Toxic Overload: Organophosphorus Poisoning

In this episode of MedSpeak – The Medical Podcast, we unpack one of the most common and life-threatening toxicological emergencies encountered in clinical practice: Organophosphorus (OP) Poisoning.

Designed especially for MBBS students, this episode takes you through the mechanism of action, clinical features, mnemonics like DUMBELS, and step-by-step management—all simplified and easy to retain.

We explore how OP compounds block acetylcholinesterase, leading to dangerous levels of acetylcholine in the body, and how this results in the classic triad of muscarinic, nicotinic, and CNS symptoms.

You’ll also learn how to quickly recognize the signs, interpret lab findings, and initiate the correct use of antidotes like Atropine and Pralidoxime.

Whether you’re preparing for an exam or brushing up your clinical skills, this episode is your quick audio companion to mastering a high-yield topic.