This final episode in KDIGO’s four-part IgAN series focuses on the challenges and opportunities of implementing the updated KDIGO IgAN Guideline in clinical practice. The conversation examines a shifting treatment paradigm that emphasizes earlier intervention and simultaneous, multi-targeted therapy, while addressing persistent barriers to guideline adoption, including gaps in disease awareness, diagnostic precision, and risk stratification. Drawing on insights from recent clinical trials, the d...
Dec 18, 2025•18 min
This third episode in KDIGO’s four-part IgAN series explores how to apply KDIGO guidance in real-world IgAN care through two illustrative patient cases. Building on earlier episodes in the series, the discussion highlights dynamic risk assessment, treatment selection, and monitoring strategies, along with practical decisions about RAS inhibitors versus DEARAs, TRF-budesonide versus systemic glucocorticoids, and the use of SGLT2 inhibitors. The episode also addresses complex scenarios, including ...
Dec 04, 2025•21 min
In the final episode of KDIGO’s three-part Conversations in Nephrology series on APOL1 kidney disease, host Kirk Campbell, MD (University of Pennsylvania, United States), speaks with Titilayo Ilori, MD (Boston University, United States), and kidney health advocate Joshua Albright (United States) about how APOL1 genetic testing can shape the future of kidney care. Their conversation brings together clinical expertise and lived experience to examine why early detection matters, how to overcome bar...
Oct 28, 2025•14 min
In this second installment of KDIGO’s three-part podcast series on APOL1 kidney disease, host Kirk Campbell, MD (University of Pennsylvania, United States), welcomes Barry Freedman, MD (Wake Forest University School of Medicine, United States) for a practical discussion on patient management. They examine how APOL1 risk variants influence progression, review current therapeutic approaches, and explore emerging targeted treatments designed to improve care and outcomes for affected individuals. Le...
Oct 28, 2025•19 min
This is the first episode of a three-part KDIGO Conversations in Nephrology series on APOL1 kidney disease. Host Kirk Campbell, MD (University of Pennsylvania, United States), speaks with Bessie Young, MD (University of Washington, United States) about the discovery, burden, and biology of APOL1 kidney disease. Their discussion explores how APOL1 variants contribute to increased kidney disease risk in people of African ancestry, recent findings on protective variants, and ongoing research toward...
Oct 28, 2025•13 min
This second episode in KDIGO’s four-part IgAN series addresses the treatment revolution in IgAN. Join Dana Rizk, MD (University of Alabama at Birmingham, US), and Shikha Wadhwani, MD (University of Texas Medical Branch, US) in understanding how disease pathophysiology is fueling a wave of new therapies that go beyond traditional supportive care. Key topics include what's changed since the KDIGO 2021 Guideline, the four-hit hypothesis and its role in driving novel therapies, key factors to consid...
Oct 02, 2025•15 min
This is the first episode in KDIGO's four-part series on the KDIGO 2025 IgAN/IgAV Guideline. Join Dana Rizk, MD (University of Alabama at Birmingham, United States), and Brad Rovin, MD (Ohio State University, United States), Co-Chair of the 2025 KDIGO IgAN Guideline, for a deep dive into the latest updates in patient care. Their conversation explores the key takeaways from the new guideline, the critical role of kidney biopsies in diagnosis and prognosis, the use of the IgAN prediction tool for ...
Oct 02, 2025•19 min•Ep. 24
What does life with a rare kidney disease really look like? Marianne Silkjaer Nielsen (Founder of CompCure , Denmark) offers a powerful voice for patients and caregivers. She reflects on the long diagnostic journey, the challenges of managing rare kidney disease, and the need for better awareness, advocacy, and international registries to improve outcomes. This episode is part of a four-part KDIGO Conversations in Nephrology series on complement-mediated kidney diseases, hosted by Dr. Carla Nest...
Sep 03, 2025•12 min•Ep. 23
What does the future of treatment for C3 Glomerulopathy (C3G) look like? Dr. Nicole van de Kar (Radboud University Medical Center, The Netherlands) unpacks the pathophysiology of C3G, from genetic and autoantibody factors to the central role of the alternative pathway. She explores the limits of current C5 therapies and the potential of new strategies targeting C3 activation that could reshape patient care worldwide. This episode is part of a four-part KDIGO Conversations in Nephrology series on...
Sep 03, 2025•23 min•Ep. 22
How do patients with C3 Glomerulopathy (C3G) present, and why is confirming the diagnosis so complex? Dr. David Kavanagh (National Renal Complement Therapeutics Centre, United Kingdom) walks through the diagnostic process, the shortcomings of traditional immunosuppression, and the promise of emerging therapies like alternative pathway inhibitors. He also tackles one of the toughest challenges: managing post-transplant recurrence. This episode is part of a four-part KDIGO Conversations in Nephrol...
Sep 03, 2025•16 min•Ep. 21
Why does it matter if a kidney disease is complement-driven or complement-associated? Dr. Matthew Pickering (Imperial College London, United Kingdom) explains this critical distinction and why it changes how clinicians approach diagnosis and treatment. The discussion explores promising new therapies such as C3 and C5 inhibitors and how biomarkers are paving the way for precision medicine in nephrology. This episode is part of a four-part KDIGO Conversations in Nephrology series on complement-med...
Sep 03, 2025•20 min•Ep. 20
Episode 19 is the third episode in KDIGO's three-episode series on acute kidney injury (AKI), hosted by Dr. Kathleen Liu (University of California at San Francisco, United States). In this episode, Dr. Liu and Dr. Claudio Ronco (International Renal Research Institute of San Bortolo Hospital, Italy) discuss recent advancements and best practices surrounding Extracorporeal Blood Purification within the complex scenario of multiorgan support. This thought-provoking discussion, explores: Recent clin...
Mar 21, 2024•11 min•Ep. 19
Episode 18 is the second episode in KDIGO's three-episode series on acute kidney injury (AKI), hosted by Dr. Kathleen Liu (University of California at San Francisco, United States). In this episode, Dr. Liu is joined by Dr. Kianoush Kashani (Mayo Clinic, United States) to discuss the rising importance of personalized care in AKI treatment. They delve into the world of digital health, exploring how digital decision support tools can empower clinicians and improve patient outcomes. This episode wi...
Mar 21, 2024•12 min•Ep. 18
This is the first episode in KDIGO's new 3-episode series on acute kidney injury (AKI), hosted by Dr. Kathleen Liu (University of California at San Francisco, United States). In this episode, Dr. Liu is joined by Dr. Jay Koyner (University of Chicago, United States) to discuss the emerging field of persistent acute kidney injury (AKI). They delve into the question: what exactly is persistent AKI, and how does it differ from severe AKI? Dr. Liu and Dr. Koyner explore the key factors clinicians sh...
Mar 21, 2024•10 min•Ep. 17
In this episode, Dr. Peter Lin (Canadian Heart Research Centre, Canada) and Ikechi Okpechi (University of Alberta, Canada) discuss the right time to refer patients with CKD to a nephrologist. This episode also addresses rapid CKD progression and the utility of risk prediction equations. This episode is supported by an independent educational grant from AstraZeneca.
Jul 11, 2023•16 min•Ep. 16
Join host Dr. Peter Lin (Canadian Heart Research Centre, Canada) in conversation with Dr. Joel Topf (Oakland University, William Beaumont School of Medicine, USA) as they discuss how to combat CKD progression and the role of non-pharmacological vs pharmacological interventions. This episode will explore whether foundational therapies are underused and how to tailor the right treatment for the right patient at the right time. This episode is supported by an independent educational grant from Astr...
Jul 11, 2023•15 min•Ep. 15
In this episode, Dr. Peter Lin (Canadian Heart Research Centre, Canada) and Dr. Magdalena Madero (National Heart Institute Mexico City, Mexico) discuss best practices for CKD evaluation and measurement. This episode focuses on the importance of assessing GFR and albuminuria, identifying the causes of CKD, CKD progression, and when more accurate GFR measures (such as cystatin) should be conducted. This episode is supported by an independent educational grant from AstraZeneca.
Jul 11, 2023•16 min•Ep. 14
Join host, Dr. Peter Lin (Canadian Heart Research Centre, Canada) and Dr. Lekha Tummalapalli (Weill Cornell Medicine, United States) as they discuss the importance of early CKD detection. This episode explores risk factors, screening for CKD, and country specific factors to take into account when screening for CKD. This episode is supported by an independent educational grant from AstraZeneca. Show Notes: https://kdigo.org/conferences/early-identification/ https://www.theisn.org/blog/2023/05/22/...
Jul 11, 2023•9 min•Ep. 13
In this episode, host Dr. Vladimir Tesar (General University Hospital, Prague) and Dr. David Jayne (Addenbrooke's Hospital, United Kingdom) discuss the roles of various agents in the induction and maintenance treatment of ANCA- associated vasculitis. They will explore the use of rituximab and complement inhibition in treating ANCA-associated vasculitis. This episode will address the gaps in knowledge and ongoing research in the field of ANCA-associated vasculitis. This episode is supported by Am...
Feb 22, 2023•15 min
In this episode, host Dr. Vladimir Tesar (General University Hospital, Prague) and Dr. Micheal Walsh (McMaster University, Canada) explore the benefits of plasma exchange for patients with ANCA-associated vasculitis. This episode discusses how to identify patients who may benefit from plasma exchange and the role of plasma exchange in patients with double-positive ANCA and anti-GBM. The utility of rituximab in those also treated with plasma exchange will be addressed. This episode is supported b...
Feb 22, 2023•15 min
Join host, Dr. Vladimir Tesar (General University Hospital, Prague), in conversation with Dr. Duvuru Geetha (Johns Hopkins University School of Medicine, United States) as they discuss the main causes of delays in diagnosis of ANCA-associated vasculitis and the different ways to increase awareness of the disease. This episode will also discuss the role of kidney biopsy in the optimal management and monitoring of these patients. This episode is supported by Amgen.
Feb 22, 2023•13 min
Join host, Dr. Marlies Ostermann (Guy's and St Thomas' Hospital, United Kingdom), in conversation with Dr. Sandra Kane-Gill (University of Pittsburgh School of Pharmacy, United States) as they discuss the importance of drug stewardship when treating critically ill patients. This episode will examine various terms such as drug-induced acute kidney injury, drug-associated acute kidney injury, and nephrotoxicity. Dr. Kane-Gill will also discuss how multiorgan support may influence drug dosing and a...
Nov 21, 2022•17 min•Ep. 9
In this episode, KDIGO Conversations in Nephrology host, Dr. Marlies Ostermann (Guy's and St Thomas' Hospital, United Kingdom), and Dr. Rinaldo Bellomo (University of Melbourne, Australia) will discuss the importance of hemodynamic stabilization in protecting kidney function for patients on kidney replacement therapy. This episode will also discuss the different strategies and therapies available for maintaining such stability. Urgent questions for future research will also be addressed. This ep...
Nov 21, 2022•22 min•Ep. 8
Join host, Dr. Marlies Ostermann (Guy's and St Thomas' Hospital, United Kingdom), in conversation with Dr. Javier Neyra (University of Alabama in Birmingham, United States) as they explore the role of kidney replacement therapy in managing fluid overload. They will discuss optimal monitoring and how best to remove fluid safely and effectively, including the evaluation of patients’ response to fluid removal prescription. This episode will also address the ongoing gaps in knowledge in the field. T...
Nov 21, 2022•22 min•Ep. 7
Join KDIGO Conversations in Nephrology host, Dr. Roberto Pecoits-Filho, in conversation with Dr. Chuck Herzog as they explore the challenges that occur when managing dyskalemia. They address the consequences of hyperkalemia and hypokalemia. They also discuss how both hospitalized patients and outpatients are affected by hyperkalemia. Dr. Roberto Pecoits-Filho is Senior Research Scientist at Arbor Research and Professor of Medicine at the Pontifical Catholic University of Paraná. Dr. Chuck Herzog...
Sep 30, 2021•20 min
Join KDIGO Conversations in Nephrology host, Dr. Roberto Pecoits-Filho, in conversation with Dr. Patrick Rossignol as they discuss approaches to RASi optimization. Additional topics include: Monitoring of creatinine and potassium What happens after? Is the GP responsible for follow-up? When to discontinue, when to return? Lack of communication between specialties How different specialties react differently to different values Dr. Roberto Pecoits-Filho is a nephrologist and Senior Research Scient...
Sep 29, 2021•13 min
Join host, Dr. Roberto Pecoits-Filho, and Dr. Catherine Clase as they discuss the benefits of RASi utilization. Additional topics include: The role of RASi in the management of CKD progression Outcomes ACE / ARBs Is RASi underutilized? Is it worth not to discontinue? The impact of the KDIGO Blood Pressure Management in CKD Guideline and Diabetes Management in CKD Guideline on RAASi utilization and future challenges Dr. Roberto Pecoits-Filho is Senior Research Scientist at Arbor Research and Prof...
Sep 29, 2021•21 min
Dr. Ravi Mehta and Theresa Mottes discuss which key components are needed when starting a quality improvement program (QI) for acute dialysis and why those components are needed. They also discuss how to get leverage to implement a QI program and the keys to a successful CRRT quality program. This episode was supported by Baxter.
Aug 10, 2021•13 min
Dr. Ravi Mehta and Dr. Ashita Tolwani discuss best practices on anticoagulation and citrate use, why circuit patency and integrity are important for CRRT, and how and when to use anticoagulation. They also discuss preferred methods for anticoagulation and the parameters that should be monitored for circuit integrity. This episode was supported by Baxter.
Aug 10, 2021•16 min
In this episode, Dr. Ravi Mehta and Dr. Marlies Ostermann discuss the controversy around defining the optimal timing for starting dialysis in critically ill patients. Dr. Osterman highlights the most relevant parameters that influence when to offer, start, and stop dialysis and gives a comprehensive review of the recent trials on the timing of dialysis. And finally, both presenters address the challenges of managing patients during the COVID-19 pandemic. This episode was supported by Baxter.
Aug 10, 2021•14 min
