Alkaline Phosphatase (ALK PHOS) Lab Values
May 10, 2023•4 min
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Episode description
Objective:
Determine the significance and clinical use of alkaline phosphatase in clinical practice
Lab Test Name:
Alkaline Phosphatase – ALP
Description:
Measures amount of ALP in circulation
Located in several places in the body:
- Liver
- Intestines
- Biliary tract
- Bones
- Placenta
Different isoenzymes of ALP are used to determine:
- Liver, bone, intestine and other cancers
- Bone turnover in postmenopausal women
Indications:
Evaluation of ALP:
- Hepatobiliary disease
- Malignancies
- Bone disease
- Bone damage in renal patients
Normal Therapeutic Values:
Normal – 40-130 U/L
Collection:
- Plasma separator tube
What would cause increased levels?
Increased levels assessed in:
- Liver disease
- Bone disease
- Pregnancy
- Amyloidosis
- Lung cancer
- Pancreatic cancer
- Congestive heart failure
- Ulcerative colitis
- Hodgkin's disease
- Chronic renal failure
- Sarcoidosis
What would cause decreased levels?
- Hypophosphatasia (spelling error on existing outline on NURSING.com)
- Anemia
- Kwashiorkor
- Cretinism
- Hypothyroidism
- Zinc or magnesium deficiency
- Scurvy
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