In this podcast, I talk with Irwin Sherman, professor emeritus at the University of California at Riverside, about the century-long quest for a vaccine against malaria. Scientists have been trying to make a vaccine for the disease almost since the discovery of the parasite that causes malaria. Yet decade after decade, they've encountered setbacks and failures. We talked about why it's so hard to make a malaria vaccine, and how likely it is that scientists will ever be able to do so in the future...
May 05, 2010•55 min
In this podcast I talk to Keith Klugman , William H. Foege Chair of Global Health at Emory University. Dr. Klugman studies the disease that is the number one killer of children worldwide. If you guessed malaria or AIDS, you’d be wrong. It’s pneumonia. Two million children under five die every year from it every year--one child every 15 seconds. Dr. Klugman and I spoke about his research on how pneumonia causes so much devastation, its hidden role in the 50 million deaths in the 1918 flu pandemic...
Apr 21, 2010•27 min
Dr. Peter Daszak is a disease ecologist and President of the Wildlife Trust , an international organization of scientists dedicated to the conservation of biodiversity. He is a leader in the field of conservation medicine and is well known for uncovering the wildlife origin of the SARS virus. Dr. Daszak also identifed the first case of a species extinction caused by a disease and has demonstrated a link between global trade and disease emergence via a process called "pathogen pollution." In this...
Apr 07, 2010•42 min
In this podcast I talk to Curtis Suttle, a professor and associate dean at the University of British Columbia.Suttle studies the diversity and population of viruses across the entire planet. He has helped show that viruses are by far the most common life forms on the planet. They also contain most of the genetic diversity of life, and they even control how much oxygen we have to breathe. I talked to Suttle about coming to terms with the fact that we live on a virus planet, and how hard it is to ...
Mar 24, 2010•27 min
In this podcast, I talk to James Collins , an investigator at the Howard Hughes Medical Institute and a professor at Boston University. Ten years ago Collins helped launch a new kind of science called synthetic biology. I talked to Collins about the achievements of synthetic biology over the past decade, such as engineering E. coli that can count, and about the future of synthetic biology--from using bacteria to make fuel to reprogramming the bacteria in our guts to improve our health....
Mar 04, 2010•37 min
In this episode, I talk to Michael Worobey , an associate professor at the University of Arizona. Worobey is virus detective, gathering clues about how some of the world's deadliest pathogens have emerged and spread across the globe. Worobey and I talked about the harrowing journeys he has made in search of the origin of HIV, as well as the round-the-clock data-processing he and his colleagues used to discover the hidden history of the new H1N1 flu strain....
Feb 18, 2010•43 min
In this episode, I speak to Rob Knight , an assistant professor in the Department of Chemistry and Biochemistry at the University of Colorado, Boulder. Knight studies our inner ecology: the 100 trillion microbes that grow in and on our bodies. Knight explained how hundreds of species can coexist on the palm of your hand, how bacteria manipulate your immune system and maybe even your brain, and how obesity and other health problems may come down to the wrong balance of microbes. Links to studies ...
Feb 03, 2010•52 min
In this episode I speak to Julian Davies , professor emeritus in the Department of Microbiology & Immunology at the University of British Columbia. Dr. Davies is one of the world's experts on antibiotics. I talked to Davies about how the discovery of antibiotics changed the course of modern medicine, and how we now face a growing threat from the evolution of antibiotic-resistant bacteria. We also talked about some enduring mysteries about antibiotics. Most of us think of antibiotics as a way...
Jan 20, 2010•23 min
In this episode I speak to Sallie "Penny" Chisholm , the Lee and Geraldine Martin Professor of Environmental Studies at MIT. Dr. Chisholm studies photosynthesis—the way life harnesses the energy of the sun. Plants carry out photosynthesis, but so do microbes in the ocean. Dr. Chisholm studies the most abundant of these photosynthetic microbes, a species of bacteria called Prochlorococcus. There are a trillion trillion Prochlrococcus on Earth. Dr. Chisholm researches these microbial lungs of the ...
Jan 06, 2010•20 min
John Wooley is Associate Vice Chancellor of Research and Professor of Chemistry-Biochemistry and of Pharmacology at the University of California San Diego. Wooley is a leader in the young field of metagenomics: the science of gathering vast numbers of genes from the oceans, soils, air, and the human body. A generation ago biologist knew the sequences of a few thousand genes. Since then that figure has jumped to several million genes and it's only going to continue to leap higher in years to come...
Dec 23, 2009•25 min
In this episode I talk with Paul Turner , an associate professor of ecology and evolutionary biology at Yale University.2009 saw the emergence of a new strain of H1N1 flu. Scientists soon determined that the virus had leaped from pigs to humans and then spread to millions of people. When viruses make this kind of leap it's a reason to worry. In 1918 when a strain of flu leapt from birds to humans, 50 million people died in a matter of months. So far the new H1N1 flu strain is behaving like a rel...
Dec 07, 2009•33 min
Jonathan Eisen is a professor at the University of California, Davis Genome Center . Over the course of his career, he has pioneered new ways of sequencing microbial genomes and analyzing them. I talked to Eisen about some of the weirdest creatures he's studied, such as bacteria that only live on the bellies of worms at the bottom of the ocean, and how we may be able to exploit their genomes for our own benefit. We also discussed the new movement for open access to scientific literature, a subje...
Nov 05, 2009•53 min
Hazel Barton is the Ashland Professor of Integrative Science at Northern Kentucky. She explores some of the world's most remote caves to study the remarkable diversity of microbes that thrive in their dark rececesses. I spoke to Barton about how she first became captivated by these bizarre organisms, what it's like to do delicate microbiology when you're hip-deep in mud, and why she wants to explore caves on Mars in search of Martians....
Oct 23, 2009•24 min
Dennis Bray is an active professor emeritus in both the Department of Physiology and Department of Neuroscience at the University of Cambridge. He studies the behavior of microbes--how they "decide" where to swim, when to divide, and how best to manage the millions of chemical reactions taking place inside their membranes. For Bray, microbes are tiny, living computers, with genes and proteins serving the roles of microprocessors. In this interview, I talked with Bray about his provocative new bo...
Oct 09, 2009•34 min
Michael Cunliffe is a microbiologist in the Department of Biological Sciences at the University of Warwick in England. He studies the microbes that live in the thin layer of water at the very surface of the ocean. His research is shedding light on an ecosystem that's both mysterious and huge, spanning three-quarters of the surface of the planet. In this interview, I talked with Cunliffe about the discovery of this sea-surface ecosystem, and the influence it has over the Earth's climate....
Sep 11, 2009•13 min
Pratik Shah is a graduate student in the Department of Microbiology at the University of Mississippi Medical Center in Jackson, and he’s a 2009 recipient of ASM’s Raymond W. Sarber award, granted to recognize students for research excellence and potential.His research focuses on polyamines and polyamine biosynthesis and transport systems in Streptococcus pneumoniae. He’s studying polyamines with the goal of finding potential targets for pneumococcal vaccines and prophylactic interventions agains...
Aug 28, 2009•9 min
Abigail Salyers is a Professor of Microbiology and the G. William Arends Professor of Molecular and Cell Biology at the University of Illinois at Urbana-Champaign, and her research focuses on the ecology of microorganisms in the human body and the comings and goings of antibiotic resistance genes, particularly genes in Bacteroides species. Dr. Salyers is ASM’s 2009 Graduate Microbiology Teaching Awardee. If you’ve ever tried teaching or mentoring, you know it’s not always easy, but for an eminen...
Aug 13, 2009•21 min
Arthur Guruswamy is a clinical microbiologist in Virginia’s Department of General Services Division of Consolidated Laboratory Services and the winner of ASM's Scherago-Rubin Award in recognition of an outstanding, bench-level clinical microbiologist. His particular interest lies in mycobacterial and fungal diseases, including tuberculosis. In his work, Mr. Guruswamy places a lot of emphasis on helping others. A while back, he traveled to his native Sri Lanka to train clinic staff in the use of ...
Jul 29, 2009•10 min
Dr. Frances Arnold is a professor of Chemical Engineering and Biochemistry at the California Institute of Technology (most of us know it as Caltech). Dr. Arnold’s research focuses on evolutionary design of biological systems, an approach she is currently applying to engineer cellulases and cellulolytic enzymes for manufacturing biofuels. This country’s energy security can look pretty bleak when you think about it: the need to address global warming, strife in oil-rich nations, and depletion of f...
Jul 15, 2009•13 min
Stanley Plot kin is Professor Emeritus at the Wistar Institute and the University of Pennsylvania, Philadelphia. A renowned vaccinologist, Dr. Plotkin is, perhaps, best known for developing a highly successful vaccine for rubella back in 1968. We are still using the same vaccine 40 years later. Dr. Plotkin has been honored with the inaugural Maurice Hilleman / Merck Award for his lifetime of dedication to vaccinology. For most people, rubella amounts to a bad rash and a crummy week, but for a fe...
Jul 01, 2009•14 min
Christine Biron is the chair of the Department of Molecular Microbiology and Immunology at Brown University in Providence, and she focuses her research program on the mechanisms of the innate immune system – the body’s system of non-specific munitions for fighting off pathogens. Dr. Biron is also a newly elected fellow of the American Academy of Microbiology . When a pathogen gets on or in your body, your innate immune system is on the front lines, working against the pathogen is a non-specific ...
Jun 18, 2009•16 min
Joseph DeRisi is a Professor of Biochemistry and Biophysics at the University of California, San Francisco and a Howard Hughes Medical Institute Investigator. His research focuses on two distinct areas: malaria and new viral pathogen discovery. Dr. DeRisi is this year’s recipient of the Eli Lilly and Company Research Award, granted in recognition of fundamental research of unusual merit in microbiology or immunology by an individual on the threshold of his or her career. Discovering new viral pa...
Jun 02, 2009•16 min
Melanie Cushion holds down two jobs: she’s a research career scientist at the Veterans Administration Medical Center in Cincinnati, Ohio, and she’s also professor and associate chair for research in the department of internal medicine at the University of Cincinnati College of Medicine. Dr. Cushion focuses her research on the fungus, Pneumocystis carinii, which is a harmless commensal for most people, but a deadly pathogen for others. Pneumocystis carinii was shrouded in obscurity for many years...
May 14, 2009•24 min
Ian Orme is a professor in the Department of Microbiology, Immunology, and Pathology at Colorado State University, and his research focuses on the immune response to tuberculosis (TB) – a bacterial disease that most often infects the lungs. He's speaking at the American Society for Microbiology's Conference for Undergraduate Educators ( ASMCUE ). In the U.S., TB seems like a thing of the past. Here, public health measures and medical care have all but wiped out the threat from this infection. Bu...
May 07, 2009•24 min
Parisa Ariya is a professor in the Department of Atmospheric and Oceanic Sciences and the Chemistry Department at McGill University in Montreal. Dr. Ariya works mostly in atmospheric chemistry, but she’s also done a good deal of work with bioaerosols and airborne microorganisms. She’ll deliver a talk at the ASM General Meeting in May titled Bioaerosols: Impact on Physics and Chemistry of the Atmosphere. Bioaerosols – microscopic clumps of microorganisms and organic debris – arise through any of ...
Apr 23, 2009•19 min
Jeff Bender is a professor of veterinary public health at the University of Minnesota, and his research interests lie in the intersection of animal health and human health, including animal-borne diseases of humans, food safety, and antibiotic resistant pathogens in animals. Dr. Bender will speak on “Methicillin-resistant Staphylococcus aureus ( MRSA ) in Veterinary Practice” at the American Society for Microbiology’s General Meeting in Philadelphia this May. To a microorganism, vertebrates can ...
Apr 17, 2009•19 min
Jo Handelsman is a professor at the University of Wisconsin, where she’s a member of the Department of Plant Pathology and chair of the Department of Bacteriology. Dr. Handelsman’s research focuses on microbial communities – their composition, how they’re structured, and how they work. Thanks to her work to improve the quality of undergraduate education, Dr. Handelsman is this year’s recipient of the American Society for Microbiology’s Carski Foundation Undergraduate Teaching Award. Dr. Handelsm...
Apr 10, 2009•18 min
David Knipe is the Higgins Professor of Microbiology and Molecular Genetics at Harvard Medical school. A virologist, Dr. Knipe focuses his research efforts on the herpes simplex virus 2 (HSV-2) – the virus we have to thank for genital herpes. An astonishing 20% of Americans have been infected with HSV-2, and whether they’ve had a recognizable outbreak of sores or not, they can still carry the virus. Once you contract the HSV-2 it lays low in your nerve cells, waiting for the right moment to crea...
Mar 31, 2009•16 min
Dr. Andrew Knoll is the Fisher Professor of Natural History in Harvard University’s Department of Organismic and Evolutionary Biology, where he studies ancient life, its impacts on the environment, and how the environment, in turn, shaped the evolution of life. In recognition of the 200th anniversary of Charles’ Darwin’s birth and the 150th anniversary of the first printing of his book, “On the Origin of Species”, the American Society for Microbiology has invited Dr. Knoll to deliver the opening...
Mar 17, 2009•21 min
Roberto Kolter is a professor of Microbiology andMolecular Genetics at Harvard’s Medical School. Dr. Kolter’s research interests are broad, but he says his eclectic program boils down to an interest in the ecology and evolution of microbes, bacteria in particular, and on how these forces operate at the molecular level. Although he’s worked in a number of different systems, lately Dr. Kolter is spending a lot of time with Bacillus subtilis , a modest little bacterium that doesn’t get the headline...
Mar 12, 2009•24 min
