JACC This Week - podcast cover

JACC This Week

American College of Cardiologywww.jacc.org
A weekly co-hosted podcast featuring JACC Editor-in-Chief Harlan M. Krumholz, MD, SM, FACC and JACC Senior Consulting Editor Carolyn S.P. Lam, MBBS, PhD, giving readers context on our weekly issues. Listen in as they break down the latest trends and share practical tips that are changing the way heart care works globally.
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Episodes

The Super Bowl & HCM Proteomics | JACC Baran

In this second entry in the JACC-Baran Japanese language series, JACC Executive Associate Editor Mitsuaki Sawano, MD, Shun Kohsaka, MD, FACC, and Yuichi Shimada, MD, MPH, speak on topics ranging from all things Super Bowl to Dr. Shimada's recently published JACC paper, Comprehensive Proteomic Profiling of Human Myocardium Reveals Signaling Pathways Dysregulated in Hypertrophic Cardiomyopathy.

Feb 18, 202537 min

Standardized Definitions of Changes in Kidney Function in Trials of Heart Failure: JACC Expert Panel From the HF-ARC

Dr. Valentin Fuster discusses the February 2025 issue of JACC, which focuses on advancements in heart failure research. The discussion covers five key sections: heart failure with preserved ejection fraction, hypertrophic cardiomyopathy, cardiac amyloidosis, standardization of kidney function, and ICD therapy for primary prevention in heart failure patients. Experts explore emerging therapies, diagnostic thresholds, and the potential impact of blood pressure and genetics on patient outcomes, und...

Feb 17, 20251 hr 2 min

Myocardial Fibroblast Activation After Acute Myocardial Infarction: A Positron Emission Tomography and Magnetic Resonance Study

In this podcast, Dr. Valentin Fuster discusses a groundbreaking study by Dr. Anna Barton and her team on myocardial fibroblast activation following acute myocardial infarction. Using advanced imaging techniques, the research uncovers how fibroblast activity plays a critical role in heart remodeling, revealing that fibrosis is dynamic and may offer new therapeutic opportunities for preventing heart failure and improving long-term recovery after heart attacks.

Feb 10, 202512 min

Treating Older Patients in Cardiogenic Shock With a Microaxial Flow Pump: Is it DANGERous?

In this podcast, Dr. Valentin Fuster discusses a study on the use of the microaxial flow pump (Impella) in treating older patients with cardiogenic shock following a myocardial infarction. The findings suggest that while the Impella pump can reduce mortality in younger patients, its effectiveness diminishes in those over 77, highlighting the need for age-based patient selection to optimize outcomes in this complex condition.

Feb 10, 20259 min

Associations of Short-Term Ozone Exposure With Hypoxia and Arterial Stiffness

In this podcast, Dr. Valentin Fuster discusses a study examining the impact of short-term ozone exposure on arterial stiffness and cardiovascular health. The research reveals that ozone may reduce oxygen availability, triggering compensatory responses like increased red blood cell count, which contributes to arterial stiffness, and emphasizes the need for further research into the biological mechanisms linking ozone exposure to cardiovascular diseases.

Feb 10, 202510 min

Randomized Comparison of Novel Low-Dose Sirolimus-Eluting Biodegradable Polymer Stent vs Second-Generation DES: TARGET-IV NA Trial

In this podcast, Dr. Valentin Fuster discusses the Target for NA trial, which compares biodegradable polymer stents to second-generation drug-eluting stents for coronary intervention. While the results showed the biodegradable stents were non-inferior in preventing target lesion failure, questions remain regarding their real-world performance and procedural handling in clinical practice.

Feb 10, 202512 min

JACC - Preprints: A Revolution in Cardiovascular Science

Don't miss this new editorial from Harlan M Krumholz, MD, SM, FACC, FAHA, and Joshua D. Wallach, PhD, MS, which discusses the transformative role of preprints in scientific publishing, particularly in cardiovascular research, highlighting their potential to accelerate discoveries, foster collaboration, and increase transparency. It outlines the updated policy of the JACC that encourages authors to post preprints before submission, emphasizes transparency and version control, and integrates with ...

Feb 10, 20258 min

2024 ACC Expert Consensus Decision Pathway on Practical Approaches for Arrhythmia Monitoring After Stroke: A Report of the American College of Cardiology Solution Set Oversight Committee

In this episode of JACC, Dr. Valentin Fuster explore the 2024 ACC Expert Consensus on arrhythmia monitoring following a stroke, outlining critical insights on stroke types, arrhythmia detection, and anticoagulation strategies. The discussion highlights the complexities of identifying atrial fibrillation post-stroke and the challenges of choosing optimal antithrombotic therapy in diverse stroke cases.

Feb 10, 202513 min

JACC - February 18, 2025 Issue Summary

In this February 18, 2025 issue of the JACC, Dr. Valentin Fuster presents groundbreaking studies on topics such as biodegradable polymer stents, myocardial fibroblast activation after heart attacks, and the role of microaxial flow pumps in treating cardiogenic shock. The issue also explores the dangers of ozone exposure on arterial stiffness and highlights expert consensus on arrhythmia monitoring after strokes, offering valuable insights for both cardiology practitioners and researchers.

Feb 10, 202526 min

Management of Coronary Stent Underexpansion

In this podcast, Dr. Valentin Fuster introduces a detailed review on managing coronary stent under-expansion, a critical issue that increases risks like restenosis and myocardial infarction. The discussion highlights the causes, challenges, and treatment strategies for under-expanded stents, emphasizing the importance of intravascular imaging and individualized approaches to optimize patient outcomes.

Feb 10, 20256 min

Secondary Prevention Medications in 17 Countries Grouped by Income Level (PURE): A Prospective Cohort Study

Section 1: Introduction (0:00 - 5:30) Dr. Valentin Fuster introduces a special issue on Prevention, covering societal and individual prevention aspects and key cardiovascular risk factors. He highlights issues like medication adherence, obesity, and the need for better education and healthcare systems. Section 2: Prevention in Society (5:30 - 35:30) Adherence to Medications The PURE trial shows low medication adherence (31% at follow-up) across 17 countries, despite technological advancements in...

Feb 03, 20251 hr 3 min

Incidental and Progressive Tobacco Smoking in Childhood and Subsequent Risk of Premature Cardiac Damage

Section 1: Introduction (0:00 - 5:30) Dr. Valentin Fuster introduces a special issue on Prevention, covering societal and individual prevention aspects and key cardiovascular risk factors. He highlights issues like medication adherence, obesity, and the need for better education and healthcare systems. Section 2: Prevention in Society (5:30 - 35:30) Adherence to Medications The PURE trial shows low medication adherence (31% at follow-up) across 17 countries, despite technological advancements in...

Feb 03, 20251 hr 3 min

Intensive Lifestyle Intervention, Cardiac Biomarkers, and Cardiovascular Outcomes in Diabetes: Look AHEAD Cardiac Biomarker Ancillary Study

Section 1: Introduction (0:00 - 5:30) Dr. Valentin Fuster introduces a special issue on Prevention, covering societal and individual prevention aspects and key cardiovascular risk factors. He highlights issues like medication adherence, obesity, and the need for better education and healthcare systems. Section 2: Prevention in Society (5:30 - 35:30) Adherence to Medications The PURE trial shows low medication adherence (31% at follow-up) across 17 countries, despite technological advancements in...

Feb 03, 20251 hr 3 min

Accelerometer-Measured Sedentary Behavior and Risk of Future Cardiovascular Disease

Section 1: Introduction (0:00 - 5:30) Dr. Valentin Fuster introduces a special issue on Prevention, covering societal and individual prevention aspects and key cardiovascular risk factors. He highlights issues like medication adherence, obesity, and the need for better education and healthcare systems. Section 2: Prevention in Society (5:30 - 35:30) Adherence to Medications The PURE trial shows low medication adherence (31% at follow-up) across 17 countries, despite technological advancements in...

Feb 03, 20251 hr 3 min

Intraindividual Variability in Serial Lipoprotein(a) Concentrations Among Placebo-Treated Patients in the OCEAN(a)-DOSE Trial

Section 1: Introduction (0:00 - 5:30) Dr. Valentin Fuster introduces a special issue on Prevention, covering societal and individual prevention aspects and key cardiovascular risk factors. He highlights issues like medication adherence, obesity, and the need for better education and healthcare systems. Section 2: Prevention in Society (5:30 - 35:30) Adherence to Medications The PURE trial shows low medication adherence (31% at follow-up) across 17 countries, despite technological advancements in...

Feb 03, 20251 hr 3 min

Long-Term Lipid Lowering With Evolocumab in Older Individuals

Section 1: Introduction (0:00 - 5:30) Dr. Valentin Fuster introduces a special issue on Prevention, covering societal and individual prevention aspects and key cardiovascular risk factors. He highlights issues like medication adherence, obesity, and the need for better education and healthcare systems. Section 2: Prevention in Society (5:30 - 35:30) Adherence to Medications The PURE trial shows low medication adherence (31% at follow-up) across 17 countries, despite technological advancements in...

Feb 03, 20251 hr 3 min

Social Determinants of Health, Cardiovascular Health, and Mortality in Sexual Minority Individuals in the United States

Section 1: Introduction (0:00 - 5:30) Dr. Valentin Fuster introduces a special issue on Prevention, covering societal and individual prevention aspects and key cardiovascular risk factors. He highlights issues like medication adherence, obesity, and the need for better education and healthcare systems. Section 2: Prevention in Society (5:30 - 35:30) Adherence to Medications The PURE trial shows low medication adherence (31% at follow-up) across 17 countries, despite technological advancements in...

Feb 03, 20251 hr 3 min

Navigating the 2024 ESC Hypertension Guidelines: What Is New, Context, and Future Directions

Section 1: Introduction (0:00 - 5:30) Dr. Valentin Fuster introduces a special issue on Prevention, covering societal and individual prevention aspects and key cardiovascular risk factors. He highlights issues like medication adherence, obesity, and the need for better education and healthcare systems. Section 2: Prevention in Society (5:30 - 35:30) Adherence to Medications The PURE trial shows low medication adherence (31% at follow-up) across 17 countries, despite technological advancements in...

Feb 03, 20251 hr 3 min

Real-World Efficacy and Safety of Inclisiran: A Single-Country, Multicenter, Observational Study (CHOLINET Registry)

Section 1: Introduction (0:00 - 5:30) Dr. Valentin Fuster introduces a special issue on Prevention, covering societal and individual prevention aspects and key cardiovascular risk factors. He highlights issues like medication adherence, obesity, and the need for better education and healthcare systems. Section 2: Prevention in Society (5:30 - 35:30) Adherence to Medications The PURE trial shows low medication adherence (31% at follow-up) across 17 countries, despite technological advancements in...

Feb 03, 20251 hr 3 min

Higher Aircraft Noise Exposure Is Linked to Worse Heart Structure and Function by Cardiovascular MRI

Section 1: Introduction (0:00 - 5:30) Dr. Valentin Fuster introduces a special issue on Prevention, covering societal and individual prevention aspects and key cardiovascular risk factors. He highlights issues like medication adherence, obesity, and the need for better education and healthcare systems. Section 2: Prevention in Society (5:30 - 35:30) Adherence to Medications The PURE trial shows low medication adherence (31% at follow-up) across 17 countries, despite technological advancements in...

Feb 03, 20251 hr 3 min

Semaglutide Improves Cardiovascular Outcomes in Patients With History of Coronary Artery Bypass Graft and Obesity

Section 1: Introduction (0:00 - 5:30) Dr. Valentin Fuster introduces a special issue on Prevention, covering societal and individual prevention aspects and key cardiovascular risk factors. He highlights issues like medication adherence, obesity, and the need for better education and healthcare systems. Section 2: Prevention in Society (5:30 - 35:30) Adherence to Medications The PURE trial shows low medication adherence (31% at follow-up) across 17 countries, despite technological advancements in...

Feb 03, 20251 hr 3 min

Advancing Prevention: Insights From JACC's Focus Issue

Section 1: Introduction (0:00 - 5:30) Dr. Valentin Fuster introduces a special issue on Prevention, covering societal and individual prevention aspects and key cardiovascular risk factors. He highlights issues like medication adherence, obesity, and the need for better education and healthcare systems. Section 2: Prevention in Society (5:30 - 35:30) Adherence to Medications The PURE trial shows low medication adherence (31% at follow-up) across 17 countries, despite technological advancements in...

Feb 03, 20251 hr 3 min

JACC - Transforming Publishing: Your Paper, Your Way at JACC

Harlan Krumholz, MD, FACC, FAHA, presents the "Your Paper, Your Way" (YPYW) initiative by JACC, which streamlines the manuscript submission process to prioritize content quality over formatting requirements. By minimizing logistical barriers, providing rapid review decisions, and fostering collaboration post-acceptance, JACC aims to respect authors' time and advance high-quality science efficiently.

Jan 28, 20257 min

Contributors and Solutions to High Out-of-Pocket Costs for Heart Failure Medications: A State-of-the-Art Review

In this podcast, Dr. Valentin Fuster discusses the growing issue of high out-of-pocket costs for heart failure medications and highlights potential solutions. The review covers a range of cost-saving strategies, such as prescription discount cards and patient assistance programs, and also explores policy changes, like those introduced by the Inflation Reduction Act, that aim to reduce medication costs for Medicare beneficiaries starting in 2025.

Jan 27, 202511 min

A Contemporary Picture of Coagulase-negative Staphylococcal Endocarditis: A Nationwide GAMES Cohort Study

In this podcast, Dr. Valentin Fuster discusses a study on Coagulase-negative Staphylococcal Endocarditis (CoNS), a growing concern in the healthcare setting, particularly among the elderly and those with comorbidities. The study's findings on high mortality rates, surgical interventions, and the promising future role of artificial intelligence in diagnosing and predicting the disease are highlighted, offering new perspectives on this complex and life-threatening condition.

Jan 27, 202511 min

2024 ACC Expert Consensus Decision Pathway on Strategies and Criteria for the Diagnosis and Management of Myocarditis

In this podcast, Dr. Valentin Fuster explores the 2024 ACC Expert Consensus on myocarditis, highlighting critical advancements in the understanding, diagnosis, and treatment of this condition. Key takeaways include the introduction of a new four-stage classification, updated diagnostic criteria, and the emphasis on timely referrals, while also addressing the importance of genetic counseling, ongoing patient follow-up, and the need for further research in this evolving field.

Jan 27, 202516 min

The Association of Hospital-Cardiologist Integration with Patient Outcomes, Care Quality, and Utilization

In this podcast, Dr. Valentin Fuster discusses a study comparing patient outcomes and care quality between cardiologists who transitioned from independent practice to hospital employment and those who remained independent. Despite a significant rise in hospital-employed cardiologists, the study reveals minimal differences in patient outcomes and care quality, challenging the assumption that hospital employment leads to better healthcare results.

Jan 27, 20258 min

Diagnostic Performance and Clinical Impact of Photon-Counting Detector Computed Tomography in Coronary Artery Disease

In this podcast, Dr. Valentin Fuster discusses a groundbreaking study comparing photon counting detector (PCD) CT technology with traditional EIDCT for diagnosing coronary artery disease. The research suggests that PCDCT offers superior specificity and diagnostic accuracy, potentially replacing older methods, and could revolutionize cardiac imaging by reducing the need for invasive procedures and improving patient outcomes.

Jan 27, 20259 min

P2Y12 Inhibitor Pretreatment in Non-ST Elevation Acute Coronary Syndrome: The NCDR Chest Pain-MI Registry

In this podcast, Dr. Valentin Fuster discusses a study on the use of P2Y12 inhibitor pretreatment in patients with non-ST elevation acute coronary syndrome, revealing significant variability in its application across institutions and operators. Despite initial hypotheses of benefit, the findings indicate no significant difference in patient outcomes, suggesting that routine pretreatment may not be necessary, especially when treatment is initiated within 24 hours of symptom onset.

Jan 27, 20259 min

JACC - February 4, 2025 Issue Summary

In this episode of JACC podcast, Dr. Valentin Fuster highlights key studies from the February 4th, 2025 issue, including the rising prevalence and mortality of coagulase-negative staphylococcal endocarditis and the clinical implications of new diagnostic technologies like photon-counting detector CT for coronary artery disease. Other highlights include discussions on P2Y12 inhibitor pretreatment in acute coronary syndrome, cardiologist integration into hospital systems, and reviews on heart fail...

Jan 27, 202525 min
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