Mastering Nutrition

Chris Masterjohn, PhD•thedailylipid.libsyn.com

Welcome to the Mastering Nutrition podcast. Mastering Nutrition is hosted by Chris Masterjohn, a nutrition scientist focused on optimizing mitochondrial health, and founder of BioOptHealth, a program that uses whole genome sequencing, a comprehensive suite of biochemical data, cutting-edge research and deep scientific insights to optimize each person's metabolism by finding their own unique unlocks. He received his PhD in Nutritional Sciences from University of Connecticut at Storrs in 2012, served as a postdoctoral research associate in the Comparative Biosciences department of the University of Illinois at Urbana-Champaign's College of Veterinary Medicine from 2012-2014, served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College from 2014-2017, and now works independently in science research and education.

Last refreshed: January 2nd, 2026 at 6:42 AM ⓘ

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Episodes

Iron deficiency without anemia? | Masterjohn Q&A Files #252

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Iron deficiency without anemia? I would just say that I would b...

Aug 09, 2021•8 min

How to Calculate the Amount of a Nutrient in a Complex | Masterjohn Q&A Files #251

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: How to Calculate the Amount of a Nutrient in a Complex So this ...

Aug 06, 2021•6 min

Eggs, Choline Bisulfate, and TMAO | Masterjohn Q&A Files #250

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Eggs, Choline Bisulfate, and TMAO If you really want to know wh...

Aug 05, 2021•19 min

Floxed: How to Recover From Cipro | Masterjohn Q&A Files #249

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Floxed: How to Recover From Cipro And a lot of these things pro...

Aug 04, 2021•25 min

If you correct a deficiency too fast, can you make it worse? | Masterjohn Q&A Files #248

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: If you correct a deficiency too fast, can you make it worse? I ...

Aug 03, 2021•14 min

If my methionine is high, do I need to worry about betaine? | Masterjohn Q&A Files #247

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: If my methionine is high, do I need to worry about betaine? If ...

Aug 02, 2021•4 min

How do I eat to protect my joints? | Masterjohn Q&A Files #246

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: How do I eat to protect my joints? From a nutritional perspecti...

Jul 30, 2021•8 min

Why do glycine and salt help with sleep? | Masterjohn Q&A Files #245

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Why do glycine and salt help with sleep? The glycine is probabl...

Jul 29, 2021•5 min

Will lowering my PTH with calcium reverse my atherosclerosis? | Masterjohn Q&A Files #244

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Will lowering my PTH with calcium reverse my atherosclerosis? A...

Jul 28, 2021•7 min

How long does it take environment to change gene expression, epigenetics, and genetics? | Masterjohn Q&A Files #243

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: How long does it take environment to change gene expression, ep...

Jul 27, 2021•11 min

What does it mean if you're helped by SAMe? | Masterjohn Q&A Files #242

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: What does it mean if you're helped by SAMe? It could indicate t...

Jul 26, 2021•3 min

Why would glutathione cause a headache? | Masterjohn Q&A Files #241

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Why would glutathione cause a headache? Probably sulfur intoler...

Jul 23, 2021•3 min

Can antioxidants increase homocysteine? | Masterjohn Q&A Files #240

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Can antioxidants increase homocysteine?An underappreciated reas...

Jul 22, 2021•3 min

Why is methylfolate the off-switch for the glycine buffer system? | Masterjohn Q&A Files #239

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Why is methylfolate the off-switch for the glycine buffer syste...

Jul 21, 2021•4 min

Potassium supplements for salt-sensitive high blood pressure? | Masterjohn Q&A Files #238

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Potassium supplements for salt-sensitive high blood pressure? S...

Jul 20, 2021•5 min

Can a high-protein diet hurt nitric oxide and raise blood pressure? | Masterjohn Q&A Files #237

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Can a high-protein diet hurt nitric oxide and raise blood press...

Jul 19, 2021•6 min

General supplement recommendations for a physically active male in his 30s | Masterjohn Q&A Files #236

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: General supplement recommendations for a physically active male...

Jul 16, 2021•5 min

For how long does methionine from a meal support methylation? | Masterjohn Q&A Files #235

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: For how long does methionine from a meal support methylation? W...

Jul 15, 2021•5 min

Could collagen hurt absorption of iron from iron bisglycinate? | Masterjohn Q&A Files #234

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Could collagen hurt absorption of iron from iron bisglycinate? ...

Jul 14, 2021•3 min

Combining carbs and fat, LDL-C, calcification, and atherosclerosis | Masterjohn Q&A Files #233

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Combining carbs and fat, LDL-C, calcification, and atherosclero...

Jul 13, 2021•13 min

Could low-normal phosphorus be from my calcium intake? | Masterjohn Q&A Files #232

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Could low-normal phosphorus be from my calcium intake?Given tha...

Jul 12, 2021•6 min

Exercising in the fasted state | Masterjohn Q&A Files #231

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Exercising in the fasted state The answer is necessarily subjec...

Jul 09, 2021•12 min

What does an upregulated GGT gene do to glutathione status? | Masterjohn Q&A Files #230

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Access the show notes, transcript, and comments here . Question: What doe...

Jul 08, 2021•4 min

A question on urinary lactate, pyruvate, and Krebs Cycle metabolites | Masterjohn Q&A Files #229

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: A question on urinary lactate, pyruvate, and Krebs Cycle metabo...

Jul 07, 2021•12 min

High-dose EPA, triglycerides, and general health | Masterjohn Q&A Files #228

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Access the show notes, transcript, and comments here . Question: High-dos...

Jul 06, 2021•8 min

Are there any downsides to eating lots of nuts and seeds? | Masterjohn Q&A Files #227

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Are there any downsides to eating lots of nuts and seeds?I woul...

Jul 05, 2021•5 min

Low cystine & sulfate, mid-range methionine, high homocysteine: what to do? | Masterjohn Q&A Files #226

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Low cystine & sulfate, mid-range methionine, high homocyste...

Jul 02, 2021•11 min

Is TMG a good source of glycine? | Masterjohn Q&A Files #225

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Is TMG a good source of glycine?And so glycine is a methyl buff...

Jul 01, 2021•6 min

Zonulin: what nutrients to look at if it's high? | Masterjohn Q&A Files #224

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: Zonulin: what nutrients to look at if it's high? I think of tha...

Jun 30, 2021•9 min

My iron won't go up even though I'm supplementing | Masterjohn Q&A Files #223

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic , https://chrismasterjohnphd.com/paleovalley , https://chrismasterjohnphd.com/seekinghealth , https://chrismasterjohnphd.com/ancestralsupplements , https://chrismasterjohnphd.com/magicspoon , https://chrismasterjohnphd.com/lmnt Plenty more at https://chrismasterjohnphd.com/support ! Question: My iron won't go up even though I'm supplementing The top thing...

Jun 29, 2021•18 min

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