JACC Specialty Journals - podcast cover

JACC Specialty Journals

American College of Cardiology•www.jacc.org
Health & Fitness
Medicine
Science
Life Sciences
In this podcast series, editors-in-chief from the JACC family of specialty journals provide highlights and summarize key findings for select issues. Published by the American College of Cardiology, the JACC Journals publish peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies, translational investigations with clear clinical relevance, state-of-the art papers, and review articles. They are top ranked for impact factor and their manuscripts are among the most covered by media outlets, most talked about on social media, and most read online.
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Episodes

A Pulsed Field Ablation-Based Endocardial Strategy for Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy | JACC: Clinical Electrophysiology

In this podcast, Francis Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a novel pulsed field ablation–based endocardial strategy for ventricular tachycardia in patients with arrhythmogenic right ventricular cardiomyopathy. The paper presents an early consecutive experience demonstrating the feasibility, acute effectiveness, and safety of PFA for VT without the need for epicardial access. Dr. Marchlinski highlights the clinical implications of this approach and how ...

Apr 23, 2026•4 min

Incidence of Worsening Aortic Regurgitation After Mapping and Ablation in the Aortic Cusps | JACC: Clinical Electrophysiology

In this podcast, Francis Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a large multicenter study evaluating the incidence and clinical significance of aortic regurgitation following mapping and ablation of ventricular arrhythmias in the aortic cusps and commissures. Drawing on contemporary data from four high‑volume centers, the paper provides important reassurance regarding the safety of aortic cusp ablation, demonstrating that clinically significant aortic regur...

Apr 23, 2026•4 min

Long PR Interval Leads to Atrial Remodeling, Fibrosis and Inducible Atrial Fibrillation in a Swine Model | JACC: Clinical Electrophysiology

Deputy Editor Kenneth Ellenbogen presents an in‑depth discussion of the study "Long PR Interval Leads to Atrial Remodeling, Fibrosis and Inducible Atrial Fibrillation in a Swine Model." In this episode, Dr. Ellenbogen walks listeners through how prolonged atrioventricular conduction can drive structural and electrical remodeling in the atria, leading to fibrosis and increased susceptibility to atrial fibrillation. He highlights the significance of these findings for understanding AF pathophysiol...

Apr 23, 2026•3 min

Cardiac Biomarker Complete Response in AL Amyloidosis | JACC: CardioOncology

Dr. Michel G. Khouri reviews a landmark study examining patients with AL amyloidosis who achieved a complete cardiac biomarker response, highlighting profound improvements in cardiac structure, function, and long-term survival that rival the general population. The discussion underscores the transformative impact of early diagnosis and modern plasma cell–directed therapies, while reminding clinicians that ongoing multidisciplinary cardiac care remains essential even after sustained cardiac remis...

Apr 21, 2026•4 min

Myocardial Expression of PD-L1 as a Marker of Poor Prognosis in Immune Checkpoint Inhibitor–Associated Myocarditis | JACC: CardioOncology

Research fellow, Adrian Chen, discusses a multicenter study evaluating myocardial PD‑L1 expression as a prognostic biomarker in immune checkpoint inhibitor–associated myocarditis. The conversation highlights how elevated myocardial PD‑L1 identifies patients at markedly higher risk for early adverse cardiac events and explores its potential role in improving risk stratification and guiding earlier, more aggressive therapy in this high‑risk population.

Apr 21, 2026•2 min

Cardiovascular Adverse Events Associated with Bispecific T-cell Engager Therapy | JACC: CardioOncology

Dr. Qun Shao discusses two multicenter studies evaluating cardiovascular adverse events associated with bispecific T‑cell engager therapies. Drawing on data from over 700 patients, the episode highlights the incidence, predictors, and clinical impact of cardiovascular complications, emphasizing the importance of baseline risk assessment, targeted monitoring, and multidisciplinary management as use of these therapies continues to expand.

Apr 21, 2026•3 min

The Future of Cardio-Oncology: Progress and Priorities | ACC.26 | JACC: CardioOncology

At ACC.26, Dr. Tharshini Ramalingam speaks with JACC: CardioOncology Editor-in-Chief Dr. Bonnie Ky about the rapid evolution of cardio-oncology, the field's most urgent priorities, and the need for stronger evidence, risk prediction, cardioprotective strategies, and global implementation. Dr. Ky also shares practical advice for early-career investigators on mentorship, resilience, and what makes a manuscript impactful, rigorous, and truly additive to the field.

Apr 14, 2026•5 min

Cardiogenic Shock From ICI Myocarditis With Predominant RV Failure | ACC.26 | JACC: CardioOncology

In this ACC.26 interview, Dr. Tharshini Ramalingam speaks with Dr. Eric Yang of UCLA about a rare and sobering case presented at ACC.26 of immune checkpoint inhibitor myocarditis with predominant right ventricular failure and cardiogenic shock. Their discussion highlights the diagnostic complexity of atypical myocarditis, the importance of recognizing unusual presentations, and the need for better screening, imaging, and phenotyping strategies in cardio-oncology care and research.

Apr 14, 2026•6 min

The Future of Cardio-Oncology: Progress and Priorities | ACC.26 | JACC: CardioOncology

At ACC.26, Dr. Tharshini Ramalingam speaks with JACC: CardioOncology Editor-in-Chief Dr. Bonnie Ky about the rapid evolution of cardio-oncology, the field's most urgent priorities, and the need for stronger evidence, risk prediction, cardioprotective strategies, and global implementation. Dr. Ky also shares practical advice for early-career investigators on mentorship, resilience, and what makes a manuscript impactful, rigorous, and truly additive to the field.

Apr 14, 2026•6 min

Return-to-Play for Athletes with Desmosomal Arrhythmogenic Cardiomyopathy: A Single Center Experience | JACC: Clinical Electrophysiology

Deputy Editor Kenneth Ellenbogen hosts a focused discussion on the study "Return‑to‑Play for Athletes with Desmosomal Arrhythmogenic Cardiomyopathy: A Single Center Experience." In this episode, Dr. Ellenbogen examines how desmosomal arrhythmogenic cardiomyopathy impacts athletic participation and highlights real‑world insights from a single‑center cohort. He walks listeners through the clinical considerations, risk assessment strategies, and decision‑making frameworks that guide safe return‑to‑...

Apr 14, 2026•6 min

Functional Conduction Block During Extra-Stimulus Mapping Masks Deceleration Zones and Reveals Additional VT Substrate | JACC: Clinical Electrophysiology

Deputy Editor Francis Marchlinski hosts a deep‑dive discussion on the study "Functional Conduction Block During Extra‑Stimulus Mapping Masks Deceleration Zones and Reveals Additional VT Substrate." In this episode, Dr. Marchlinski explores how extra‑stimulus pacing can alter the visualization of critical conduction deceleration zones and uncover previously hidden components of the ventricular tachycardia substrate. He breaks down the clinical implications of these dynamic changes and what they m...

Apr 14, 2026•5 min

His Pacing vs Biventricular Pacing for Cardiac Resynchronization Therapy | JACC: Clinical Electrophysiology

In this episode, Dr. Kenneth Ellenbogen, Deputy Editor of JACC: Clinical Electrophysiology, discusses new long-term findings from the His-Alternative I trial, the first European randomized study comparing His-bundle pacing with conventional biventricular pacing for cardiac resynchronization therapy (CRT). He highlights five-year outcomes demonstrating that when His-bundle pacing is achieved with low implant thresholds, its long-term performance—including lead stability, generator replacements, a...

Apr 13, 2026•3 min
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