Mind & Matter - podcast cover

Mind & Matter

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.


Not medical advice.

At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.


As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.


I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.


My beliefs:


Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

  • “Γνῶθι σεαυτόν” (Know thyself)
  • “Μηδὲν ἄγαν” (Nothing in excess)
  • “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)
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Episodes

Consciousness, Dissociation, Metacognition, Idealism, Materialism, Philosophy, Psychedelics, Death & Mind | Bernardo Kastrup | Episode 60

Send us Fan Mail Nick talks to computer scientist and philosopher Bernardo Kastrup about various topics related to consciousness and the nature of reality. They discuss: psychological dissociation; the scientific study of 'neural correlates of consciousness'; the nature of perception and the influence of language on the mind; why the 'Hard Problem' of consciousness is so difficult; Bernardo's philosophy of analytic idealism; Jungian psychology & psychological archetypes; psychedelic experien...

Mar 02, 20222 hr 38 minSeason 2Ep. 60

CBD (Cannabidiol), Antiviral Drugs, SARS-CoV-2 & Cancer Biology | Marsha Rosner | 59

Send us Fan Mail Nick Jikomes talks to cancer biologist Dr. Marsha Rosner, who is a Professor of Cancer Research at the University of Chicago. Her lab focuses largely on understanding the biochemical signaling mechanisms that lead to the generation of tumor cells, as well as how and why cancer cells metastasize, which is when they travel from one part of the body to another. Nick and Dr. Rosner and discuss mainly a recent study she led about the antiviral effects of cannabidiol (CBD) against SAR...

Feb 23, 20221 hr 26 minSeason 2Ep. 59

Genomics, PCR, COVID Testing, mRNA Vaccines, Blockchain Technology, Psilocybin Mushroom & Cannabis Genomes | Kevin McKernan | 58

Send us Fan Mail Kevin McKernan is a renowned leader in DNA sequencing technology. He led a research team part of the original Human Genome Project and is the founder and Chief Science Officer of Medicinal Genomics, a life sciences company that distributes genetics-based platforms for quality and safety testing of legal cannabis. Nick and Kevin discussed the Cannabis genome, the genome of Psilocybe cubensis (magic mushrooms); Polymerase Chain Reaction (PCR) technology, how it works, and how it's...

Feb 15, 20221 hr 43 minSeason 2Ep. 58

Sci-Hub, Open Data, Freedom of Information & the Democratization of Science | Alexandra Elbakyan | 57

Send us Fan Mail Nick talks to Alexandra Elbakyan, the founder of Sci-hub, a shadow library website that provides free access to millions of research papers and books, without regard to copyright, by bypassing publishers' paywalls in various ways. Sci-hub is used by millions of people around the world each month, granting them free and easy access to scientific research findings. Nick spoke to Alexandra about how Sci-hub works, why she built it, and some of the legal challenges she has faced fro...

Feb 10, 202238 minSeason 2Ep. 57

Gut Microbiome, Diet, Inflammation, Probiotics, Skin Care, Acne, Obesity & IBS | Suzanne Devkota | 56

Send us Fan Mail Nick talks to Dr. Suzanne Devkota, a microbiologist whose lab studies the gut microbiome in health and disease. They discuss a variety of topics related to the gut microbiome: how it is influenced by diet; how antibiotics and probiotics affect it; different disease states and metabolic disorders, such as IBS and obesity; how gut microbes can affect the brain and behavior; the microbiome beyond the gut, including the skin; and more. *Not medical advice. Support the show Health Pr...

Feb 03, 20221 hr 14 minSeason 2Ep. 56

Diet, Eating Habits, Obesity, Food Addiction, Psychedelics, Nutrition & the Brain | Amy Reichelt | 55

Send us Fan Mail Nick talks to Dr. Amy Reichelt, a neuroscientist and expert on the effects of diet and nutrition on the brain. They discussed how the brain is wired to help us learn about food, how what we eat influences the function of circuits within the brain, how certain diets can actually cause damage to the brain and negatively impact learning, obesity, and other topics related to nutrition and feeding behavior in humans and animals. They also discuss the potential role that psychoactive ...

Jan 27, 20221 hr 36 minSeason 2Ep. 55

Dinosaurs, Paleontology, Mass Extinctions, Evolution, Past & Future of Life on Earth | Paul Barrett | 54

Send us Fan Mail Nick talks to Dr. Paul Barrett, a paleontologist at the Natural History Museum in London, UK. Paul has spent nearly 30 years as a paleontologist studying the evolution and biology of dinosaurs and other extinct reptiles. He has authored over 200 scientific papers, and his speciality is in non-avian dinosaurs. Nick talked to Paul about all things dinosaurs, including what a dinosaur actually is; how and when dinosaurs first evolved, changed over time, and eventually went extinct;...

Jan 20, 20221 hr 59 minSeason 2Ep. 54

Phytochemistry, Biochemistry, Genomics & Breeding of Commercial Cannabis | Reggie Gaudino | 53

Send us Fan Mail Nick talks to Dr. Reggie Gaudino, a molecular geneticist and expert in the phytochemistry, biochemistry, genomics, and breeding of commercial Cannabis . He is the former Chief Science Officer of Steep Hill, one of the first cannabis testing labs in the US, and is currently VP of Research & Development at Frontrange Biosciences. Nick & Reggie discuss various topics related to the science of commercial Cannabis , including: it's botanical characteristics and history, the e...

Jan 13, 20221 hr 30 minSeason 2Ep. 53

Painkillers, Opioids, Heroin, Fentanyl, Oxycodone, NSAIDs, & Neuroscience of Pain | David Roberson | 52

Send us Fan Mail Nick Jikomes talks to Dr. David Roberson, a neuroscientist and co-founder of three ongoing biotech companies: Nocion Therapeutics, Blue Therapeutics, and Blackbox Bio. David is an expert in the neuroscience of pain and the conversation focuses mainly on pain: how does our brain sense and perceive pain? Why does pain sometimes become chronic, and last for a long-time? How do various classes of pain drugs work to relieve pain? They discuss NSAIDs and opioids, including oxycodone, ...

Jan 06, 20221 hr 43 minSeason 2Ep. 52

Systems Thinking, Organizational Structures, Building Startups, Remote Work & Control vs. Enablement | Alexandros Marinos | 51

Send us Fan Mail Nick talks to Alexandros Marinos, PhD, founder & CEO of the edge computing technology startup, Balena. They discuss the internal organization of complex human systems. Alex talked about how he thinks about the organizational structure of his own company and how organizational structures impact group dynamics, growth, conflicts of interest, and innovation. One interesting area Alex provided commentary and analysis on towards the end is how to make sense of the behavior of lar...

Dec 30, 20211 hr 33 minSeason 1Ep. 51

Medical Glass, Materials Science & the COVID Vaccine Supply Chain | Chris Weikart | 50

Send us Fan Mail Nick Jikomes talks to materials scientist Dr. Chris Weikart, who is currently chief scientist at SiO2, an advanced materials science company that combines chemistry and engineering to create containers and surfaces for use by biotechnology, genomics, diagnostics, and consumer products companies. They discuss how SiO2 created a new kind of vaccine vial, which combines both glass and plastic that are superior for storing and transporting biologics, such as vaccines. SiO2 is curren...

Dec 23, 202158 minSeason 1Ep. 50

Does Adolescent Marijuana (Cannabis) Use Cause Psychosis? | Jonathan Schaefer | 49

Send us Fan Mail Nick talks to Dr. Jonathan Schaefer about the link between adolescent cannabis (marijuana) use and psychosis. Jonathan has a PhD in clinical psychology and he is currently a research psychologist at the University of Minnesota Institute of Child Development. His research focuses largely on the relationship between people’s environments that influence their mental health. He has conducted a number of longitudinal studies using cohorts of identical and fraternal twins, which allow...

Dec 16, 20211 hr 27 minSeason 1Ep. 49

Autism, the Cerebellum, Learning, Brain Development | Sam Wang | Episode 48

Send us Fan Mail Nick Jikomes talks to Sam Wang, PhD professor of neuroscience at Princeton University. Dr. Wong’s lab investigates how brains learn from sensory experience, in adulthood and development, with relevance for autism. A lot of their work focuses on a part of the brain called the cerebellum. They talk about the cerebellum and what we’re learning about its functions, as well as how it’s tied to autism, and what the causes and nature of autism actually are. This included both the genet...

Dec 09, 20211 hr 18 minSeason 1Ep. 48

Metabolism, Blood Sugar, Diabetes, Microbiome, Diet, Aging, Digital Phenotyping & Personalized Medicine | Nathan Price | Episode 47

Send us Fan Mail Nick Jikomes talks to Dr. Nathan Price, who has a Ph.D. in bioengineering and has been faculty at the University of Washington and the Institute of Systems Biology. He was also CEO of a health intelligence startup called Onegevity, which recently merged with Thorne HealthTech, where he is the Chief Science Officer. Nathan and Nick discussed various topics in personalized medicine, digital phenotyping, and systems biology, including metabolism and blood sugar monitoring, the micr...

Dec 02, 20211 hr 43 minSeason 1Ep. 47

Psychedelics, Psychoplastogens, Microdosing, Brain Chemistry, Mental Health, Novel Drugs | David Olson | Episode 46

Send us Fan Mail Nick Jikomes talks to medicinal chemist Dr. David Olson whose lab at the University of California-Davis studies a class of compounds called ‘psychoplastogens,’ which are small molecules capable of promoting neural plasticity. His lab is on the cutting edge when it comes to understanding the mechanisms by which psychedelics and other psychoactive drugs work in the brain. They touch on: latest research from his lab, new tools they're developing and using to understand these drugs,...

Nov 24, 20211 hr 7 minSeason 1Ep. 46

The Mystery of SARS-CoV-2 & Origins of COVID-19 | Alina Chan | Episode 45

Send us Fan Mail Nick Jikomes talks to genetic engineer Dr. Alina Chan about the origins of the SARS-CoV-2 virus responsible for the COVID-19 pandemic. They discuss Alina's new book, "Viral: The Search For the Origin of COVID-19," which she co-wrote with Matt Ridley. The book thoroughly documents the events & people relevant to COVID's origins. They discuss everything from the original SARS-1 epidemic in China, wildlife spillover vs. accidental lab leak hypotheses; pangolins, bats, and other...

Nov 16, 20211 hr 27 minSeason 1Ep. 45

Consciousness, Perception, Hallucinations, Selfhood, Neuroscience, Psychedelics & "Being You" | Anil Seth | 44

Send us Fan Mail Nick talks with Dr. Anil Seth, a neuroscientist and professor of cognitive & computational neuroscience at the University of Sussex. The conversation is all about the neuroscience of consciousness, which is the subject of his Dr. Seth's book, “Being You: A New Science of Consciousness.“ They touch on everything from what consciousness actually is, whether or not neuroscientists can measure different levels of consciousness in the brain, what characterizes psychedelic experie...

Nov 11, 20211 hr 34 minSeason 1Ep. 44

Sleep, Dreaming, Deep Neural Networks, Machine Learning & Artificial Intelligence, Overfitted Brain Hypothesis, Evolution of Fiction & Art | Erik Hoel | Episode 43

Send us Fan Mail Nick talks to neuroscientist and writer Dr. Erik Hoel. Erik is a professor of biology at Tufts University. He received his PhD in neuroscience from the University of Wisconsin, where he studied under the sleep and consciousness researcher, Giulio Tononi. He did postdoctoral work at Columbia University, where he used information theory and other analytical tools to explore the biological basis of consciousness. He has come up with the so-called Overfitted Brain Hypothesis of drea...

Nov 04, 20211 hr 27 minSeason 1Ep. 43

THC, CBD, Omega-3 Fatty Acids, L-Theanine, Opioids, Pregnancy, Brain Development, Addiction, Anxiety & Schizophrenia | Steve Laviolette | Episode 42

Send us Fan Mail Nick Jikomes talks to Dr. Steven Laviolette, a neuroscientist at the University of Western Ontario. They discuss how different types of drugs impact emotion, cognition, brain development and the development of psychiatric conditions (e.g. addition, schizophrenia); drug interactions (THC + CBD, THC + L-Theanine, CBD + Omega-3 Fatty Acids), how drugs can affect brain development when consumed during adolescence, or by pregnant women; how cannabinoids interact with opioids in diffe...

Oct 27, 20211 hr 21 minSeason 1Ep. 42

Cannabinoids, Inflammation, Brain Injury, Diabetes, Gut Health & Academia vs. Industry | Saoirse O'Sullivan | Episode 41

Send us Fan Mail Nick Jikomes talks to Saoirse O'Sullivan, PhD, a physiologist specializing in the physiological effects of cannabinoids. Dr. O'Sullivan ran a lab at the University of Nottingham for many years before becoming a consultant and Vice President of Translational Research at Artello Biosciences. They discuss some of the physiological effects of cannabinoids in the body, including endogenous cannabinoids our own bodies produce, and plant cannabinoids associated with the Cannabis plant ...

Oct 21, 20211 hr 23 minSeason 1Ep. 41

Drug Addiction, Cocaine, Nicotine, Caffeine, Amphetamines, Opioids, THC & Neuroscience | Christian Luscher | Episode 40

Send us Fan Mail Christian Luscher, MD, PhD is a neuroscientist and neurologist who runs a research lab at the University of Geneva in Switzerland. Dr. Lusher's lab studies the mechanisms that underlie drug reinforcement and addiction in the brain and he is an expert in the neuroscience of drug addiction. Christian talks to Nick about: what is addiction is and what some key parts of the brain and neurotransmitter systems are involved in drug addiction; differences in the addictive potential of d...

Oct 14, 20211 hr 8 minSeason 1Ep. 40

Origins of COVID-19 & SARS-CoV-2 Virus: Lab Leak or Wildlife Spillover? | Nicholas Wade | 39

Send us Fan Mail Nick Jikomes talks to writer and science journalist Nicholas Wade about the origins of the SARS-CoV-2 virus and the COVID-19 pandemic. Nicholas describes how this story has evolved since the start of the pandemic, and contrasts the the two main hypotheses for the origins of COVID: wildlife spillover vs. lab leak. He describes how viruses in the past (e.g. SARS1) emerged, peculiarities of the SARS2 genome, Peter Daszak & EcoHealth Alliance, Wuhan Institute of Virology, and va...

Sep 30, 20211 hr 13 minSeason 1Ep. 39

Human Evolution, Ancient Drug Use, Ritual Burials, Homo Naledi, Origins of Human Mind, Paleoanthropology | Lee Berger | 38

Send us Fan Mail Nick Jikomes talks to paleoanthropologist Dr. Lee Berger about human evolution. Dr. Berger is a professor of anthropology in South Africa, explorer-in-residence for National Geographic, and author of, "Becoming Human." Lee's team has mapped and explored caves all over South Africa, discovering a treasure trove of ancient human fossils. This includes the discovery of Homo naledi , an ancient human ancestor that had a much smaller brain than humans, but may have nonetheless appear...

Sep 24, 20211 hr 25 minSeason 1Ep. 38

Brain Development, Neuroplasticity, Learning, Sensory Maps & Simulations | Michael Crair | 37

Send us Fan Mail Nick talks to physicist and neuroscientist Dr. Michael Crair. Michael runs a lab at Yale University studying mechanisms of brain development. He discussed research related to neural plasticity, learning & memory, sensory maps, and critical periods of plasticity. Dr. Crair also described recent findings from his lab show that parts of the developing brain can simulate future sensory experiences, before animals ever open their eyes and see the external world. *Not medical advi...

Sep 17, 20211 hr 17 minSeason 1Ep. 37

Evolutionary Toolkit for the 21st Century | Heather Heying & Bret Weinstein | Episode 36

Send us Fan Mail Applying evolutionary principles to navigate modern challenges like health, culture, and society. Not medical advice. TOPICS DISCUSSED: Human niche as niche-switching: Humans uniquely adapt by changing behaviors and environments, enabling survival across diverse conditions, unlike specialized animals. Culture vs. consciousness: Culture encodes efficient, habitual behaviors passed down generations, while consciousness drives innovation in novel situations, creating a balance disr...

Sep 09, 20212 hr 49 minSeason 1Ep. 36

Psychiatry, Depression, Anxiety, Autism, Dissociation & "Projections: A Story of Human Emotions" | Karl Deisseroth | 35

Send us Fan Mail Nick talks to Stanford psychiatrist and neuroscientist Dr. Karl Deisseroth. They discuss a range of topics about the brain, including autism, depression, bipolar disorder, dissociation, and more. They also talk about optogenetics, a technique Karl co-developed which uses light to control specific neurons in the brain, allowing neuroscientists to turn circuits in the brain on and off to reveal how the brain generates perception, emotion, and behavior. They also talk about Karl's ...

Sep 03, 20211 hr 39 minSeason 1Ep. 35

Social Status, Luxury Beliefs, Social Psychology & Human Social Behavior | Rob Henderson | Episode 34

Send us Fan Mail Nick to talks to psychology student Rob Henderson about social status, social signaling, luxury beliefs, and related topics in social psychology and human behavior. *Not medical advice. Support the show Health Products by M&M Partners: AquaTru : Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. OmegaQuant : At-home blood ...

Aug 27, 20211 hr 21 minSeason 1Ep. 34

LSD, Mescaline, DMT, MDMA, Medicinal Chemistry & Psychedelic Medicine | David Nichols | 33

Send us Fan Mail Nick talks to medicinal chemist Dr. David Nichols, who has spent decades studying the chemistry and pharmacology of psychedelics. Dr. Nichols shared his knowledge of psychedelic tryptamines, including LSD and DMT, as well as phenethylamines, such as mescaline and MDMA. He also discussed his relationship with the late Dr. Alexander "Sasha" Shulgin and how his thoughts on companies trying to make non-hallucinogenic drugs derived from psychedelics. *Not medical advice. Support the ...

Aug 19, 20211 hrSeason 1Ep. 33

SARS-CoV-2 Variants, mRNA Vaccines, Virology, Evolution & Future of COVID-19 | Sarah Otto | 32

Send us Fan Mail Nick talks with evolutionary biologist Dr. Sarah Otto about the evolutionary dynamics of SARS-CoV-2, the emergence of new variants, whether she thinks we will need shots every year (like with the flu), mRNA vaccines, and more. *Not medical advice. Support the show Health Products by M&M Partners: AquaTru : Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Un...

Aug 11, 20211 hr 8 minSeason 1Ep. 32

Cognition, Decision Making, Learning, Schemas & the Brain | Aaron Gruber | Episode 31

Send us Fan Mail Nick talks to neuroscientist Dr. Aaron Gruber about topics related to cognition and learning in the brain, including what we know about how the brain detects salience and assigns value, makes decisions, and constructs flexible models of the world, sometimes called ‘schemas.’ They also discuss how neuropsychiatric disorders like depression can influence the brain’s schemas, as well as how they can be impacted by psychoactive drugs, ranging from stimulants to psychedelics. *Not me...

Aug 06, 20211 hr 41 minSeason 1Ep. 31
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