Journal of Clinical Oncology (JCO) Podcast - podcast cover

Journal of Clinical Oncology (JCO) Podcast

American Society of Clinical Oncology (ASCO)sites.libsyn.com
The Journal of Clinical Oncology Podcast presents analyses and discussions centered on the latest findings published in ASCO's flagship Journal of Clinical Oncology. Host Dr. Davide Soldato facilitates interviews and scholarly discourse on the most impactful published findings. The Journal of Clinical Oncology Podcast is the trusted resource that empowers you to integrate cutting-edge evidence into clinical practice. The year's fellows interview authors and summarize the top Journal of Clinical Oncology articles in the series, JCO Article Insights.
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Episodes

Phase 2 Study of Multi-Cancer Detection from Breath Samples

Guests Akash Kulgod and Dr. Sanjeev Kulgod and host Dr. Davide Soldato discuss JCO article, " Canine Olfaction Combined with Bayesian Modeling for Multi Cancer Detection from Breath Samples, a Phase 2 Study in India " and the innovative breath-based canine olfaction for multi-cancer detection in low-resource settings, the Bayesian modeling integration, and future prospects for scalable, non-invasive cancer screening methods. LINK TO FULL TRANSCRIPT...

Jun 11, 202620 min

JCO at ASCO 2026: Individualized Neoantigen Therapy Plus Pembrolizumab in Melanoma

JCO Editorial Fellow Dr. Ash Gurumurthi and JCO Associate Editor Dr. Grant McArthur discuss the ASCO 2026 Simultaneous Publication paper " Intismeran Autogene Plus Pembrolizumab Versus Pembrolizumab Alone in High-Risk Resected Melanoma: 5-Year Update of the Randomized Phase 2b KEYNOTE-942 Study ." LINK TO FULL TRANSCRIPT...

Jun 01, 202610 min

JCO at ASCO 2026: Pemigatinib Phase 3 FIGHT-302 Trial in Cholangiocarcinoma

JCO Podcast host Dr. Davide Soldato and JCO Associate Editor Dr. Dr. Eileen M. O'Reilly discuss the ASCO 2026 Simultaneous Publication paper " Pemigatinib for Unresectable or Metastatic Cholangiocarcinoma With Fibroblast Growth Factor Receptor-2 Rearrangement: Results From the Phase 3 FIGHT-302 Trial ." LINK TO FULL TRANSCRIPT...

Jun 01, 202612 min

JCO at ASCO 2026: Neoadjuvant Sacituzumab in MIBC

JCO Editorial Fellow Dr. Jake New and JCO Associate Editor Dr. Umang Swami discuss the ASCO 2026 Simultaneous Publication paper " Neoadjuvant Sacituzumab Govitecan in Patients with Muscle-Invasive Bladder Cancer: Primary Results of SURE-01 Trial ." LINK TO FULL TRANSCRIPT

May 31, 20269 min

JCO at ASCO 2026: Intravesical Recombinant BCG with Chemo-Immunotherapy in MIBC

JCO Editorial Fellow Dr. Jake New and JCO Associate Editor Dr. Andrea Necchi discuss the ASCO 2026 Simultaneous Publication paper " Addition of Intravesical Recombinant BCG to Perioperative Chemo-Immunotherapy in Muscle-Invasive Bladder Cancer: Primary Analysis of the Single Arm Phase 2 Trial SAKK 06/19 ." LINK TO FULL TRANSCRIPT...

May 29, 202613 min

Adjuvant Durvalumab and the Future of Early-Stage NSCLC

Guest Dr. Glenwood Goss and host Dr. Davide Soldato discuss JCO article, " Adjuvant Durvalumab in Completely Resected Early-Stage Non-Small Cell Lung Cancer " and the implications of minimal residual disease, results regarding the efficacy of immunotherapy in the adjuvant setting, and the evolving strategies for patient care in lung cancer treatment. LINK TO FULL TRANSCRIPT

May 14, 202620 min

Infections in Two Diet Strategies in HSCT and Leukemia Patients

Guest Dr. John Wingard and host Dr. Davide Soldato discuss JCO article, " Randomized Non-inferiority Trial of a Liberalized Diet Versus the Neutropenic Diet in Hematopoietic Stem Cell Transplant and Acute Leukemia Patients ," the reason behind the trial, its design, methodology, results, and the implications for future dietary approaches in hematology. LINK TO FULL TRANSCRIPT...

Apr 09, 202621 min

JCO Article Insights: ctDNA in DLBCL - Ready for Prime Time?

In this episode of JCO Article Insights, host Dr. Ash Gurumurthi summarizes JCO articles, " Phased Variant–Supported Circulating Tumor DNA as a Prognostic Biomarker After First-Line Treatment in Large B-Cell Lymphoma: Findings From the DIRECT Study " and " Prospective Validation of Circulating Tumor DNA Measurable Residual Disease After First-Line Therapy in Large B-Cell Lymphoma " TRANSCRIPT Ash Gurumurthi: Hi and welcome to JCO Article Insights . I'm your host, Ash Gurumurthi, and today we wil...

Mar 30, 202614 min

The CISTO Study: Radical Cystectomy or Bladder-Sparing Therapy for Recurrent NMIBC

Guest Dr. John Gore and host Dr. Davide Soldato discuss JCO article, " 12-Month Results from the CISTO Study Comparing Radical Cystectomy Versus Bladder-Sparing Therapy for Recurrent Non-Muscle Invasive Bladder Cancer ," which compares radical cystectomy and bladder sparing therapy for patients with recurrent high-grade non-muscle invasive bladder cancer. Dr. Gore and Dr. Soldato focus on the study's patient-centered approach, eligibility criteria, and quality of life after treatment. TRANSCRIPT...

Mar 12, 202619 min

JCO Article Insights: Atezolizumab, Bevacizumab, and Non-Platinum Chemotherapy for PROC

In this episode of JCO Article Insights, host Dr. Melis Canturk summarizes the article, " Atezolizumab With Bevacizumab and Nonplatinum Chemotherapy for Recurrent Ovarian Cancer: Final Results From the Placebo-Controlled AGO-OVAR 2.29/ENGOT-ov34 Phase III Trial, " by Harter et al. TRANSCRIPT Melis Canturk: Hello, and welcome to the JCO Article Insight . I'm your host, Melis Canturk, and today we will be discussing the JCO article, " Atezolizumab With Bevacizumab and Nonplatinum Chemotherapy for ...

Feb 23, 20266 min

JCO Article Insights: Ribociclib Plus Letrozole in Recurrent LGSOC: GOG 3026

In this episode of JCO Article Insights, host Dr. Melis Canturk summarizes the article, " Phase 2 Trial of Ribociclib plus Letrozole in Women with Recurrent Low-Grade Serous Cancer of the Ovary, Fallopian Tube, or Peritoneum: A GOG Partners Trial, " by Slomovitz et al. TRANSCRIPT Melis Canturk: Hello, and welcome to JCO Article Insights . I'm your host, Melis Canturk, and today we will be discussing the JCO article, " Phase 2 Trial of Ribociclib plus Letrozole in Women with Recurrent Low-Grade S...

Feb 23, 20267 min

NCI Working Group on Biochemically Recurrent Prostate Cancer

Host Dr. Davide Soldato and guests Dr. David Einstein and Dr. Ravi Madan discuss JCO article, " National Cancer Institute's Working Group on Biochemically Recurrent Prostate Cancer: Clinical Trial Design Considerations ," underscoring the need for a consensus on clinical trial designs implementing novel endpoints in this population and the importance of PSA doubling time as a prognostic factor, with an emphasis on treatment de-escalation to limit toxicity and improve patient outcomes. TRANSCRIPT...

Feb 12, 202628 min

Association Between EOL SACT and Healthcare Utilization

Host Dr. Davide Soldato and guests Dr. Kerin Adelson and Dr. Maureen Canavan discuss JCO article " Association Between Systemic Anticancer Therapy Administration Near the End of Life with Health Care and Hospice Utilization in Older Adults: A SEER Medicare Analysis of End-of-Life Care Quality ," highlighting adverse outcomes for patients who receive any type of systemic anticancer therapy(SACT) at EOL (end of life) and the need for better communication between oncologists and patients regarding ...

Jan 08, 202623 min

Milan Consensus Endpoints for Bladder Preservation in MIBC

Guests Dr. Andrea Necchi, Dr. Ashish Kamat and host Dr. Davide Soldato discuss JCO article " End Points for the Next-Generation Bladder-Sparing Perioperative Trials for Patients With Muscle-Invasive Bladder Cancer ," focusing on the evolving treatment landscape of MIBC (muscle-invasive bladder cancer) and the need to properly design novel trials investigating non-operative management while including the incorporation of biomarkers and patient perspectives in clinical trials. TRANSCRIPT The discl...

Dec 11, 202527 min

JCO at 2025 ASH: Pirtobrutinib in Untreated CLL

JCO Editor-in-Chief Dr. Jonathan Friedberg is joined by colleagues Dr. Jennifer Woyach, Dr. Wojciech Jurczak, and Dr. Matthew Davids to discuss simultaneous publications presented at ASH 2025 on pertibrutinib, a new upfront treatment option for patients with chronic lymphocytic leukemia. TRANSCRIPT The disclosures for guests on this podcast can be found in the show notes. Dr. Jonathan Friedberg: I'm Jonathan Friedberg, editor of Journal of Clinical Oncology , and welcome to JCO After Hours , whe...

Dec 09, 202520 min

JCO at ASH 2025: A New Validated Staging System for AL Amyloidosis: AL-ISS

JCO Editorial Fellow Peter Li and author Dr. Jahanzaib Khwaja discuss the ASH 2025 Simultaneous Publication article, " A New Validated Staging System for AL Amyloidosis With Stage lllC Defining Ultra-Poor Risk: AL International Staging System ." TRANSCRIPT The disclosures for guests on this podcast can be found in the show notes. Dr. Peter Li: Welcome to this episode of JCO Article Insights . I am Dr. Peter Li, JCO 's Editorial Fellow, and today, I am joined by Dr. Jahanzaib Khwaja on a new vali...

Dec 07, 202515 min

JCO Article Insights: Simultaneous Durvalumab and CRT in Unresectable Stage III NSCLC

In this episode of JCO Article Insights, host Dr. Ece Cali Daylan interviews author Dr. Jeffrey Bradley about the article, " Simultaneous Durvalumab and Chemoradiotherapy in Unresectable Stage III Non–Small Cell Lung Cancer " by Bradley, et al published October 13, 2025. TRANSCRIPT Dr. Ece Cali: Welcome to this episode of JCO Article Insights . This is Dr. Ece Cali, JCO Editorial Fellow. Today I'm joined by Dr. Jeffrey Bradley, Professor of Radiation Oncology at the University of Pennsylvania, t...

Nov 24, 202511 min

Health Outcomes in Older Childhood Cancer Survivors

Guest Dr. Rusha Bhandari and host Dr. Davide Soldato discuss JCO article "Health Outcomes Beyond Age 50 Years in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study, " with a particular focus on mortality data, development of secondary malignancies and the importance of education for both patients and healthcare providers regarding long-term follow-up and care. TRANSCRIPT The guest on this podcast episode has no disclosures to declare. Dr. Davide Soldato: Hello, and ...

Nov 20, 202521 min

Long-Term Remission After Cilta-cel in Patients With RRMM

Guest Dr. Sundar Jagannath and host Dr. Davide Soldato discuss JCO article " Long-Term (≥5-Year) Remission and Survival After Treatment With Ciltacabtagene Autoleucel in CARTITUDE-1 Patients With Relapsed/Refractory Multiple Myeloma ," and the efficacy of CAR-T cell therapy in patients with heavily pretreated RRMM (relapsed/refractory multiple myeloma). TRANSCRIPT Dr. Davide Soldato: Hello and welcome to JCO After Hours , the podcast where we sit down with authors from some of the latest article...

Nov 13, 202528 min

JCO Article Insights: Xevinapant Plus Chemoradiotherapy in Unresected LA SCCHN

In this episode of JCO Article Insights, host Dr. Lauren Shih summarizes the article, " Xevinapant or Placebo Plus Platinum-Based Chemoradiotherapy in Unresected Locally Advanced Squamous Cell Carcinoma of the Head and Neck (TrilynX): A Randomized, Phase III Study " by Bourhis, et al published September 03, 2025 TRANSCRIPT

Oct 27, 20258 min

Income Among Adolescents and Young Adults Surviving Cancer

Host Dr. Shannon Westin and guest Dr. Giancarlo Di Guiseppe discuss the JCO article " Long-Term Dynamic Financial Impacts Among Adolescents and Young Adults With Cancer: A Longitudinal Matched-Cohort Study " TRANSCRIPT The guest on this podcast episode has no disclosures to declare. Dr. Shannon Westin: Hi everybody and welcome to another episode of JCO After Hours , the podcast where we go in depth on manuscripts that are published in the Journal of Clinical Oncology . I'm your host, Dr. Shannon...

Oct 09, 202516 min

JCO Article Insights: Phase I DLL3/CD3 T-Cell Engager in DLL3-Positive SCLC or NECs

In this JCO Article Insights episode, Dr. Ece Cal interviews Dr. Martin Wermke, author of the JCO article, " Phase I Dose-Escalation Results for the Delta-Like Ligand 3/CD3 IgG-Like T-Cell Engager Obrixtamig (BI 764532) in Patients With Delta-Like Ligand 3+ Small Cell Lung Cancer or Neuroendocrine Carcinomas ." TRANSCRIPT The disclosures for guests on this podcast can be found in the transcript. Dr. Ece Cali: Welcome to this episode of JCO Article Insights . This is Dr. Ece Cali, JCO editorial f...

Sep 29, 202513 min

TTFields in Locally Advanced Pancreatic Adenocarcinoma

Host Dr. Shannon Westin and guest Dr. Hani Babiker discuss the JCO article " Tumor Treating Fields With Gemcitabine and Nab-Paclitaxel for Locally Advanced Pancreatic Adenocarcinoma: Randomized, Open-Label, Pivotal Phase III PANOVA-3 Study. " TRANSCRIPT TTFields in Locally Advanced Pancreatic Adenocarcinoma Dr. Shannon Westin: Hello everyone, and welcome to another episode of JCO After Hours , the podcast where we get in depth with manuscripts that have been published in the Journal of Clinical ...

Sep 11, 202519 min

JCO at WCLC: Multinational Pivotal Study of Sunvozertinib in Exon20ins NSCLC

JCO fellow Dr. Ece Cali speaks with JCO Associate Editor Dr. Thomas E. Stinchcombe to discuss the JCO article "Phase 2 Dose-Randomized Study of Sunvozertinib in Platinum-Pretreated Non-Small-Cell Lung Cancer with Epidermal Growth Factor Receptor Exon 20 Insertion Mutations (WU-KONG1B)" , that was simultaneously released at the IASLC 2025 World Conference on Lung Cancer. TRANSCRIPT Dr. Ece Cali: Hello, and welcome to our series where we cover some of the top JCO papers published simultaneously wi...

Sep 09, 20258 min

Racial and Ethnic Disparities Among Medicare Beneficiaries

Host Davide Soldato and guest Dr. John K. Lin discuss the JCO article " Racial and Ethnic Disparities Along the Treatment Cascade Among Medicare Fee-For-Service Beneficiaries with Metastatic Breast, Colorectal, Lung, and Prostate Cancer ." TRANSCRIPT The guest on this podcast episode has no disclosures to declare. Dr. Davide Soldato: Hello, and welcome to JCO After Hours , the podcast where we sit down with authors of the latest articles published in the Journal of Clinical Oncology . I'm your h...

Aug 28, 202529 min

JCO Article Insights: Lymph Node Dissection for Lung Cancer

In this JCO Article Insights episode, Dr. Joseph Matthew interviews authors Dr. Yang Zhang and Dr. Haiquan Chen about their recently published JCO article, " Phase III Study of Mediastinal Lymph Node Dissection for Ground Glass Opacity–Dominant Lung Adenocarcinoma " TRANSCRIPT Joseph Mathew: Welcome to the Journal of Clinical Oncology Article Insights episode for the August issue of the JCO . This is Joseph Mathew, editorial fellow for JCO, and today, it is my pleasure to have with us Dr. Haiqua...

Aug 25, 202522 min

JCO Article Insights: IMS-IMWG Consensus on High-Risk Multiple Myeloma

In this JCO Article Insights episode, Michael Hughes summarizes "International Myeloma Society and International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma" by Avet-Loiseau et al. published on June 09, 2025 along with an interview with author Dr Nikhil C. Munshi, MD. TRANSCRIPT Michael Hughes: Welcome to this episode of JCO Article Insights . This is Michael Hughes, JCO 's editorial fellow. Today I am interviewing Dr. Nikhil Munshi on the " In...

Jul 28, 202525 min

JCO Article Insights: Pooled Taletrectinib Efficacy and Safety

In this JCO Article Insights episode, host Peter Li summarizes " Taletrectinib in ROS1-Mutated Non–Small Cell Lung Cancer: TRUST " by Pérol et al, published April 03, 2025, followed by an interview with first author, Dr Maurice Pérol. TRANSCRIPT The disclosures for guests on this podcast can be found in the show notes. Dr. Peter Li: Welcome to this episode of JCO Article Insights . I am Dr. Peter Li, JCO 's editorial fellow, and today I am joined by Dr. Maurice Pérol on " Taletrectinib in ROS1-M...

Jun 30, 202515 min
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