HIV

HIV is one of the worst epidemics in human history, and has had a devastating impact on populations worldwide. Our HIV podcasts describe the leading efforts by NDM researchers to develop new treatments and possible vaccines for HIV, as well as to understand and prevent its transmission, to help reduce the global HIV disease burden and improve outcomes for patients worldwide.

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Episodes

Can we eradicate HIV?

Dr John Frater talks about his research into finding a cure for HIV. It is increasingly apparent that highly active antiretroviral therapy (HAART) may not be the long-term solution to the management of HIV infection, and that other avenues need to be explored. As a result of various recent cases, the idea of eradicating HIV altogether is becoming less unimaginable to some scientists. Dr John Frater's work focuses on quantification of viral reservoirs, sequence analysis, immunology, as well as fu...

Dec 12, 2012•6 min

HIV Vaccine Development

Professor Tomas Hanke tells us about his research on HIV vaccine development. The enormous variations in HIV present big challenges in the development of a vaccine. Professor Tomáš Hanke focuses on the most conserved regions of the HIV-1 proteome, with the aim of developing a vaccine for both adult and mother-to-child transmission. Professor Hanke's group tests novel ideas and vaccine strategies, and focusses on a safe but rapid translation of the most promising laboratory results to phase I/II ...

May 22, 2012•6 min

HIV and children in Africa

Professor Sarah Rowland-Jones tells us about her work on HIV with children in Africa. HIV behaves very differently in children: while most adults are able to control the virus after infection, children often struggle to do so, resulting in an extremely high mortality rate. Professor Sarah Rowland-Jones aims to contribute to the design of vaccines and immunotherapies against HIV infection, including HIV-2 infection, for both adults and children, in developing countries where an effective vaccine ...

Feb 07, 2012•6 min

How can we live with HIV?

Dr Lucy Dorrell tells us how our immune system controls HIV and how we can live with this virus. There are currently around 91,000 people in the UK living with HIV/AIDS. HIV is a challenging target for a vaccine because it can mutate its genetic makeup. Dr Lucy Dorrell aims to develop immunotherapy to reduce dependence on antiretroviral therapy (ART), the current standard treatment for those infected with HIV-1. Worldwide, 9 million of the estimated 33 million people living with HIV/AIDS today a...

Jan 10, 2012•4 min

HIV immunology for Vaccine Design

Dr Seph Borrow tells us how her research on HIV Immunology helps design better vaccines. There is an urgent need for vaccines to combat persistent infections like HIV. The earliest interactions between HIV and host immune responses determine the course of the disease. Dr Seph Borrow is studying factors affecting virus control by HIV-specific CD8+ T cells, to inform the design of T cell-based HIV vaccines. Dr Borrow is also exploring the possibility of harnessing innate immune responses to combat...

Nov 01, 2011•8 min

Aiming for a HIV vaccine

Professor Sir Andrew McMichael tells us about recent developments in the search for a vaccine against HIV. As HIV infection continues to spread, particularly in developing countries there is an urgent need for a vaccine. After investigating the immune response to flu virus, Professor Sir Andrew McMichael turned his attention to HIV. Professor McMichael's current lines of research include analysing early molecular events in HIV infection, T cell immune response to HIV and the use of vaccination t...

Sep 13, 2011•7 min

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