MeSsy with Christina Applegate & Jamie Lynn Sigler

Wishbone Production

On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.

Last refreshed: January 20th, 2026 at 10:44 AM ⓘ

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Episodes

Can I Be Honest?

This week, Christina and Jamie discuss feeling obligated to be strong, the importance of being there for each other, wearing diapers, and much more. They also answer some listener questions. Parts of this episode were recorded in 2023. Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Maybelline - If you, or someone you know is experiencing anxiety or depression, Maybelline New York is funding free, confi...

Apr 23, 2024•49 min•Ep. 6

Martin Short

This week, Christina and Jamie are joined by Christina's friend, the one and only Martin Short. They reminisce about working together, share funny stories, discuss colonoscopy parties, and much more. Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by/brought to you by BetterHelp. Give online therapy a try at betterhelp.com/messy and get on your way to being your best self....

Apr 16, 2024•1 hr 8 min•Ep. 5

It’s Okay to Be the Caboose

This week, Christina and Jamie discuss traveling, the feeling of being a burden, the importance of listening to your body, and more. They also answer some listener questions. Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by/brought to you by BetterHelp. Give online therapy a try at betterhelp.com/messy and get on your way to being your best self. *Parts of this episode were recorded in 2023. Jamie-Lynn Si...

Apr 09, 2024•50 min•Ep. 4

The Power of Now

This week, Christina and Jamie discuss the importance of being honest about how they're feeling, their love of New York, how to be less hard on themselves, and more. They also answer some listener questions. Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch *Parts of this episode were recorded in 2023.

Apr 02, 2024•58 min•Ep. 3

Edie Falco

This week, Christina and Jamie are joined by Edie Falco, who starred on "The Sopranos" with Jamie. They share their perceptions of each other while working on the show, and discuss parenting, cancer, the importance of being vulnerable, and more. Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch

Mar 26, 2024•50 min•Ep. 2

How Are You?

On the first episode of MeSsy, Christina and Jamie share how they became friends and what they've learned from each other. They also discuss the importance of setting boundaries, how they've learned to handle doubt, and much more. Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch Jamie-Lynn Sigler is a paid spokesperson for Novartis. This podcast is independent from Jamie-Lynn Sigler’s collaboration with Novartis....

Mar 19, 2024•47 min•Ep. 1

Introducing: MeSsy

Christina Applegate and Jamie-Lynn Sigler are getting vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life. New episodes available beginning March 19th! This show is executive produced by Christina Applegate, Jamie-Lynn Sigler, and Allison Br...

Mar 04, 2024•1 min

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