|9| WTF Part 3 - Septic Shock (Brandon Carey, NRP)

In this episode, we discuss treatment recommendations found in recent literature, in regards to fluid administration in septic shock. We also discuss the updates to the definition of sepsis, and the criteria for diagnosing a patient with sepsis. In this episode, we discuss SOFA, and QSOFA, as well as the elimination of SIRS and "Severe Sepsis" from the sepsis spectrum. 

Join us as we dive in to the pathophysiology of septic shock, and how fluid administration is still considered a staple treatment. We discuss how third spacing occurs secondary to overzealous fluid administration, resulting in potential worsening of hypoperfused tissues and organs. In this episode, we also discuss the ProMISe, ARISE, and CENSER trials, and discuss the suggestions of early vasopressor therapy using norepinephrine has proven to be beneficial. We also briefly discuss the potential benefits of pre-hospital administration of broad spectrum antibiotics, and the Phantasy trial, and propose to revisit a similar study with more objective methods. 

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