Medizin - Open Access LMU - Teil 03/22

Precursors and post-translational transport of proteins in the assembly of the mitochondrial inner membrane

Transport of Proteins into Mitochondria

The mitochondrial ADP/ATP carrier is an integral transmembrane protein of the inner membrane. It is synthesized on cytoplasmic ribosomes. Kinetic data suggested that this protein is transferred into mitochondria in a posttranslational manner. The following results provide further evidence for such a mechanism and provide information on its details. 1. In homologous and heterologous translation systems the newly synthesized ADP/ATP carrier protein is present in the postribosomal supernatant. 2. A...

Assembly of mitochondria

The majority of mitochondrial proteins are synthesized on cytoplasmic ribosomes and transferred to the mitochondria where they are assembled to supramolecular structures. The intracellular transfer of these proteins appears to occur by a post-translational mechanism, i.e., it involves extramitochondrial precursor forms which are translocated in a step independent from translation. The synthesis and transfer of individual proteins was investigated in vivo, or in vitro employing homologous and het...

Funktionsergebnisse nach Fingerreplantation mit Zerstörung von Gelenkflächen

Transplantation of lymphvessels on rats as well as first application on the experimental lamphedema of the dog

Kein Inhaltsverzeichnis vorhanden.

Isolation and characterization of secretory vesicles from bovine neurophyses

Plasma catecholamines during activation of the sympathetic nervous system in a patient with Shy-Drager syndrome.

Plasma catecholamines and circulation parameters were studied in a patient with a Shy-Drager syndrome. Basal values of free noradrenaline and dopamine were within the normal range, whereas the adrenaline level was decreased. The response of plasma catecholamines to different kinds of physical activity was pathological. The inability to maintain elevated catecholamine levels during prolonged activity corresponded to impaired circulatory regulation and may provide an additional tool for diagnosis ...

Serumfolsäurespiegel unter antiepileptischer Langzeittherapie.

Das Kearns-Sayre-Syndrom.

Foreign H-2-like ,olecules on a murine tumor (MCG4)

Generation of virus-specific cytotoxic T cells in vitro II. Induction requirements with functionally inactivated virus preparations

Using noninfectious Sendai virus preparations after selective enzymatic digestion of either of the two viral envelope glycoproteins, it was possible to study the effect of different virion-cell membrane interactions on virus-specific cytotoxic T lymphocyte (CTL) induction in vitro. Three different virus preparations having capacity for virus- cell fusion, for virus-cell adsorption or lacking the ability to bind to cell membranes, were all active in the generation of virus-specific primary and se...

Recognition of viral glycoproteins by influenza A-specific cross- reactive cytolytic T lymphocytes

Two populations of cytolytic T lymphocytes (CTL) generated after influenza A virus infection can be distinguished into one with specificity for the sensitizing hemagglutinin type and a second with cross-reactivity for antigens induced by other type-A influenza viruses. The molecules carrying the antigenic determinants recognized by the cross-reactive CTL were studied. In L-929 cells abortively infected with fowl plague virus, matrix (M) protein synthesis is specifically inhibited, whereas the en...

Kombinierte Humangonadotropintherapie bei idiopathischer Oligozoospermie

Ärztliche Führung des Krebskranken

Nichtdiagnostizierte Thoraxverletzungen aus gerichtsmedizinischer Sicht

Parameters of thyroid function in thyroid autonomy

Correlation of total cholesterol and protein in urine in patients with the nephrotic syndrome

The excretion of protein and cholesterol in 24 h urine was measured in 42 patients with the nephrotic syndrome. The finding of a positive correlation (r=0.76,p<0.01) between urinary cholesterol and urinary protein would be compatible with an enhanced glomerular filtration of plasma lipoproteins as the cause of lipiduria in the nephrotic syndrome.

Components of evoked hyperpolarization in the spinal motoneuron of the cat

Zwischenfälle bei endoskopischen Eingriffen und ihre Beurteilung aus rechtsmedizinischer Sicht

Ungewöhnliche cardiale Todesfälle aus nicht coronarer Ursache

Das Münchner Modell bei der Organbeschaffung zu Transplantationszwecken

Kunstfehlervorwürfe gegen ärztliches Hilfspersonal und Heilpraktiker

Die Bedeutung der Y-chromosomalen Kerngeschlechtsbestimmung in der forensischen Spurenkunde

Zur Zeitabhängigkeit pneumonischer Veränderungen nach suicidaler Schlafmittelintoxikation

Purine metabolism in cultured endothelial cells

Studies on cultured coronary endothelial cells

Synaptic modulation of calcium-dependent potassium conductance in myenteric neurones in the guinea-pig.

1. Ganglion cells of the myentric plexus of the guinea-pig small intestine were studied with intracellular recording methods. 2. Electrical stimulation of the interganglionic connectives elicited slow synaptic excitation (slow e.p.s.p.) that was associated with an increase in the input resistance of the cell. The slow e.p.s.p.s continued for several seconds after termination of stimulation, and they occurred only in neurones in which prolonged hyperpolarizing after-potentials followed an action ...

Presynaptic actions of 4-Aminopyridine and γ-aminobutyric acid on rat sympathetic ganglia in vitro

Responses to bath-applications of 4-aminopyridine (4-AP) and -aminobutyric acid (GABA) were recorded intracellularly from neurones in the rat isolated superior cervical ganglion. 4-aminopyridine (0.1–1.0 mmol/l) usually induced spontaneous action potentials and excitatory postsynaptic potentials (EPSPs), which were blocked by hexamethonium. Membrane potential was unchanged; spike duration was slightly increased. Vagus nerve B-and C-fibre potentials were prolonged. In 4-AP solution (0.1–0.3 mmol/...

Facilitatory actions of guanidine on synaptic transmission in mammalian brain slices

Guanidine administration may be beneficial in the treatment of amyotrophic lateral sclerosis and related diseases; however, the actions of guanidine on the mammalian central nervous system have not been investigated. We studied the effects of this compound on neuronal properties and synaptic transmission in isolated slices of guinea pig olfactory cortex using intra- and extracellular recording mothods. Addition of guanidine to the superfusate (≥300 μ ) produced the following effects. (a) Excitat...

Mitochondrial DNA Replication Does Not Involve DNA Polymerase alpha