Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's I will be covering details about Dosing schedules. I will be narrating definition, aims and objectives, different conditions and states as far as duration of half lives are concerned.You will notice how importantly duration of half life affects the route of drug administration, the frequency of dosing, the dosage form, the dosing schedule! Thats the essence of the topic, Later, I will be summarising important poin...
Jul 19, 2021•14 min•Season 17Ep. 75
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, I will be emphasizing on the value of Wait, Patience and waiting for worthwhile things in life! That actually makes a lot of sense!The heading of today's talk dancing in fonts is the "plasma half life of drug".To start with, its a good ritual to define the topic and then discuss the minute details, and so will I do. After definition, I will be focussing on deriving a formula for the same and very efficien...
Jul 07, 2021•10 min•Season 17Ep. 74
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode I will be emphasizing the essence and feel of returning home after long work hours or days out, its actually great and conveyed today in a quite melodious way!! Hope you all like it. Today's topic is Zero Order Elimination Kinetics. I will discuss the importance, examples and very nicely describe the mechanism and characteristics in bullet points. The effect on half life, clearance , all will be crystal c...
Jun 28, 2021•10 min•Season 17Ep. 73
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Today I will be emphasizing on the upper hand power of listening over hearing! Yes, both are so different, we actually rarely listen!! Today, I want you all to listen to me. What are the different features of First order kinetics of elimination and what is the essence of knowing it all? All these quests will be resolved in today's episode. No delays and i will break into the features straightaway of First Order Kinetics of ...
Jun 22, 2021•9 min•Season 16Ep. 72
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, I will be emphasizing the hand in hand coordination of knowledge and wisdom. To start with, I will tell you the essence of knowledge of Drug elimination kinetics. I will define the topics and areas it covers, what all and why do we need to know it thoroughly!! The beginnings will be stated by defining the subhead for the day and it sounds like 'Drug Clearance". I will first be defining it, then I will gi...
Jun 17, 2021•10 min•Season 15Ep. 71
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, I know the essence of French Open Tournament, wishing your favourite player the bestest of luck and wishes, if I am interrupting the score commentary, I do apologise, and promising a laconic set of colloque for the great Sunday, I break the ice with left over pizza pieces, i mean conversation about renal routes of drug elimination, in that too specifically , I will limit my talks to one process i.e. tubu...
Jun 13, 2021•7 min•Season 14Ep. 70
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. I will be starting today's episode with a beautiful thought compilation about "Lantern" and the book "Sky Lantern" by Matt Makeloto, its a lovely contemplation! Then i will cover the start of last route of Drug Elimination for our list and it is the Renal Excretion. Its the interplay and mathematics of three key processes namely Glomerular filtration, Tubular reabsorption and Tubular Secretion. For the bright today, I will ...
Jun 10, 2021•9 min•Season 13Ep. 69
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's bonus episode, i will be covering a true bonus value topic about Drug dosage, there are 5 types that I will talk about, namely 1. Fixed Dose 2. Variable dose (with crude adjustments) 3. Variable dose (with fine adjustments) 4. Maximum tolerated dose 5. Minimum tolerated Dose. Describing the essence of a bonus episode on Bonus Sunday, do l et me what it means for you? With a short lived bonus episode, I will be wr...
Jun 05, 2021•9 min•Season 12Ep. 68
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode I will talk about the whole details, mechanics and essence of Elimination of drugs in breast milk. Why this knowledge is important? is the first question answered. Then I will discuss some physiological rules, mechanism of action governing it, all the processes involved and much more.... Next I will give few examples, explain the much involved Ion trapping mechanism, etc I will be covering a list of Drugs...
Jun 05, 2021•12 min•Season 11Ep. 67
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Live your life by a compass not by a clock, with this mantra, I will break the ice for today's episode, always try to be a compass, not an anchor, not a ship! With a compass, you will realise that all those who wander are not lost!! Today's education compass points towards Various routes of Drug Elimination and while I continue the untold part further, today's first head of talk is Feacal elimination, I will discuss in deta...
Jun 02, 2021•8 min•Season 10Ep. 66
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, I will answer your question , the one centred around topic of the day-"How drugs are eliminated?"Then I will tell you the difference in terms Excretion and Elimination. I will then start off the talk with discussions about Presystemic metabolism or First pass metabolism. After deriving an equation about Hepatic Extraction Ratio, I will officially start my talks about topic of the day i.e. Introduction to...
May 31, 2021•11 min•Season 9Ep. 65
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Let us be quite very truly, genuinely be thoughtful, in deepest mindset very thankful to lord for the blessings countable and easily experienced as cool showers amongst hot humid weathers! The trendy topic for a thankful Thursday is knowledge of factors affecting drug metabolism or drug biotransformation. The most important ones are age, genetic variations, diet, food, nutrition components , drug interactions and pathologic...
May 27, 2021•15 min•Season 8Ep. 64
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode I will talk about definition, important details, clinical relevance and apt examples regarding both enzyme induction and enzyme inhibition. Though a little lengthy episode but no regrets for action, its only meant for inaction!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually c...
May 23, 2021•17 min•Season 7Ep. 63
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, my advice to be expanded all throughout today's tell tales is "Follow the river and you will reach the sea". Yes to embrace the immensity, vastness of sea, you need to follow the particular mannerism and fashion of a task consistently in order to experience the completion and sufficiency. With this thread in our hand, lets start spinning up the introduction to our episode, it starts with Phase 1 reaction...
May 20, 2021•15 min•Season 6Ep. 62
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Wonder is the beginning of wisdom!! I'd rather open my mind with wonder than close it with belief!! That's the mantra for today as I start the topic of day which goes on like "Drug Metabolising Enzymes-1" I will start my convo by classifying metabolising enzymes into Microsomal and Non microsomal. Then I will throw light on each of the characteristics, features, sub heads and examples of each type, their details though not ...
May 18, 2021•12 min•Season 5Ep. 61
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. I will make you through a joyride of the zoo, the yester tears you explored fondantly the wildlife, the giraffe, the monkeys, the royal bengal tiger!! I know it was a trip or picnic or educational tour, if it were not a zoo, many species would have become extinct. Cleverly, I will shift your mindset to the topic of the day i.e. chemical reactions of biotransformation of drugs.The drugs primarily go through two main reaction...
May 15, 2021•10 min•Season 4Ep. 60
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. A little floating in days of my painting lessons, I describe my still life painting as I post it today on my audiogram, this is how I begin today's convo, the colors of today's episode stand out to tell the topic of day, the drug metabolism or biotransformation of drugs! I will be defining it for you all, will tell its essence and features. Then I will throw some light on the variety, mainly three consequences of the proces...
May 13, 2021•8 min•Season 2Ep. 59
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. I'm gonna sing a song by Maher Zain in the beginning of the episode as a true epitope of admiration for all the mothers, mine, yours, and everyone's. Then I will start my short and sensible talk about Redistribution of drugs! Well I will start with definition, the basic features, then explanation with examples of apt drugs will govern the discussion heads, that is how I will explain the whole topic, its essence and its vari...
May 09, 2021•6 min
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. A poetic standing ovation for all the blessed weavers worldwide, I begin today's colloque in way written by the great Sarojini Naidu, the Nightingale of India,I read this poem in my primary section and performed well so remember it really nice, the motto of the day will be to weave new sentences out of old tales, the topic sounds like the "Apparent volume of distribution" I will explain the definition, the concept, then i w...
May 07, 2021•15 min
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode I will be giving you all a riddle to answer, travelling through the classical days of mailbox, that would make remember Benjamin Franklin, cards and letters, hope you enjoy this visit and the beautiful poetic riddle! Today's mail for the day has its topic enclosed as Plasma Protein Binding, under this head I will discuss the acidic and basic drug binding proteins, their rules, strategies, fixed mechanism,...
May 04, 2021•13 min
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode I will be opening the verbal documentary about various drug reservoirs found in our body apart from plasma proteins! One thing you need to get real clear in your mind is that Drug Binding is not equal to drug action! Hope that gets real well understood! I will start my talk with tissue binding of drug, to nucleoproteins, etc. Then I will lay emphasis on the importance of sites/tissues/places like aqueous ...
May 03, 2021•10 min
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, my head to head begins from an utter remembrance and admiration for the ruler of Grand slams, my favourite tennis player. Then I will bend the tides of talk by continuing yesterday's chat about barriers to drug distribution , my description will start by describing structural details of Blood-CSF and CSF-Brain barrier, the drugs that can or cannot pass through and then I will complete the words and detai...
May 01, 2021•8 min
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Today I will taking you all through the looney tunes home theatre to a new topic all in all namely the Distribution of Drugs. Describing initially the definition , finally I will discuss the first barrier to drug distribution namely the Blood Brain Barrier (BBB) .I will make you all remember and revise a little anatomical details that will help you understand the mechanism nicely. Keeping my confabulations short and crisp t...
Apr 30, 2021•8 min
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Taking you all through a long drive experience amongst the open skies, dawn time and mountain view, I would be inquiring within your choice of cars small or big and would be sharing my thoughts as to car defines not your personality but much of your budget defines the size of car. Well the car talk is just to let you all know, I got my car today, to drive my own ways!! Thats really enthralling.Finally we will find our termi...
Apr 29, 2021•17 min
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. With remembering and refreshing thoughts of the best days, the school days, specially beginnings of new class sessions, I will break the ice of today's episode in words of Dano Perino, this will arise the spirit of quest and query for the day's head of discussion, which is Bioavailability of Drugs! defining the term, Bioavailability, i will give a sneek peak into the historical origin of drug, then I will tell the measuring...
Apr 27, 2021•14 min
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Today is celebrated day to go for the 50th episode special of my podcast! To make it really special, I have taken a break from ongoing series and got a bonus episode for all of you discussing all the insights, the tots-bits of childrens depression psychopharmacology. yes its a really common problem in so many homes, lands and regions and needs a real talk today, so why hesitate? Let's talk about it today and open the associ...
Apr 24, 2021•25 min
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Hey!Hey!Hey! here comes the Friday, the weekend start and I have a real good news for you all that soon my half century will be hit and I will bring for you al La Fete episode which gonna be tres speciale! Today I will adding one more ring in the chain of Pharmacokinetics rigamarole, the discussion to form the preface of another day's chapter that unfolds something like this, the debut talks are about Inhalation route, in t...
Apr 23, 2021•13 min
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Today I will take you to the virtual pool of wishes coming true as you splash the coins facing your back towards it! The hour demands to wish harmony peace and health for all, wiping away this coin game scene, I will be introducing today's topic, absorption via parenteral routes of drug, in this today I will be talking about sub cutaneous, intra muscular and finally intra venous route, after discussing the complete absorpti...
Apr 21, 2021•10 min
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode I will talk about the relevance of administering drug via enteral route in regard to drug absorption. I will be discussing all the pros and cons of drug absorption as the drug is administered via different enteral routes like from mouth, into intestine, both small and large intestine, from sublingual, rectal routes. The whole talk will be in much detail with apt examples and yes! a word about first pass e...
Apr 20, 2021•15 min
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Its Sunday Matinee time and I am not the audience, but the host, As I steal a few moments from your precious day's time, I engrave and inscribe your lockdown diaries and learning via the chisel of my tongue. In today's episode I will be talking about "A" of the "ADME" study, it stands for absorption! I will broadly cover the little introductory part and then the basic determinants of absorption like area of absorption, vasc...
Apr 18, 2021•10 min
