Mind & Matter - podcast cover

Mind & Matter

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.


Not medical advice.

At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.


As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.


I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.


My beliefs:


Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

  • “Γνῶθι σεαυτόν” (Know thyself)
  • “Μηδὲν ἄγαν” (Nothing in excess)
  • “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)

Episodes

Psychedelic Chemistry, Magic Mushrooms, Kratom, Gray Market Research Chemicals, Vape Shops | Andrew Chadeayne | 231

Send us a text Episode Summary: Dr. Andrew Chadeayne discusses the chemistry of psilocybin and other psychedelics, their potential therapeutic applications, and the challenges of commercializing them in a shifting biotech market. The conversation delves into the complexities of magic mushroom composition, debunking myths like "lemon tekking," and uncovers the booming, unregulated alternative products industry, including kratom and synthetic psilocybin analogs sold in vape shops. About ...

May 25, 20251 hr 39 minSeason 5Ep. 231

Psilocybin & MDMA: Inflammation, Stress & Brain-Body Communication | Michael Wheeler | 230

Send us a text Episode Summary: Dr. Michael Wheeler talks about neuroimmune interactions, exploring how the immune system and brain communicate, particularly through the blood-brain barrier and meninges; how chronic stress and inflammation can alter brain circuits, contributing to mood disorders like depression; how drugs like psilocybin and MDMA may reduce inflammation by modulating immune cells in the meninges, offering potential therapeutic benefits. About the guest: Michael Wheeler, PhD is a...

May 20, 20251 hr 10 minSeason 5Ep. 230

Linoleic Acid, Seed Oils, mTOR & Breast Cancer | Nikos Koundouros & John Blenis | 229

Send us a text Episode Summary: New research on how dietary fats, particularly omega-6 fatty acids like linoleic acid, influence triple-negative breast cancer progression by activating the mTOR pathway, a key regulator of cell growth; role of the FABP5 protein in enhancing cancer cells’ sensitivity to omega-6 fats; differences between breast cancer subtypes; broader implications of dietary balance for health. About the guest: John Blenis, PhD is a Professor of Pharmacology at the Meyer Cancer Ce...

May 15, 20251 hr 47 minSeason 5Ep. 229

Rhythms, Memory, Time, Place, Representation & the Brain | György Buzsáki | 228

Send us a text Episode Summary: Dr. Gyorgy Buzsaki discusses the hippocampus’s role beyond memory and spatial navigation, delving into its broader functions in cognition, action planning, and brain-body interactions; how hippocampal rhythms, like sharp wave ripples, influence memory consolidation, glucose regulation, and metabolic health, challenging conventional neuroscience assumptions; the interplay of brain rhythms, sleep, and preconfigured neural dynamics; the history and conceptual foundat...

May 10, 20251 hr 49 minSeason 5Ep. 228

Biophysics of Life: Biophotons, Light, Quantum Biology, Regeneration & Cancer | Nirosha Murugan | 227

Send us a text The biophysics of life, exploring how light & energy shape biology, with biophysicist Dr. Nirosha Murugan. Episode Summary: Dr. Murugan discusses the role of biophysics in biology, focusing on how light, particularly biophotons emitted by cells, influences processes like wound healing, neural activity, and cancer detection; how microtubules may act as biological fiber optics, the impact of modern light environments on health; her work inducing limb regeneration in frogs using ...

May 05, 20251 hr 39 minSeason 5Ep. 227

Psychedelics & Cerebral Cortex: Neuroplasticity, Psilocybin, Ketamine | Alex Kwan | 226

Send us a text Short Summary: Dr. Alex Kwan unpacks the latest neuroscience research on how psychedelics like ketamine & psilocybin reshape the brain. About the guest: Alex Kwan, PhD, is an associate professor of biomedical engineering at Cornell University. His lab employs advanced imaging to study how psychedelics and other drugs affect the mammalian brain. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube . Partial versions are ...

May 01, 20251 hr 18 minSeason 5Ep. 226

Nutrition Epidemiology: Fake Science? | John Speakman | 225

Send us a text Short Summary: The flaws of nutrition epidemiology with Dr. John Speakman About the guest: John Speakman, PhD is a professor at the University of Aberdeen and runs a lab in Shenzhen, China, focusing on energy balance, obesity, and aging. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube . Partial versions are available elsewhere. Transcript and other information on Substack. Episode Summary: Dr. John Speakman explores th...

Apr 26, 20251 hr 6 minSeason 5Ep. 225

Cancer Biology: Metabolism, Mitochondria & Energy | Thomas Seyfried | 224

Send us a text Short Summary: Cancer’s metabolic roots with Dr. Thomas Seyfried. About the guest: Thomas Seyfried, PhD is a professor of biology at Boston College. He has researched cancer metabolism, epilepsy, and lipid biochemistry for over 40 years. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube . Partial versions are available elsewhere. Transcript and other information on Substack. Episode Summary: Dr. Thomas Seyfried discusses...

Apr 23, 20251 hr 52 minSeason 5Ep. 224

Ketogenic Diet: Cholesterol, Plaque & Heart Heart | Matthew Budoff | 223

Send us a text Short Summary: Heart health and the ketogenic diet, with expert insights from a cardiologist and researcher. About the guest: Matthew Budoff, MD, is a preventive cardiologist and professor of medicine at UCLA School of Medicine. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube . Partial versions are available elsewhere. Transcript and other information on Substack. Episode Summary: Dr. Matthew Budoff discusses cholester...

Apr 19, 202559 minSeason 5Ep. 223

Genetics & Neurobiology of Obesity: Hypothalamus, Leptin, Gut Hormones, Weight Loss Drugs | Giles Yeo | 222

Send us a text Short Summary: The science of obesity and appetite regulation, blending genetics and neurobiology with practical insights About the guest: Giles Yeo, PhD is a professor of molecular neuroendocrinology at the University of Cambridge. He leads a lab studying obesity and appetite regulation. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube . Partial versions are available elsewhere. Full transcript and other information on...

Apr 15, 20251 hr 34 minSeason 5Ep. 222

Regenerative Energy & the Light Inside You | Jack Kruse | M&M 221

Send us a text Short Summary: A mind-bending dive into evolutionary biology and health through a biophysicist’s lens, with Dr. Jack Kruse delivering provocative insights about biology, medicine, and health. About the guest: Jack Kruse, MD, is a neurosurgeon known for integrating biophysics into medicine. He challenges conventional biochemistry with his “leptin prescription” and decentralized health approach. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack a...

Apr 11, 20252 hr 27 minSeason 5Ep. 221

Cell Death, Oxidative Stress, PUFAs & Antioxidants | Pamela Maher | 220

Send us a text Short Summary: A deep dive into the science of oxidative stress, antioxidants, aging, and neurodegenerative diseases like Alzheimer’s. About the guest: Pamela Maher, PhD is a professor at the Salk Institute in San Diego, California, with a focus on neurodegenerative diseases, oxidative stress, and antioxidants. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube . Partial versions are available elsewhere. Full transcript a...

Apr 08, 20251 hr 40 minSeason 5Ep. 220

Shamanism, Human Culture & the Evolution of Religion | Manvir Singh | 219

Send us a text Short Summary: A detailed examination of shamanism with anthropologist Manvir Singh, blending evolutionary theory and vivid storytelling. About the guest: Manvir Singh, PhD is an anthropologist at the University of California, Davis. His new book, "Shamanism: The Timeless Religion," comes out on May 25, 2025. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube . Partial versions are available elsewhere. Full tran...

Apr 04, 20251 hr 44 minSeason 5Ep. 219

Chemical Exposures, Neurodegenerative Disease & Exposomics | Gary Miller | 218

Send us a text Short Summary: How environmental chemical exposures affect neurodegenerative disease and health. About the guest: Gary Miller, PhD is a Professor of Environmental Health Sciences at Columbia University. His research bridges pharmacology, toxicology, and neuroscience to explore neurodegeneration, particularly Parkinson’s and Alzheimer’s diseases. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube . Partial versions are ava...

Mar 31, 20251 hr 33 minSeason 5Ep. 218

Communication & Social Cognition in Elephants & Animals | Mickey Pardo | 217

Send us a text Short Summary: Do elephants and other animals have language-like abilities, such as the ability to use individual names to refer to themselves and others? About the guest: Michael Pardo, PhD studies animal behavior at Cornell University, where he focused on animal communication and cognition. His work includes extensive field research with African elephants in Kenya. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube . Pa...

Mar 27, 20251 hr 40 minSeason 5Ep. 217

Can Aspirin Prevent Cancer Metastasis? | Rahul Roychoudhuri | 216

Send us a text Short Summary: The science of cancer and immunity with Dr. Roychoudhuri, blending cutting-edge research with everyday implications like aspirin’s role in fighting tumor metastasis. About the guest: Rahul Roychoudhuri, PhD is a Professor of Cancer Immunology at the University of Cambridge. His research bridges basic science and clinical applications, focusing on immune responses to cancer development and spread. Note: Podcast episodes are fully available to paid subscribers on the ...

Mar 23, 20251 hr 27 minSeason 5Ep. 216

Cancer Metabolism: Sugar, Fructose, Lipids & Fasting | Gary Patti | 215

Send us a text Short Summary: How dietary fructose affects the growth rate of cancer. About the guest: Gary Patti, PhD is a professor at Washington University in St. Louis, holding appointments in chemistry, medicine, and genetics Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube . Partial versions are available elsewhere. Full transcript and other information on Substack. Episode Summary: Nick Jikomes talks to Dr. Patti, exploring how...

Mar 19, 20251 hr 45 minSeason 5Ep. 215

Gut Microbiome Plasticity | Peter Turnbaugh | 214

Send us a text Short Summary: How diet shapes the gut microbiome and impacts health, with microbiologist Dr. Peter Turnbaugh breaking down the complex science. About the guest: Peter Turnbaugh, PhD is a professor of microbiology and immunology at the University of California, San Francisco, where he leads a lab studying the gut microbiome’s role in nutrition and drug response. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube . Partial...

Mar 14, 202541 minSeason 5Ep. 214

Causes of Diabetes: Insulin, Mitochondria, Genetics, Metabolism | Scott Soleimanpour | 213

Send us a text Short Summary: The science of diabetes with Dr. Scott Soleimanpour, blending personal insights and cutting-edge research that gets into mitochondrial biology and more. About the guest: Scott Soleimanpour, MD, is a physician-scientist at the University of Michigan, where he runs a lab studying pancreatic beta cell biology and mitochondrial quality control in diabetes. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube . Pa...

Mar 10, 202549 minSeason 5Ep. 213

How Science Works: Meta-Research, Publishing, Reproducibility, Peer Review, Funding | John Ioannidis | 212

Send us a text Short Summary: A rare, insider’s look at the messy realities of scientific research with Stanford’s Dr. John Ioannidis. The good, the bad, and the ugly about how scientific research actually works. About the guest: John Ioannidis, MD, PhD is a professor at Stanford University in medicine, epidemiology, population health, and biomedical data science, with an MD from the University of Athens and a PhD from Harvard in biostatistics. He directs the Meta-Research Innovation Center at S...

Mar 05, 202554 minSeason 5Ep. 212

Short-Chain Fatty Acids, Diabetes Subtypes & Wearable HealthTech | Michael Snyder | 211

Send us a text Short Summary: Personalized health monitoring with Professor Michael Snyder, blending cutting-edge science with practical tips and actionable insights. About the guest: Michael Snyder, PhD is a Professor of Genetics at Stanford University School of Medicine. He directs the Center for Genomics and Personalized Medicine, which focuses on big data and health innovation. Snyder holds a PhD from Caltech and completed postdoctoral work at Stanford. His career has spanned yeast genomics ...

Mar 01, 202551 minSeason 5Ep. 211

Public Health & Trust in Science in the Post-COVID Era | Martin Kulldorff | 210

Send us a text Short Summary: Insider’s look at the COVID-19 pandemic response from a seasoned epidemiologist, unraveling myths and lessons with straightforward science. About the guest: Martin Kulldorff, PhD is an epidemiologist and biostatistician with decades of experience in infectious disease monitoring and vaccine safety. He was formerly a professor at Harvard Medical School. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack . Partial versions are avail...

Feb 26, 202538 minSeason 5Ep. 210

Thyroid Biology in Health & Aging | Diana van Heemst | 209

Send us a text Short Summary: Thyroid biology, offering insights into its role in metabolism, development, and longevity, making it a fascinating listen for those interested in how our bodies manage energy and health across the lifespan. Guest: Diana van Heemst, PhD is a biologist at Leiden University Medical Center, specializing in gerontology and geriatrics. Her research focuses on the neuroendocrine biology of aging and longevity in humans, particularly involving thyroid functions. Note: Podc...

Feb 14, 202539 minSeason 5Ep. 209

Glyphosate, Choline & Alzheimer's: Toxins & Nutrition to Prevent Neurodegeneration | Ramon Velazquez | 208

Send us a text Short Summary: The complexities of neurodegenerative disease, particularly Alzheimer's, environmental influences like glyphosate, and the crucial role of nutrients like choline, with actionable insights into brain health management. About the guest: Dr. Ramon Valazquez is an Assistant Professor at Arizona State University, leading a research lab at the Neurodegenerative Disease Research Center. His work focuses on environmental factors related to Alzheimer's and other de...

Feb 08, 202543 minSeason 5Ep. 208

Glycosylation, CDGs & Role of Sugars Beyond Energy Production | Eva Morava | 207

Send us a text Short Summary: The science of glycosylation, its impact on health, and potential treatments for congenital disorders of glycosylation (CDGs). About the guest: Dr. Eva Morava is a pediatric geneticist originally from Hungary, who has specialized in inborn errors of metabolism, particularly CDGs. She has a background in pediatrics and genetics from training in Hungary and the U.S. and is director of the Inherited Metabolic Disorders Section at GGS. Note: Podcast episodes are fully a...

Feb 03, 202549 minSeason 5Ep. 207

Cultural Evolution, Religion & the Origins of WEIRD Psychology | Joseph Henrich | 206

Send us a text Short Summary: How human culture and psychology have evolved, particularly exploring the unique psychological traits of "WEIRD" (Western, Educated, Industrialized, Rich, Democratic) societies, providing insights into why our minds and societies are the way they are today. About the Guest: Joe Henrich, PhD is a professor of human evolutionary biology at Harvard University. His research focuses on applying evolutionary theory to understand the human mind and culture, parti...

Jan 29, 202547 minSeason 5Ep. 206

Systems Biology, Personalized Medicine, AI & the Future of Health | Lee Hood | 205

Send us a text Short Summary: Deep dive into systems biology and personalized medicine, exploring how technology and data can revolutionize health care, artificial intelligence, biotechnology, and the future of medicine. About the Guest: Dr. Lee Hood is a pioneering scientist with a 60-year career in biology, notably at Caltech and the University of Washington. He co-founded the Institute for Systems Biology and has significantly contributed to molecular immunology and the Human Genome Project, ...

Jan 24, 202558 minSeason 5Ep. 205

Preventive Medicine, Personalized Nutrition & Changing Your Microbiome | Momo Vuyisich | 204

Send us a text Short Summary: Deep dive into preventive medicine, personalized nutrition, and systems biology, providing listeners with actionable insights on optimizing health through diet & microbiome management. About the guest: Momo Vuyisich is a biologist with a background in government science, focusing on drug development before shifting to preventive medicine. He holds a PhD in biochemistry and is currently Chief Science Officer of Viome, a startup company dedicated to personalized h...

Jan 17, 202552 minSeason 5Ep. 204

Metagenomics, Microbiome Transmission, Gut Microbiome in Health & Disease | Nicola Segata | 203

Send us a text Short Summary: A deep dive into the enigmatic world of sleep, exploring its biological functions, evolutionary origins, and diverse manifestations across different species. About the Guest: Nicola Segata, PhD is a professor at the University of Trento in Italy. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and on YouTube . Partial versions are available elsewhere. Episode Summary: Dr. Segata explains metagenomics, the study of genetic mater...

Jan 12, 202540 minSeason 5Ep. 203

Why Do Animals Sleep? | Vlad Vyazovskiy | 202

Send us a text Short Summary: A deep dive into the enigmatic world of sleep, exploring its biological functions, evolutionary origins, and the diverse manifestations across different species. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and on YouTube . Partial versions are available elsewhere. About the Guest: Vlad Vyazovskiy, PhD is a Professor of Sleep Physiology at the Department of Physiology, Anatomy, and Genetics at Oxford University. Key Takeaway...

Jan 06, 202550 minSeason 5Ep. 202
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