JAMAevidence JAMA Guide to Statistics and Methods

Interviews with authors of JAMA Guide to Statistics and Methods chapters about common and new statistics and methods used in clinical research and reported in medical journals.

Last refreshed: November 25th, 2025 at 4:55 PM ⓘ

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Episodes

Multiple Comparison Procedures from the JAMA Guide to Statistics and Methods

JAMA Deputy Editor Edward Livingston, MD, discusses " Multiple Comparison Procedures " with Dr. Jing Cao, PhD

Mar 04, 2021•23 min

Logistic Regression—What It Is and How to Use It in Clinical Research

Logistic regression is one of the most commonly used statistical analytic tools in the medical literature. William Meurer, MD, from the University of Michigan, and Juliana Tolles, MD, from UCLA, discuss a JAMA Guide to Statistics and Methods article they wrote entitled "Logistic Regression Diagnostics: Understanding How Well a Model Predicts Outcomes." Related Article: Logistic Regression

Jan 07, 2021•33 min

Randomization in Clinical Trials from the JAMA Guide to Statistics and Methods

Roger J. Lewis, MD, PhD, discusses Randomization in Clinical Trials from the JAMA Guide to Statistics and Methods Related Article(s): Randomization in Clinical Trials

Dec 03, 2020•23 min

The Stepped-Wedge Clinical Trial: Evaluation by Rolling Deployment

Cluster randomized trials are performed when an intervention must be delivered to a group of patients like when testing new nursing protocols on award or different means for cleaning beds on a ward. One type of cluster trials is called a stepped-wedge where every cluster in the study ultimately undergoes the intervention. How this works it is explained by Susan Ellenberg, PhD, from the Department of Biostatistics, Epidemiology, and Informatics at the University of Pennsylvania School of Medicine...

Sep 03, 2020•18 min

Minimal Clinically Important Difference: Defining What Really Matters to Patients

JAMA Deputy Editor Edward Livingston, MD, discusses Minimal Clinically Important Difference: Defining What Really Matters to Patients with Anna E. McGlothlin, PhD

Aug 06, 2020•12 min

Sample Size Calculation for a Hypothesis Test With Dr Lynne Stokes

One of the most common causes for problems we see in manuscripts at JAMA is an inappropriately calculated study sample size. This seemingly mysterious process is explained by Lynne Stokes, PhD, professor of Statistical Science at Southern Methodist University in Dallas, Texas.

Jul 02, 2020•12 min

Pragmatic Trials: Practical Answers to "Real-world" Questions With Harold C. Sox, MD

JAMA Deputy Editor Edward Livingston, MD, discusses Pragmatic Trials: Practical Answers to "Real-world" Questions with Harold C. Sox, MD, of PCORI

Jun 25, 2020•21 min

Cluster Randomized Trials: Evaluating Treatments Applied to Groups With William J. Meurer, MD

JAMA Deputy Editor Edward Livingston, MD, discusses "Cluster Randomized Trials: Evaluating Treatments Applied to Groups" with William J. Meurer, MD, MS

May 07, 2020•24 min

Noninferiority Trials: Is a New Treatment Almost as Effective as Another? with Dr Amy Kaji

Ed Livingston, MD, FACS, AGAF, discusses Noninferiority Trials: Is a New Treatment Almost as Effective as Another? with Amy Kaji, MD, PhD

Feb 06, 2020•11 min

JAMA Guide to Statistics and Methods

Clinical researchers and biostatisticians use highly specialized language to help them discuss statistics and research methods efficiently. In 2019 JAMA published the JAMA Guide to Statistics and Methods , a book of short reviews that translate that specialized language and explain statistics and methods to a broad physician readership. The book's editors and authors, Edward Livingston, MD, and Roger J. Lewis, MD, PhD, discuss their approach to choosing statistical topics and their objectives in...

Dec 05, 2019•14 min

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