Alanine Aminotransferase (ALT) Lab Values
May 03, 2023•4 min
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Episode description
Objective:
Determine the significance and clinical use of Alanine Aminotransferase in clinical practice
Lab Test Name:
Alanine Aminotransferase – ALT
Description:
Measures amount of ALT, an enzyme produced by the liver, present in circulation
Found in:
Most abundantly in liver
Heart
Skeletal muscle
kidney
Increases in lab values indicate liver disease or liver damage
Indications:
Evaluation of ALT:
- Progression of liver disease
- Monitoring response to treatment
Normal Therapeutic Values:
Normal – 40-130 U/L
Collection:
- Plasma separator tube
What would cause increased levels?
INCREASED:
- Cirrhosis
- Muscle damage
- Preeclampsia
- Biliary tract obstruction
- Burns
- Pancreatitis
- Long-term alcohol abuse
- Liver Cancer
- Muscular dystrophy
- MI
- Myositis
- Shock
- Infection-mononucleosis
What would cause decreased levels?
DECREASED:
- Pyridoxal phosphate deficiency
- A rare genetic metabolic disorder
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