Sebastian Caliri is Partner at 8VC with a focus on healthcare investing. Previously, Sebastian spent four years at Palantir where he was responsible for growing its commercial healthcare business. In this episode, Sebastian diagnoses the core problems in U.S. healthcare and explains why traditional fee-for-service care misaligns incentives, resulting in rising costs and inferior health outcomes. He makes the case for new models like value-based care and also highlights the potential of psychedel...
Aug 09, 2022•32 min•Ep. 39
Tony Fadell is one of the great engineers, designers, and business leaders of our time, responsible for creating the iPod, iPhone, and Nest Thermostat. He runs the investment firm Future Shape and recently released his memoir titled “Build: An Unorthodox Guide to Making Things Worth Making." In this episode, he discusses the lessons he learned at General Magic (which was building the iPhone 15 years too early) and Philips Electronics that paved the way for building some of the world's most popul...
May 20, 2022•39 min•Ep. 38
Joe Lonsdale sits down with Zach Latta, Founder of Hack Club, a non-profit network of high school coding clubs with over 15,000 members worldwide. At age 15, Zach helped design one of the most popular apps in the world. At 16, he dropped out of high school to become a programmer before founding Hack Club. He then received a Thiel Fellowship and decided to forgo college to build Hack Club full-time. In this episode, he talks about rethinking education and challenges teenagers to look beyond conve...
Apr 27, 2022•31 min•Season 2Ep. 37
Gene Berdichevsky is the co-founder and CEO of Sila, a next-gen battery technology company. Previously, he was the seventh employee at Tesla, where he served as Principal Engineer on the Roadster battery and led the development of the world’s first mass-produced lithium-ion car battery. In this episode, he explains how Sila's new battery chemistry innovations can improve efficiency, reduce costs, and help electrify the future. He discusses the challenges in mining rare metals, battery recycling,...
Apr 21, 2022•31 min•Season 2Ep. 36
Francisco Gimenez is Partner at 8VC and focuses on Bio-IT investments. He received his Ph.D. from Stanford in Biomedical Informatics and B.S. in Electrical Engineering and Computer Sciences from UC Berkeley. In this episode, Francisco explains how breakthroughs in AI, gene editing, and cell therapies converged to jumpstart a new age in biology. He predicts that biomanufacturing platforms, armed with mountains of data and new tools, will bring down the costs of creating and commercializing drugs ...
Apr 18, 2022•46 min•Season 2Ep. 35
Jacob DeWitte is the Co-Founder and CEO of Oklo, a nuclear energy startup building small advanced reactors that can reuse spent fuel from conventional reactors. In this episode, DeWitte explains how the regulatory state has stymied new reactor designs for decades, and how he's working to break through and bring game-changing nuclear power technology to market. Shortly after the initial conversation was filmed, the U.S. Nuclear Regulatory Commission (NRC) denied Oklo's application for its new sma...
Apr 06, 2022•42 min•Ep. 34
Dr. Mark Esper served as the U.S. Secretary of Defense from 2019 to 2020 and Secretary of the Army from 2017 to 2019. He's currently the Distinguished Chair of the Modern War Institute at West Point and sits on the Board of Directors of Epirus [a defense startup co-founded by Joe]. His forthcoming memoir is titled "A Sacred Oath: Memoirs of a Secretary of Defense During Extraordinary Times.” In this episode, he dissects Russia's military weaknesses and explains how its invasion of Ukraine may ul...
Mar 31, 2022•33 min•Season 2Ep. 33
Judge Glock is the Director of Research and Policy at the Cicero Institute and an expert on housing and homelessness in the U.S. In this episode, Glock dissects the root causes of America's affordable housing shortage and explains how the right incentives can jumpstart development and bring down home costs for working-class families. He also exposes how policies like “Housing First” encourage the homeless to live and die on the streets while waiting for free and permanent housing, which won’t so...
Mar 23, 2022•45 min•Season 2Ep. 32
Dr. Jeannette zu Fürstenberg is Co-Founder and General Partner of “La Famiglia”, a Berlin-based Venture Capital fund, and holds a Ph.D. in Philosophy and Entrepreneurship from the Free University of Berlin. She’s also a princess of one of Europe’s oldest royal families by marriage, as well as a thoughtful leader in the innovation and business world. In this episode, she traces the birth of entrepreneurship from the Renaissance and explains how breaking down the silos of guilds led to a creative ...
Mar 16, 2022•44 min•Season 2Ep. 31
Jared Meyer is the Executive Director of Cicero Action. In this episode, Jared discusses how special interests stifle competition and why Cicero Action is using the special interests' playbook against them to promote innovative, bottom-up reforms. He explains the government affairs strategy that creates real policy changes in states across the country, from expanding telehealth and improving parole and probation reforms, to realigning higher education incentives and fixing homelessness. This con...
Mar 09, 2022•35 min•Season 2Ep. 30
Thomas Chatterton Williams is a writer, cultural critic, fellow at the American Enterprise Institute, and author of two critically-acclaimed books on race in America, most recently "Self-Portrait in Black and White: Unlearning Race." In this episode, he discusses the dangers of Critical Race Theory and how to move beyond race-first, collectivist mindsets. He also discusses his forthcoming book, "Nothing Was the Same," which traces the recent rise of illiberalism and polarization in the U.S. Even...
Mar 02, 2022•39 min•Season 2Ep. 29
Hayes Barnard is the Founder and CEO of GoodLeap, one of the fastest-growing and largest financial technology companies in the renewable energy sector. In 2008, Barnard founded Paramount Solar, which was later acquired by SolarCity and then Tesla. Barnard discusses his role on the leading edge of America's solar energy expansion and what he learned working alongside Elon Musk. He also highlights his non-profit GivePower and its innovative work to bring clean water and electricity to Africa via s...
Feb 23, 2022•34 min•Season 2Ep. 28
Tyler Cowen is a professor, best-selling author, blogger, podcaster, and one of the most influential economists of this generation. In the early days of the pandemic, Cowen launched the Fast Grants program, which funded COVID-related science in less than 48 hours -- a remarkable feat in the medical sector. He discusses his efforts to accelerate innovation, including his work to transform how investors identify and back the next generation of brilliant entrepreneurs. An all-around polymath, Cowen...
Feb 16, 2022•37 min•Season 2Ep. 27
Pano Kanelos is the President of the University of Austin (UATX), the most ambitious new university venture in America in decades. Recognizing the plight of America's higher education system, Pano stepped down as the President of St. John's College to build a new institution rooted in the pursuit of truth, open inquiry, and educating the next generation of American leaders. In this episode, Joe and Pano discuss the failures of modern academia and why it's time to take on the bold task of buildin...
Feb 10, 2022•35 min•Season 2Ep. 26
Ambassador Kelly Craft is a businesswoman, philanthropist, and former diplomat who served as U.S. ambassador to the United Nations from 2019 to 2021 and U.S. ambassador to Canada from 2017 to 2019. She played an integral role in shaping major foreign policy decisions and achievements, such as the landmark Abraham Accords and the USMCA trade agreement. In this episode, she discusses some of the most pressing U.S. challenges abroad, including speaking up for human rights during the Beijing Olympic...
Feb 02, 2022•45 min•Season 2Ep. 25
Charles Koch, Chairman and CEO of Koch Industries, is one of the great business minds of our time. He grew a small engineering firm from $21 million in revenue to over 10,000 times the revenue. Yet in both his business and philanthropic work, he is first and foremost a philosopher. Koch explains how thinkers such as Abraham Maslow and Joseph Schumpeter shaped his outlook on the conditions for human flourishing, and why it's important to enable every employee to self-actualize. Rejecting centrali...
Jan 26, 2022•41 min•Season 2Ep. 24
Chris Sprowls is the Speaker of the Florida House of Representatives. Under his leadership, Florida has set itself apart as one of the most innovative state legislatures in the country, slashing regulations that prop up entrenched interests and injecting true competition into the marketplace. We discuss his strategy for successfully combatting cronyism in healthcare, pioneering the biggest school choice expansion in the country, and other courageous reforms -- many of which passed on a bipartisa...
Jan 20, 2022•32 min•Season 2Ep. 23
Congressman Ro Khanna is the Democratic Congressman from California’s 17th District, which covers large swaths of Silicon Valley. A self-described "progressive capitalist," Khanna bucks the current political norms and works to advance meaningful bipartisan legislation. In this episode, we debate income inequality, wealth taxes, and other hot-button issues, but also find common ground on reasonable regulations for Big Tech, introducing more innovation into healthcare, and promoting nuclear energy...
Jan 14, 2022•35 min•Season 2Ep. 22
Dhani Jones spent 11 seasons in the NFL as a middle linebacker, the linchpin of the defensive unit. Since then, he has become a leader in other arenas: hosting TV shows, launching charities, and investing in startups. His passion is bringing out the best in others. In this episode, he pushes back against the notion of lowering standards to minimize disparities. He explains why adversity, competition, and the pursuit of excellence are some of the best ways to lift up others and improve their live...
Jan 05, 2022•39 min•Season 2Ep. 21
Mike Reeser and Michael Bettersworth are the Chancellor and Chief Innovation Officer, respectively, at Texas State Technical College (TSTC). In 2014, TSTC became the FIRST college in the country to fully align its public funding with its students' future earnings. Since then, graduates have seen their earnings increase over 100 percent! Their success is an antidote to the crisis of bad incentives in education today and should inspire other states to pursue similar reforms.
Dec 29, 2021•32 min•Season 2Ep. 20
Maleka Momand is the co-founder and CEO of Esper, a technology platform that transforms how governments oversee the regulatory process. In recent decades, the size of the administrative state has exploded. Yet, many regulators still operate via Word, Excel, and, in some cases, pen and paper! This has led to a lack of transparency and accountability, not to mention a morass of outdated, disjointed regulations. By applying data analytics and artificial intelligence to augment regulators and regula...
Dec 22, 2021•30 min•Season 2Ep. 19
Over the past few decades, the U.S. military’s long-held advantages have waned. Today, we are reliant on outdated technologies and in jeopardy of falling behind China. Bo Marr, the co-founder and Chief Technology Officer of Epirus, is bucking the trend. Marr and his team invented the world’s most powerful phased array, Leonidas, that can disable drones and other electronic systems from great distances. This modern force field fills a vital technological gap for the U.S. military as it prepares f...
Dec 16, 2021•32 min•Season 2Ep. 18
Daniel Lubetzky is the founder of Peaceworks, the OneVoice Movement, and the multi-billion dollar snack company KIND. The son of a Holocaust survivor, Lubetzky’s upbringing inspired him to use business to bridge cultural and economic divides. In this episode, he explains America’s unique role in the world and why we must work together to repair our social fabric and break out of our tribal instincts. His newest venture, Starts With Us, does just that by instilling greater courage, curiosity, and...
Dec 15, 2021•35 min•Season 2Ep. 17
Maureen Hillenmeyer is the Founder and CEO of Hexagon Bio, a cutting-edge biotech company whose mission is to harvest new drugs and cures from the natural world, beginning with fungi. In 1928, Sir Alexander Fleming’s accidental discovery of penicillin launched a new age of antibiotics derived from fungi. However, the process of discovery was slow and laborious. In this episode, Hillenmeyer explains how Hexagon is using genomic sequencing and artificial intelligence to analyze the millions of typ...
Sep 24, 2021•26 min•Season 1Ep. 16
In 1978, John Mackey co-founded his first natural foods store in Austin, Texas with only $45,000. Two years later, he and his business partners launched the first Whole Foods Market, which quickly became the nation's fastest-growing organic grocery store. In 2017, Amazon acquired the company for over $13 billion. In this episode, the Whole Foods Founder and CEO discusses his journey from democratic socialism to "Conscious Capitalism" -- the title of his book in defense of free markets and how bu...
Sep 15, 2021•40 min•Season 1Ep. 15
Jake Kloberdanz is the CEO and Founder of ONEHOPE Wine, an award-winning vineyard located in the heart of Napa Valley. What sets ONEHOPE apart is its unique business model: every bottle of wine sold helps fund a charitable organization. Kloberdanz is a champion of cause-centric commerce, and to date, ONEHOPE has donated over seven million dollars to organizations that help disadvantaged communities break the cycle of poverty. In this episode, he describes his journey from selling wine out of the...
Sep 09, 2021•36 min•Season 1Ep. 14
This week's episode features three talented and successful innovators behind many game-changing technologies and companies. First is Sal Churi, a former law professor who is now general partner at Trust Ventures -- an Austin-based venture capital firm. Churi helps founders overcome the collision points of innovation and regulation, and explains how 3D printed houses, small modular nuclear reactors, and other breakthroughs can transform our country if we fix the outdated laws holding them back. N...
Sep 03, 2021•44 min•Ep. 13
Adrian Fenty is currently a founding managing partner at MaC Venture Capital, a former advisor at Andreessen Horowitz, and served as the Mayor of Washington, D.C. from 2007-2011. During his tenure as Mayor, he took on special interests and the teachers' unions, fought for accountability in government and greater opportunities for children while also overseeing a dramatic reduction in violent crime. His courage reshaped the direction of the city and is much needed in our nation today. In this epi...
Aug 25, 2021•24 min•Season 1Ep. 12
Niall Ferguson is a renowned historian, Senior Fellow at the Hoover Institution, and prolific author of more than a dozen best-selling works on economics, culture, and politics. His newest book, "Doom: The Politics of Catastrophe,” examines how our leaders and societies have dealt with disasters, including pandemics, and how we must learn from the past to better manage future crises. In this episode, Ferguson explains why the rise and fall of civilizations do not fit into predictable patterns an...
Aug 18, 2021•28 min•Season 1Ep. 11
Balaji Srinivasan is a bold and forward-thinking writer, investor, and entrepreneur, who was formerly the Chief Technology Officer of Coinbase and general partner at Andreessen Horowitz. Currently, he's launching innovative ventures, such as his 1729 Project, while also advocating for cryptocurrency and the larger decentralized finance movement. In this episode, Srinivasan explains how to understand the world by looking through the lenses of three competing factions: the Chinese Communist Party,...
Aug 11, 2021•48 min•Season 1Ep. 10
