From the 2024 Society for Leukocyte Biology meeting, Immune talks with Holger Heine about the discovery of immune recognition of bacterial lipopolysaccharide and innate immunity to organisms within the kingdom Archaea. Hosts: Cindy Leifer and Brianne Barker Guest: Holger Heine Become a patron of Immune! Links for this episode MicrobeTV Discord Server TLR8 recognizes human gut-associated archaeon (Front Immunol) The human archaeome and its relevance for health and disease (FEBS) Structural insigh...
May 13, 2025•24 min
Immune talks with David Peterson and Kim Klonowski from the University of Georgia about their careers, their People, parasites, and plagues podcast, placental malaria immunity, and and how interferons in the thymus affect T cell repertoire selection. Hosts: Vincent Racaniello , Cindy Leifer , Steph Langel , and Brianne Barker Guests: David Peterson and Kim Klonowski Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server People, p...
Apr 29, 2025•1 hr•Ep. 91
From the 2024 Society for Leukocyte Biology meeting, Immune talks with Amy Hise about her career in science, her current research using mouse models for investigating fungal immunity and navigating the challenges of being a mom in science. Hosts: Cindy Leifer and Brianne Barker Guest: Amy Hise MicrobeTV Discord Server Mouse model for testing drugs to treat Candida fungal infection Inflammasomes in Aspergillos is Society for Leukocyte Biolog y Subscribe (free): Apple Podcasts , RSS , email Become...
Apr 09, 2025•25 min
Immune 90: Immunology of Injury March 25, 2025 From the 2024 Society for Leukocyte Biology meeting at Michigan State University, home of the Spartans, Immune's Cindy and Brianne talk with Liz Kovacs and Jim Lederer about their careers, dirty mice, old mice, and immunity during trauma. Hosts: Cindy Leifer and Brianne Barker Guests: James Lederer and Elizabeth Kovacs Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Jim Ledere...
Mar 25, 2025•53 min•Ep. 90
Immune Booster #10 HIV in the brain with Amanda Brown March 18, 2025 From the The Society for Leukocyte Biology 2024 conference at Michigan State University, Cindy and Brianne sit down with Amanda Brown from Johns Hopkins School of Medicine to talk about her career and the research of her laboratory on mechanisms of neuroinflammation in disease, especially during HIV infection. Hosts: Cindy Leifer and Brianne Barker Guest: Amanda Brown Society for Leukocyte Biolog y Subscribe (free): Apple Podca...
Mar 17, 2025•31 min
Immune discusses how non-neutralizing antibodies can still be protective…intracellularly, and a technically innovative paper that uses Lipstic to label antigen-presenting cells responsible for gut tolerance to food antigens. Hosts: Vincent Racaniello , Cindy Leifer , Steph Langel , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Non-neutralizing antibodies protect against CCHFV (Nat Comm) APC-T cell inte...
Feb 26, 2025•1 hr 23 min•Ep. 89
Immune describes the use of bespoke antibodies to characterize immune cell populations in cave nectar bats, and co-option of retrotransposons to activate hematopoietic stem cells and erythropoiesis. Hosts: Vincent Racaniello , Cindy Leifer , Steph Langel , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immune cells in cave nectar bats (Cell Rep) Cave nectar bat colony (J Am Asso Lab An Sci) Retrotranspo...
Jan 29, 2025•1 hr 29 min•Ep. 89
Immune discusses basophils as regulators of of lung inflammation over space and time, and neoself-antigens as the primary target for autoreactive T cells in human lupus. Hosts: Vincent Racaniello , Cindy Leifer , Steph Langel , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Basophils promote asthma (J Exp Med) Basophils regulate lung inflammation (J Exp Med) Neoself antigens are primary T cell targets i...
Jan 14, 2025•1 hr 9 min•Ep. 87
Immune explains how distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense, and failure to establish durable SARS-CoV-2-specific plasma cells in the bone marrow long-lived compartment after mRNA vaccination. Hosts: Vincent Racaniello , Cindy Leifer , Steph Langel , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Nasal mucsosal macrophages , neuronal maintenanc...
Nov 26, 2024•1 hr 5 min•Ep. 86
Immune explores the immunological diversity in the upper airway, including memory B and T cells and germinal center B cells, and how chronic infection with Plasmodium parasites leads to development of B cell cancers. Hosts: Vincent Racaniello , Cindy Leifer , Steph Langel , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immune memory diversity in human upper airway (Nature) How Plasmodium infection prom...
Oct 29, 2024•1 hr 12 min•Ep. 85
Petter Brodin joins Immune to discuss immune system adaptation in individuals assigned female sex at birth and undergoing gender affirming testosterone therapy (trans-men). Hosts: Vincent Racaniello , Cindy Leifer , Steph Langel , and Brianne Barker Guest: Petter Brodin Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Petter Brodin on TWiV 568 Gender-affirming testosterone treatment (Nature) Time stamps by Jolene . Thanks! ...
Sep 24, 2024•1 hr 5 min•Ep. 84
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Mark Shlomchik to talk about his career and the research of his laboratory on systemic autoimmune diseases, long-lived B cell immunity, and immunopathogenesis. Hosts: Cindy Leifer and Steph Langel Guest: Mark Shlomchik Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Music by Tatami . Logo image by Blausen Medical Send your immunology questions and comments to immune@m...
Sep 10, 2024•25 min
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Heather Caslin to talk about her training and the research of her laboratory on how diet and exercise affect innate immune cells in health and disease. Hosts: Cindy Leifer and Brianne Barker Guest: Heather Caslin Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Music by Tatami . Logo image by Blausen Medical Send your immunology questions and comments to immune@micro...
Sep 03, 2024•27 min
Immune discusses two stories of immune cells eating other cells: microglia engulfing brain neurons to shape cortical development and behavior, and mast cells trapping neutrophils to increase their functional and metabolic fitness. Hosts: Vincent Racaniello , Cindy Leifer , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Microglia shape cortical development and behavior (Cell) Neutrophil trapping by mast ...
Aug 27, 2024•1 hr 24 min•Ep. 83
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with David Martinez to talk about his career, the research of his laboratory on viral pathogens of global health importance, and his advice to be persistent and enjoy the journey. Hosts: Cindy Leifer and Steph Langel Guest: David Martinez Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Music by Tatami . Logo image by Blausen Medical Send your immunology questions and comme...
Aug 20, 2024•24 min
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Robert Binder to talk about his career, the research of his laboratory on the role of heat shock proteins in cancer immunosurveillance, and the importance of inspiring students as early as possible to think about science. Hosts: Cindy Leifer and Brianne Barker Guest: Robert Binder Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Music by Tatami . Logo image by Blause...
Aug 13, 2024•27 min
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Rafael Polidoro to talk about his career, the research of his laboratory on how the gut microbiome modulates the local and systemic immune responses during infections. Hosts: Cindy Leifer and Steph Langel Guest: Rafael Polidoro Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Music by Tatami . Logo image by Blausen Medical Send your immunology questions and comments to...
Aug 06, 2024•29 min
Immune reviews the local and systemic responses after human SARS-CoV-2 challenge infection, and how bat antibodies display elevated antigen binding strength and diversity at higher temperatures that are characteristic of flight. Hosts: Vincent Racaniello , Cindy Leifer , Stephanie Langel and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Responses to human SARS-CoV-2 challenge (Nature) Temperature-sensitivi...
Jul 30, 2024•1 hr 15 min•Ep. 82
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Jane Buckner to talk about her career, and the research of her laboratory on mechanisms by which regulation of the adaptive immune response fails or is overcome in the setting of human autoimmunity. Hosts: Cindy Leifer and Steph Langel Guest: Jane Buckner Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Music by Tatami . Logo image by Blausen Medical Send your immunolo...
Jul 23, 2024•20 min
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Tonya Webb to talk about her career, the role of NKT cells in cancer, and her efforts to ensure diversity, equity, and inclusion in research. Hosts: Cindy Leifer and Brianne Barker Guest: Tonya Webb Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Music by Tatami . Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Content ...
Jul 16, 2024•29 min
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Michal Tal to talk about her career, sex differences in immune responses, and how one giant mouse uterus changed the trajectory of her research career. Hosts: Cindy Leifer and Brianne Barker Guest: Michal Tal Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Music by Tatami . Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.t...
Jul 09, 2024•28 min
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne where meet up with Luis Montaner to talk about his career and his research on boosting the immune system to combat viral diseases or cancer progression. Hosts: Cindy Leifer and Brianne Barker Guest: Luis Montaner Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Links for this episode Community engagement in research (Res Involv Engag) Susceptibility to HIV bnAbs during ART (AIDS)...
Jul 02, 2024•26 min
Immune travels to Chicago for the American Association of Immunologists conference where they meet up with Joseph Larkin III to talk about his career and his research on the contribution of T lymphocyte subsets and functions in maintaining tolerance. Hosts: Stephanie Langel and Brianne Barker Guest: Joseph Larkin III Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Th17 cells in immunity and autoimmunity (J Immunol Res) COV...
Jun 25, 2024•41 min•Ep. 81
Immune presents three stories: intranasal neomycin and antiviral immunity, sexual dimorphism in skin immunity, and maternal diet changes infant microbes that alter gut DC responses and respiratory health. Hosts: Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Intranasal neomycin as antiviral (PNAS) Sexual dimorphism in skin immunity (Science) Maternal diet and infant r...
May 28, 2024•1 hr 16 min•Ep. 80
Immune explains how antibody-mediated depletion of myeloid-hematopoietic stem cells in aged mice restores characteristic features of a more youthful immune system, including increasing common lymphocyte progenitors, naive T cells and B cells, while decreasing age-related markers of immune decline. Hosts: Vincent Racaniello , Cynthia Leifer , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Serv...
May 26, 2024•1 hr 4 min•Ep. 79
Immune discusses responses in a COVID hypervaccinated individual, synthetically glycosylated antigens for the antigen-specific suppression of established immune responses, gut bacteria–derived serotonin promotes immune tolerance in early life, and mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge. Hosts: Vincent Racaniello , Steph Langel , Cynthia Leifer , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patro...
Mar 26, 2024•1 hr 24 min•Ep. 78
Immune reviews research showing that the migration of neutrophils between endothelial cells activates bactericidal function via mechanosensing. Hosts: Vincent Racaniello , Steph Langel , Cynthia Leifer , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Trans endothelial migration activates neutrophil killing (Immunity) Time stamps by Jolene . Thanks! Music by Steve Neal. Immune logo imag...
Feb 27, 2024•57 min•Ep. 77
Juliet Morrison joins Immune to discuss her career and the research of her laboratory showing that pleural macrophages translocate to the lung during infection to promote improved influenza outcomes. Hosts: Vincent Racaniello , Steph Langel , Cynthia Leifer , and Brianne Barker Guest: Juliet Morrison Click arrow to play Download Immune 76 (48 MB .mp3, 67 min) Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Serve...
Jan 30, 2024•1 hr 7 min•Ep. 76
Ang Cui joins Immune to discuss her career and her work on establishing the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo. Hosts: Vincent Racaniello , Cynthia Leifer , and Brianne Barker Guest: Ang Cui Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode MicrobeTV Disco...
Dec 28, 2023•1 hr 15 min•Ep. 75
Carla Nowosad joins Immune to discuss her career and her work on germinal centers, the structure in secondary lymphoid tissues where B cells proliferate, differentiate, and diversify their immunoglobulin genes by somatic hypermutation. Hosts: Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Carla R. Nowosad Subscribe (free): Apple Podcasts , Google Podcasts . RSS , email Become a patron of Immune! Links for this episode MicrobeTV Discord Server B cells and the intestinal microbiome ...
Dec 11, 2023•1 hr 11 min•Ep. 74
