The Transmural Activation Interval in Dilated Cardiomyopathy: A New Mapping Tool for Intramural VT Substrates | JACC: Clinical Electrophysiology
Commentary by JACC: Clinical Electrophysiology Deputy Editor Francis Marchlinski, MD.
Feb 18, 2026•4 min
JACC Specialty Journals
In this podcast series, editors-in-chief from the JACC family of specialty journals provide highlights and summarize key findings for select issues. Published by the American College of Cardiology, the JACC Journals publish peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies, translational investigations with clear clinical relevance, state-of-the art papers, and review articles. They are top ranked for impact factor and their manuscripts are among the most covered by media outlets, most talked about on social media, and most read online.
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Episodes
February 2026 Full Issue Summary | JACC: CardioOncology
JACC: CardioOncology Volume 8 Issue 1 Full Issue Summary with Introduction by Dr. Bonnie Ky, Editor-in-Chief
Feb 17, 2026•15 min
Polygenic risk for cardiometabolic and cardiovascular disease in a multi-ethnic cohort of breast cancer survivors | JACC: CardioOncology
Polygenic risk scores showed associations with several cardiometabolic outcomes in breast cancer survivors but did not improve prediction beyond traditional clinical factors. Their performance varied across ancestry groups and was weakened in patients exposed to cardiotoxic therapies, highlighting limits of current genetic risk tools.
Feb 17, 2026•3 min
Systemic Manifestations and Mortality Risk in Transthyretin V142I Variant Carriers: A Million Veteran Program Analysis | JACC: CardioOncology
This study analyzes over 2,600 transthyretin V142I variant carriers in the Million Veteran Program and finds significantly elevated risks of heart failure, cardiomyopathy, arrhythmias, neuropathy, and musculoskeletal complications compared with matched controls. Despite these risks, amyloidosis was rarely diagnosed clinically, underscoring major gaps in recognition and the need for earlier identification and multidisciplinary intervention.
Feb 17, 2026•3 min
Atrial Fibrillation Following Autologous Stem Cell Transplantation in Multiple Myeloma: Incidence, Predictors, and Prognostic Impact | JACC: CardioOncology
This study of 801 multiple myeloma patients found that atrial fibrillation occurred in 5.5% within 90 days after autologous stem cell transplantation—nearly double previously reported rates—indicating disease‑specific risks. AF strongly predicted mortality from non‑relapse causes and may serve as a marker of physiological vulnerability, emphasizing the value of expanded pre‑transplant cardiac assessment and monitoring.
Feb 17, 2026•3 min
CRISPR/Cas9 screens implicate RARA and SPNS1 in doxorubicin cardiotoxicity | JACC: CardioOncology
Researchers used genome‑wide CRISPR/Cas9 loss‑of‑function screens in cardiomyocytes to identify RARA and SPNS1 as key modulators of doxorubicin cardiotoxicity, highlighting pathways that influence both injury susceptibility and intracellular drug handling. Activation of RARA reduced toxicity without impairing anticancer effects, while SPNS1 loss caused harmful drug accumulation, offering new mechanistic insights and potential therapeutic targets.
Feb 17, 2026•3 min
Genotype-Guided vs. Conventional P2Y12 Inhibitors in ACS | JACC: CV Interventions | JACC: Cardiovascular Interventions
Mirza Umair Khalid, MD, Social Media Editor for JACC: Cardiovascular Interventions, and Mattio Galli, MD, PhD, discuss a recently published original research paper analyzing the role of genotype-guided escalation or de-escalation of antiplatelet therapy in acute coronary syndrome (ACS).
Feb 13, 2026•7 min
Bleeding in infarct related cardiogenic shock: DanGer Shock substudy | JACC: CV Interventions | JACC: Cardiovascular Interventions
Mirza Umair Khalid, MD, Social Media Editor for JACC: Cardiovascular Interventions, and Rikke Sørensen, MD, PhD, discuss a recently published original research paper from DanGer Shock substudy analyzing the bleeding events in patients with infarct related cardiogenic shock.
Feb 13, 2026•6 min
Brief Introduction - Sex Disparities in Ischemic Heart Disease in South Asia: The Role of Dietary Factors
Commentary by Dr. Jian'an Wang.
Feb 06, 2026•57 sec
Brief Introduction - Risk Prediction Models of Cardiotoxicity in Patients With Breast Cancer: Multicenter Prospective CHECK HEART-BC Study | JACC: Asia
Commentary by Dr. Jian'an Wang.
Feb 06, 2026•44 sec
Brief Introduction - Interconnected Pathways and Therapeutic Implications for Cardiovascular Aging and Diseases | JACC: Asia
Commentary by Dr. Jian'an Wang.
Feb 06, 2026•34 sec
Brief Introduction - Sleep Patterns and Blood Pressure Among Chinese Adults in Different Ethnic Groups Across Varied Altitudes | JACC: Asia
Commentary by Dr. Jian'an Wang.
Feb 06, 2026•48 sec
Brief Introduction - Stepwise Assessment of Computational Coronary Physiology and Plaque Vulnerability: Impact on Coronary Revascularization Decision Making | JACC: Asia
Commentary by Dr. Jian'an Wang.
Feb 06, 2026•1 min
Brief Introduction - Effect of Proton Pump Inhibitors in Patients Undergoing Percutaneous Coronary Intervention With Aspirin-Free Strategy | JACC: Asia
Commentary by Dr. Jian'an Wang.
Feb 06, 2026•1 min
Brief Introduction - Associations Between Right Ventricular Remodeling, Exercise and Circulating Metabolites in Volume and Pressure Overload States | JACC: Asia
Commentary by Dr. Jian'an Wang.
Feb 06, 2026•44 sec
Integrated Use of Late Gadolinium Enhancement and Left Ventricular Global Longitudinal Strain in Hypertrophic Cardiomyopathy | JACC: Asia
Commentary by Dr. Thomas Zegkos.
Feb 03, 2026•4 min
Sleep Patterns and Blood Pressure Among Chinese Adults in Different Ethnic Groups Across Varied Altitudes | JACC: Asia
Commentary by Dr. Chhabi Satpathy.
Feb 03, 2026•4 min
New-Onset Conductance Disturbances After TTVR | JACC: CV Interventions | JACC: Cardiovascular Interventions
Mirza Umair Khalid, MD, social media editor of JACC: Cardiovascular Interventions, and Dr. Rebecca Hahn, MD discuss a recently published study examining new onset conduction disturbances after TTVR.
Jan 30, 2026•6 min
Additive Benefit of Guideline-Directed Medical Therapies at Discharge in Reducing 30-Day Readmissions in Heart Failure | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Additive Benefit of Guideline-Directed Medical Therapies at Discharge in Reducing 30-Day Readmissions in Heart Failure.
Jan 28, 2026•3 min
Vascular Health and Early Atherosclerosis in Childhood Cancer Survivors: Reassuring Findings From Comprehensive Noninvasive Assessment | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Vascular Health and Early Atherosclerosis in Childhood Cancer Survivors: Reassuring Findings From Comprehensive Noninvasive Assessment.
Jan 28, 2026•3 min
Association Between Air Pollution and Monday Peak Mortality From Acute Myocardial Infarction | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Association Between Air Pollution and Monday Peak Mortality From Acute Myocardial Infarction.
Jan 28, 2026•3 min
Associations of Electromechanical Activation Time With Cardiac Structure and Function and Clinical Outcomes | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Associations of Electromechanical Activation Time With Cardiac Structure and Function and Clinical Outcomes.
Jan 28, 2026•3 min
Association of Pulmonary Artery Compliance and Adverse Cardiac Events | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Association of Pulmonary Artery Compliance and Adverse Cardiac Events.
Jan 28, 2026•3 min
The Association Between Office, Video, and Telemanagement Encounters and GDMT Optimization in Advanced HFrEF | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on The Association Between Office, Video, and Telemanagement Encounters and GDMT Optimization in Advanced HFrEF.
Jan 28, 2026•3 min
Long-Term Outcomes: Beta-Blocker Use and Permanent Pacing in Patients With Heart Failure Preserved Ejection Fraction | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Long-Term Outcomes: Beta-Blocker Use and Permanent Pacing in Patients With Heart Failure Preserved Ejection Fraction.
Jan 28, 2026•2 min
Clinical Decision-Making of Artificial Intelligence vs Medical Professionals in Patients With Syncope | JACC: Advances
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Clinical Decision-Making of Artificial Intelligence vs Medical Professionals in Patients With Syncope.
Jan 28, 2026•3 min
Cerebrovascular Ischemic Lesions After Pulsed Field Ablation for Atrial Fibrillation Using Variable-Loop Ablation Catheter | JACC: Clinical Electrophysiology
Dr. Emile Daoud, Deputy Editor of JACC Clinical Electrophysiology discusses Cerebrovascular Ischemic Lesions After Pulsed Field Ablation for Atrial Fibrillation Using Variable-Loop Ablation Catheter.
Jan 27, 2026•15 min
Transcatheter Tricuspid Valve Replacement in Patients with Cardiac Implantable Electronic Device Endocardial Leads: The TRIPLACE Registry | JACC: Clinical Electrophysiology
Commentary by JACC: Clinical Electrophysiology Executive Editor Emile Daoud, MD.
Jan 27, 2026•11 min
January 2026 Issue Summary | JACC: Asia
Audio Summary of the January 2026 Issue of JACC: Asia, by Dr. Jian'an Wang.
Jan 16, 2026•12 min
Brief Introduction - Transcatheter Electrosurgery in the Asia-Pacific: Implementation and Innovations | JACC: Asia
Commentary by Dr. Jian'an Wang.
Jan 16, 2026•57 sec
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