of effects of cannabinoids and terpenes, to the efficacy of cannabidiol (CBD), to sex- and age-dependent differences in how cannabinoids affect the body. *Not medical advice. Support the show All episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra —Ketone body BHB + potassiu...

Mar 26, 20211 hr 30 minSeason 1Ep. 15

Demetrix & Bioengineering Rare Cannabinoids | Jeff Ubersax | 14

Send us a text Nick Jikomes talks to Jeff Ubersax, PhD, CEO of the biotechnology company Demetrix (who supported this episode). Jeff discussed the science behind how Demetrix is engineering baker's yeast to produce cannabinoids at an industrial scale, with a focus on making rare cannabinoids other than THC and CBD. Jeff also discussed how he transitioned from academic science to running his own company, and offered advice for academic scientists in training who might be thinking about moving int...

Mar 20, 20211 hr 20 minSeason 1Ep. 14

Social Networks, Dominance Hierarchies & Animal Behavior | Elizabeth Hobson | 13

Send us a text Nick talks to Elizabeth Hobson, PhD, whose lab studies the evolution of decision-making, social cognition, social networks, and dominance hierarchies using a combination of naturalistic field observations of animal behavior combined with computational modeling and network analysis. They discuss social behavior in animals, including when and why members of a group display aggression, how animal dominance hierarchies form and change, and how changes in the environment can cause sudd...

Mar 12, 20211 hr 33 minSeason 1Ep. 13

Cities, Companies, Organisms and the Science of Growth & Scale | Geoffrey West | 12

Send us a text Nick talks to theoretical physicist Dr. Geoffrey West about the universal scaling laws that describe how organisms, companies, and cities grow and die. Dr. West is the Shannan Distinguished Professor and former President of the Santa Fe Institute, as well as author of, "Scale: The Universal Laws of Life, Growth, and Death in Organisms, Cities, and Companies." *Not medical advice Support the show All episodes, show notes, transcripts, and more at the M&M Substack Affiliates: Ke...

Mar 04, 20211 hr 56 minSeason 1Ep. 12

Endocannabinoid System, Stress & PTSD | Matthew Hill | 11

Send us a text Nick talks to Dr. Matthew Hill about the role of the endocannabinoid system in regulating stress and emotional behavior. They also discuss how plant cannabinoids from Cannabis , such as THC and CBD, impact the endocannabinoid system. *Not medical advice. Support the show All episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra —Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% o...

Feb 27, 20211 hr 46 minSeason 1Ep. 11

Human Evolution, Neanderthals, Paleoanthropology, Ancient DNA & Human Diversity | John Hawks | 10

Send us a text Nick talks to paleoanthropologist John Hawks about the story of human evolution. Listen to a more recent conversation with John Hawks. Support the show All episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra —Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. C...

Feb 19, 20212 hr 26 minSeason 1Ep. 10

Medical Marijuana, Plant Medicine, Cannabis, Cannabinoids, Terpenes & the Entourage Effect | Ethan Russo | 9

Send us a text Nick talks to neurologist and plant medicine expert Dr. Ethan Russo about medical cannabis and related topics, such as cannabinoids (e.g. THC, CBD, CBG, THCV), terpenes (myrcene, limonene, beta-caryophyllene), endocannabinoid biology, and Ethan's thoughts on the legal cannabis industry, including whether the terms "Indica" and "Sativa" are meaningful. *Not medical advice. Support the show All episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra...

Feb 15, 20211 hr 33 minSeason 1Ep. 9

Empathy, Addiction, MDMA ("Ecstasy"), Psychedelics & Social Cognition | Katrin Preller | 8

Send us a text Nick talks to neuropsychologist Katrin Preller, PhD about psychedelics like LSD and psilocybin, empathogens like MDMA, and stimulants like cocaine. Katrin explains how each type of drug affects the brain differently and what that means for their impact on empathy, social cognition, and their addictive potential. *Not medical advice. Support the show All episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra —Ketone body BHB + potassium, calcium &...

Feb 06, 20211 hr 12 minSeason 1Ep. 8

Salvia divinorum, Dissociation & Psychotherapy | Peter Addy | 7

Send us a text Nick talks to Peter Addy, PhD about the atypical, dissociative psychedelic, salvia. Peter is a psychotherapist and spent several years at the Yale, studying human experiences with atypical psychedelics such as Salvia divinorum . Nick and Peter talked about salvia, including how it works and how it differs from other psychedelics, as well as dissociative and dysphoric effects, and how his research has informed his psychotherapy practice. *Not medical advice. Support the show All ep...

Jan 30, 20211 hr 36 minSeason 1Ep. 7

Psychedelics, DMT, Ayahuasca, Ibogaine, Amphetamines & Hamilton's Pharmacopeia | Hamilton Morris | 6

Send us a text Nick talks to Hamilton Morris, creator of the show, "Hamilton's Pharmacopeia," about the third and final season. They discuss: the last season of his show, including the content itself and what it took to actually make it; a variety of drugs and their effects, ranging from stimulants like methamphetamine, dissociatives (e.g. ketamine), psychedelics & to various forms of DMT, ibogaine and xenon gas. *Not medical advice. Support the show All episodes, show notes, transcripts, an...

Jan 23, 20212 hr 9 minSeason 1Ep. 6

Cannabis Science, Plant Chemistry & Marijuana Startups | Jon Page | 5

Send us a text Jonathan Page, PhD is a botanist and entrepreneur with deep expertise in Cannabis. Nick and Jon talked about all things Cannabis science including the botany and natural history of Cannabis, the chemistry and biology of Cannabis and its psychoactive effects, and whether or not different types of Cannabis can cause different effects. Jon also shared amazing stories about transitioning from scientific research to starting, building, and selling a cannabis company, and his thoughts o...

Jan 16, 20212 hr 43 minSeason 1Ep. 5

Drugs, Brain Receptors, Zen Meditation, Nondualism & Psychedelics | Bryan Roth | 4

Send us a text Bryan Roth, MD, PhD discusses his career studying how psychedelics and other psychoactive drugs affect the brain, the massive $27 million research effort he is leading to understand psychedelics and develop novel drugs for psychiatric disease, and the practice of zen meditation. *Not medical advice. Support the show All episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra —Ketone body BHB + potassium, calcium & magnesium, formulated with ki...

Jan 09, 20211 hr 49 minSeason 1Ep. 4

Chance, Evolution & the Nature of Innovation | Sean B. Carroll | 3

Send us a text Sean B. Carroll, PhD is an award-winning biologist, author, and filmmaker. Nick and Sean discuss everything from Sean's unique career trajectory and writing process, to dinosaurs and snake venom, to COVID19, the evolution of viruses, and why comedians and scientists are kindred spirits. Support the show All episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra —Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health i...

Jan 01, 20211 hr 37 minSeason 1Ep. 3

Psilocybin, LSD, Ketamine, DMT Facts & Myths, Inflammation & Novel Psychedelic Medicines | Charles Nichols | 2

Send us a text Dr. Nichols is a professor of pharmacology at Louisiana State University. He has been studying the molecular, genetic, and behavioral effects of psychedelics for nearly 25 years and is considered one of the world’s top experts on the biological effects of psychedelics in the brain and body. Nick spoke to Charles for almost two hours, covering a wide range of topics related to how psychedelics work. They discuss everything from how psychedelics impact the serotonin system in the br...

Dec 25, 20201 hr 53 minSeason 1Ep. 2

Psychedelics, Civilization, Religion, Ancient History, Plant Medicine & Death | Brian Muraresku | 1

Send us a text Brian is the author of the New York Times-bestselling book, "The Immortality Key: The Secret History of the Religion With No Name." Brian is fluent in Ancient Greek, Latin, and Sanskrit, and spent over a decade putting together an incredible story about the intentional use of psychoactive plants in the ancient world, including scientific evidence for the ritual use of spiked beers and wines. Nick and Brian cover topics related to his book, including the use of psilocybin mushrooms...

Dec 14, 20201 hr 30 minSeason 1Ep. 1
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