Hope Lies in Dreams - podcast cover

Hope Lies in Dreams

Nature Biotechnologywww.nature.com
Stan Crooke rose from poverty to found a company that pioneered antisense drugs. After decades of struggle and years of public doubt, the company created a treatment that has saved thousands of children from the brutal disease spinal muscular atrophy.

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Episodes

Chapter 10: Dr. Crooke

The biggest deal ⬩ In the black ⬩ End of an era ⬩ n of 1 ⬩ Small places ⬩ A life of control ⬩ The doctor will see you now Hosted on Acast. See acast.com/privacy for more information.

Nov 10, 202151 minEp. 10

Chapter 9: the last of his kind

Award season ⬩ NURTURE, and Gabriel ⬩ Kyle Derkowski’s new future ⬩ The drugs of SMA ⬩ Piece of magic ⬩ Frank’s Super Bowl Hosted on Acast. See acast.com/privacy for more information.

Nov 03, 202139 minEp. 9

Chapter 8: part of something big

Ethics lessons ⬩ Biogen re-ups ⬩ The ultimate sacrifice ⬩ FDA as partner ⬩ Emma’s phase 3 ⬩ Doug Kerr’s bright idea ⬩ Isis to Ionis ⬩ Spinraza approval Hosted on Acast. See acast.com/privacy for more information.

Oct 27, 202142 minEp. 8

Chapter 7: the SMA gang

The Larsons ⬩ The skunkworks project ⬩ The most unmet need ⬩ Instant synergy ⬩ Another first for antisense ⬩ The clinic, again ⬩ The achievements of Kathie Bishop Hosted on Acast. See acast.com/privacy for more information.

Oct 20, 202140 minEp. 7

Chapter 6: lone voice in the wilderness

Rosanne saves the company ⬩ Ibis is sold ⬩ An approval ⬩ Souring on Genzyme ⬩ The end of Genta ⬩ The discovery of the SMA gene Hosted on Acast. See acast.com/privacy for more information.

Oct 13, 202143 minEp. 6

Chapter 5: valley of antisense

The genomics bubble ⬩ Affinitak fails ⬩ Lynne saves the company ⬩ Hybridon pivots ⬩ New chemistries ⬩ Regulus formed ⬩ Isis as cult Hosted on Acast. See acast.com/privacy for more information.

Oct 06, 202142 minEp. 5

Chapter 4: three kinds of failure

Stumbling out of the gate ⬩ Launch of Vitravene ⬩ Questions about antisense ⬩ The field thins ⬩ Clinical failure ⬩ The darkest days Hosted on Acast. See acast.com/privacy for more information.

Sep 29, 202144 minEp. 4

Chapter 3: San Diego restart

Rosanne ⬩ An investor emerges ⬩ Founding Isis ⬩ The old garage ⬩ A proper space ⬩ A growing antisense scene ⬩ Starting a pipeline ⬩ Isis goes public Hosted on Acast. See acast.com/privacy for more information.

Sep 22, 202148 minEp. 3

Chapter 2: a winding path

Quits Purdue ⬩ Pharmacy school ⬩ Off to Baylor ⬩ Harris Busch ⬩ Bristol Labs ⬩ SmithKline ⬩ The death of Nancy Crooke ⬩ The end of SmithKline Hosted on Acast. See acast.com/privacy for more information.

Sep 15, 202147 minEp. 2

Chapter 1: an ugly place

Stan Crooke is born ⬩ A tenuous existence ⬩ Life with his mother ⬩ The Tech Corner ⬩ Arsenal Tech High School ⬩ Nancy ⬩ Hoodlum ways ⬩ Off to Purdue Hosted on Acast. See acast.com/privacy for more information.

Sep 08, 202132 minEp. 1

Hope Lies in Dreams trailer

Trailer for upcoming 10-part series, Hope Lies in Dreams. Hosted on Acast. See acast.com/privacy for more information.

Sep 01, 20212 min
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