Lifespan with Dr. David Sinclair

Lifespan Communications LLC•www.lifespanpodcast.com

Join Dr. David Sinclair, Ph.D. in Lifespan, a popular health podcast that brings the cutting edge of aging and longevity science straight to you. Hear about the latest developments in aging research, lifestyle practices for longevity, exercise and nutrition science, and more. This podcast is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice.

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Episodes

Biotracking, Age Reversal & Other Advanced Health Technologies | Episode 8

In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. In addition to discussing the utility of wearable sensors and biological age measurements, they highlight innovative research aimed at reversing biological age. The societal effects of therapies that successfully extend healthspan and/or lifespan are also considered. Thank you to our sponsors: Levels - https://levels.link/sinclair Athletic Green...

Feb 23, 2022•1 hr 9 min•Season 1Ep. 8

The Science of Keeping the Brain Healthy | Episode 7

In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep. Thank you to our sponsors: Athletic Greens - https://athleti...

Feb 16, 2022•1 hr 2 min•Season 1Ep. 7

The Science of Looking Younger, Longer | Episode 6

In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections. Thank you to our sponsors: Athletic Greens - https://athleticg...

Feb 09, 2022•1 hr 10 min•Season 1Ep. 6

Medical Interventions (TRT, HGH, Stem Cells, Peptides, etc.) For Longevity | Episode 5

In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed. Thank you to our sponsors: Athletic Greens ...

Feb 02, 2022•59 min•Season 1Ep. 5

NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4

In this week’s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters, resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effec...

Jan 26, 2022•1 hr 10 min•Season 1Ep. 4

Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3

In Episode 3 of the Lifespan Podcast, Dr. David Sinclair and Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exercise, high-intensity aerobic exercise, and weight training) protect against age-related disease and enhance longevity. David and Matthew additionally highlight the latest evidence behind hyperbaric oxygen therapy, cold the...

Jan 19, 2022•1 hr 11 min•Season 1Ep. 3

What to Eat & When to Eat for Longevity | Episode 2

In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. They discuss the science behind how a "low energy state," which can be induced by a period of fasting, combats aging and promotes health. They also walk through research that points to the benefits of a mostly plant-based diet for slowing aging and offer key insights into when to eat and what to eat to maximize longevity. Thank you to o...

Jan 12, 2022•1 hr 8 min•Season 1Ep. 2

The Science Behind Why We Age | Episode 1

In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and how all of this makes up the "Information Theory of Aging", and the difference between "biological age" and "chronological age" and how we can measu...

Jan 05, 2022•1 hr 2 min•Season 1Ep. 1

Welcome to Lifespan with Dr. David Sinclair

Welcome to Lifespan with Dr. David Sinclair. Dr. David Sinclair is a professor of genetics and co-director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research . Season 1 will be 8 episodes in total and will launch on Wednesday, January 5, 2022. New episodes will be released every Wednesday morning of both January and February 2022. This podcast can also be found on YouTube: https://www.youtube.com/davidsinclairpodcast My goal in creating this podcast is to discuss the ...

Dec 22, 2021•1 min