101: Structural Biology Insights into Ebola Virus with Erica Ollmann Saphire

Erica Ollmann Saphire discusses her research on Ebola virus glycoprotein and the changing nature of structural biology.

The Ebola virus glycoprotein sequence can vary up to 50% between Ebola virus species, presenting a challenge to develop pan-Ebola therapeutics or vaccines. Erica Ollmann Saphire discusses her work on antibodies that neutralize all Ebola virus species and the changing nature of the structural biology toolkit used to study them.

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• MTM Listener Survey: asm.org/mtmpoll
• Ollmann-Saphire Lab Site
• Protein Database
• Isolation of Potent Neutralizing Antibodies from a Survivor of the 2014 Ebola Virus Outbreak. Science 2016.
• Systemic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Proteciton. Cell 2018.
• Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope. mBio 2018.
• Tenacious Researchers Identify a Weakness in All Ebolaviruses. mBio 2018.
• HOM Tidbit: How “Lassa,” a small Nigerian Town, was Stigmatized by having a Killer Virus Named after it.