In this JCO PO Article Insights episode, Harold Nathan Tan summarizes findings from the JCO PO article, " Circulating Tumor DNA as a Prognostic Biomarker for Recurrence in Patients With Locoregional Esophagogastric Cancers With a Pathologic Complete Response ." TRANSCRIPT Harold Nathan Tan: Welcome to JCO Precision Oncology Article Insights where we explore cutting-edge discoveries in the world of cancer treatment and research. I'm Harold Nathan Tan, your host for today's episode. Let's dive int...
Jan 29, 2025•6 min
JCO PO author Dr. David R. Gandara at UC Davis Comprehensive Cancer Center, shares insights into his JCO PO article, " Plasma Proteome–Based Test for First-Line Treatment Selection in Metastatic Non–Small Cell Lung Cancer ," one of the Top Articles of 2024. Host Dr. Rafeh Naqash and Dr. Gandara discuss how the PROphet® blood test supports first-line immunotherapy treatment decisions for metastatic NSCLC patients. TRANSCRIPT Dr. Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversati...
Jan 15, 2025•21 min
JCO PO authors Dr. Philippe Bedard (Staff Medical Oncologist at Princess Margaret Cancer Centre and Professor of Medicine at University of Toronto) and Dr. Alberto Hernando Calvo (Medical Oncologist at Vall d´Hebron University Hospital) share insights into their JCO PO article, " Combined Transcriptome and Circulating Tumor DNA Longitudinal Biomarker Analysis Associates With Clinical Outcomes in Advanced Solid Tumors Treated With Pembrolizumab ," one of the top downloaded articles of 2024. Host ...
Dec 18, 2024•23 min
In this JCO Precision Oncology Article Insights episode, Miki Horiguchi summarizes two articles: " Germline Susceptibility to Renal Cell Carcinoma and Implications for Genetic Screening ," by Dr. Kate I. Glennon et al. published on August 01, 2024, and " Incidental Pathogenic Variants in Renal Cell and Urothelial Carcinoma: Is It Time for Universal Screening? " by Dr. Salvador Jaime-Casas, et al. published on August 01, 2024. TRANSCRIPT Miki Horiguchi: Hello and welcome to JCO Precision Oncology...
Nov 27, 2024•10 min
JCO PO author Dr. Michael J. Hall, Professor of Medicine, Chairman of the Department of Clinical Genetics, and Co-Leader of the Cancer Prevention and Control Program at Fox Chase Cancer Center in Philadelphia, PA, shares insights into the JCO PO article, " Uptake of Aspirin Chemoprevention in Patients with Lynch Syndrome ." Host Dr. Rafeh Naqash and Dr. Hall discuss the finding that only about 1 in 3 patients with Lynch Syndrome use aspirin for cancer chemoprevention. TRANSCRIPT Dr. Rafeh Naqash...
Nov 15, 2024•31 min
In this JCO Precision Oncology Article Insights episode, Mitchell Elliot summarizes the article " Talazoparib in Patients With Solid Tumors With BRCA1/2 Mutation: Results From the Targeted Agent and Profiling Utilization Registry Study " by Dr. Jordan Srkalovic et al. published on June 12th, 2024. TRANSCRIPT Mitchell Elliott: Hello, welcome to JCO Precision Oncology Article Insights . I'm your host Mitchell Elliott, an ASCO Journals Editorial Fellow. Today I'll be providing a summary of the arti...
Oct 30, 2024•7 min
JCO PO author Dr. Amar U. Kishan, Professor, Executive Vice Chair, and Chief of Genitourinary Oncology Service in the Department of Radiation Oncology at the University of California, Los Angeles, shares insights into his JCO PO article, " Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography: A Multicenter Retrospective Study. " Host Dr. Rafeh Naqash and Dr. Kishan discuss the relation...
Oct 16, 2024•27 min
In this JCO Precision Oncology Article Insights episode, Mitchell Elliot summarizes an editorial: " A Targeted Methylation–Based Multicancer Early Detection Blood Test Preferentially Detects High-Grade Prostate Cancer While Minimizing Overdiagnosis of Indolent Disease " by Dr. Brandon A. Mahal, et al. published on August 29, 2024. TRANSCRIPT Mitchell Elliott: Hello and welcome to JCO Precision Oncology Article Insights . My name is Mitchell Elliott, a JCO Editorial Fellow. Today, I'll be discuss...
Sep 25, 2024•8 min
JCO PO author Dr. Alok A. Khorana, MD, FASCO, Professor of Medicine, Cleveland Clinic and Case Comprehensive Cancer Center, shares insights into the JCO PO article, " Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers ." Host Dr. Rafeh Naqash and Dr. Khorana discuss how multiomic analysis shows higher FGFR2 fusions and immunotherapy marker variations in early-onset biliary cancer. TRANSCRIPT Dr. Rafeh Naqash: Hello, and welcome to...
Sep 18, 2024•25 min
In this JCO Precision Oncology Article Insights episode, Miki Horiguchi summarizes an editorial: " Expanding the Reach of Personalized Medicine in Cancer Care: Current Progress and Future Directions of JCO Precision Oncology " by Dr. Yushu Shi et al. published on May 30, 2024. TRANSCRIPT Hello and welcome to JCO Precision Oncology Article Insights . I'm your host Miki Horiguchi, an ASCO Journals Editorial Fellow. Today, I will be providing a summary of the article titled " Expanding the Reach of...
Aug 28, 2024•11 min
JCO PO author Dr. Jonathan D. Tward, M.D., Ph.D., FASTRO, at the HCI Genitourinary Cancers Center and the Huntsman Cancer Institute at the University of Utah, shares insights into his JCO PO article, " Using the Cell-Cycle Risk Score to Predict the Benefit of Androgen-Deprivation Therapy Added to Radiation Therapy in Patients With Newly Diagnosed Prostate Cancer. " Host Dr. Rafeh Naqash and Dr. Tward discuss how the cell-cycle risk score predicts the benefit of androgen-deprivation therapy in pr...
Aug 21, 2024•24 min
In this JCO Precision Oncology Article Insights episode, Miki Horiguchi summarizes two articles: " Biomarker-Driven Oncology Trial Design and Subgroup Characterization: Challenges and Potential Solutions " by Wang, et al. published on June 7, 2024, and " Biomarkers in Oncology: Complexities in Biomarker-Driven Studies and Statistical Analysis " by Uno, et al. published on July 22, 2024. TRANSCRIPT Miki Horiguchi: Hello and welcome to JCO Precision Oncology Article Insights . I'm your host, Miki ...
Jul 31, 2024•10 min
In this JCO Precision Oncology Article Insights episode, Fergus Keane provides a summary on " Multi-Institutional Study Evaluating the Role of Circulating Tumor DNA in the Management of Appendiceal Cancers " by Belmont, et al published on May 9th, 2024. TRANSCRIPT Fergus Keane: Hello and welcome to JCO Precision Oncology Article Insights . I'm your host, Fergus Keane, an ASCO editorial fellow. Today I will be providing a summary of the article entitled, " Multi-Institutional Study Evaluating the...
Jun 26, 2024•9 min
JCO PO author Dr. Samuel J. Klempner shares insights into his JCO PO article, "PD-L1 Immunohistochemistry in Gastric Cancer: Comparison of Combined Positive Score and Tumor Area Positivity across 28-8, 22C3, and SP263 assays". Host Dr. Rafeh Naqash and Dr. Klempner discuss assessing the analytical comparability of three commercially available PD-L1 assays and two scoring algorithms used to assess PD-L1 status in gastric cancer samples. TRANSCRIPT Dr. Abdul Rafeh Naqash: Hello and welcome to JCO ...
Jun 19, 2024•22 min
In this JCO Precision Oncology Article Insights episode, Mitchell Elliot provides a summary on " Serial Postoperative Circulating Tumor DNA Assessment Has Strong Prognostic Value During Long-Term Follow-Up in Patients With Breast Cancer " by Shaw, et al published on May 1st, 2024. TRANSCRIPT The guest on this podcast episode has no disclosures to declare. Mitchell Elliott: Hello and welcome to the JCO Precision Oncology Article Insights . I'm your host, Mitchell Elliott, an ASCO Journal editoria...
May 29, 2024•7 min
JCO PO author Dr. Jun Gong shares insights into his JCO PO articles, " Phase II Study of Erdafitinib in Patients with Tumors with FGFR Amplifications: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Sub-protocol K1 " and " Phase II Study of Erdafitinib in Patients with Tumors with FGFR Mutations or Fusions: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Sub-protocol K2 ". Host Dr. Rafeh Naqash and Dr. Gong discuss the limited activity of FGFR inhibition in solid tumors with FGFR ampli...
May 15, 2024•29 min
In this JCO PO Article Insights episode, Miki Horiguchi provides a summary on the article, " TARGET: A Randomized, Noninferiority Trial of a Pretest, Patient-Driven Genetic Education Webtool Versus Genetic Counseling for Prostate Cancer Germline Testing and explains what a non-inferiority trial is. TRANSCRIPT Miki Horiguchi: Hello and welcome to JCO Precision Oncology Article Insights . I'm your host Miki Horiguchi, an ASCO Journal's Editorial Fellow. Today, I'll be providing a summary of the ar...
Apr 24, 2024•10 min
JCO PO author Dr. Christian Rolfo shares insights into his JCO PO article, " Liquid Biopsy of Lung Cancer Before Pathological Diagnosis Is Associated With Shorter Time to Treatment ." Host Dr. Rafeh Naqash and Dr. Rolfo discuss how early liquid biopsy in aNSCLC in parallel with path dx is associated with shorter time to treatment. TRANSCRIPT Dr. Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversations , where we bring you engaging conversations with authors of clinically relevant ...
Apr 17, 2024•33 min
In this JCO PO Article Insights episode, Fergus Keane provides a summary on " Microsatellite Instability Is Insufficiently Used as a Biomarker for Lynch Syndrome Testing in Clinical Practice ", by Papadopoulou, et al published January 25, 2024 TRANSCRIPT The guest on this podcast episode has no disclosures to declare. Fergus Keane: Hello and welcome to JCO Precision Oncology Article Insights . I'm your host, Fergus Keane, an ASCO Editorial Fellow. Today, I will be providing a summary of the arti...
Mar 27, 2024•6 min
JCO PO authors Lauren C. Leiman and Dr. Emma Alme share insights into their JCO PO article, " Recommendations for the Equitable and Widespread Implementation of Liquid Biopsy for Cancer Care ". Host Dr. Rafeh Naqash and guests discusses increasing access to liquid biopsy for cancer, reviewing the barriers and examining the proposed solutions. TRANSCRIPT Dr. Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversations , where we bring you engaging conversations with authors of clinical...
Mar 20, 2024•42 min
In this JCO Precision Oncology Article Insights episode, Mitchell Elliot provides a summary on " Prediction of Benefit From Adjuvant Pertuzumab by 80-Gene Signature in the APHINITY (BIG 4-11) Trial ," by Krop, et al published on January 18th, 2024. TRANSCRIPT Mitchell Elliott: Hello and welcome to JCO Precision Oncology Article Insights . I'm your host, Mitchell Elliott, an ASCO Journal Editorial Fellow. Today, I will be providing a summary of the article titled " Prediction of Benefit from Adju...
Feb 28, 2024•8 min
JCO PO author Dr. Eric Klein shares insights into his JCO PO article, " Performance of a Cell-Free DNA-Based Multi-Cancer Detection Test in Individuals Presenting with Symptoms Suspicious for Cancers " Host Dr. Rafeh Naqash and Dr. Klein discuss how a multi-cancer detection test may facilitate workup and stratification of cancer risk in symptomatic individuals. TRANSCRIPT Dr. Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversations , where we bring you engaging conversations with ...
Feb 21, 2024•27 min
In this JCO Precision Oncology Article Insights episode, Miki Horiguchi provides a summary on " Clinical Trial Diversity: A Bend in the Arc Towards Justice ", by Tannenbaum, et al published on September 19, 2023 in JCO Precision Oncology. The editorial discusses the need for inclusion of under-represented groups in clinical trials. See the accompanying Original Report, " Representativeness of Patients Enrolled in the Lung Cancer Master Protocol (Lung-MAP) ," by Vaidya, et al as well as an interv...
Jan 31, 2024•9 min
JCO PO author Dr. Amit Mahipal shares insights into his JCO PO article, " Tumor Mutational Burden in Real-world Patients with Pancreatic Cancer: Genomic Alterations and Predictive Value for Immune Checkpoint Inhibitor Effectiveness ." Host Dr. Rafeh Naqash and Dr Mahipal discuss real world evidence of immune checkpoint inhibitors in pancreatic ductal adenocarcinoma. TRANSCRIPT Dr. Rafeh Naqash: Welcome to JCO Precision Oncology Conversations , where we bring you engaging conversations with autho...
Jan 24, 2024•27 min
JCO PO author Dr. Mary Redman shares insights into her JCO PO article, " Representativeness of Patients Enrolled in the Lung Cancer Master Protocol (Lung-MAP) " Host Dr. Rafeh Naqash and Dr. Redman discuss the background of LungMAP and how it was developed to accelerate drug development and biomarker-driven therapies in lung cancer. Dr. Redman shares the initiatives undertaken to increase participant diversity in LungMAP and invites junior investigators to get involved in the project. TRANSCRIPT...
Dec 20, 2023•25 min
JCO PO author Dr. Sanjeevani Arora shares insights into her JCO PO article, " Exploring Stakeholders' Perspectives on Implementing Universal Germline Testing for Colorectal Cancer: Findings from a Clinical Practice Survey " Host Dr. Rafeh Naqash and Dr. Arora discuss germline genetic testing for all colorectal cancer (CRC) patients and advantages and barriers of implementing universal germline testing (UGT). TRANSCRIPT Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversations where...
Nov 22, 2023•24 min
JCO PO author Dr. Bryson Katona shares insights into his JCO PO article, "Outcomes of the IMMray PanCan-dTM test in High-Risk Individuals Undergoing Pancreatic Surveillance: Pragmatic Data and Lessons Learned." Host Dr. Rafeh Naqash and Dr. Katona discuss IMMray PanCan-d: A Blood-based Test for Early Detection of Pancreatic Cancer. TRANSCRIPT Dr. Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversations , where we bring you engaging conversations with authors of clinically relevant...
Oct 26, 2023•30 min
JCO PO author Dr. Jens Rueter Chief Medical Officer at The Jackson Laboratory and Medical Director of the Maine Cancer Genomics Initiative, shares insights into his JCO PO article, " The Maine Cancer Genomics Initiative: Implementing a Community Cancer Genomics Program Across an Entire Rural State ." Host Dr. Rafeh Naqash and Dr. Rueter discuss this successful initiative for patients and its implementation for access to precision oncology in rural settings. TRANSCRIPT Dr. Rafeh Naqash: Hello and...
Sep 20, 2023•34 min
JCO PO author Dr. Apar K. Ganti shares insights into his JCO PO article, "Pertuzumab Plus Trastuzumab in Patients With Lung Cancer With ERBB2 Mutation or Amplification: Results From the Targeted Agent and Profiling Utilization Registry Study." Host Dr. Rafeh Naqash and Dr. Ganti discuss clinical decision-making regarding biopsy; HER2 amplification, mutation, and targeted therapy; drug combinations; and aspects of the TAPUR and DESTINY-Lung studies. Click here to read the article! TRANSCRIPT Dr. ...
Aug 16, 2023•28 min
JCO PO author Dr. Alicia Latham shares insights into her JCO PO article, "Prevalence and Clinical Implications of Mismatch Repair-Proficient Colorectal Cancer in Patients With Lynch Syndrome." Host Dr. Rafeh Naqash and Dr. Latham discuss microsatellite instability-high status as well as familial risk and testing. Click here to read the article! TRANSCRIPT Dr. Rafeh Naqash: Hello, and welcome to JCO Precision Oncology Conversations , where we bring you engaging conversations with authors of clini...
Jul 19, 2023•26 min
