Avoiding the Cliff: Screening for Early-Stage Multiple Myeloma

Joseph Mikhael, MD, and Irene Ghobrial, MD, discuss screening high-risk populations for early-stage multiple myeloma and new techniques to detect it.

Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/964336). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Long-Term Follow-up of Monoclonal Gammopathy of Undetermined Significance https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852672/

Prevalence of Monoclonal Gammopathies and Clinical Outcomes in a High-Risk US Population Screened by Mass Spectrometry: A Multicentre Cohort Study https://linkinghub.elsevier.com/retrieve/pii/S2352-3026(22)00069-2

Iceland Screens, Treats, or Prevents Multiple Myeloma (iStopMM): A Population-Based Screening Study for Monoclonal Gammopathy of Undetermined Significance and Randomized Controlled Trial of Follow-up Strategies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128921/

International Myeloma Working Group Updated Criteria for the Diagnosis of Multiple Myeloma https://linkinghub.elsevier.com/retrieve/pii/S1470-2045(14)70442-5

The IMWG 2/20/20 Risk Stratification Model for Smoldering Multiple Myeloma https://multiplemyelomahub.com/medical-information/the-imwg-22020-risk-stratification-model-for-smoldering-multiple-myeloma