Short Answer: It could be byproducts of any of the three amino acids that make up the glutathione molecule, which include the individual amino acids, ammonia, hydrogen sulfide, sulfite, and propionyl CoA, or it could be microbial metabolites of glutathione produced in the gut. The full answer contains seven hypothesis-driven tests that can be done at home to determine the cause. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access...
Feb 06, 2023•30 min
Short Answer: From the trials, statins seem to reduce heart disease risk and total mortality, but it is impossible to separate this from conflicts of interest and industry funding. There are plausible mechanisms by which they may hurt mitochondrial function and promote soft tissue calcification. Dietary sulfur appears to lower cholesterol. While Lester Morrison showed 1500 milligrams per day of chondroitin sulfate could reduce cardiac events 7-fold, this has a theoretical potential to hurt the m...
Jan 23, 2023•29 min
Short Answer: I believe most methyl donor intolerances are a result of deficiencies in the glycine buffer system, which requires glycine, vitamin A, fasting (glucagon), androgens, riboflavin, unmethylated folate (THF), and iron. No one should expect to tolerate 30 milligrams of folate, however, and there is almost never a reason to use doses that high. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples usi...
Jan 09, 2023•16 min
Short Answer: The main problem with too much protein, particularly animal protein, is that acidity may hurt the bones and increase the risk of calcium oxalate kidney stones, but this can be obviated by balancing it with organic acids, which have bicarbonate-sparing effects that are alkalinizing. The best index of the organic acid content of foods is the potassium content. This balance can be achieved with 750 to 1500 milligrams of potassium for every 100 grams of protein. This is not specific to...
Dec 26, 2022•19 min
High-dose biotin supplements can cause a multitude of false lab tests, masking recent heart attacks, pregnancies, or allergies, giving false signals about tumors, and far more. In this episode, I lay out for you the nature, scope, and magnitude of the problem, and develop actionable strategies you can use to protect your lab tests from generating false information as a result of this phenomenon. You can find the written and fully referenced version of this episode here: https://chrismasterjohnph...
Dec 20, 2022•1 hr 55 min
Short Answer: Energy metabolism in general declines across the body with aging, but energy metabolism seems to stay healthy enough in the brain in people who do not experience cognitive decline. Cognitive decline does appear to be driven by decreases in brain energy metabolism, but these are not best described as a specific impairment in glucose handling. MCT oil can be modestly beneficial and a ketogenic diet can probably be somewhat more beneficial in people who have cognitive decline from any...
Dec 12, 2022•39 min
Short Answer: If it can't be explained by the dose of salt, it may be that the salt is not being absorbed orally. Glucose, starch, or simply a meal consumed alongside the salted water may help with this. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-protein-and-longevity-1a2 In that batch of free episodes you will also find the an...
Nov 28, 2022•3 min
Get my new 7-page quick guide on how to not get sick for free when you sign up to my Substack: https://chrismasterjohnphd.substack.com/p/staying-immune-through-the-winter Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome .
Nov 23, 2022•53 sec
Short Answer: SHBG is increased by adiponectin (vitamin K2, insulin sensitivity), thyroid hormone, fasting physiology (AMPK, fat oxidation), and estrogen (especially estrone), while it is decreased by insulin resistance, obesity, the fed state and carbohydrate-dominant physiology, androgens, and polyunsaturated fat. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohn...
Nov 14, 2022•15 min
I am done with my work on COVID vaccines, at least until I finish my Vitamins and Minerals 101 Book , so I am now making my scientific review on the likely causes of COVID vaccine side effects public. This is an excerpt of pages 19-52 of my Healing From COVID Vaccine Side Effects guide ( free to Masterpass members here ). You can read the written version on Substack using this link, which contains 139 of the 221 references. It does not contain the protocol, but rather the scientific review used ...
Nov 05, 2022•1 hr 51 min
Short Answer: While protein restriction may have value in people with established cancer or kidney disease, cycling robustly between fasting and feeding states is likely to provide all the value that restriction of protein or calories might otherwise provide, and a high protein intake supports bone mass, muscle mass, and the detoxification of carcinogens, all of which are important to longevity. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episod...
Oct 24, 2022•33 min
Short answer: Low or low-normal alkaline phosphatase may raise the plasma B6 level over the cellular level. Tryptophan metabolites in urine reflect the B6 requirement for the kynurenine pathway, and this requirement increases with more estrogen, more inflammation, or a higher protein intake. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link: https://chrismasterjohnphd.substack.com/p/quest...
Oct 10, 2022•7 min
Short answer: 4-6 hours after a meal the small intestine is emptied and the insulin-to-glucagon ratio declines; 25 hours after, hepatic glycogen is emptied; 5 days later the brain is adapted to ketones and gluconeogenesis reaches its minimal level. Moving from one to the other cannot occur with a small piece of signaling like the bite of an apple. It requires the preponderance of signaling. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, yo...
Sep 26, 2022•15 min
Short answer: Probably not. Animal studies showing a difference use huge doses in an unrealistic context. Human studies show they don't at doses used. Human effect on PSA is vulnerable to regression to the mean and thoroughly unconvincing. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free e...
Sep 12, 2022•18 min
Short answer: Trust the CGM. HbA1c is confounded by red blood cell turnover and fructosamine 3-kinase activity. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions: What's the difference between 25(OH)D and 1,25(OH)2D when it comes to...
Aug 22, 2022•5 min
My friend Steve, who is the one who originally introduced me to the Essex Farm CSA that now supplies me with almost all my food, has invented a new tortilla chip that launches today! MASA chips are made from organic corn from small New England farms. The corn is nixtimalized, which frees the niacin, makes it more digestible, and eliminates 97-100% of the mycotoxins (based on studies with aflatoxin). Then they are fried in grass-fed beef tallow! They are full-bodied and feel nourishing, and they ...
Jul 21, 2022•5 min
Nick Hiebert and I debate the value of ancestral health as a framework for approaching health in the modern era. For my summary of and reflections on the debate, as well as time stamps, relevant links, and a transcript, head to: https://chrismasterjohnphd.substack.com/p/the-ancestral-health-debate If you found this valuable, please like, share, and comment on the Substack version to get it before more eyeballs. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria tes...
Jun 23, 2022•2 hr 16 min
In this interview, Mathew Crawford walks me through his slide presentation of data showing that, at some point between 2020 and 2021, the 2016-2019 data from the US Military's health database was altered in a way that hides the explosion of poorly-defined illness among troops that happened in 2021 as the COVID vaccines were rolled out. For the video with the slides, a more complete summary, and a transcript, head over to Substack with this link: https://chrismasterjohnphd.substack.com/p/mathew-c...
Jun 22, 2022•2 hr 18 min
Part 2 of how NUTRITION has a HUGE impact on your BRAIN! Everything in your brain is something you ate, something you made from something you ate, or, in a few cases, something your mother ate. Nutrition impacts your mental and emotional health, the function of your five senses, and your conscious and unconscious control over your body movements. Join me as I lead you in a safari through the textbook, "Neuroscience," pointing out along the way all the interesting connections to nutrition. Listen...
Jun 09, 2022•1 hr 39 min
This new model I developed explains how the depletion of arginine and tryptophan and the sequestration of cysteine leads to T cell suppression in severe COVID and may reflect the rapid onset of a somewhat cancer-reminiscent state where vitamins A and D and other myeloid differentiation factors run out. The written version with references and links to research is available here: https://chrismasterjohnphd.substack.com/p/a-new-paradigm-for-severe-covid If you find this valuable, please like, share...
May 25, 2022•1 hr 11 min
Short answer: You should be able to see changes on imaging within a few weeks if your approach is working well, but ultimately this is entirely dependent on how negative your "delta fatty liver = (fat in) - ((fat out) + (fat burned))" equation is. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch o...
Apr 30, 2022•16 min
Short answer: 25(OH)D is 1000 times weaker at activating the VDR than 1,25(OH)D, but 1000 times more abundant. This is why I advocate measuring both, and ultimately believe we need to create a calculated index of "biological vitamin D activity" from them. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that...
Apr 29, 2022•7 min
Rising Food Prices Part 4: Can Regenerative Agriculture Solve the Food Crisis? This is the 4th in a series of interviews I am conducting to try to better understand why food prices have been rising, where they are going as we move toward a potential food crisis, how this will impact the evolving landscape of food availability, and what we should do about it. Allen Williams joins me to talk about conventional, organic, and regenerative agriculture, and how fuel and fertilizer inputs differ betwee...
Apr 18, 2022•1 hr 33 min
Tony Greer joins me to talk about how lockdowns, politics, and the commodity trade contribute to rising food prices. Tony Greer is partly responsible for my awareness of the emerging food crisis as I had initially learned of Doomberg from him last year. He has been a macro trader for over thirty years, is a regular on the Real Vision Daily Briefing, and is editor of the Morning Navigator. Tony brings us unique insights as a trader who saw the rise in commodity prices early. Will the rotation out...
Apr 08, 2022•47 min
With Dr. Michael Howell, PhD. This is the second in a series of interviews I am conducting to try to better understand why food prices have been rising, where they are going as we move toward a potential food crisis, how this will impact the evolving landscape of food availability, and what we should do about it. Michael Howell, PhD joins me to discuss whether "money printing" and the liquidity cycle might be playing a role in rising food prices. Howell has a PhD in Economics and specializes in ...
Apr 06, 2022•1 hr 7 min
This is the first in a series of interviews I am conducting to try to better understand why food prices have been rising, where they are going as we move toward a potential food crisis, how this will impact the evolving landscape of food availability, and what we should do about it. Josh Young and Tracy Schuchart are here to talk about why oil and fertilizer are in short supply and why their prices have been steadily rising. Josh Young is Chief Investment Officer and Founder of Bison Interests, ...
Apr 02, 2022•1 hr 29 min
The spike protein pokes holes in cell membranes at concentrations much lower than those achieved with vaccination, contributing to COVID-like illness and mitochondrial damage. But is the J&J immune? This is not medical advice. This podcast was originally published in written form as a Substack article, fully referenced, found here: https://chrismasterjohnphd.substack.com/p/the-spike-protein-as-a-pore-forming This is the first in a series of posts in which I will outline the potential mechani...
Mar 30, 2022•55 min
My tentative view on what is causing it and what to do about it. This is NOT caused primarily by the conflict in Ukraine and a sudden peaceful solution to the conflict will not avert it. The written version with links to sources can be found here: https://chrismasterjohnphd.substack.com/p/the-emerging-food-crisis Please Show The Substack Post Some Love Please hit up the Substack post and let me know what you think in the comments! And please like the post if you found it valuable, and share the ...
Mar 29, 2022•34 min
https://chrismasterjohnphd.com/paradox Please subscribe to my Substack at https://chrismasterjohnphd.substack.com Subscription is completely free but if you take the option to pay $5 a month or $30 per year, you will get access to exclusive content, as well as my COVID guide for free and 50% off my Masterpass membership program. Please like, comment on, and share the Substack version of this post. This will help spread it far and wide, as subscriber engagement drives the Substack algorithm. Enga...
Mar 04, 2022•1 hr 18 min
I'm recording from "Youtube Jail," where I'll be until Monday morning. Two more strikes and I'm out. Please help our community stay connected by joining my email list at https://chrismasterjohnphd.com/uncensored Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome .
Jan 30, 2022•20 min
